The matabolic fuel regulatory system: implications for protein-sparing therapies during caloric deprivation and disease.

No abstract is available for this paper.

• Publication year

  1974

• Venue

  American Journal of Clinical Nutrition

• Publication date

  1974-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/AJCN/27.2.175PMID 4204849
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunoassay of endogenous plasma insulin in man.

  1996cited by this paper
• Protein Sparing Therapy during Periods of Starvation with Sepsis or Trauma

  1973cited by this paper
• Peripheral intravenous feeding with isotonic amino acid solutions.

  1973cited by this paper
• The intravenous use of fat for the total parenteral nutrition of the infant

  1972cited by this paper
• Role of the increased adipose tissue mass in the apparent insulin insensitivity of obesity.

  1972cited by this paper
• Carbohydrate and lipid oxidation in normal human subjects: its influence on glucose tolerance and insulin response to glucose.

  1972cited by this paper
• The biological significance of the prostaglandins.

  1971cited by this paper
• Insulin and glucose to reduce catabolic response to injury in burned patients.

  1971cited by this paper
• Carbohydrate metabolism in man: effect of elective operations and major injury.

  1971cited by this paper
• The effect of alanine on glucagon secretion.

  1971cited by this paper
• Hyperosmolar nonketotic coma with hyperglycemia: abnormalities of lipid and carbohydrate metabolism.

  1971cited by this paper
• [Utilization of non-esterified fatty acids and ketone nbodies in human brain].

  1971cited by this paper
• The influence of the antecedent diet upon glucagon and insulin secretion.

  1971cited by this paper
• Glucagon physiology and pathophysiology.

  1971cited by this paper
• The Banting Memorial Lecture 1971. Physiology of insulin in man.

  1971cited by this paper
• Some endocrine and metabolic aspects of obesity.

  1970cited by this paper
• Intravenous hyperosmolar alimentation.

  1970cited by this paper
• Significance of insulin in the metabolic adaptation of rats to meal ingestion.

  1970cited by this paper
• Intravenous hyperalimentation.

  1970cited by this paper
• Plasma Amino Acid Levels in Diabetic Ketoacidosis

  1970cited by this paper
• Effect of insulin and acute diabetes on plasma FFA and ketone bodies in the fasting rat.

  1970cited by this paper
• Glucagon levels and metabolic effects in fasting man.

  1970cited by this paper
• How metabolism affects clinical problems.

  1970cited by this paper
• Alanine: Key Role in Gluconeogenesis

  1970cited by this paper
• The control by insulin of amino acid accumulation in muscle.

  1970cited by this paper
• Stimulation of urea synthesis in the fasting rat by the antilipolytic agent 3,5-dimethylisoxazole.

  1970cited by this paper
• In vitro effects of isoproterenol and propranolol on human adipose tissue.

  1970cited by this paper
• Synergistic Effect of Essential Amino Acids and Glucose upon Insulin Secretion in Man

  1970cited by this paper
• Human insulin secretion: as integrated approach.

  1970cited by this paper
• Liver and kidney metabolism during prolonged starvation.

  1969cited by this paper
• Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels.

  1969cited by this paper
• Turnover and oxidation of plasma glucose in lean and obese humans.

  1969cited by this paper
• Ketogenesis and its regulation.

  1968cited by this paper
• Turnover rates of ketone bodies in normal, starved and alloxan-diabetic rats.

  1968cited by this paper
• Effect of acute hypophysectomy and growth hormone on FFA mobilization, nitrogen excretion and cardiac glycogen in fasting rats.

  1968cited by this paper
• Suppression of pyruvate oxidation in liver mitochondria in the presence of long-chain fatty acid.

  1968cited by this paper
• The redox state of nicotinamide adenine dinucleotide in the cytoplasm and mitochondria of rat liver.

  1967cited by this paper
• Brain metabolism during fasting.

  1967cited by this paper
• Effects of nicotinic acid on the choice of substrates utilized during fasting.

  1967cited by this paper
• Physiologic Effects of Metabolic Fuels on Carbohydrate Metabolism: I. Acute Effect of Elevation of Plasma Free Fatty Acids on Hepatic Glucose Output, Peripheral Glucose Utilization, Serum Insulin, and Plasma Glucagon Levels

  1967cited by this paper
• Turnover rate of plasma FFA in humans and in dogs.

  1967cited by this paper
• Studies in the ketosis of fasting.

  1967cited by this paper
• Stimulation of insulin secretion by amino acids.

  1966cited by this paper
• Metabolic balance of obese subjects during fasting.

