Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature

• Publication date

  2002-09-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nature01023PMID 12214235
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT.

  2002cited by this paper
• Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects: systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma.

  2002cited by this paper
• Toll-like receptors and innate immunity

  2001cited by this paper
• Possible new role for NF-κB in the resolution of inflammation

  2001cited by this paper
• Possible new role for NF-kappaB in the resolution of inflammation.

  2001cited by this paper
• Soluble CD14 Mediates Efflux of Phospholipids from Cells1

  2001cited by this paper
• Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins.

  2001cited by this paper
• Atherosclerosis : Vascular biology

  2000cited by this paper
• Toll-like receptors in the induction of the innate immune response

  2000cited by this paper
• Tlr4: central component of the sole mammalian LPS sensor.

  2000cited by this paper
• Cutting Edge: Cationic Antimicrobial Peptides Block the Binding of Lipopolysaccharide (LPS) to LPS Binding Protein1

  2000cited by this paper
• Salmonella-Type Heptaacylated Lipid A Is Inactive and Acts as an Antagonist of Lipopolysaccharide Action on Human Line Cells

  2000cited by this paper
• Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction*

  1999cited by this paper
• Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils.

  1999cited by this paper
• Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

  1998cited by this paper
• Lactoferrin Inhibits the Endotoxin Interaction with CD14 by Competition with the Lipopolysaccharide-Binding Protein

  1998cited by this paper
• Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo *

  1997cited by this paper
• Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids.

  1997cited by this paper
• Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid.

  1997cited by this paper
• Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14

  1996cited by this paper
• E5531, a pure endotoxin antagonist of high potency.

  1995cited by this paper
• Lipopolysaccharide binding protein participation in cellular activation by LPS.

  1995cited by this paper
• Molecular mapping and detoxification of the lipid A binding site by synthetic peptides.

  1993cited by this paper
• In vitro inactivation of bacterial endotoxin by human lipoproteins and apolipoproteins

  1992cited by this paper
• Soluble CD14 participates in the response of cells to lipopolysaccharide

  1992cited by this paper
• Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.

  1991cited by this paper
• Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.

  1982cited by this paper

• From Damage Signals to Immune Modulators: Oxidized Lipids in Immunometabolic Inflammation.

  2026cites this paper
• Modification of the dermal matrix by senescence associated lipids and its functional consequence.

  2026cites this paper
• Phospholipid metabolism in innate immunity and inflammation: from basic to clinic

  2025cites this paper
• Integrated multi-omics analysis reveals the effect of glucose selenol improves rat immunity.

  2025cites this paper
• Specificity mechanism of Group VIA calcium-independent phospholipase A2 toward truncated-oxidized phospholipids and its application for specific inhibitor design.

  2025cites this paper
• Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections.

  2025cites this paper
• The non‐enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases

  2024influential citation
• LC-HRMS analysis of phospholipids bearing oxylipins.

  2024cites this paper
• Caspase-5: Structure, Pro-Inflammatory Activity and Evolution

  2024cites this paper
• CAF-associated genes putatively representing distinct prognosis by in silico landscape of stromal components of colon cancer

  2024influential citation
• Fatty Acid Release and Gastrointestinal Oxidation Status: Different Methods of Processing Flaxseed

  2024cites this paper
• How membrane phospholipids containing long chain polyunsaturated fatty acids and their oxidation products orchestrate lipid raft dynamics to control inflammation.

  2024cites this paper
• Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models

  2023cites this paper
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  2023cites this paper
• Impact of Truncated Oxidized Phosphatidylcholines on Phospholipase A2 Activity in Mono- and Polyunsaturated Biomimetic Vesicles

  2023cites this paper
• OxPAPC stabilizes liquid-ordered domains in biomimetic membranes.

