GM-CSF Produced by Nonhematopoietic Cells Is Required for Early Epithelial Cell Proliferation and Repair of Injured Colonic Mucosa

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Immunology

• Publication date

  2013-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1202368PMID 23325885PMCID PMC3563922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TLR3, TRIF, and Caspase 8 Determine Double-Stranded RNA-Induced Epithelial Cell Death and Survival In Vivo

  2013cited by this paper
• Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease.

  2011cited by this paper
• Role of IL-17A in the development of colitis-associated cancer.

  2011influential reference
• Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

  2011cited by this paper
• GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen.

  2010cited by this paper
• Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury

  2010influential reference
• Granulocyte‐macrophage colony‐stimulating factor elicits bone marrow‐derived cells that promote efficient colonic mucosal healing

  2010influential reference
• GM-CSF: a role in immune and inflammatory reactions in the intestine

  2010cited by this paper
• Steroid-sparing properties of sargramostim in patients with corticosteroid-dependent Crohn’s disease: a randomised, double-blind, placebo-controlled, phase 2 study

  2009cited by this paper
• Intestinal lamina propria dendritic cell subsets have different origin and functions.

  2009cited by this paper
• Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.

  2009cited by this paper
• Origin of the lamina propria dendritic cell network.

  2009cited by this paper
• Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease.

  2009cited by this paper
• STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

  2009influential reference
• IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

  2009influential reference
• Granulocyte macrophage colony‐stimulating factor ameliorates DSS‐induced experimental colitis

  2008influential reference
• The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation

  2008influential reference
• Colony-stimulating factors in inflammation and autoimmunity

  2008cited by this paper
• GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis.

  2007cited by this paper
• Dysregulation of reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes

  2006cited by this paper
• Functions of granulocyte-macrophage colony-stimulating factor.

  2005cited by this paper
• Sargramostim for active Crohn's disease.

  2005cited by this paper
• Clearance of Citrobacter rodentium Requires B Cells but Not Secretory Immunoglobulin A (IgA) or IgM Antibodies

  2004cited by this paper
• Microarray truths and consequences.

  2004cited by this paper
• Identification of GM-CSF in Paneth cells using single-cell RT-PCR.

  2003cited by this paper
• Increased Expression of HIP/PAP and Regenerating Gene III in Human Inflammatory Bowel Disease and a Murine Bacterial Reconstitution Model

  2003cited by this paper
• Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF.

  2003cited by this paper
• Biology of common β receptor–signaling cytokines: IL-3, IL-5, and GM-CSF

  2003cited by this paper
• In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.

  2002cited by this paper
• Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor.

  2002cited by this paper
• The influence of conditioned medium from mouse intestinal epithelial cells on the proliferative activity of crypt cells: role of granulocyte-macrophage colony-stimulating factor

  2002influential reference
• Effects of Granulocyte-Macrophage Colony-Stimulating Factor Produced by Intestinal Epithelial Cells on Functional Activity of Hemopoietic Stem Cells

  2002cited by this paper
• The immunology of mucosal models of inflammation.

  2002cited by this paper
• GM-CSF in inflammation and autoimmunity.

  2002cited by this paper
• Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I.

  2001cited by this paper
• Increased Secretion of Granulocyte-Macrophage Colony-Stimulating Factor in Mucosal Lesions of Inflammatory Bowel Disease

  2001cited by this paper
• Increased mucosal production of granulocyte colony‐stimulating factor is related to a delay in neutrophil apoptosis in Inflammatory Bowel disease

  1999cited by this paper
• GM‐CSF gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens

  1998cited by this paper
• FLT3 ligand gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens

  1998cited by this paper
• Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines

  1998cited by this paper
• The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells.

  1998cited by this paper
• Expression of GM-CSF and a functional GM-CSF receptor in the human colon carcinoma cell line SW403.

  1995cited by this paper
• A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

  1995cited by this paper
• Clinicopathologic study of dextran sulfate sodium experimental murine colitis.

  1993cited by this paper
• A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

  1990cited by this paper
• A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice.

