Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Food and Chemical Toxicology

• Publication date

  2011-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.fct.2011.05.012PMID 21605616
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis, Spectral and Thermal Studies of New Rutin Vanadyl Complexes

  2010cited by this paper
• Cilastatin Attenuates Cisplatin-Induced Proximal Tubular Cell Damage

  2010cited by this paper
• Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo.

  2009cited by this paper
• Assessment the Ameliorative Effect of Pomegranate and Rutin on Chlorpyrifos-ethyl-Induced Oxidative Stress in Rats

  2009cited by this paper
• Cisplatin regulates Sertoli cell expression of transferrin and interleukins.

  2008cited by this paper
• Increased Macrophage Infiltration and Fractalkine Expression in Cisplatin-Induced Acute Renal Failure in Mice

  2008cited by this paper
• Cisplatin-Induced Acute Renal Failure Is Associated with an Increase in the Cytokines Interleukin (IL)-1β, IL-18, IL-6, and Neutrophil Infiltration in the Kidney

  2007cited by this paper
• Parthenolide reduces cisplatin-induced renal damage.

  2007cited by this paper
• Cisplatin Nephrotoxicity: A Review

  2007cited by this paper
• Clinical Status of Cisplatin, Carboplatin, and Other Platinum‐Based Antitumor Drugs

  2006cited by this paper
• Selective nuclear factor κ‐B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxicity induced by gentamicin

  2006cited by this paper
• Cisplatin : chemistry and biochemistry of a leading anticancer drug

  2006cited by this paper
• Mitochondrial regulation of apoptotic cell death.

  2006cited by this paper
• Protective effect of the ethanol extract of the roots of Brassica rapa on cisplatin-induced nephrotoxicity in LLC-PK1 cells and rats.

  2006cited by this paper
• Cellular processing of platinum anticancer drugs

  2005cited by this paper
• Immunohistochemical distribution of activated nuclear factor κB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats

  2005cited by this paper
• Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats.

  2005cited by this paper
• MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis.

  2005cited by this paper
• Glutathione metabolism and its implications for health.

  2004cited by this paper
• Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation.

  2004cited by this paper
• Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer.

  2004cited by this paper
• Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney

  2004cited by this paper
• Inducible nuclear factor-κB activation contributes to chemotherapy resistance in gastric cancer1 ☆

  2004cited by this paper
• The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats.

  2004cited by this paper
• The effects of desferrioxamine on cisplatininduced lipid peroxidation and the activities of antioxidant enzymes in rat kidneys

  2004cited by this paper
• Nuclear factor-kappaB and its role in sepsis-associated organ failure.

  2003cited by this paper
• Role of poly(ADP-ribose)polymerase in cisplatin-induced injury in LLC-PK1 cells.

  2003cited by this paper
• Nuclear Factor—κB and Its Role in Sepsis-Associated Organ Failure

  2003cited by this paper
• Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative

  2003cited by this paper
• NF-kappaB activation and inhibition: a review.

  2002cited by this paper
• L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine.

  2002cited by this paper
• Kinetics of cisplatin binding to cellular DNA and modulations by thiol-blocking agents and thiol drugs.

  2002cited by this paper
• TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity.

  2002cited by this paper
• Protein Kinase C- (cid:1) and ERK1/2 Mediate Mitochondrial Dysfunction, Decreases in Active Na (cid:2) Transport, and Cisplatin-induced Apoptosis in Renal Cells*

  2002cited by this paper
• Effects of rutin supplementation on antioxidant status and iron, copper, and zinc contents in mouse liver and brain

  2002cited by this paper
• Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice.

  2002cited by this paper
• Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways.

  2002cited by this paper
• TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

  2002cited by this paper
• Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide.

  2001cited by this paper
• Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction inuduced by cisplatin.

  2001cited by this paper
• Flavonoids: a review of probable mechanisms of action and potential applications.

  2001cited by this paper
• (cid:2) -Glutamyl Transpeptidase-Deficient Mice Are Resistant to the Nephrotoxic Effects of Cisplatin

  2001cited by this paper
• Apoptotic death sensor: an organelle's alter ego?

  2001cited by this paper
• Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells.

  2001cited by this paper
• Naturally occurring polyphenolic antioxidants modulate IgE‐mediated mast cell activation

  2000cited by this paper
• Antioxidant flavonols from fruits, vegetables and beverages: measurements and bioavailability.

  2000cited by this paper
• The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells

  1999cited by this paper
• Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.

