Relative bioavailability of RRR- and all-rac-alpha-tocopheryl acetate in humans: studies using deuterated compounds.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  American Journal of Clinical Nutrition

• Publication date

  1994-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1093/AJCN/60.3.397PMID 8074072
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacokinetics and Bioavailability of the RRR and All Racemic Stereoisomers of Alpha‐Tocopherol in Humans After Single Oral Administration

  1993cited by this paper
• Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol.

  1992cited by this paper
• Efficacy of dietary D-alpha-tocopherol and DL-alpha-tocopheryl acetate for weanling pigs.

  1992cited by this paper
• Purification and characterization of the alpha-tocopherol transfer protein from rat liver.

  1991cited by this paper
• Purification and characterization of the α‐tocopherol transfer protein from rat liver

  1991cited by this paper
• Plasma tocopherol concentrations in response to supplemental vitamin E.

  1991cited by this paper
• RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins.

  1990cited by this paper
• Vitamin E: antioxidant activity, biokinetics, and bioavailability.

  1990cited by this paper
• Intra- and interindividual variation in measurements of beta-carotene, retinol, and tocopherols in diet and plasma.

  1987cited by this paper
• Serum concentrations of alpha-tocopherol after ingestion of various vitamin E preparations.

  1984cited by this paper
• Medical uses of vitamin E.

  1983cited by this paper
• Stereoisomers of alpha-tocopheryl acetate. II. Biopotencies of all eight stereoisomers, individually or in mixtures, as determined by rat resorption-gestation tests.

  1982cited by this paper
• Fundamentals of Clinical Trials

  1982cited by this paper
• Improved assay for alpha-tocopherol in the picogram range, using gas chromatography--mass spectrometry.

  1981cited by this paper
• Improved assay for α-tocopherol in the picogram range, using gas chromatography-mass spectrometry

  1981cited by this paper
• Vitamin E: A Comprehensive Treatise

  1980cited by this paper
• Effects of retinoic acid on the mobilization of vitamin A from the liver in rats.

  1979cited by this paper
• Influence of dietary fat level and dietary tocopherols on plasma tocopherols of human subjects.

  1977cited by this paper
• RELATIONSHIP BETWEEN TOCOPHEROL AND SERUM LIPID LEVELS FOR DETERMINATION OF NUTRITIONAL ADEQUACY *

  1972cited by this paper
• Modern Nutrition in Health and Disease

  1965cited by this paper
• RECOMMENDED DIETARY ALLOWANCES.

  1964cited by this paper
• Dorland's Illustrated Medical Dictionary

  1957cited by this paper
• The relative utilization of alpha-tocopherol and alpha-tocopheryl acetate by humans.

  1952cited by this paper
• PLASMA TOCOPHEROL IN MAN AT VARIOUS TIMES AFTER INGESTING FREE OR ACETYLATED TOCOPHEROL

  1951cited by this paper
• Physiological Availability of Vitamins. Study of Methods for Determining Availability of Vitamins in Pharmaceutical Products

  1945cited by this paper

• Differential Enhancement of Fat-Soluble Vitamin Absorption and Bioefficacy via Micellization in Combination with Selected Plant Extracts In Vitro

  2025cites this paper
• Vitamin E: Not only a single stereoisomer.

  2024cites this paper
• Natural Vitamin E Supplementation during Pregnancy in Rats Increases RRR-α-Tocopherol Stereoisomer Proportion and Enhances Fetal Antioxidant Capacity, Compared to Synthetic Vitamin E Administration

  2023cites this paper
• Brain α-Tocopherol Concentration and Stereoisomer Profile Alter Hippocampal Gene Expression in Weanling Mice.

  2020cites this paper
• Determinants of antioxidant status in humans

  2019cites this paper
• Effects of dietary RRR &agr;-tocopherol vs all-racemic &agr;-tocopherol on health outcomes

  2018cites this paper
• Bioavailability of Vitamin E

  2018cites this paper
• Analytical strategies to assess the functional metabolome of vitamin E.

  2016cites this paper
• Maternal Supplementation With Natural or Synthetic Vitamin E and Its Levels in Human Colostrum

  2015cites this paper
• Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol

  2015cites this paper
• Infant nutritional product with RRR alpha-tocopherol

  2014cites this paper
• Bioavailability of vitamin E in humans: an update.

  2013cites this paper
• A comparative review of vitamin E and associated equine disorders.

  2012cites this paper
• Tocopherol isoforms evoke specific modulation of oxidative and inflammatory responses in Caco-2 and FHs 74 Int intestinal cell lines

  2012cites this paper
• Vitamins and Vitamin Utilization in Swine

  2012cites this paper
• Vitamin E Bioavailability: Past and Present Insights

  2011cites this paper
• Quantitation of [5-14CH3]-(2R, 4'R, 8'R)-α-tocopherol in humans.

