BRCA1 phosphorylation: Biological consequences

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Biology & Therapy

• Publication date

  2006-03-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cbt.5.5.2845PMID 16721040
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.

  2006cited by this paper
• Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining.

  2006cited by this paper
• BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis.

  2005cited by this paper
• Molecular mechanisms of caspase regulation during apoptosis

  2004cited by this paper
• BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition*

  2004cited by this paper
• Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations

  2004cited by this paper
• Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

  2004cited by this paper
• Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1

  2004cited by this paper
• Breast Cancer Risk and the DNA Double-Strand Break End-Joining Capacity of Nonhomologous End-Joining Genes Are Affected by BRCA1

  2004cited by this paper
• BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

  2003cited by this paper
• Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.

  2003cited by this paper
• Extracellular Matrix Enhances Heregulin-Dependent BRCA1 Phosphorylation and Suppresses BRCA1 Expression through Its C Terminus

  2003cited by this paper
• AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

  2003cited by this paper
• Cell Cycle Differences in DNA Damage-induced BRCA1 Phosphorylation Affect Its Subcellular Localization*

  2003cited by this paper
• The BRCT Domain Is a Phospho-Protein Binding Domain

  2003cited by this paper
• BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks*

  2002cited by this paper
• Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

  2002cited by this paper
• Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

  2002cited by this paper
• Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells

  2002cited by this paper
• Concomitant inactivation of p53 and Chk2 in breast cancer

  2002cited by this paper
• A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining

  2002cited by this paper
• Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines

  2002cited by this paper
• Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase*

  2002cited by this paper
• Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells

  2002cited by this paper
• Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

  2001cited by this paper
• A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

  2001cited by this paper
• Identification of a gamma-tubulin-binding domain in BRCA1.

  2001cited by this paper
• Direct removal in the mouse of a floxed neo gene from a three‐loxp conditional knockout allele by two novel approaches

  2001cited by this paper
• Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation

  2001cited by this paper
• Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

  2001cited by this paper
• Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

  2001cited by this paper
• ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

  2000cited by this paper
• Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.

  2000cited by this paper
• Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

  2000cited by this paper
• CBP/p300 interact with and function as transcriptional coactivators of BRCA1.

  2000cited by this paper
• Brca1 required for T cell lineage development but not TCR loci rearrangement

  2000cited by this paper
• Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

  2000cited by this paper
• hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

  2000cited by this paper
• Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage.

  2000cited by this paper
• ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

  2000cited by this paper
• Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.

  1999cited by this paper
• Heregulin Induces Phosphorylation of BRCA1 through Phosphatidylinositol 3-Kinase/AKT in Breast Cancer Cells*

  1999cited by this paper
• Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members*

  1999cited by this paper
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

  1999cited by this paper
• BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site

  1999cited by this paper
• The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53

  1999cited by this paper
• Brca1 controls homology-directed DNA repair.

  1999cited by this paper
• A role for ATR in the DNA damage-induced phosphorylation of p53.

  1999cited by this paper
• Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.

  1999cited by this paper
• Genetic analysis of BRCA1 function in a defined tumor cell line.

  1999cited by this paper
• BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

  1999cited by this paper
• A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

  1998cited by this paper
• BRCA1 is associated with the centrosome during mitosis.

  1998cited by this paper
• Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

  1998cited by this paper
• Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

  1998cited by this paper
• Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

  1998cited by this paper
• Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.

  1998cited by this paper
• Enhanced phosphorylation of p53 by ATM in response to DNA damage.

  1998cited by this paper
• A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

  1998cited by this paper
• Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

  1998cited by this paper
• Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

  1997cited by this paper
• Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart.

  1997cited by this paper
• Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.

  1997cited by this paper
• BRCA1 is a cell cycle-regulated nuclear phosphoprotein.

  1997cited by this paper
• Heregulin‐stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity

  1997cited by this paper
• Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.

  1997cited by this paper
• DNA damage induces phosphorylation of the amino terminus of p53.

  1997cited by this paper
• Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

  1996cited by this paper
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  1996cited by this paper
• The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

  1996cited by this paper
• The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor*

  1996cited by this paper
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  1996cited by this paper
• Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

  1996cited by this paper
• Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

  1996cited by this paper
• The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

  1994cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• The retinoblastoma protein and the regulation of cell cycling.

  1992cited by this paper
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

  1992cited by this paper

• DGKζ depletion attenuates BRCA1-mediated DNA repair mechanism.

  2025cites this paper
• Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer

  2025cites this paper
• Obesity partially potentiates dimethylbenz[a]anthracene-exposed ovotoxicity by altering the DNA damage repair response in mice

  2023cites this paper
• Functional analysis of ATM variants in a high risk cohort provides insight into missing heritability.

  2022cites this paper
• Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice

  2022cites this paper
• PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining

  2022cites this paper
• BRCA1 transports the DNA damage signal for CDDP‐induced centrosome amplification through the centrosomal Aurora A

  2022cites this paper
• The BRCA1/BARD1 ubiquitin ligase and its substrates.

  2021cites this paper
• Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability

  2021influential citation
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• Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1

  2020cites this paper
• The BRCA1 c.4096+3A>G Variant Displays Classical Characteristics of Pathogenic BRCA1 Mutations in Hereditary Breast and Ovarian Cancers, But Still Allows Homozygous Viability

  2019cites this paper
• Aberrant Accumulation of BRCA1 in Alzheimer Disease and Other Tauopathies.

  2019cites this paper
• Genetic instability upon the loss of the tumour suppressor folliculin (FLCN)

  2019cites this paper
• Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors

  2018cites this paper
• Phosphodiesterase 4B plays a role in benzophenone‐3‐induced phototoxicity in normal human keratinocytes

  2018cites this paper
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  2018cites this paper
• 7 Structure-Function Relationship of DNA Repair Proteins : Lessons from BRCA 1 and RAD 51 Studies

  2017cites this paper
• RAD9A Stabilization and Destabilization Processes in Checkpoint Maintenance and Checkpoint Recovery

  2015cites this paper
• Exploring ATM and Methylation in Cancer: Emphasizing on Brain Tumors

  2015cites this paper
• Relationship of Breast Cancer with Ovarian Cancer

  2015cites this paper
• Changes in the expression of DNA double strand break repair genes in primordial follicles from immature and aged rats.

  2015cites this paper
• Searching the molecular mechanism by which p-cadherin expression confers resistance to DNA damage in normal and breast cancer cell lines

  2014cites this paper
• Opportunities and hurdles in the treatment of BRCA1-related breast cancer

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• Roles of Estrogens in Prostate Cancer Development via the Modulation of DNA-Repair System

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• Cancer of the Breast and Female Reproductive Tract

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  2013cites this paper
• DNA Damage Response Research, Inherent and Future Nano-Based Interfaces for Personalized Medicine

  2012cites this paper
• Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

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• Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome

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• PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells☆

  2012cites this paper
• The BRCA1 alternative splicing variant Δ14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells.

  2012cites this paper
• BRCA1 contributes to transcription‐coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein

  2011cites this paper
• DNA Damage Signaling Downstream of ATM

  2011cites this paper
• Structure-Function Relationship of DNA Repair Proteins: Lessons from BRCA1 and RAD51 Studies

  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
• Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

  2009cites this paper
• Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis.

  2009cites this paper
• The 4154delA mutation carriers in the BRCA1 gene share a common ancestry

  2008cites this paper
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  2008influential citation
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• Targeted and nontargeted effects of ionizing radiation that impact genomic instability.

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  2007cites this paper