Interrelationships of surface immunoglobulin and Fc receptors on mouse B lymphocytes.

Receptors for the Fc portion of immunoglobulin (Ig) molecules have been detected on mouse B lymphocytes by an immunofluorescence technique, employing immune complexes of fluorescein-conjugated KLH and rabbit anti-KLH antibody. At 37 degrees C, membrane-bound complexes rapidly undergo capping and clearing from the surface. Modulation of Fc receptors does not alter the amount of distribution of surface Ig, indicating that these two molecules are independent moieties. However, capping of surface Ig by intact or pepsin-digested anti-Ig antibody leads to co-capping of Fc receptors. These results suggest that ligand binding to surface Ig induces some alteration which allows the Ig to enter into an association with Fc receptors.

• Publication year

  1975

• Venue

  Journal of Immunology

• Publication date

  1975-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.115.6.1665PMID 1102608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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