  2011cites this paper
• Quantitation of (5- 14 CH3)-(2R, 4'R, 8'R)-a-Tocopherol in Humans 1-3

  2011cites this paper
• Nutrition-based health in modern animal production

  2011cites this paper
• α-tocopherol concentrations in equine serum and cerebrospinal fluid after vitamin E supplementation

  2010cites this paper
• Synthesis of alpha-tocohexaenol (alpha-T6) a fluorescent, oxidatively sensitive polyene analogue of alpha-tocopherol.

  2010cites this paper
• Gene-Regulatory Activity of α-Tocopherol

  2010cites this paper
• Effect of dietary Ricetrienol contents level on vitamin E concentration in egg yolk and yolk lipid peroxidation status of laying hens

  2009cites this paper
• Soy constituents: modes of action in low-density lipoprotein management.

  2009cites this paper
• Utilization of stereoisomers from alpha-tocopherol in livestock animals.

  2009cites this paper
• Low Molecular Weight Antioxidants and Other Biologically Active Components of Buckwheat Seeds

  2009cites this paper
• 7 Chemistry of Tocotrienols

  2009cites this paper
• Efeito da radiação gama sobre o conteúdo de tocoferóis em produtos naturais e industrializados e avaliação sensorial

  2009cites this paper
• Stable isotope studies into the kinetics and bioavailability of vitamin K₁ in humans

  2007cites this paper
• Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis.

  2007cites this paper
• Vitamin E biochemistry and function: a case study in male rabbit.

  2007cites this paper
• Bioavailability of α-tocopherol stereoisomers in rats depends on dietary doses of all-rac- or RRR-α-tocopheryl acetate

  2006cites this paper
• Vitamin E in renal therapeutic regimens

  2006cites this paper
• 5-Trideuteromethyl-α-tocotrienol and 5-14CH3-α-tocotrienol as biological tracers of tocotrienols

  2006cites this paper
• Einfluss der Matrix-Zusammensetzung von Vitamin E auf die Bioverfügbarkeit bei wachsenden Schweinen

  2006cites this paper
• Vitamin E Reduces Symptoms In a CFA-induced Model of Monoarthritis

  2006cites this paper
• Bioavailability of alpha-tocopherol stereoisomers in rats depends on dietary doses of all-rac- or RRR-alpha-tocopheryl acetate.

  2006cites this paper
• A feasibility study quantifying in vivo human α-tocopherol metabolism

  2006cites this paper
• Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects.

  2006cites this paper
• A feasibility study quantifying in vivo human alpha-tocopherol metabolism.

  2006cites this paper
• Nutrient Requirements and Interactions Vitamin C Nutriture Has Little Short-Term Effect on Vitamin E Concentrations in Healthy Women 1 ' 2 ' 3

  2006cites this paper
• Biodisponibilidade de vitaminas lipossolúveis

  2005cites this paper
• Human Nutrition and Metabolism Noncompetitive Plasma Biokinetics of Deuterium-Labeled Natural and Synthetic -Tocopherol in Healthy Men with an apoE4 Genotype

  2005influential citation
• Noncompetitive plasma biokinetics of deuterium-labeled natural and synthetic alpha-tocopherol in healthy men with an apoE4 genotype.

  2005cites this paper
• Biodiscrimination of a-tocopherol stereoisomers in humans after oral administration 13

  2005cites this paper
• Comparative 2 H-labelled a -tocopherol biokinetics in plasma, lipoproteins, erythrocytes, platelets and lymphocytes in normolipidaemic males

  2005cites this paper
• Vitamin E bioavailability in humans.

  2005cites this paper
• {alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status.

  2005cites this paper
• Plasma a-tocopherol concentrations after supplementation with water- and fat-soluble vitamin E13

  2005influential citation
• Vitamin and mineral status: effects on physical performance.

  2004cites this paper
• Re-evaluation of the relative potency of synthetic and natural alpha-tocopherol: experimental and clinical observations.

  2004cites this paper
• Vitamin E from supplements has good bioavailability.

  2004cites this paper
• Vitamin E as a Cancer Chemopreventive Agent

  2004cites this paper
• Vitamin E from supplements has good bioavailability

  2004cites this paper
• Physiological Factors Influencing Vitamin E Biokinetics

  2004cites this paper
• Influence of sources of dietary vitamin E on the maternal transfer of α-tocopherol to fetal and neonatal guinea pigs as determined by a stable isotopic technique

  2003cites this paper
• Infants discriminate between natural and synthetic vitamin E.