  1966cited by this paper
• Effect of insulin on adenosine 3',5'-monophosphate in the rat epididymal fat pad.

  1966cited by this paper
• Effect of glucocorticoids on plasma insulin.

  1966cited by this paper
• GLUCOSE UPTAKE BY INCUBATED RAT EPIDIDYMAL ADIPOSE TISSUE. RATE-LIMITING STEPS AND SITE OF INSULIN ACTION.

  1965cited by this paper
• OXIDATION OF AMINO ACIDS BY ISOLATED RAT DIAPHRAGM AND THE INFLUENCE OF INSULIN.

  1965cited by this paper
• Correlation between ketone body and free fatty acid concentrations in the plasma during early starvation in man.

  1965cited by this paper
• Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles.

  1964cited by this paper
• EFFECTS OF THE PROSTAGLANDINS ON HORMONE-INDUCED MOBILIZATION OF FREE FATTY ACIDS.

  1964cited by this paper
• THE HYPOGLYCEMIC ACTION OF KETONES. II. EVIDENCE FOR A STIMULATORY FEEDBACK OF KETONES ON THE PANCREATIC BETA CELLS.

  1964cited by this paper
• ACTIVATION OF AN EPINEPHRINE-SENSITIVE LIPOLYTIC ACTIVITY FROM ADIPOSE TISSUE BY ADENOSINE 3',5'-PHOSPHATE.

  1964cited by this paper
• INFLUENCE OF FREE-FATTY-ACID METABOLISM ON GLUCOSE TOLERANCE.

  1964cited by this paper
• The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.

  1963cited by this paper
• Studies on the metabolism of adipose tissue. XII. The effects of insulin and epinephrine on free fatty acid and glycerol production in the presence and absence of glucose.

  1963cited by this paper
• Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay

  1963cited by this paper
• Regulation of glucose uptake in muscle. I. The effects of insulin and anoxia on glucose transport and phosphorylation in the isolated, perfused heart of normal rats.

  1961cited by this paper
• Studies on rat adipose tissue in vitro. VI. Effect of epinephrine on glucose metabolism.

  1960cited by this paper
• INSULIN‐STIMULATED GLYCOGEN FORMATION IN RAT DIAPHRAGM *

  1959cited by this paper
• Studies on rat adipose tissue in vitro. I. Effects of insulin on the metabolism of glucose, pyruvate, and acetate.

  1958cited by this paper
• Experience with administration of an intravenous fat emulsion to surgical patients.

  1957cited by this paper
• An Approach to the Prediction of Diabetes Mellitus by Modification of the Glucose Tolerance Test with Cortisone

  1954cited by this paper
• Changes in body composition and respiratory quotient of adult female rats treated with purified growth hormone.

  1953cited by this paper
• Action of insulin on the 'permeability' of cells to free hexoses, as studied by its effect on the distribution of galactose.

  1950cited by this paper
• The role of insulin in the metabolism of amino acids.

  1949cited by this paper
• The distribution of nitrogen and sulphur in the urine during conditions of increased catabolism.

  1931cited by this paper

• Ketogenic diets in chronic kidney disease patients: a review for skeptics by skeptics

  2025cites this paper
• Association between ß-hydroxybutyrate plasma concentrations after hypocaloric ketogenic diets and changes in body composition.

  2023cites this paper
• The Use of Evidence-Based Dietary Interventions for the Management of Obesity

  2023cites this paper
• Effects of ketone bodies on energy expenditure, substrate utilization, and energy intake in humans

  2023cites this paper
• Composition of weight lost during short-term weight reduction. Metabolic responses of obese subjects to starvation and low-calorie ketogenic and nonketogenic diets.

  2018cites this paper
• Scientific Opinion on the essential composition of total diet replacements for weight control

  2018cites this paper
• Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

  2018cites this paper
• Protein sparing therapies in acute illness and obesity: a review of George Blackburn's contributions to nutrition science.

