Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature

• Publication date

  2014-08-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nature13660PMID 25156254PMCID PMC4214887
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

  2013cited by this paper
• Panta rhei: The APC/C at steady state

  2013cited by this paper
• Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

  2013cited by this paper
• Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex

  2013cited by this paper
• An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination

  2012cited by this paper
• Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

  2012cited by this paper
• Structure of the mitotic checkpoint complex

  2012cited by this paper
• APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1

  2012cited by this paper
• Cohesion Fatigue Explains Why Pharmacological Inhibition of the APC/C Induces a Spindle Checkpoint-Dependent Mitotic Arrest

  2012cited by this paper
• Cubism and the cell cycle: the many faces of the APC/C

  2011cited by this paper
• A Time-Series Method for Automated Measurement of Changes in Mitotic and Interphase Duration from Time-Lapse Movies

  2011cited by this paper
• Cubism and the cell cycle: the many faces of the APC/C

  2011cited by this paper
• How cyclin A destruction escapes the spindle assembly checkpoint

  2010cited by this paper
• The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit

  2010cited by this paper
• Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.

  2010cited by this paper
• Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.

  2010cited by this paper
• Substrate binding on the APC/C occurs between the co-activator CDH1 and the processivity factor DOC1

  2010cited by this paper
• Features and development of Coot

  2010cited by this paper
• Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

  2010cited by this paper
• Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

  2009cited by this paper
• Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

  2009cited by this paper
• MolProbity: all-atom structure validation for macromolecular crystallography

  2009cited by this paper
• A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment.

  2008cited by this paper
• Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

  2008cited by this paper
• Cdc20: a WD40 activator for a cell cycle degradation machine.

  2007cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

  2006cited by this paper
• An architectural map of the anaphase-promoting complex.

  2006cited by this paper
• Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

  2006cited by this paper
• The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

  2005cited by this paper
• Coactivator functions in a stoichiometric complex with anaphase‐promoting complex/cyclosome to mediate substrate recognition

  2005cited by this paper
• Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts.

  2005cited by this paper
• Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.

  2005cited by this paper
• The APC subunit Doc1 promotes recognition of the substrate destruction box.

  2005cited by this paper
• Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain

  2004cited by this paper
• research papers Acta Crystallographica Section D Biological

  2003cited by this paper
• Doc1 mediates the activity of the anaphase‐promoting complex by contributing to substrate recognition

  2003cited by this paper
• TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

  2003cited by this paper
• Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC

  2001cited by this paper
• Correspondence e-mail:

  2000cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Cell cycle extracts.

  1991cited by this paper
• Chapter 30 Cell Cycle Extracts

  1991cited by this paper
• Electronic Reprint Biological Crystallography Phenix : a Comprehensive Python-based System for Macromolecular Structure Solution

  year unknowncited by this paper

• Viral rewiring of APC/C-CDC20 drives Aurora B hyperubiquitination, mitotic regression and polyploidy

  2026cites this paper
• Beyond Binding Affinity: Detailed Profiling of Protein-Ligand Interactions with Time-Resolved FRET.

  2026cites this paper
• Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome

  2025cites this paper
• De Novo-Designed APC/C Inhibitors Provide a Rationale for Targeting RING-Type E3 Ubiquitin Ligases

  2025cites this paper
• The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

  2025cites this paper
• Epirubicin Induces Cell Cycle Arrest in Multiple Myeloma Cells by Downregulating CDC20 Expression.

  2025cites this paper
• Design, synthesis and optimization of Apcin analogues as Cdc20 inhibitors for triple-negative breast cancer therapy.

