The dynamics of CD4+ T-cell depletion in HIV disease

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature

• Publication date

  2001-04-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/35073648PMID 11309627
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
• DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

  2000cited by this paper
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• Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.

  2000cited by this paper
• Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.

  2000cited by this paper
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  2000cited by this paper
• Ageing of lymphocytes and lymphocytes in the aged.

  2000cited by this paper
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  2000cited by this paper
• CD95's deadly mission in the immune system

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy.

  2000cited by this paper
• Factors influencing T-cell turnover in HIV-1-seropositive patients.

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Measurement of T-cell kinetics: recent methodologic advances.

  1999cited by this paper
• Markers of lymphocyte homing distinguish CD4 T cell subsets that turn over in response to HIV-1 infection in humans.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART). Swiss HIV Cohort Study.

  1998cited by this paper
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  1998cited by this paper
• CCR5- and CXCR4-Utilizing Strains of Human Immunodeficiency Virus Type 1 Exhibit Differential Tropism and Pathogenesis In Vivo

  1998cited by this paper
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  1998cited by this paper
• Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication.

  1998cited by this paper
• Looking after your neighbours Seattle-style.

  1998cited by this paper
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  1998cited by this paper
• Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

  1998cited by this paper
• High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

  1998cited by this paper
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  1998cited by this paper
• Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection.

  1998cited by this paper
• Direct HIV cytopathicity cannot account for CD4 decline in AIDS in the presence of homeostasis: a worst-case dynamic analysis.

  1998cited by this paper
• Immunopathogenesis of human immunodeficiency virus.

  1998cited by this paper
• Immune activation in the context of HIV infection

  1998cited by this paper
• The influence of human immunodeficiency virus-1 on hematopoiesis.

  1998cited by this paper
• Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease.

  1997cited by this paper
• Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

  1997cited by this paper
• Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

  1997cited by this paper
• Mechanisms of lymphocyte killing by HIV

  1997cited by this paper
• Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection

  1997cited by this paper
• Thymic function in HIV-1 disease.

  1997cited by this paper
• HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor κB

  1997cited by this paper
• Influence of age at infection on human immunodeficiency virus disease progression to different clinical endpoints: the SEROCO cohort (1988-1994). The Seroco Study Group.

  1997cited by this paper
• HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.

  1997cited by this paper
• T-cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host

  1997cited by this paper
• Liver Regeneration

  1997cited by this paper
• Reduced CD4 cell counts in blood do not reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV‐1 infection

  1996cited by this paper
• Early progression of disease in HIV-infected infants with thymus dysfunction.

  1996cited by this paper
• Lymphocyte Homing and Homeostasis

  1996cited by this paper
• Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1

  1996cited by this paper
• CD4+ cell turnover

  1995cited by this paper
• HIV results in the frame. CD4+ cell turnover.

  1995cited by this paper
• HIV results in the frame. CD4+ cell turnover.

  1995cited by this paper
• Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection.

  1995cited by this paper
• HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo.

  1995cited by this paper
• AIDS. Virological mayhem.

  1995cited by this paper
• Are HIV-specific CTL responses salutary or pathogenic?

  1995cited by this paper
• Altered representation of naive and memory CD8 T cell subsets in HIV-infected children.

  1995cited by this paper
• Viral dynamics in human immunodeficiency virus type 1 infection

  1995cited by this paper
• Virological mayhem

  1995cited by this paper
• CD4+ cell turnover

  1995cited by this paper
• CD4+ cell turnover

  1995cited by this paper
• Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

  1995cited by this paper
• HIV results in the frame. CD4+ cell turnover.

  1995cited by this paper
• The Hematopathology of HIV-1 Disease: Experimental Analysis in Vivo

  1995cited by this paper
• HUMAN HEMATOPOIESIS IN SCID MICE

  1995cited by this paper
• CD8 naive T cell counts decrease progressively in HIV-infected adults.

  1995cited by this paper
• Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1.

  1994cited by this paper
• Textbook of AIDS Medicine

  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• From HIV infection to AIDS: are the manifestations of effective immune resistance misinterpreted?

  1993cited by this paper
• Pathogenesis of human immunodeficiency virus infection

  1993cited by this paper
• HIV-1: the infective process in vivo.

  1991cited by this paper
• Differential distribution of antigen-specific helper T cells and cytotoxic T cells after antigenic stimulation in vivo. A functional study using limiting dilution analysis.

  1990cited by this paper
• Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system?

  1990cited by this paper
• Naive and memory T cells show distinct pathways of lymphocyte recirculation

  1990cited by this paper
• Pathogenesis of Human Immunodeficiency Virus Infection

  1989cited by this paper
• Non‐random migration of cd4 and cd8 t cells: changes in the cd4: cd8 ratio and interleukin 2 responsiveness of efferent lymph cells following in vivo antigen challenge

  1989cited by this paper
• The spleen in lymphocyte migration.

  1988cited by this paper
• Incubation periods for paediatric AIDS patients

  1988cited by this paper
• Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization.

  1986cited by this paper

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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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