Experimental Models of Inflammatory Bowel Diseases

The understanding of the intestinal inflammation occurring in the inflammatory bowel diseases (IBD) has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD studies has been enabled by our improved knowledge of mucosal immunity and thus our improved ability to interpret the complex responses of mice with various causes of colitis; in addition, it has been powered by the availability of models in which the mice have specific genetic and/or immunologic defects that can be related to the origin of the inflammation. Finally, and more recently, it has been enhanced by our newly acquired ability to define the intestinal microbiome under various conditions and thus to understand how intestinal microorganisms impact on inflammation. In this brief review of murine models of intestinal inflammation, we focus mainly on the most often used models that are, not incidentally, also the models that have yielded major insights into IBD pathogenesis.

• Publication year

  2015

• Venue

  Cellular and Molecular Gastroenterology and Hepatology

• Publication date

  2015-01-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jcmgh.2015.01.006PMID 26000334PMCID 4435576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease.

  2014cited by this paper
• Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.

  2014cited by this paper
• IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis

  2014cited by this paper
• Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

  2014cited by this paper
• 410 Impaired Epithelial Barrier for Macromolecules in Ulcerative Colitis Is Caused by Downregulation of the Tricellular Tight Junction Protein Tricellulin, Mediated by the Interleukin-13 Receptor α2-Activated Pathway

  2014cited by this paper
• IL-13 Orchestrates Resolution of Chronic Intestinal Inflammation via Phosphorylation of Glycogen Synthase Kinase-3β

  2014cited by this paper
• The Alarmin IL-33 Promotes Regulatory T Cell Function in the Intestine

  2014cited by this paper
• NOD2 Down-Regulates Colonic Inflammation by IRF4-Mediated Inhibition of K63-Linked Polyubiquitination of RICK and TRAF6

  2014cited by this paper
• The Role of CXCR3 in DSS-Induced Colitis

  2014cited by this paper
• Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice.

  2014cited by this paper
• TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

  2014cited by this paper
• Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis

  2014cited by this paper
• Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis

  2014cited by this paper
• Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

  2014cited by this paper
• References Subscriptions Permissions Email Alerts A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene, mdr1a, Spontaneously Develop Colitis

  2013cited by this paper
• Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

  2013cited by this paper
• Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms

  2013cited by this paper
• GM-CSF Produced by Nonhematopoietic Cells Is Required for Early Epithelial Cell Proliferation and Repair of Injured Colonic Mucosa

  2013cited by this paper
• Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

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• Paneth cells as a site of origin for intestinal inflammation

  2013cited by this paper
• Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice.

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• Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation

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• The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

  2012cited by this paper
• MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10 deficient mice

  2012cited by this paper
• Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

  2012cited by this paper
• MyD 88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

  2012cited by this paper
• Induction and molecular signature of pathogenic TH17 cells

  2012cited by this paper
• Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

  2012cited by this paper
• Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

  2012cited by this paper
• IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

  2012cited by this paper
• Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

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• Paradoxically Increased FOXP3+ T Cells in IBD Do Not Preferentially Express the Isoform of FOXP3 Lacking Exon 2

  2012cited by this paper
• Commensal and Probiotic Bacteria Influence Intestinal Barrier Function and Susceptibility to Colitis in Nod1−/−;Nod2−/− Mice

  2012cited by this paper
• Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

  2012cited by this paper
• Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

  2012cited by this paper
• Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

  2011cited by this paper
• NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.

  2011cited by this paper
• Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.

  2011cited by this paper
• Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis.

  2011cited by this paper
• An essential role of the transcription factor GATA-3 for the function of regulatory T cells.

  2011cited by this paper
• Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases.

  2011cited by this paper
• This information is current as Inflammation and Tumorigenesis A Functional Role for Nlrp 6 in Intestinal and

  2011cited by this paper
• Interleukin-33 biology with potential insights into human diseases

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• Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells.

  2011cited by this paper
• Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.

  2011cited by this paper
• IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

  2011cited by this paper
• GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.

  2011cited by this paper
• Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

  2011cited by this paper
• The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.

  2011cited by this paper
• Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis

  2011cited by this paper
• Substance P modulates colitis-associated fibrosis.

  2010cited by this paper
• Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity*

  2010cited by this paper
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

  2010cited by this paper
• OX40 is required for regulatory T cell–mediated control of colitis

  2010cited by this paper
• Innate lymphoid cells drive IL-23 dependent innate intestinal pathology

  2010cited by this paper
• Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling

  2010cited by this paper
• MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

  2010cited by this paper
• The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation

  2010cited by this paper
• Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

  2010cited by this paper
• Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

  2010cited by this paper
• Characterization of the novel ST2/IL‐33 system in patients with inflammatory bowel disease

  2010cited by this paper
• Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis

  2010cited by this paper
• Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

  2010cited by this paper
• Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury

  2010cited by this paper
• Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis

  2010cited by this paper
• IL-33 is upregulated in colonocytes of ulcerative colitis.

  2010cited by this paper
• The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.

  2010cited by this paper
• Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases.

  2010cited by this paper
• Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

  2009cited by this paper
• Long-Lived Colitogenic CD4+ Memory T Cells Residing Outside the Intestine Participate in the Perpetuation of Chronic Colitis1

  2009cited by this paper
• STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

  2009cited by this paper
• Mechanisms of foxp3+ T regulatory cell-mediated suppression.

  2009cited by this paper
• Late developmental plasticity in the T helper 17 lineage.

  2009cited by this paper
• TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.

  2009cited by this paper
• A protective function for interleukin 17A in T cell–mediated intestinal inflammation

  2009cited by this paper
• Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.

  2009cited by this paper
• Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

  2009cited by this paper
• RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

  2009cited by this paper
• Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

  2008cited by this paper
• A microbial symbiosis factor prevents intestinal inflammatory disease

  2008cited by this paper
• IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis.

  2008cited by this paper
• Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

  2008cited by this paper
• XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.

  2008cited by this paper
• How regulatory T cells work

  2008cited by this paper
• A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis.

  2008cited by this paper
• A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease.

  2008cited by this paper
• Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

  2008cited by this paper
• Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

  2008cited by this paper
• Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

  2007cited by this paper
• Epithelial NEMO links innate immunity to chronic intestinal inflammation

  2007cited by this paper
• Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.

  2007cited by this paper
• Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.

  2007cited by this paper
• Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.

  2007cited by this paper
• IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

  2007cited by this paper
• Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.

  2007cited by this paper
• Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans

  2007cited by this paper
• Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.

  2007cited by this paper
• IL-7 Is Essential for the Development and the Persistence of Chronic Colitis1

  2007cited by this paper
• TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

  2007cited by this paper
• Role of toll-like receptors in spontaneous commensal-dependent colitis.

  2006cited by this paper

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