  2025cites this paper
• Biallelic mutations in CDC20 cause female infertility due to oocyte maturation abnormality

  2025cites this paper
• Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex

  2025cites this paper
• Ubiquitin-dependent proteolysis of KNL2 driven by APC/CCDC20 is critical for centromere integrity and mitotic fidelity

  2025cites this paper
• Pan-Cdk inhibitor ZK304709 suppresses Cdc20 expression and potentiates the anticancer activity of apcin in HeLa cervical cancer cells

  2025cites this paper
• Clearance of protein aggregates during cell division

  2025cites this paper
• The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

  2025cites this paper
• Condensin I confers Stiffness and Centromeric Cohesion to Mitotic Chromosomes

  2025cites this paper
• Comprehensive analysis of CDC20 as a prognostic biomarker in lung adenocarcinoma

  2025cites this paper
• Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer

  2025cites this paper
• The Use of APC/C Antagonists to Promote Mitotic Catastrophe in Cancer Cells.

  2025cites this paper
• Molecular glue degrader function of SPOP inhibitors enhances STING-dependent immunotherapy efficacy in melanoma models

  2025cites this paper
• Discovery of Cdc20/Hsp90 Dual-Target Inhibitors with Potent Antitumor Activity for Therapy of Acquired Resistant Melanoma.

  2025cites this paper
• APC/C coactivators Cdh1 and Cdc20: Mechanistic insights into cancer progression and therapeutic opportunities.

  2025cites this paper
• Spatial control of the APC/C ensures the rapid degradation of cyclin B1

  2024cites this paper
• Specialized replication mechanisms maintain genome stability at human centromeres.

  2024cites this paper
• Cell cycle machinery in oncology: A comprehensive review of therapeutic targets

  2024cites this paper
• Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis

  2024cites this paper
• Activation of the Anaphase Promoting Complex Restores Impaired Mitotic Progression and Chemosensitivity in Multiple Drug-Resistant Human Breast Cancer

  2024cites this paper
• The C-terminal disordered loop domain of Apc8 unlocks APC/C mitotic activation.

  2024cites this paper
• Suppressing Anaphase-Promoting Complex/Cyclosome–Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles

  2024cites this paper
• Targeting APC/CCDC20 by Pro-TAME Suppresses Tumor Proliferation and Induces Apoptosis in Endometrial Carcinoma

  2024cites this paper
• Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer

  2024cites this paper
• Mitoxantrone 2HCl’s adroit activity against cervical cancer replication and maintenance proteins: a multitargeted approach

  2024influential citation
• A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins

  2024cites this paper
• A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres

  2024influential citation
• Expanding the ligand spaces for E3 ligases for the design of protein degraders.

  2024cites this paper
• A resource to enable chemical biology and drug discovery of WDR Proteins

  2024cites this paper
• The cross talk of ubiquitination and chemotherapy tolerance in colorectal cancer

  2024cites this paper
• Kinetochore deterioration concommitant with centromere weakening during aging in mouse oocyte meiosis‐I

  2023cites this paper
• Structure-based virtual screening for identification of potential CDC20 inhibitors and their therapeutic evaluation in breast cancer

  2023cites this paper
• Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction

  2023cites this paper
• Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer

  2023cites this paper
• Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.

  2023cites this paper
• The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

  2023cites this paper
• Targeting Proliferation Signals and the Cell Cycle Machinery in Acute Leukemias: Novel Molecules on the Horizon

  2023cites this paper
• Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates.

  2023cites this paper
• SCFβTrCP-mediated degradation of SHARP1 in triple-negative breast cancer

  2023cites this paper
• CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of β-catenin.

  2023cites this paper
• CDC20: a novel therapeutic target in cancer.

  2023cites this paper
• AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation

  2023cites this paper
• p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma

  2023cites this paper
• Ubiquitin ligases: guardians of mammalian development

  2022cites this paper
• Design, Synthesis, and Biological Evaluation of Apcin-Based CDC20 Inhibitors.

  2022cites this paper
• Mobility of kinetochore proteins measured by FRAP analysis in living cells

  2022cites this paper
• Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C

  2022cites this paper
• Targeting Cdc20 for cancer therapy.

  2022cites this paper
• Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma

  2022cites this paper
• Centrosome Clustering & Chemotherapy.