  2023cites this paper
• Antimicrobial Tear Lipids in the Ocular Surface Defense

  2022cites this paper
• Biting the hand that feeds: Metabolic determinants of cell fate during infection

  2022cites this paper
• Low Concentrations of Oxidized Phospholipids Increase Stress Tolerance of Endothelial Cells

  2022cites this paper
• Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77

  2022cites this paper
• Oxidized phospholipids are biomarkers, drug targets, and drug leads

  2022cites this paper
• Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research.

  2022cites this paper
• Formulated Phospholipids as Non-Canonical TLR4 Agonists

  2022cites this paper
• Trans-Compartmental Regulation of Tight Junction Barrier Function

  2022cites this paper
• The Anti-Inflammatory Effect of Nanoarchaeosomes on Human Endothelial Cells

  2022cites this paper
• Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

  2022cites this paper
• Immunomodulatory effects of Isochrysis galbana incorporated diet on Oreochromis sp. (red hybrid tilapia) via Sera-1H NMR metabolomics study.

  2022cites this paper
• Innate immune detection of lipid oxidation as a threat assessment strategy

  2021cites this paper
• Oxidized Phospholipids in Control of Endothelial Barrier Function: Mechanisms and Implication in Lung Injury

  2021cites this paper
• Characterization of the Structural Diversity and Structure-Specific Behavior of Oxidized Phospholipids by LC-MS/MS.

  2021cites this paper
• Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer

  2021cites this paper
• Extension of Endogenous Field

  2021cites this paper
• Oxidized phospholipids on alkyl-amide scaffold demonstrate anti-endotoxin and endothelial barrier-protective properties.

  2021cites this paper
• 5-Dodecanolide, a Compound Isolated from Pig Lard, Presents Powerful Anti-Inflammatory Properties

  2021influential citation
• Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids

  2021cites this paper
• Novel Mechanisms of Ozone-Induced Pulmonary Inflammation and Resolution, and the Potential Protective Role of Scavenger Receptor BI.

  2021cites this paper
• Plasma Phospholipids: A Promising Simple Biochemical Parameter to Evaluate COVID-19 Infection Severity

  2021cites this paper
• 2D Black Phosphorus-Based Cytomembrane Mimics with Stimuli-Responsive Antibacterial Action Inspired by Endotoxin-Associated Toxic Behavior.

  2021cites this paper
• The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation

  2021cites this paper
• A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

  2021cites this paper
• Integration of transcriptional and metabolic control in macrophage activation

  2021cites this paper
• Péritoine : immunité, infections et cicatrisation péritonéale

  2021cites this paper
• Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection

  2021cites this paper
• Toll-Like Receptor-4-Mediated Inflammation is Involved in Intermittent Hypoxia-Induced Lung Injury

  2020cites this paper
• Innate Immune Interference Attenuates Inflammation In Bacillus Endophthalmitis

  2020cites this paper
• Therapeutic potential of lipids obtained from γ-irradiated PBMCs in dendritic cell-mediated skin inflammation

  2020cites this paper
• Reversible cross-tolerance to platelet-activating factor signaling by bacterial toxins

  2020cites this paper
• Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

  2020cites this paper
• Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome

  2020cites this paper
• Bacillus S-Layer-Mediated Innate Interactions During Endophthalmitis

  2020cites this paper
• Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways.

  2020cites this paper
• Epilipidomics of senescent dermal fibroblasts identify lysophosphatidylcholines as pleiotropic SASP factors.

  2020cites this paper
• An overview of the non-canonical inflammasome.

  2020cites this paper
• Oxidized phospholipids affect small intestine neuromuscular transmission and serotonergic pathways in juvenile mice

  2020cites this paper
• Oxidized Phospholipids in Healthy and Diseased Lung Endothelium

  2020influential citation
• Oregano (Origanum vulgare), St John's-wort (Hypericum perforatum), and lemon balm (Melissa officinalis) extracts improved the growth rate, antioxidative, and immunological responses in Nile tilapia (Oreochromis niloticus) infected with Aeromonas hydrophila

  2020cites this paper
• Gain of function mechanisms triggering biological effects of oxidized phospholipids

  2020cites this paper
• Oxidized phospholipid signaling: Distress to eustress

  2020cites this paper
• CD14: Not Just Chaperone, But a Key-Player in Inflammation

  2020cites this paper
• Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

  2019cites this paper
• Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy

  2019cites this paper
• Inflammasomes: Threat-Assessment Organelles of the Innate Immune System.

