Serotonin stimulates DNA synthesis in fibroblasts acting through 5–HT1B receptors coupled to a Gi-protein

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Nature

• Publication date

  1988-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/335254A0PMID 3045568
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C.

  1988cited by this paper
• Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide‐specific phospholipase C.

  1988cited by this paper
• Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

  1988cited by this paper
• Molecular analysis of signal transduction by growth factors.

  1988cited by this paper
• Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway.

  1988cited by this paper
• Molecular pharmacology and biology of 5-HT1C receptors.

  1988cited by this paper
• Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

  1988cited by this paper
• Polyphosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein, Gp

  1987cited by this paper
• Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

  1987cited by this paper
• Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

  1987cited by this paper
• Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway.

  1987cited by this paper
• 5-HT: The Enigma Variations

  1987cited by this paper
• Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat.

  1986cited by this paper
• Early signals in the mitogenic response.

  1986cited by this paper
• Stimulation of aortic smooth muscle cell mitogenesis by serotonin.

  1986cited by this paper
• Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin.

  1986cited by this paper
• Pertussis toxin inhibits thrombin‐induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.

  1986cited by this paper
• G proteins: a family of signal transducers.

  1986cited by this paper
• Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites.

  1986cited by this paper
• Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activity.

  1986cited by this paper
• Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

  1985cited by this paper
• Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation.

  1985cited by this paper
• Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

  1985cited by this paper
• Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.

  1984cited by this paper
• Reduction of epidermal growth factor receptor affinity by heterologous ligands: evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C.

  1984cited by this paper
• Serum, bradykinin and vasopressin stimulate release of inositol phosphates from human fibroblasts.

  1984cited by this paper
• Ni-mediated inhibition of human platelet adenylate cyclase by thrombin.

  1984cited by this paper
• Vasopressin inhibits the adenylate cyclase activity of human platelet particulate fraction through V1‐receptors

  1983cited by this paper
• Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

  1983cited by this paper
• Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

  1983cited by this paper
• Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.

  1982cited by this paper
• Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

  1982cited by this paper
• Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin.

  1981cited by this paper
• Role of cyclic nucleotides in growth control.

  1975cited by this paper

• The Role of the Tumor Microenvironment in Gastroenteropancreatic Neuroendocrine Tumors

  2025cites this paper
• Serotonin-modulating therapies for the management of chronic wounds

  2025cites this paper
• Congestive Heart Failure and Arrhythmias Among Hospitalized Patients With Carcinoid Syndrome

  2025cites this paper
• Environmental fluoxetine promotes skin cell proliferation and wound healing.

  2024cites this paper
• Carcinoid Heart Disease Management: A Multi-Disciplinary Collaboration

  2023cites this paper
• Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth in vivo

  2023cites this paper
• First quantitative dosages: Strong correlations between non-5-HT2Rs serotonin receptors on normal human heart valves

  2022influential citation
• Molecular Cloning and Functional Characterization of Three 5-HT Receptor Genes (HTR1B, HTR1E, and HTR1F) in Chickens

  2021cites this paper
• FAPI PET/CT: Will It End the Hegemony of 18F-FDG in Oncology?

  2020cites this paper
• Multicenter phase 2 trial of nintedanib in advanced nonpancreatic neuroendocrine tumors

  2020cites this paper
• Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocine Neoplasms: A Systematic Review

  2020cites this paper
• G protein-coupled receptors and signaling pathways

  2020cites this paper
• 5-Hydroxytryptophan (5-HTP)-induced intracellular syndrome in mouse non-neural embryonic cells is associated with inhibited proliferation and cell death.

  2019cites this paper
• Immunohistochemically characterization of serotonin reuptake transporter; 5-HT1B, 5-HT2A, 5-HT2B receptors, and tryptophan-5-hydroxylase expression in normal human hearts

  2018cites this paper
• Neuroendocrine tumours and fibrosis: An unsolved mystery? Running title: Neuroendocrine tumours and fibrosis Authors:

  2018cites this paper
• Role of the tumor microenvironment in digestive neuroendocrine tumors

  2018cites this paper
• Neuroendocrine tumors and fibrosis: An unsolved mystery?