  2003cites this paper
• Clinical Pharmacokinetics of Antioxidants and Their Impact on Systemic Oxidative Stress

  2003cites this paper
• The content of tocopherols in Cruciferae sprouts.

  2003cites this paper
• Beyond _-Tocopherol: The Role of the Other Tocopherols and Tocotrienols

  2002cites this paper
• Antioxidants and atherosclerosis

  2002cites this paper
• Nutrient Requirements Lactating Sows and Suckling Piglets Preferentially Incorporate RRR-over All-rac-- Tocopherol into Milk , Plasma and Tissues 1

  2002cites this paper
• Bioavailability and biopotency of vitamin E in humans: an ongoing controversy.

  2002cites this paper
• Lactating sows and suckling piglets preferentially incorporate RRR- over all-rac-alpha-tocopherol into milk, plasma and tissues.

  2002cites this paper
• The Linear Systems

  2002cites this paper
• Dynamics of Chromatography: Principles and Theory

  2002cites this paper
• Vitamin E Status of Thoroughbred Horses and the Antioxidant Status of Endurance Horses

  2002influential citation
• Noncompartmentally-based pharmacokinetic modeling.

  2001cites this paper
• Rôle de la vitamine E dans la prévention du risque cardiovasculaire

  2001cites this paper
• Biotransfer und Biotransformation von bioaktiven Futterinhaltsstoffen ins Ei

  2001cites this paper
• Determination of RS,E/Z-tocotrienols by HPLC.

  2001cites this paper
• Vitamin E Bioavailability, Biokinetics, and Metabolism

  2001cites this paper
• Maternal transfer of vitamin E to fetal and neonatal guinea pigs utilizing a stable isotopic technique

  2001cites this paper
• Bioactive compounds in the cereal grains before and after hydrothermal processing

  2001cites this paper
• Vitamin E in fortified cow milk uniquely enriches human plasma lipoproteins.

  2001cites this paper
• Urinary α-tocopherol metabolites in α-tocopherol transfer protein-deficient patients

  2000cites this paper
• Some of the Clinical Conditions Associated with Oxidative Injury Ischemia / reperfusion injury Atheroma Cervical cancer Diabetes Chronic obstructive airway disease Aging Retinopathy of prematurity Parkinson ’ s disease

  2000cites this paper
• Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.

  2000cites this paper
• Urinary alpha-tocopherol metabolites in alpha-tocopherol transfer protein-deficient patients.

  2000cites this paper
• Bioavailability and potency of natural-source and all-racemicα-tocopherol in the human: a dispute

  2000cites this paper
• The role of oxidative stress in the pathogenesis of age-related macular degeneration.

  2000cites this paper
• Diet and antioxidant status.

  1999cites this paper
• Relative bioavailabilities of natural and synthetic vitamin E formulations containing mixed tocopherols in human subjects.

  1999cites this paper
• Vitamin E: function and metabolism

  1999cites this paper
• Vitamin E and its effect on skeletal muscle

  1998cites this paper
• Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E.

  1998cites this paper
• Medical treatment of Parkinson’s disease

  1998cites this paper
• Vitamin E dose-response studies in humans with use of deuterated RRR-alpha-tocopherol.

  1998cites this paper
• Transport of deuterium-labeled tocopherols during pregnancy.

  1998cites this paper
• Antioxidant transport by the human placenta.

  1998cites this paper
• Biodiscrimination of alpha-tocopherol stereoisomers in humans after oral administration.

  1997cites this paper
• Bioavailability of vitamin E.

  1997cites this paper
• Antioxidants and Cardiovascular Risk

  1996cites this paper
• DESIRABLE VERSUS POTENTIALLY HARMFUL LEVELS OF VITAMIN E INTAKE

  1996cites this paper
• Plasma alpha-tocopherol concentrations after supplementation with water- and fat-soluble vitamin E.

  1996cites this paper
• Vitamin C nutriture has little short-term effect on vitamin E concentrations in healthy women.

  1996cites this paper
• Update on the biological characteristics of the antioxidant micronutrients: vitamin C, vitamin E, and the carotenoids.

  1996cites this paper
• Bioavailability for Rats of Vitamin E from Fortified Breakfast Cereals

  1996cites this paper
• Long-term oral vitamin E supplementation in cystic fibrosis patients: RRR-alpha-tocopherol compared with all-rac-alpha-tocopheryl acetate preparations.

  1996cites this paper
• Considerations of the scientific substantiation for antioxidant vitamins and beta-carotene in disease prevention.

  1995cites this paper