  2019cites this paper
• The Good and Bad Faces of Oxidized Phospholipids: Friends or Foes of Vascular Endothelium?

  2019cites this paper
• Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives

  2019cites this paper
• Lipids that directly regulate innate immune signal transduction

  2019cites this paper
• Oxidized lipids: not just another brick in the wall 1.

  2019influential citation
• An update on lipid oxidation and inflammation in cardiovascular diseases.

  2019cites this paper
• Phosphoinositide Regulation of Intracellular Nucleic Acid Sensors

  2019cites this paper
• Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

  2019influential citation
• Amendment history : Erratum ( October 2013 ) WAVE 1 mediates suppression of phagocytosis by phospholipid-derived DAMPs

  2018cites this paper
• Interferon regulatory factor 1–Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury

  2018cites this paper
• Lipid mediators in the regulation of endothelial barriers

  2018cites this paper
• Synthesis and Structure-Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues.

  2018cites this paper
• Association of Circulating Oxidized Lipids with Cardiovascular Outcomes

  2018cites this paper
• Oxidant Signaling Mediated by Nox2 in Neutrophils Promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage

  2018cites this paper
• Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis

  2018cites this paper
• The role of mitochondrial KATP channel in anti-inflammatory effects of uridine in endotoxemic mice.

  2018cites this paper
• A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids

  2018cites this paper
• Effects of Resistance Exercise Intensity on Cytokine and Chemokine Gene Expression in Atopic Dermatitis Mouse Model

  2018cites this paper
• The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

  2018cites this paper
• Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation.

  2017cites this paper
• Alpha linolenic acid decreases apoptosis and oxidized phospholipids in cardiomyocytes during ischemia/reperfusion

  2017cites this paper
• Multi-receptor detection of individual bacterial products by the innate immune system

  2017cites this paper
• Injured lung endothelium: mechanisms of self-repair and agonist-assisted recovery (2017 Grover Conference Series)

  2017cites this paper
• The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge

  2017cites this paper
• Study of the effects of docosahexaenoic acid ( DHA ) and a structured phospholipid containing DHA on physiological and pathological conditions of neurogenesis in vitro

  2017cites this paper
• Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation.

  2017cites this paper
• Platelet-activating factor and oxidized phosphatidylcholines do not suppress endotoxin-induced pro-inflammatory signaling among human myeloid and endothelial cells

  2017cites this paper
• Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development

  2017cites this paper
• Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell–Mediated Generation of LXA4

  2017cites this paper
• Adaptive and Innate Immune Systems

  2017cites this paper
• Study of the effects of docosahexaenoic acid (DHA) and a structured phospholipid containing DHA on physiological and pathological conditions of neurogenesis in vitro

  2017cites this paper
• OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes.

  2017cites this paper
• Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation.

  2017cites this paper
• The effect of oxidized phospholipids on phenotypic polarization and function of macrophages

  2017cites this paper
• Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

  2017cites this paper
• Pleiotropic effects of oxidized phospholipids.

  2017cites this paper
• Synthesis and Identification of AceDoxyPC, a Protectin-Containing Structured Phospholipid, Using Liquid Chromatography/Mass Spectrometry

  2017cites this paper
• Innate Immune Receptors as Competitive Determinants of Cell Fate.

  2017cites this paper
• Oxidized phospholipids exert a dual effect on bile acid-induced CCL2 expression in pancreatic acini.

  2017cites this paper