  2017cites this paper
• Critical Aspects of Integrated Nonclinical Drug Development

  2017cites this paper
• The 5‐HT1A/1B‐receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and “waiting” impulsivity, but increases “stopping” impulsivity

  2017cites this paper
• The role of 5-HT1A and 5-HT1B receptors in MDMA self-administration

  2016cites this paper
• Cardiovascular Toxicity of Noncardiovascular Drugs

  2015cites this paper
• Diabetes Mellitus Causes Changes in the Heart Intrinsic Serotonergic System During the Development of the Cardiomyopathy

  2015cites this paper
• The 5-hydroxytryptamine transporter is functional in human coronary artery smooth muscle cells proliferation and is regulated by Interleukin-1 beta.

  2015cites this paper
• Increased endogenous serotonin level in diabetic conditions may lead to cardiac valvulopathy via reactive oxygen species regulation

  2015cites this paper
• Carcinoid Heart Disease: From Pathophysiology to Treatment - ‘Something in the Way It Moves'

  2015cites this paper
• Serotonin Enhances Megakaryopoiesis and Proplatelet Formation via p‐Erk1/2 and F‐Actin Reorganization

  2014cites this paper
• Implication de la sérotonine et des récepteurs 5-HT2 dans le remodelage valvulaire cardiaque

  2014cites this paper
• Development of inhibitors of heterotrimeric Gαi subunits.

  2014cites this paper
• Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension.

  2013cites this paper
• Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents

  2013cites this paper
• Serotonin and the 5‐HT7 receptor: The link between hepatocytes, IGF‐1 and small intestinal neuroendocrine tumors

  2013cites this paper
• Role of Serotonin in Angiogenesis in Diabetes

  2013cites this paper
• Circulating plasma and platelet 5-hydroxytryptamine in carcinoid heart disease: a pilot study.

  2013cites this paper
• Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement.

  2012cites this paper
• Serotonin activates angiogenic phosphorylation signaling in human endothelial cells

  2012cites this paper
• Serotonin: good or bad for bone.

  2012cites this paper
• Echocardiographic Evidence for Valvular Toxicity of Benfluorex: A Double-Blind Randomised Trial in Patients with Type 2 Diabetes Mellitus

  2012cites this paper
• Collagenous colitis and ileitis under treatment with duloxetine.

  2012cites this paper
• Role of the serotonergic system in alcohol dependence: from animal models to clinics.

  2011cites this paper
• A re-evaluation of the mitogenic effect of serotonin on vascular endothelial cells.

  2011cites this paper
• 5-HT 2A Receptor: A Newer Target for Obesity

  2011cites this paper
• Small intestinal neuroendocrine cell pathobiology: ‘carcinoid’ tumors

  2011cites this paper
• Dopamine Receptors and Parkinson's Disease

  2011cites this paper
• Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation

  2011cites this paper
• Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans.

  2010cites this paper
• Functional expression of 5-HT2A receptor in osteoblastic MC3T3-E1 cells.

  2010cites this paper
• The 5‐HT2B receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment

  2010cites this paper
• Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines

  2009cites this paper
• Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA).

  2009cites this paper
• Drug-induced fibrotic valvular heart disease.

  2009cites this paper
• Serotonergic drugs and valvular heart disease

  2009cites this paper
• Appetite suppressants, cardiac valve disease and combination pharmacotherapy.

  2009cites this paper
• Dual dopamine/serotonin releasers: potential treatment agents for stimulant addiction.

  2008cites this paper
• Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts.

  2008cites this paper
• Dopamine/serotonin releasers as medications for stimulant addictions.

  2008cites this paper
• Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking

  2008cites this paper
• Decreased Hepatic 5-HT1A Receptors During Liver Regeneration and Neoplasia in Rats

  2008cites this paper
• Fluoxetine inhibits the extracellular signal regulated kinase pathway and suppresses growth of cancer cells

  2008cites this paper
• Long-term serotonin effects in the rat are prevented by terguride.

  2007cites this paper
• Echocardiographic diagnosis of carcinoid disease: exceptional evolution after ovarian tumor resection without cardiac surgery.

