Stimulation of immediate early gene expression in striatal neurons by nitric oxide.

Exposure of primary cultures of embryonic rat striatal neurons to agents releasing nitric oxide (NO), including sin-1 molsidomine, S-nitroso-n-acetyl-penicillamine (SNAP), and S-nitrosoglutathione, resulted in an increase in the levels of expression of the immediate early genes c-fos and zif/268 in the cultured neurons. The membrane-permeable cGMP analogue, 8-bromo-cGMP, did not significantly affect c-fos and zif/268 mRNA levels, and the highly selective inhibitor of cGMP-dependent protein kinase, KT5823, was unable to inhibit the elevation in c-fos and zif/268 mRNA levels induced by SNAP. The induction of c-fos by the calcium ionophore A23187 was reduced by treatment with SNAP or 8-bromo-cGMP. Inhibitors of ADP-ribosyltransferases attenuated the stimulation of c-fos expression by SNAP. These results demonstrate for the first time that NO can induce immediate early gene expression in neurons, suggesting that NO may act as a mediator of neuronal plasticity via alterations in the expression of downstream genes. In addition, the results suggest that NO may exert these effects through a pathway that does not involve guanylate cyclase and cGMP-dependent protein kinase.

• Publication year

  1995

• Venue

  Journal of Biological Chemistry

• Publication date

  1995-10-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.270.42.24740PMID 7559590
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Induction of c-fos and zif/268 gene expression in rat striatal neurons, following stimulation of D1-like dopamine receptors, involves protein kinase A and protein kinase C.

  1995cited by this paper
• Cyclic GMP inhibition of stimulated phosphoinositide hydrolysis in neuronal cultures.

  1995cited by this paper
• Haloperidol and Fluphenazine Induce junB Gene Expression in Rat Striatum and Nucleus Accumbens

  1994cited by this paper
• An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation.

  1994cited by this paper
• Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation

  1994cited by this paper
• Stimulation of the Cyclic GMP Pathway by NO Induces Expression of the Immediate Early Genes c‐fos and junB in PC12 Cells

  1994cited by this paper
• Redox signaling: nitrosylation and related target interactions of nitric oxide.

  1994cited by this paper
• Basic fibroblast growth factor induces c-fos expression in primary cultures of rat striatum.

  1994cited by this paper
• Phenotypic characterisation of rat striatal neurones in primary culture.

  1994cited by this paper
• Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.

  1994cited by this paper
• Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production.

  1993cited by this paper
• Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells

  1993cited by this paper
• A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

  1993cited by this paper
• cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis

  1993cited by this paper
• Novel action of nitric oxide as mediator of N-methyl-D-aspartate-induced phosphatidylinositol hydrolysis in neonatal rat cerebellum.

  1993cited by this paper
• Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.

  1993cited by this paper
• Nitric oxide-regulated endogenous ADP-ribosylation of rod outer segment proteins.

  1993cited by this paper
• Mono ADP‐ribosylation of transducin catalyzed by rod outer segment extract

  1992cited by this paper
• Cyclic GMP increases the rate of the calcium extrusion pump in intact human platelets but has no direct effect on the dense tubular calcium accumulation system.

  1992cited by this paper
• Modulation of endogenous ADP-ribosylation in rat brain.

  1992cited by this paper
• Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons.

  1992cited by this paper
• Nitric oxide decreases cytosolic free calcium in Balb/c 3T3 fibroblasts by a cyclic GMP-independent mechanism.

  1991cited by this paper
• Endogenous ADP‐Ribosylation in Brain: Initial Characterization of Substrate Proteins

  1991cited by this paper
• Glutamate, nitric oxide and cell-cell signalling in the nervous system.

  1991cited by this paper
• The regulation and function of c-fos and other immediate early genes in the nervous system.

  1990cited by this paper
• D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons.

  1990cited by this paper
• Differential expression of immediate early genes in the hippocampus and spinal cord.

  1990cited by this paper
• Messengers mediating long-term desensitization in cerebellar Purkinje cells.

  1990cited by this paper
• Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

  1989cited by this paper
• Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents.

  1989cited by this paper
• Neuronal localisation of neuropeptide Y gene expression in rat brain

  1989cited by this paper
• D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behaviour.

  1989cited by this paper
• Histochemical characterization of neuronal NADPH-diaphorase.