  1999cited by this paper
• Attenuation of cisplatin-induced acute renal failure is associated with less apoptotic cell death.

  1999cited by this paper
• NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.

  1998cited by this paper
• Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application.

  1997cited by this paper
• Cisplatin-induced renal toxicity: possible reversal by N-acetylcysteine treatment.

  1997cited by this paper
• Bioavailability of rutin and quercetin in rats

  1997cited by this paper
• Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

  1995cited by this paper
• Cisplatin generates superoxide anion by interaction with DNA in a cell-free system.

  1994cited by this paper
• Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity.

  1994cited by this paper
• Comparative nephrotoxicity of a novel platinum compound, cisplatin, and carboplatin in male Wistar rats.

  1994cited by this paper
• Hepatotoxicity Associated with Cisplatin Chemotherapy

  1993cited by this paper
• Reaction of cis- and trans-[PtCl2(NH3)2] with reduced glutathione inside human red blood cells, studied by 1H and 15N-[1H] DEPT NMR.

  1990cited by this paper
• Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation.

  1989cited by this paper
• Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues.

  1987cited by this paper
• Occupational exposure to anticancer drug--potential and real hazards.

  1985cited by this paper
• Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney. Possible implications in analgesic nephropathy.

  1984cited by this paper
• Cytosolic factors which affect microsomal lipid peroxidation in lung and liver.

  1981cited by this paper
• Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages--induction by multiple nonphagocytic stimuli.

  1981cited by this paper
• Platinum nephrotoxicity.

  1978cited by this paper
• The renal pathology in clinical trials of Cis‐platinum (II) diamminedichloride

  1977cited by this paper
• Purification and characterization of the flavoenzyme glutathione reductase from rat liver.

  1975cited by this paper
• Postillumination adenosine triphosphate synthesis in Rhodospirillum rubrum chromatophores. II. Stimulation by a K+ diffusion potential.

  1975cited by this paper
• Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.

  1974cited by this paper
• -Glutamyl cyclotransferase. Distribution, isozymic forms, and specificity.

  1973cited by this paper
• The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O).

  1969cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• Endogenous Creatinine in Serum and Urine.∗ †

  1950cited by this paper

• Development of a new polymeric formulation of rutin by supercritical antisolvent precipitation and evaluation of its nephroprotective capacity against cisplatin nephrotoxicity in rats

  2026cites this paper
• Comprehensive Evaluation of the Anti-Inflammatory Potential of Cucurbita maxima Leaf Extract: LC-MS Phytochemical Profiling Coupled with In Vitro, In Vivo, and In Silico Approaches.

  2026cites this paper
• A Review of the Plant Sources, Chemical Properties, Pharmacological Effects, Pharmacokinetics, Toxicity, and Clinical Applications of Rutin

  2026cites this paper
• Protective effect of WON-21 on ethanol-induced gastritis in rats

  2025cites this paper
• The potential role of rutin, a flavonoid, in the management of cancer through modulation of cell signaling pathways

  2025cites this paper
• Natural Antioxidants: New Possibilities For The Treatment and Prevention of Acute Pancreatitis

  2025cites this paper
• Antihyperlipidemic, Hepatoprotective, and Nephroprotective Activity of Two Different Matricaria pubescens Methanolic Extracts in Rats

  2025cites this paper
• Protective effects of Crataegus monogyna against cisplatin-induced liver and kidney toxicity in rats

  2025cites this paper
• Prospecting of the Antioxidant Activity from Extracts Obtained from Chañar (Geoffroea decorticans) Seeds Evaluated In Vitro and In Vivo Using the Tenebrio molitor Model

  2024cites this paper
• Metabolite profiling, enzyme inhibitory activity and antioxidant potential of different extracts from Glycyrrhiza foetida Desf. (Fabaceae, Galegeae, Glycyrrhizinae).

  2024cites this paper
• Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula for the treatment of silicosis.

  2024cites this paper
• Alleviative Effect of Rutin on Zearalenone-Induced Reproductive Toxicity in Male Mice by Preventing Spermatogenic Cell Apoptosis and Modulating Gene Expression in the Hypothalamic–Pituitary–Gonadal Axis

  2024cites this paper
• Implementing losartan potassium-laden pegylated nanocubic vesicles as a novel nanoplatform to alleviate cisplatin-induced nephrotoxicity via blocking apoptosis and activating the wnt/β-catenin/TCF-4 pathway.

