Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Cell Science

• Publication date

  2008-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.031484PMID 18827013PMCID PMC2586290
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
• Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes.

  2006influential reference
• The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

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  1983cited by this paper
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