  2017cites this paper
• Early Enteral Feeding Vs Late Enteral Feeding in patients undergoing Upper gastrointestinal surgery in Government Rajaji Hospital, Madurai

  2015cites this paper
• Scientific Opinion on the essential composition of total diet replacements for weight control

  2015cites this paper
• Protein Nutrition, Meal Timing, and Muscle Health

  2013cites this paper
• The Effects of Substrate Oxidation on Post-exercise Food Intake in Pre-pubertal, Normal-weight Boys and Men

  2013cites this paper
• Cellular responses induced by environmental stress factors in Arctic Seabird chicks : Responses of the antioxidant defense system and autophagic lysosomal processes related to contaminant exposure and food restriction

  2011cites this paper
• What's Wrong

  2008cites this paper
• Comparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular risk

  2006cites this paper
• The treatment of obesity by carbohydrate deprivation suppresses plasma tryptophan and its ratio to other large neutral amino acids

  2005cites this paper
• Rainbow diet : a new nutrition education tool

  2004cites this paper
• Guidelines for enteral feeding in adult hospital patients

  2003cites this paper
• 3. Protein diets for obesity: metabolic and clinical aspects

  2001cites this paper
• 11 Physiological and Metabolic Control of Macronutrient Balance

  2000cites this paper
• Total parenteral nutrition on energy metabolism in children undergoing autologous peripheral blood stem cell transplantation.

  1998cites this paper
• Changes in lean body mass in obese children and adolescents treated with protein sparing modified fast

  1998cites this paper
• Treatment of childhood and adolescent obesity.

  1998cites this paper
• Glycogen levels and obesity.

  1996cites this paper
• Resting energy expenditure in patients with thalassemia major.

  1995cites this paper
• Body composition, respiratory quotient, and weight maintenance.

  1995cites this paper
• McCollum Award Lecture, 1995: diet, lifestyle, and weight maintenance.

  1995cites this paper
• [Role of anabolic hormonal factors in surgery in adults].

  1995cites this paper
• Place des facteurs hormonaux anabolisants lors de chirurgie chez l'adulte

  1995cites this paper
• Effect of NIDDM on the Kinetics of Whole-Body Protein Metabolism

  1994cites this paper
• Lipolysis and gluconeogenesis from glycerol during weight reduction with very-low-calorie diets.

  1994cites this paper
• The effect of the composition of very low‐ and low‐calorie diets on 1 week's weight loss in obese patients

  1994cites this paper
• Influence of body composition on food intake.

  1994cites this paper
• Effect of chemotherapy on the energy and protein metabolism of children near the end of treatment for acute lymphoblastic leukemia.

  1993cites this paper
• Efficiency and safety of using protein sparing modified fast in pediatric and adolescent obesity treatment

  1992cites this paper
• Body composition, nitrogen metabolism, and energy utilization with feeding of mildly restricted (4.2 MJ/d) and severely restricted (2.1 MJ/d) isonitrogenous diets.

  1992cites this paper
• Benefits and Limitations of Very-Low-Calorie Diet Therapy in Obese NIDDM

  1991cites this paper
• Evaluation of Low Energy Pack Ration by Short Term Feeding to Soldiers

  1991cites this paper
• Measurement of composition changes using dual-photon absorptiometry in obese patients undergoing semistarvation.

  1990cites this paper
• Comparison of daily diets containing 400 kcal (1.67 MJ) of either protein or glucose, and their effects on the response to subsequent total fasting in obese subjects.

  1989cites this paper
• The etiologic basis for the classification of obesity.

  1989cites this paper
• Importance of nutrient balance in body weight regulation.

  1988cites this paper
• The effect of a weight-reducing diet on the nitrogen metabolism of obese adolescents.

  1988cites this paper
• Nutritional support in the perioperative period.

  1988cites this paper
• Postaggressionsstoffwechsel und Utilisation parenteraler Nährstoffe

  1988cites this paper
• The theoretical bases of indirect calorimetry: a review.

  1988cites this paper
• Growth hormone administration conserves lean body mass during dietary restriction in obese subjects.

  1987cites this paper
• Interrelationships between dietary carbohydrates, B cell function and rate of ketogenesis during underfeeding in obese patients.

  1987cites this paper
• Lipolytic response to glucose infusion in human subjects.

  1987cites this paper
• Caloric supply in parenteral nutrition in the stress phase.

  1987cites this paper
• Urine C-Peptide As Index of Integrated Insulin Secretion in Hypocalpric States in Obese Human Subjects

  1987cites this paper
• [Metabolism-oriented postoperative nutritional therapy--possibilities and limits in the use of glucose and xylitol].

  1987cites this paper
• Parenteral nutrition in the surgical patient

  1987cites this paper
• Lipid Metabolism during Starvation and Sepsis in Relation to Fatty Acid Profile in Liver and α-Linolenic- and γ-Linolenic Acid-Enriched Diets

  1987cites this paper
• Increased protein catabolism without hypermetabolism after human orthotopic liver transplantation.

  1987cites this paper
• The negative nitrogen balance in post-operative paediatric patients.

  1986cites this paper
• Parenteral nourishment of patients undergoing surgical or traumatic stress.