  1989cited by this paper
• Dopamine D2 receptors exert tonic regulation over discrete neurotensin systems of the rat brain.

  1989cited by this paper
• Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo.

  1989cited by this paper
• Regulation of intracellular Ca2+ levels in cultured vascular smooth muscle cells. Reduction of Ca2+ by atriopeptin and 8-bromo-cyclic GMP is mediated by cyclic GMP-dependent protein kinase.

  1989cited by this paper
• Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA: contrasting effects of D1 and D2 antagonists.

  1988cited by this paper
• Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

  1988cited by this paper
• The expression of gamma-aminobutyric acid and Leu-enkephalin immunoreactivity in primary monolayer cultures of rat striatum.

  1988cited by this paper
• Memories of fos

  1987cited by this paper
• A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

  1987cited by this paper
• Neuropeptides in neurologic and psychiatric disease.

  1986cited by this paper
• Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.

  1986cited by this paper
• Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons.

  1986cited by this paper
• Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: II. Calcium Requirement

  1984cited by this paper
• NADPH‐diaphorase: A selective histochemical marker for striatal neurons containing both somatostatin‐ and avian pancreatic polypeptide (APP)‐like immunoreactivities

  1983cited by this paper

• Correlation Analysis of CXCL10, FOS, HOXC13, and WNT4 Gene Polymorphisms with Key Economic Traits—Initial Population Screening for Jiangnan Cashmere Goats

  2025cites this paper
• The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats

  2024cites this paper
• Willis, A., Pratt, J. A. and Morris, B. J. (2018) Distortion of protein analysis in primary neuronal cultures by serum albumin from culture medium: a methodological approach to improve target protein

  2020cites this paper
• Skin transcriptome analysis identifies the key genes underlying fur development in Chinese Tan sheep in the birth and Er-mao periods.

  2020cites this paper
• Blue Light-Induced Gene Expression Alterations in Cultured Neurons Are the Result of Phototoxic Interactions with Neuronal Culture Media

  2019cites this paper
• Distortion of protein analysis in primary neuronal cultures by serum albumin from culture medium: A methodological approach to improve target protein quantification.

  2018cites this paper
• Modulation of Oxidative Stress Responses by Vitamin E, or Vitamin A plus Vitamin C Treatment in Human Retinal Pigment Epithelial Cells

  2015cites this paper
• Central blockade of nitric oxide transmission impairs exercise-induced neuronal activation in the PVN and reduces physical performance.

  2014cites this paper
• Nerve Growth Factor-Mediated Regulation of Low Density Lipoprotein Receptor-Related Protein Promoter Activation

  2013cites this paper
• Neurobiological effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in experimental paradigm of Alzheimer's disease.

  2013cites this paper
• Multiple Cell Signaling Pathways Modulate the Cocaine-Induced Increase in Mu Opioid Receptor Protein Expression in PC12 Cells

  2013cites this paper
• Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells

  2012cites this paper
• Modulation of oxidative stress responses in the human retinal pigment epithelium following treatment with vitamin C

  2011cites this paper
• Nitric Oxide–Soluble Guanylyl Cyclase–Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease?

  2011cites this paper
• Molecular Responses Transduced by Serial Oxidative Stress in the Retinal Pigment Epithelium: Feedback Control Modeling of Gene Expression

  2011cites this paper
• Altered apoptotic responses in neurons lacking RhoB GTPase

  2011cites this paper
• Autoantibodies from schizophrenia patients induce cerebral cox-1/iNOS mRNA expression with NO/PGE2/MMP-3 production.

  2010cites this paper
• Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications

  2010cites this paper
• Nitric Oxide Signaling in the Striatum

  2010cites this paper
• Chapter 10 - Nitric Oxide Signaling in the Striatum

  2010cites this paper
• Quantitative AP‐1 gene regulation by oxidative stress in the human retinal pigment epithelium

  2009cites this paper
• Striatal Nitric Oxide–cGMP Signaling in an Animal Model of Parkinson’s Disease

  2009cites this paper
• Retrograde signalling within fear neurocircuitry: Nitric oxide signalling from the lateral nucleus of the amygdala regulates thalamic EGR-1 mediated alterations of presynaptic protein levels during auditory fear conditioning

  2009cites this paper
• Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol

  2008cites this paper
• Lyase, Feedback, Biochemical, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Melanoma, Models, Biological, Neoplasm Metastasis, Nitric Oxide, Stilbenes, Transcription Factor AP-1

  2008cites this paper
• Regulation of neuronal cdc20 (p55cdc) expression by the plasticity‐related transcription factor zif268

  2007cites this paper
• Independency of myocardial stunning of endothelial stunning?