  2022cites this paper
• Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast

  2022cites this paper
• CDC20-Mediated hnRNPU Ubiquitination Regulates Chromatin Condensation and Anti-Cancer Drug Response

  2022cites this paper
• APC/CCDC20 targets SCFFBL17 to activate replication stress responses in Arabidopsis.

  2022cites this paper
• Genomic and transcriptomic analyses of NF1-mutant melanoma identify potential targeted approach for treatment.

  2022cites this paper
• The Role of the APC/C and Its Coactivators Cdh1 and Cdc20 in Cancer Development and Therapy

  2022cites this paper
• Absence of a robust mitotic timer mechanism in early preimplantation mouse embryos leads to chromosome instability.

  2022cites this paper
• Up‐regulation of cell division cycle 20 expression alters the morphology of neuronal dendritic spines in the nucleus accumbens by promoting FMRP ubiquitination

  2022influential citation
• CDC20 in and out of mitosis: a prognostic factor and therapeutic target in hematological malignancies

  2022cites this paper
• CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.

  2022cites this paper
• The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development.

  2022cites this paper
• Counting Degrons: Lessons From Multivalent Substrates for Targeted Protein Degradation

  2022cites this paper
• Future prospects for mitosis-targeted antitumor therapies.

  2021cites this paper
• Potential of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges

  2021cites this paper
• The APC/C targets the Cep152–Cep63 complex at the centrosome to regulate mitotic spindle assembly

  2021cites this paper
• Ubiquitin Proteasome Pathway Transcriptome in Epithelial Ovarian Cancer

  2021cites this paper
• Cell cycle on the crossroad of tumorigenesis and cancer therapy.

  2021cites this paper
• Selected ideal natural ligand against TNBC by inhibiting CDC20, using bioinformatics and molecular biology

  2021cites this paper
• The Ubiquitin Proteasome System in Genome Stability and Cancer

  2021cites this paper
• SCIENTIFIC PROGRAMME ORGANIZING COMMITTEE

  2021cites this paper
• Chemical tools for dissecting cell division

  2021cites this paper
• Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C

  2021cites this paper
• Androgen receptor negatively regulates mitotic checkpoint signaling to induce docetaxel resistance in castration‐resistant prostate cancer

  2021cites this paper
• Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

  2021cites this paper
• Targeting mitotic exit in solid tumors.

  2021influential citation
• The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript

  2021cites this paper
• Chromosome oscillation promotes Aurora A–dependent Hec1 phosphorylation and mitotic fidelity

  2021cites this paper
• Apcin inhibits the growth and invasion of glioblastoma cells and improves glioma sensitivity to temozolomide

  2021cites this paper
• Ubiquitination of Nonhistone Proteins in Cancer Development and Treatment

  2021cites this paper
• A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models

  2021cites this paper
• SCFFbxw5 targets MCAK in G2/M to facilitate ciliogenesis in the following cell cycle

  2021cites this paper
• Inhibition of Cdc20 suppresses the metastasis in triple negative breast cancer (TNBC)

  2021influential citation
• Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents

  2021cites this paper
• Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy

  2021cites this paper
• Regulation of topoisomerase II stability and activity by ubiquitination and SUMOylation: clinical implications for cancer chemotherapy

  2021cites this paper
• Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse

  2021influential citation
• Taxanes in cancer treatment: Activity, chemoresistance and its overcoming.

  2021cites this paper
• SCFFbxw5 targets kinesin‐13 proteins to facilitate ciliogenesis

  2021cites this paper
• The Fanconi anemia ubiquitin E3 ligase complex as an anti-cancer target.

  2021cites this paper
• The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors

  2021cites this paper
• Using Budding Yeast to Identify Molecules That Block Cancer Cell ‘Mitotic Slippage’ Only in the Presence of Mitotic Poisons

  2021cites this paper
• muTarget: A platform linking gene expression changes and mutation status in solid tumors

  2020cites this paper
• Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

  2020cites this paper
• The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance

  2020cites this paper
• Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells

  2020cites this paper
• The role of ubiquitination in tumorigenesis and targeted drug discovery

  2020cites this paper