ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Molecules and Cells

• Publication date

  2018-04-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2018.02.024PMID 29576528
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Mechanisms of Deubiquitinase Specificity and Regulation.

  2017influential reference
• Activation of the ATR kinase by the RPA-binding protein ETAA1

  2016cited by this paper
• MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

  2016cited by this paper
• Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress

  2016cited by this paper
• Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

  2016influential reference
• HELB Is a Feedback Inhibitor of DNA End Resection.

  2016cited by this paper
• Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

  2015cited by this paper
• Emerging roles of Lys63‐linked polyubiquitylation in immune responses

  2015cited by this paper
• UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development

  2015cited by this paper
• Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.

  2015cited by this paper
• Role of Deubiquitinating Enzymes in DNA Repair

  2015cited by this paper
• End resection at double-strand breaks: mechanism and regulation.

  2014influential reference
• Establishment of a replication fork barrier following induction of DNA binding in mammalian cells

  2014cited by this paper
• Multiplex Genome Engineering Using CRISPR/Cas Systems

  2013cited by this paper
• Causes and consequences of replication stress

  2013cited by this paper
• Regulation of DNA damage responses by ubiquitin and SUMO.

  2013influential reference
• The dynamics of DNA damage repair and transcription.

  2013cited by this paper
• ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

  2013cited by this paper
• Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

  2012influential reference
• Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.

  2012influential reference
• Acetylation Limits 53BP1 Association with Damaged Chromatin to Promote Homologous Recombination

  2012influential reference
• Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions.

  2012influential reference
• Function and regulation of SUMO proteases

  2012cited by this paper
• DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

  2012cited by this paper
• Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

  2012cited by this paper
• The ubiquitin code.

  2012influential reference
• Ubiquitin-like proteins.

  2012cited by this paper
• The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice

  2011cited by this paper
• Structure of Ubiquitin-fold Modifier 1-specific Protease UfSP2*

  2011influential reference
• The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

  2011cited by this paper
• Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

  2011cited by this paper
• Systematic and quantitative assessment of the ubiquitin-modified proteome.

  2011cited by this paper
• A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles*

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• A Novel Type of E3 Ligase for the Ufm1 Conjugation System*

  2009cited by this paper
• Origin and function of ubiquitin-like proteins

  2009cited by this paper
• Ubiquitin-binding domains and their role in the DNA damage response.

  2009cited by this paper
• Nonproteolytic functions of ubiquitin in cell signaling.

  2009cited by this paper
• The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

  2009influential reference
• RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

  2009cited by this paper
• Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

  2009influential reference
• Global kinetic explorer: a new computer program for dynamic simulation and fitting of kinetic data.

  2009influential reference
• FitSpace explorer: an algorithm to evaluate multidimensional parameter space in fitting kinetic data.

  2009influential reference
• Active-site directed probes to report enzymatic action in the ubiquitin proteasome system

  2007cited by this paper
• Two Novel Ubiquitin-fold Modifier 1 (Ufm1)-specific Proteases, UfSP1 and UfSP2*

  2007cited by this paper
• Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5

  2006influential reference
• Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.

  2006influential reference
• Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis

  2005cited by this paper
• A genomic and functional inventory of deubiquitinating enzymes.

  2005cited by this paper
• Ubiquitin-proteasome system

  2004influential reference
• From silencing to gene expression: real-time analysis in single cells.

  2004cited by this paper
• A novel protein‐conjugating system for Ufm1, a ubiquitin‐fold modifier

  2004influential reference
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  2002cited by this paper
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  1999cited by this paper

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