  2007cites this paper
• Mechanisms involved in the regulation of mRNA for M2 muscarinic acetylcholine receptors and endothelial and neuronal NO synthases in rat atria

  2007influential citation
• Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling

  2007cites this paper
• Frontal cortical afferents facilitate striatal nitric oxide transmission in vivo via a NMDA receptor and neuronal NOS‐dependent mechanism

  2007cites this paper
• Nitric oxide synthase inhibitors modulate nerve growth factor‐mediated regulation of amyloid precursor protein expression in PC12 cells

  2007cites this paper
• Nitric oxide synthase inhibition in rostral ventrolateral medulla attenuates pressor response to psychological stress in rabbits.

  2007cites this paper
• Oxidative Stress and Changed Gene Expression Profiles in Fiber-/Particle-Induced Carcinogenesis

  2007cites this paper
• Free radical biology and medicine: it's a gas, man!

  2006cites this paper
• Cellular / Molecular Regulation of the Neuronal Proteasome by Zif 268 ( Egr 1 )

  2006cites this paper
• Regulation of the Neuronal Proteasome by Zif268 (Egr1)

  2006cites this paper
• Nitric oxide and prostaglandins potentiate the liver regeneration cascade.

  2006cites this paper
• Correlations between neuronal nitric oxide synthase and muscarinic M3/M1 receptors in the rat retina.

  2005cites this paper
• The role of prostaglandins in triggering the liver regeneration cascade.

  2005cites this paper
• Inducible nitric oxide synthase subserves cholinergic vasodilation in retina

  2005cites this paper
• Oxidative stress resistance in skeletal muscle cells: role of vitamin C and redox sensitive transcription factors NF-KB and AP-1

  2005cites this paper
• Genomic profiling of the neuronal target genes of the plasticity‐related transcription factor – Zif268

  2005cites this paper
• N-Methyl-D-aspartate and Brain-Derived Neurotrophic Factor Induce Distinct Profiles of Extracellular Signal-Regulated Kinase, Mitogen- and Stress-Activated Kinase, and Ribosomal S6 Kinase Phosphorylation in Cortical Neurons

  2005cites this paper
• Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells.

  2005cites this paper
• Human mAChR antibodies from Sjögren syndrome sera increase cerebral nitric oxide synthase activity and nitric oxide synthase mRNA level.

  2004cites this paper
• Regulation of myosin light chain phosphorylation by RhoB in neuronal cells.

  2004cites this paper
• NMDA and BDNF induce distinct profiles of Extracellular regulated kinase (ERK), Mitogen and stress activated kinase (MSK) and Ribosomal S6 kinase (RSK) phosphorylation in cortical neurones.

  2004cites this paper
• Regulation of Gene Expression in the Nervous System by Reactive Oxygen and Nitrogen Species

  2004cites this paper
• NMDA and BDNF induce distinct profiles of Extracellular regulated kinase ( ERK ) , Mitogen and stress activated kinase ( MSK ) and Ribosomal S 6 kinase ( RSK ) phosphorylation in cortical neurones

  2004influential citation
• Continuous exposure to nitric oxide enhances diazepam binding inhibitor mRNA expression in mouse cerebral cortical neurons.

  2004cites this paper
• Protein tyrosine nitration is triggered by nerve growth factor during neuronal differentiation of PC12 cells.

  2003cites this paper
• Novel insight into the mechanisms involved in the regulation of the m1 muscarinic receptor, iNOS and nNOS mRNA levels.

  2003cites this paper
• Nitrosative Stress and Transcription

  2003cites this paper
• Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP‐1 gene induction in human melanoma cell lines

  2003cites this paper
• Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity.

  2003cites this paper
• Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches.

  2003cites this paper
• Role of Mitochondrial Oxygen and Nitrogen Reactive Species in Signaling

  2003cites this paper
• Role of Free Radicals and Cellular Redox Status in Signal Transduction and Gene Expression

  2003cites this paper
• The Spectrum of Responses of Oxidants in Proliferating Cells: Concentration, Concentration, Concentration

  2002cites this paper
• Free radicals in the physiological control of cell function.