  1990cited by this paper

• Myc inhibition triggers GM-CSF-driven regression of pancreatic tumours

  2026cites this paper
• Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids

  2025cites this paper
• Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids

  2024cites this paper
• Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling

  2024cites this paper
• Dietary monoglyceride supplementation to support intestinal integrity and host defenses in health-challenged weanling pigs.

  2024cites this paper
• Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk

  2024influential citation
• Strategies for targeting cytokines in inflammatory bowel disease

  2024cites this paper
• Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells

  2024cites this paper
• Sargramostim for Prophylactic Management of Gastrointestinal Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy for Cancer

  2024cites this paper
• GM-CSF in Allogenic Hematopoietic Stem Cell Transplantation: from Graft-versus-Host Disease to Graft-versus-Tumor effect.

  2024cites this paper
• The Protective Role of TLR4 in Intestinal Epithelial Cells through the Regulation of the Gut Microbiota in DSS-Induced Colitis in Mice.

  2023cites this paper
• Tetramerization of STAT5 regulates monocyte differentiation and the dextran sulfate sodium-induced colitis in mice

  2023cites this paper
• Effects of ruminal LPS exposure on primary bovine ruminal epithelial cells.

  2023influential citation
• Effects of oral wound on the neutrophil lineage in murine bone-marrow: Modulation mechanism hindered by chlorhexidine.

  2022cites this paper
• Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which?

  2022influential citation
• Single-cell immune profiling reveals a developmentally distinct CD4+ GM-CSF+ T-cell lineage that induces GI tract GVHD

  2022cites this paper
• Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.

  2022cites this paper
• Single-cell immune pro fi ling reveals a developmentally distinct CD4 1 GM-CSF 1 T-cell lineage that induces GI tract GVHD

  2022cites this paper
• GM-CSF: A Double-Edged Sword in Cancer Immunotherapy

  2022cites this paper
• Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies

  2021cites this paper
• Type III secretion system effectors form robust and flexible intracellular virulence networks

  2021cites this paper
• Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells.

  2020cites this paper
• c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice

  2020cites this paper
• Infected macrophages engage alveolar epithelium to metabolically reprogram myeloid cells and promote antibacterial inflammation

  2020cites this paper
• Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture

  2020cites this paper
• An in vitro intestinal model captures immunomodulatory properties of the microbiota in inflammation

  2020cites this paper
• Granulocyte-macrophage colony-stimulating factor protects mice against hepatocellular carcinoma by ameliorating intestinal dysbiosis and attenuating inflammation

  2020cites this paper
• Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation.

  2020cites this paper
• Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease

  2019cites this paper
• A Novel Endogenous Damage Signal, CSF-2, Activates Multiple Beneficial Functions of Adipose Tissue-Derived Mesenchymal Stem Cells.

  2019cites this paper
• Critical Role of Toll-Like Receptor 4 (TLR4) in Dextran Sulfate Sodium (DSS)-Induced Intestinal Injury and Repair.

  2019cites this paper
• Interleukin-1β-induced IRAK1 ubiquitination is required for TH-GM-CSF cell differentiation in T cell-mediated inflammation.

  2019cites this paper
• Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease

  2019cites this paper
• Title Dendritic cell immunoreceptor 1 alters neutrophil responses inthe development of experimental colitis

  2018cites this paper
• hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer

  2017cites this paper
• A novel in vitro macrophage senescence model to study macrophaging

  2017cites this paper
• Clinical Utility of Anti- Granulocyte Macrophage-Colony Stimulating Factor Antibodies in Inflammatory Bowel Disease

  2017cites this paper
• Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS)

  2017cites this paper
• Novel Targets for Drug Development

  2017cites this paper
• Galectin-9 Produced by Intestinal Epithelial Cells Enhances Aldehyde Dehydrogenase Activity in Dendritic Cells in a PI3K- and p38-Dependent Manner

  2017cites this paper
• Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing.

  2017cites this paper
• Airway epithelial cell and macrophage regulation of pulmonary immunity

  2017cites this paper
• Molecular Targets for Therapy

  2017cites this paper
• A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

  2016cites this paper
• ASCA, ANCA, ALCA and Many More: Are They Useful in the Diagnosis of Inflammatory Bowel Disease?

