Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature

• Publication date

  2002-04-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/416874aPMID 11976689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vascular perfusion of the cochlea: Effect of potassium-free and rubidium-substituted media

  2004cited by this paper
• Drosophila AP-1: lessons from an invertebrate

  2001cited by this paper
• Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala

  2001cited by this paper
• The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates.

  2001cited by this paper
• Potassium Recycling Pathways in the Human Cochlea

  2001cited by this paper
• Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein

  2001cited by this paper
• A genetic approach to understanding auditory function

  2001cited by this paper
• Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

  2001cited by this paper
• Mammalian MAP kinase signalling cascades

  2001cited by this paper
• K-Cl Cotransport: Properties and Molecular Mechanism

  2001cited by this paper
• Barttin is a Cl- channel β-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

  2001cited by this paper
• Gap junction systems in the mammalian cochlea.

  2000cited by this paper
• Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.

  2000cited by this paper
• Neuronal KCNQ potassium channels:physislogy and role in disease

  2000cited by this paper
• nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory.

  2000cited by this paper
• KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

  2000cited by this paper
• New insights into the pathogenesis of renal tubular acidosis – from functional to molecular studies

  2000cited by this paper
• Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

  1999cited by this paper
• Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness

  1999cited by this paper
• Cloning and Characterization of KCC3 and KCC4, New Members of the Cation-Chloride Cotransporter Gene Family*

  1999cited by this paper
• Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter

  1999cited by this paper
• Drosophila larval neuromuscular junction's responses to reduction of cAMP in the nervous system.

  1999cited by this paper
• KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.

  1999cited by this paper
• Mutation of the Na-K-Cl co-transporter gene Slc12a2 results in deafness in mice.

  1999cited by this paper
• Outward rectifying potassium currents are the dominant voltage activated currents present in Deiters' cells.

  1998cited by this paper
• Evidence for a medial K+ recycling pathway from inner hair cells.

  1998cited by this paper
• puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila.

  1998cited by this paper
• Genetic analysis of synaptic development and plasticity: homeostatic regulation of synaptic efficacy.

  1998cited by this paper
• A CREB‐binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

  1997cited by this paper
• Glutamate, But Not Dopamine, Stimulates Stress-Activated Protein Kinase and AP-1-Mediated Transcription in Striatal Neurons

  1997cited by this paper
• Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants

  1997cited by this paper
• Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene.

  1997cited by this paper
• Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

  1997cited by this paper
• Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]oregulation.

  1997cited by this paper
• Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

  1997cited by this paper
• Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation.

  1997cited by this paper
• AP-1 function and regulation.

  1997cited by this paper
• Germ line chimeras from female ES cells.

  1997cited by this paper
• Inner ear defects induced by null mutation of the isk gene.

  1996cited by this paper
• Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity.

  1996cited by this paper
• The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

  1996cited by this paper
• Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity.

  1996cited by this paper
• Toward a molecular definition of long-term memory storage.

  1996cited by this paper
• CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila.

  1995cited by this paper
• Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis

  1995cited by this paper
• Fos: an immediate-early transcription factor in neurons.

  1995cited by this paper
• Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila.

  1994cited by this paper
• Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions

  1994cited by this paper
• Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.

  1993cited by this paper
• Osmolytes in renal medulla during rapid changes in papillary tonicity.

  1992cited by this paper
• Creatine kinase in epithelium of the inner ear.

  1992cited by this paper
• Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia.

  1992cited by this paper
• Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade

  1992cited by this paper
• Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB.

  1990cited by this paper
• The regulation and function of c-fos and other immediate early genes in the nervous system.

  1990cited by this paper
• Stimulus‐related potassium changes in the organ of Corti of guinea‐pig.

  1989cited by this paper
• Renal excretion of rubidium and potassium: an electron microprobe and clearance study.

  1988cited by this paper

• Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction.

  2026cites this paper
• Inhibition of potassium chloride cotransporters impairs muscle contraction and induces atrophy in C2C12 myotubes.