  2002cites this paper
• A Novel Signaling Pathway of Nitric Oxide on Transcriptional Regulation of Mouse κ Opioid Receptor Gene

  2002cites this paper
• In situ hybridization with oligonucleotide probes.

  2002cites this paper
• Inhibitors of nitric oxide synthase attenuate nerve growth factor‐mediated increases in choline acetyltransferase expression in PC12 cells

  2002cites this paper
• Involvement of NMDA receptors and a p21Ras-like guanosine triphosphatase in the constitutive activation of nuclear factor-kappa-B in cortical neurons

  2002cites this paper
• Induction of differential patterns of local cerebral glucose metabolism and immediate-early genes by acute clozapine and haloperidol.

  2002cites this paper
• Role of nitric oxide and carbon monoxide in modulating the activity of the rodent hypothalamic-pituitary-adrenal axis.

  2002cites this paper
• Involvement of NMDA receptors and a p21Ras-like guanosine triphosphatase in the constitutive activation of nuclear factor-kappa-B in cortical neurons.

  2002cites this paper
• Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1.

  2002cites this paper
• NO as a signalling molecule in the nervous system

  2002cites this paper
• Regulation of Mammalian Gene Expression by Reactive Oxygen Species

  2002cites this paper
• In situ hybridization of astrocytes and neurons cultured in vitro.

  2002cites this paper
• Nitric oxide potentiates C-Fos mRNA expression after 2/3 partial hepatectomy.

  2002cites this paper
• Nitric oxide and the regulation of gene expression.

  2001cites this paper
• Shear stress-induced nitric oxide release triggers the liver regeneration cascade.

  2001cites this paper
• Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease

  2001cites this paper
• Localization of nitric oxide synthase-like immunoreactivity in the developing nervous system of the snail Ilyanassa obsoleta

  2001cites this paper
• iNOS is not involved in shear stress-induced nitric oxide release, which triggers the liver regeneration cascade.

  2001cites this paper
• Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization.

  2001cites this paper
• Activation of dopamine D3 receptors induces c‐fos expression in primary cultures of rat striatal neurons

  2000cites this paper
• Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain.

  2000cites this paper
• Tumor necrosis factor-alpha-induced activating protein-1 activity is modulated by nitric oxide-mediated protein kinase G activation.

  2000cites this paper
• Nitrosation and oxidation in the regulation of gene expression

  2000cites this paper
• Calmodulin-dependent activation of p38 and p42/44 mitogen-activated protein kinases contributes to c-fos expression by calcium in PC12 cells: modulation by nitric oxide.

  2000cites this paper
• Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems

  2000cites this paper
• Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a.

  2000cites this paper
• Nitric Oxide Activation of p38 Mitogen-activated Protein Kinase in 293T Fibroblasts Requires cGMP-dependent Protein Kinase*

  2000cites this paper
• Regulation of Neuronal Cell Adhesion Molecule Expression by NF-κB*

  2000cites this paper
• 7 – Regulation of Signal Transduction and Gene Expression by Reactive Nitrogen Species

  2000cites this paper
• Tumor Necrosis Factor- α –Induced Activating Protein-1 Activity Is Modulated by Nitric Oxide–Mediated Protein Kinase G Activation

  2000cites this paper
• 2 – Redox Regulation of Gene Expression

  2000cites this paper
• Nitric oxide synthase inhibitors reduce sarcomere addition in rat skeletal muscle

  1999cites this paper
• Nitric Oxide Regulation of Gene Transcription via Soluble Guanylate Cyclase and Type I cGMP-dependent Protein Kinase*

  1999cites this paper
• The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors.

  1999cites this paper
• The Broad Spectrum of Responses to Oxidants in Proliferating Cells: A New Paradigm for Oxidative Stress

  1999cites this paper
• Nitric Oxide Mediates Cerebral Ischemic Tolerance in a Neonatal Rat Model of Hypoxic Preconditioning

  1999cites this paper
• Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP‐dependent protein kinase

  1999cites this paper
• 4 – REGULATION OF ENERGY METABOLISM

  1999cites this paper
• Nitric oxide and Drosophila development

  1999cites this paper
• Nitric oxide mediates LC‐3‐dependent regulation of fibronectin in ductus arteriosus intimal cushion formation

  1999cites this paper
• Nitric oxide decreases surfactant protein A gene expression in H441 cells.

  1998cites this paper