  2016cites this paper
• IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

  2016cites this paper
• Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators

  2016cites this paper
• Interferon γ-Induced Nuclear Interleukin-33 Potentiates the Release of Esophageal Epithelial Derived Cytokines

  2016cites this paper
• Dendrophthoe pentandra (L.) Miq extract effectively inhibits inflammation, proliferation and induces p53 expression on colitis-associated colon cancer

  2016cites this paper
• Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD16− Human Blood Monocytes in Serum-Free Condition

  2016cites this paper
• Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

  2016cites this paper
• Use of a feline respiratory epithelial cell culture system grown at the air-liquid interface to characterize the innate immune response following feline herpesvirus 1 infection.

  2016cites this paper
• Cellular Mechanisms of Immune and Hematopoietic Dysfunction Following Radiation and Burn Injuries

  2016cites this paper
• Granulocyte-Macrophage Colony Stimulating Factor Bioactivity and Mucosal Homeostasis in Crohn's Disease: A Role for Genetic Variation.

  2016cites this paper
• This information is current as Serum-Free Condition Human Blood Monocytes in − CD 16 high Langerhans-like Cells Can Arise from CD 14-ExpressinghighFunctional Langerin

  2016cites this paper
• GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury.

  2015cites this paper
• Systematic review: new serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes.

  2015cites this paper
• Sepsis: a roadmap for future research.

  2015cites this paper
• G-CSF and GM-CSF in Neutropenia

  2015cites this paper
• Experimental Models of Inflammatory Bowel Diseases

  2015cites this paper
• Novel Peroxisome Proliferator-Activated Receptor ( PPAR ) γ Agonist 2-Hydroxyethyl 5-Chloro-4 , 5-Didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis

  2015cites this paper
• Regulation of macrophage development and function in peripheral tissues

  2015cites this paper
• A Novel Peroxisome Proliferator-activated Receptor (PPAR)γ Agonist 2-Hydroxyethyl 5-chloro-4,5-didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis*

  2015cites this paper
• Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis

  2015cites this paper
• Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis

  2015cites this paper
• Role of GM-CSF in the inflammatory cytokine network that regulates neutrophil influx into the colonic mucosa during Clostridium difficile infection in mice

  2014influential citation
• MAbs Targeting Soluble Mediators in Phase 1 and 2 Clinical Studies Immunological Disorders

  2014cites this paper
• Granulocyte macrophage colony-stimulating factor and the 3 intestinal innate immune cell homeostasis in Crohn ' s disease

  2014cites this paper
• Promotes Intestinal Homeostasis Microbiota-Dependent Crosstalk Between Macrophages and ILC3

  2014cites this paper
• Microenvironment and Immunology Tumor-Derived GM-CSF Promotes In fl ammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF

  2014cites this paper
• Myeloperoxidase Oxidized LDL Interferes with Endothelial Cell Motility through miR-22 and Heme Oxygenase 1 Induction: Possible Involvement in Reendothelialization of Vascular Injuries

  2014cites this paper
• The intestinal epithelium is an integral component of a communications network.

  2014cites this paper
• Critical Role of the GM-CSF Signaling Pathway in Macrophage Pro-Repair Activities

  2014cites this paper
• Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF.

  2014cites this paper
• GM-CSF facilitates the development of inflammation-associated colorectal carcinoma

  2014cites this paper
• Preparing the ground for tissue regeneration: from mechanism to therapy

  2014cites this paper
• Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

  2014cites this paper
• Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn's disease.

  2014cites this paper
• intestinal innate immune cell homeostasis in Crohn's disease

  2014cites this paper
• Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis.

  2013cites this paper
• Granulocyte Macrophage Colony-Stimulating Factor Auto-Antibodies and Disease Relapse in Inflammatory Bowel Disease

  2013cites this paper
• REVIEW Experimental Models of In fl ammatory Bowel Diseases

  year unknowncites this paper
• Effects of ruminal lipopolysaccharide exposure on primary bovine ruminal epithelial cells

  year unknowninfluential citation