  2025cites this paper
• Insights into early cochlear damage induced by potassium channel deficiency

  2025cites this paper
• Highly conserved ion binding sites are not all functionally relevant in mouse KCC4

  2025cites this paper
• Detecting Convergence of Amino Acid Physicochemical Properties Underlying the Organismal Adaptive Convergent Evolution

  2025cites this paper
• The biogenesis of potassium transporters: implications of disease-associated mutations

  2024cites this paper
• LRRC8/VRAC volume-regulated anion channels are crucial for hearing

  2024influential citation
• NKCC1 in Neonatal Cochlear Support Cells Reloads Ions Necessary for Cochlear Spontaneous Activity

  2024cites this paper
• Convergent gene losses and pseudogenizations in multiple lineages of stomachless fishes

  2024cites this paper
• Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System.

  2023cites this paper
• Modus operandi of ClC-K2 Cl− Channel in the Collecting Duct Intercalated Cells

  2023cites this paper
• The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies

  2023cites this paper
• The pathophysiology of distal renal tubular acidosis

  2023cites this paper
• From Fish Physiology to Human Disease: The Discovery of the NCC, NKCC2, and the Cation-Coupled Chloride Cotransporters

  2023cites this paper
• Apelin Regulation of K-Cl Cotransport in Vascular Smooth Muscle Cells as a Potential Target for Cardiovascular Disease

  2023cites this paper
• Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression

  2023cites this paper
• ClC-K Kidney Chloride Channels: From Structure to Pathology.

  2023cites this paper
• Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences.

  2022cites this paper
• Deletion of Notch1 during Cochlear Maturation Leads to Rapid Supporting Cell Death and Profound Deafness

  2022cites this paper
• Arterial Blood Pressure, Neuronal Excitability, Mineral Metabolism and Cell Volume Regulation Mechanisms Revealed by Xenopus laevis oocytes

  2022cites this paper
• Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)

  2022cites this paper
• Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans

  2022cites this paper
• Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy

  2022cites this paper
• In Vivo Optogenetics Reveals Control of Cochlear Electromechanical Responses by Supporting Cells

  2022cites this paper
• KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia

  2022cites this paper
• Active role of glia‐like supporting cells in the organ of Corti: Membrane proteins and their roles in hearing

  2022cites this paper
• Lysosomal solute and water transport

  2022cites this paper
• Sirtuin 7 serves as a promising therapeutic target for cardiorenal diseases.

  2022cites this paper
• Lung-Kidney Interactions and Their Role in Chronic Kidney Disease-Associated Pulmonary Diseases.

  2022cites this paper
• Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule

  2021cites this paper
• Diversity of developing peripheral glia revealed by single-cell RNA sequencing.

  2021cites this paper
• Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis

  2021cites this paper
• Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke

  2021cites this paper
• Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination

  2021cites this paper
• Bioelectric signaling as a unique regulator of development and regeneration.

  2021cites this paper
• WNK4 Kinase: from structure to physiology.

  2021cites this paper
• Axon–glia interactions in the ascending auditory system

  2021cites this paper
• Renal Tubular Acidosis

  2021cites this paper
• A systems-level analysis of bile acids effects on rat colon epithelial cells.

  2021cites this paper
• High-resolution views and transport mechanisms of the NKCC1 and KCC transporters.

  2021cites this paper
• SIRT7 modulates the stability and activity of the renal K‐Cl cotransporter KCC4 through deacetylation

  2021influential citation
• The Important Role of Ion Transport System in Cervical Cancer

  2021cites this paper
• Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss

  2021cites this paper
• In vivo optogenetics reveals homeostatic control of cochlear sensitivity by supporting cells

  2020cites this paper
• Diversity of developing peripheral glia revealed by single cell RNA sequencing

  2020cites this paper
• KCC2 is a hub protein that balances excitation and inhibition

  2020cites this paper
• Developmental expression of neuronal chloride transporters in different brain regions and sensory organs

  2020cites this paper
• Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway

  2020cites this paper
• Neuronal chloride transporters in neurodegenerative diseases

  2020cites this paper
• Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses

  2020cites this paper
• Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

  2020cites this paper
• Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters

  2020cites this paper
• Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans

  2020cites this paper
• Anatomy and Development of the Inner Ear

  2020cites this paper
• Screening and function discussion of a hereditary renal tubular acidosis family pathogenic gene

  2020cites this paper
• Twenty Metabolic Genes Based Signature Predicts Survival of Glioma Patients

  2020cites this paper
• Advances in the development of novel compounds targeting cation-chloride cotransporter physiology.