  1986cites this paper
• Effect of DL-3-hydroxybutyrate infusions on leucine and glucose kinetics in burned rats receiving TPN.

  1986cites this paper
• The negative nitrogen balance in post-operative paediatric patients.

  1986cites this paper
• Mood and appetite during minimal-carbohydrate and carbohydrate-supplemented hypocaloric diets.

  1985cites this paper
• Interrelationships of glucose and protein metabolism in obese adolescents during short-term hypocaloric dietary therapy.

  1985cites this paper
• Energy expenditure before and during energy restriction in obese patients.

  1985cites this paper
• Neuroendocrine mobilization of body fuels after injury.

  1985cites this paper
• Multidisciplinary treatment of obesity with a protein-sparing modified fast: results in 668 outpatients.

  1985cites this paper
• Effect of weight loss on glucose disposal in obese and obese diabetic patients.

  1985cites this paper
• Tryptophan administration may enhance weight loss by some moderately obese patients on a protein‐sparing modified fast (PSMF) diet

  1985influential citation
• Sequential changes in blood concentrations of fuels in relation to arterial blood ketone body ratio after 70% hepatectomy in rabbits

  1985cites this paper
• The effect of intragastric infusion of glucose, lipids or acetate on fasting nitrogen excretion and blood metabolites in sheep

  1985cites this paper
• Xylitol, an energy source for intravenous nutrition after trauma.

  1985cites this paper
• Weight reduction methods of college women.

  1985cites this paper
• [Protein-sparing mechanisms of parenteral feeding. II. Clinical aspects].

  1984cites this paper
• Variability in body protein loss during protracted, severe caloric restriction: role of triiodothyronine and other possible determinants.

  1984cites this paper
• [Effect of the PSMF diet on plasma lipids and lipoproteins in obese subjects].

  1984cites this paper
• Protein metabolism during total parenteral nutrition (TPN) in injured rats using medium-chain triglycerides.

  1984cites this paper
• Childhood obesity: susceptibility, cause, and management.

  1983cites this paper
• A Key to the Literature of Total Parenteral Nutrition

  1983cites this paper
• Peripheral vein complications in patients receiving amino acid/dextrose solutions.

  1983cites this paper
• Very low calorie diets: their efficacy, safety, and future.

  1983cites this paper
• Nitrogen and protein losses in rats during weight reduction with a high protein, very low energy diet or fasting.

  1983cites this paper
• Effects of carbohydrate-containing and carbohydrate-restricted hypocaloric and eucaloric diets on serum concentrations of retinol-binding protein, thyroxine-binding prealbumin and transferrin.

  1983cites this paper
• [Physiopathology and treatment of obesity].

  1983cites this paper
• Adaptation to amino acid infusion in patients undergoing operation.

  1983cites this paper
• Nutritional care of the trauma patient.

  1983cites this paper
• Amino acids—their role as an energy source

  1983cites this paper
• Effect of high and low-carbohydrate diets on nitrogen balance during calorie restriction in obese subjects.

  1982cites this paper
• Balanced hypocaloric diet versus protein-sparing modified fast in the treatment of obesity: a comparative study.

  1982cites this paper
• Nitrogen economy during very low calorie reducing diets: quality and quantity of dietary protein.

  1982cites this paper
• Original Research Communications-general

  1982cites this paper
• Effects of fasting on muscle protein turnover, the composition of weight loss, and energy balance of obese and nonobese Zucker rats.

  1982cites this paper
• Protein wasting due to acidosis of prolonged fasting.

  1982cites this paper
• Dietary practices in obesity.

  1982cites this paper
• Theoretical aspects of weight loss in patients with cancer. Possible importance of pyruvate dehydrogenase

  1982cites this paper
• Utilization of exogenous and endogenous lipids for energy production during parenteral nutrition.

  1982cites this paper
• Effects of hypocaloric dextrose and amino acids on body composition and nitrogen balance in rats.

  1982cites this paper
• Panel report on nutrient-hormone interaction.

  1981cites this paper
• Metabolic effects of substituting carbohydrate for protein in a low-calorie diet: a prolonged study in obese patients.

  1981cites this paper
• Effects of liver damage on ketone-body production and nitrogen balance in starved rats.

  1981cites this paper
• Effects of a high protein very-low-energy diet on ambulatory subjects with special reference to nitrogen balance.

  1981cites this paper
• Nutritional care: intensive nutrition

  1981cites this paper
• The influence of intravenous nutrition on protein dynamics following surgery.

  1981cites this paper