  2007cites this paper
• Promoting Effects of Serotonin on Hematopoiesis: Ex Vivo Expansion of Cord Blood CD34+ Stem/Progenitor Cells, Proliferation of Bone Marrow Stromal Cells, and Antiapoptosis

  2007cites this paper
• Characterization of the G-protein coupling domains of the 5-HT1A receptor

  2007cites this paper
• Molecular signaling involved in regulating feeding and other motivated behaviors.

  2007cites this paper
• Molecular signaling involved in regulating feeding and other mitivated behaviors

  2007cites this paper
• In vivo model of drug-induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with echocardiography and correlation with pathology.

  2007cites this paper
• Involvement of Transforming Growth Factor-in the Formation of Fibrotic Lesions in Carcinoid Heart Disease

  2007cites this paper
• Therapeutic potentials of sarpogrelate in cardiovascular disease.

  2006cites this paper
• Long‐term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats

  2006cites this paper
• Cutaneous Manifestations of Internal Malignancy

  2006cites this paper
• The effect of 5-hydroxtryptamine on the regulation of megakaryocytopoiesis

  2006cites this paper
• 5-HT Receptor Signal Transduction Pathways

  2006cites this paper
• LES RECEPTEURS 5-HT1B : IMPLICATION DANS LE MECANISME D'ACTION DES ANTIDEPRESSEURS

  2006cites this paper
• Serotonin and fluoxetine modulate bone cell function in vitro

  2006cites this paper
• Side specific effect of 5-hydroxytryptamine on NaCl transport in the apical and basolateral membrane of rat tracheal epithelia.

  2006cites this paper
• Capsule G-Protein-coupled Receptors , Phosphoinositide Hydrolysis , and Cell Proliferation ’

  2005cites this paper
• Deficiency of the 5-Hydroxytryptamine Transporter Gene Leads to Cardiac Fibrosis and Valvulopathy in Mice

  2005cites this paper
• The 5-HT receptor — G-protein — effector system complex in depression I. Effect of glucocorticoids

  2005cites this paper
• Long-Term Serotonin Administration Induces Heart Valve Disease in Rats

  2005cites this paper
• Functional expression of mammalian opioid receptors in insect cells and high-throughput screening platforms for receptor ligand mimetics

  2005cites this paper
• The serotonin producing enterochromaffin cell, and effects of hyperserotoninemia on heart and bone.

  2005cites this paper
• 5‐HT1B receptor: a target for antidepressant drugs?

  2005cites this paper
• Cutaneous manifestations of the malignant carcinoid syndrome

  2005cites this paper
• Neuroendocrine cells in the normal, hyperplastic and neoplastic prostate

  2004cites this paper
• 5-Hydroxytryptamine 5-HT1B receptors inhibiting cyclic AMP accumulation in rat renal mesangial cells

  2004cites this paper
• Treatment with selective serotonin reuptake inhibitors for enhancing wound healing.

  2004cites this paper
• Serotonin and morphogenesis

  2004cites this paper
• Serotonin1B receptors: from protein to physiological function and behavior.

  2004cites this paper
• Functional activity of serotoninergic and melatoninergic systems expressed in the skin

  2003cites this paper
• Factors associated with progression of carcinoid heart disease.

  2003cites this paper
• Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle.

  2003cites this paper
• Serotonin and its transporter on proliferation of fetal heart cells

  2003cites this paper
• The proliferation of human T lymphoblastic cells induced by 5-HT1B receptors activation is regulated by 5-HT-moduline.

  2001cites this paper
• Multiplicity of mechanisms of serotonin receptor signal transduction.

  2001cites this paper
• Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders.

  2000cites this paper
• 5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways.

  2000cites this paper
• Impact of serotonin on tumour growth

  2000cites this paper
• INTERACTION OF TOBACCO-SPECIFIC TOXICANTS WITH NICOTINIC CHOLINERGIC REGULATION OF FETAL PULMONARY NEUROENDOCRINE CELLS: Implications for Pediatric Lung Disease

  2000cites this paper
• Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

  2000cites this paper
• Vascular smooth muscle proliferation: synergistic interaction between serotonin and low density lipoproteins.

  1999cites this paper
• Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.

  1999cites this paper