  2020cites this paper
• Molecular basis for regulation of human potassium chloride cotransporters

  2020cites this paper
• WNK4 kinase: role of chloride sensing in the distal convoluted tubule

  2020cites this paper
• Chloride transporters in physiological brain development and neurodevelopmental disorders: The case of the Down syndrome

  2020cites this paper
• Distal Convoluted Tubule Chloride Concentration is Modulated via Potassium Channels and Transporters.

  2020cites this paper
• Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development.

  2019cites this paper
• SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus

  2019cites this paper
• Discovery and Characterization of Novel Selective NKCC1 Inhibitors for Down Syndrome and Brain Disorders withDepolarizing GABAergic Transmission

  2019cites this paper
• Synthesis and biological evaluation of aza-crown ether-squaramide conjugates as anion/cation symporters.

  2019cites this paper
• The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases

  2019cites this paper
• Learning Physiology From Inherited Kidney Disorders.

  2019cites this paper
• Molecular Pathophysiology of Acid-Base Disorders.

  2019cites this paper
• Physiological roles and molecular mechanisms of K+‐Cl− cotransport in the mammalian kidney and cardiovascular system: where are we?

  2019influential citation
• Integrated K+ channel and K+-Cl− cotransporter functions regulate fin proportionality in zebrafish

  2019cites this paper
• WNK4 kinase is a physiological intracellular chloride sensor

  2019cites this paper
• Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice

  2019cites this paper
• Distal renal tubular acidosis: genetic causes and management

  2019cites this paper
• Régulation des variants d'épissage du cotransporteur rénal Na+-K+-Cl- de type 2 (NKCC2) : implication de la voie des kinases with no lysine (WNK)

  2019cites this paper
• Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs

  2019cites this paper
• Pathophysiology, diagnosis and treatment of inherited distal renal tubular acidosis

  2018cites this paper
• Phosphoregulation of K+‐Cl− cotransporters during cell swelling: Novel insights

  2018influential citation
• Mouse models of SLC4-linked disorders of HCO3--transporter dysfunction.

  2018cites this paper
• Evolution of Endolymph Secretion and Endolymphatic Potential Generation in the Vertebrate Inner Ear

  2018cites this paper
• Prestin Contributes to Membrane Compartmentalization and Is Required for Normal Innervation of Outer Hair Cells

  2018influential citation
• Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success

  2018cites this paper
• Empreinte développementale des cellules sensorielles auditives

  2018influential citation
• Renal Tubular Acidosis: H+/Base and Ammonia Transport Abnormalities and Clinical Syndromes.

  2018cites this paper
• Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi 1

  2018influential citation
• GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages

  2018cites this paper
• Improving outcomes for patients with distal renal tubular acidosis: recent advances and challenges ahead

  2018cites this paper
• Renal Chloride Channels in Relation to Sodium Chloride Transport.

  2018cites this paper
• A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development.

  2018cites this paper
• SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior

  2018cites this paper
• CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.

  2018cites this paper
• Spiking Pattern of the Mouse Developing Inner Hair Cells Is Mostly Invariant Along the Tonotopic Axis

  2018influential citation
• A role for KCC3 in maintaining cell volume of peripheral nerve fibers

  2018cites this paper
• Expression, Function, and Regulation of the K-Cl Cotransporter KCC2 isoforms in the Central Nervous System

  2018cites this paper
• Cotransporter-mediated water transport underlying cerebrospinal fluid formation

  2018cites this paper
• Quantitative Analysis of Supporting Cell Subtype Labeling Among CreER Lines in the Neonatal Mouse Cochlea

  2017cites this paper
• Dietary K+ and Cl− independently regulate basolateral conductance in principal and intercalated cells of the collecting duct

  2017cites this paper
• Molecular insights into the normal operation, regulation, and multisystemic roles of K+-Cl- cotransporter 3 (KCC3).

  2017cites this paper
• Measurements of ionic concentrations along with endocochlear potential in wild-type and claudin 14 knockout mice.

  2017cites this paper
• The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.

  2017cites this paper
• Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice

  2017cites this paper