  2024cites this paper
• Loganin Ameliorates Acute Kidney Injury and Restores Tofacitinib Metabolism in Rats: Implications for Renal Protection and Drug Interaction

  2024cites this paper
• Effect of atorvastatin on pro-inflammatory cytokines during cisplatin administration; a double-blind clinical trial study

  2024cites this paper
• Effect of Rutin on Cisplatin-Induced Oxidative Skeletal Muscle Damage in Rats

  2024cites this paper
• Rutin-Loaded Transethosomal Gel for Topical Application: A Comprehensive Analysis of Skin Permeation and Antimicrobial Efficacy

  2024cites this paper
• Rutin: Chemical properties, Pharmacokinetic properties, Biological activities

  2024cites this paper
• Protective Effect of Natural Products Against Cisplatin-Induced DNA Damage in Kidney and Liver via Its Signalling Transduction Pathways: A Review

  2024cites this paper
• Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking.

  2024cites this paper
• Rutin-Activated Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Attenuates Corneal and Heart Damage in Mice

  2024cites this paper
• Dietary rutin improves the antidiarrheal capacity of weaned piglets by improving intestinal barrier function, antioxidant capacity, and cecal microbiota composition.

  2024cites this paper
• Enhancing post-thaw quality of ram epididymal sperm by supplementation of rutin in cryopreservation extender

  2023cites this paper
• Potential Probiotic Properties of Blautia producta Against Lipopolysaccharide-Induced Acute Liver Injury

  2023cites this paper
• Phytotherapeutic Potential of Rutin Against Xenobiotic-Induced Toxicities in Preclinical Models

  2023cites this paper
• Sensitivity of Human Induced Pluripotent Stem Cells and Thereof Differentiated Kidney Proximal Tubular Cells towards Selected Nephrotoxins

  2023cites this paper
• Exploring the therapeutic potential of natural compounds for Alzheimer's disease: Mechanisms of action and pharmacological properties.

  2023cites this paper
• The underlying mechanisms of cisplatin-induced nephrotoxicity and its therapeutic intervention using natural compounds

  2023cites this paper
• Lobetyolin, a Q-marker isolated from Radix Platycodi, exerts protective effects on cisplatin-induced cytotoxicity in HEK293 cells

  2023cites this paper
• Role of Clove Essential Oil on Benzo(a)pyrene Induced Lung Toxicity in Adult Male Albino Rats

  2023cites this paper
• Potential health benefits of the plant Levisticum officinale (lovage) in relation to its polyphenolic content

  2023cites this paper
• Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury.

  2023cites this paper
• Crosstalk between phytochemicals and inflammatory signaling pathways

  2023cites this paper
• The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS

  2023cites this paper
• Harmine mitigates cisplatin-induced renal injury in male mice through antioxidant, anti-inflammatory, and anti-apoptosis effects

  2022cites this paper
• Pyroptosis in acute pancreatitis and its therapeutic regulation

  2022cites this paper
• Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP

  2022cites this paper
• Bibliometric and visual analysis of nephrotoxicity research worldwide

  2022cites this paper
• Viola tricolor Hydroalcoholic Extract Improves Behavioral Deficiencies in Rats Exposed to Chronic Immobilization Stress

  2022cites this paper
• Synergism of ellagic acid in combination with radiotherapy and chemotherapy for cancer treatment.

  2022cites this paper
• Ameliorating and protective potential of 1-isothiocyanato-4-methyl sulfonyl butane on cisplatin induced oligozoospermia and testicular dysfunction via redox-inflammatory pathway: Histomorphometric and immunohistochemical evaluation using proliferating cell nuclear antigen

  2022cites this paper
• Protective Effect of Rutin Trihydrate Against Dose-Dependent, Cisplatin-Induced Cardiac Toxicity in Isolated Perfused Rat’s Heart

  2022cites this paper
• Kidney Evaluation in Hyperuricemia Rats Treated with Green Tea Leaves (Camellia sinensis L.) Extract

  2022cites this paper
• The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds

  2022cites this paper
• Tumor-promoting aftermath post-chemotherapy: A focus on breast cancer.

  2022cites this paper
• TNF-α Inhibitors from natural compounds: An overview, CADD approaches, and their exploration for anti-inflammatory agents.

  2021cites this paper
• Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition

  2021cites this paper
• Chemotherapy: a double-edged sword in cancer treatment

  2021cites this paper
• Abrogation of cisplatin-induced nephrotoxicity in rats and HEK-293 cell lines by formononetin: in vivo and in vitro study

  2021cites this paper
• PROTECTIVE EFFECT OF MORINGA OLEIFERA SEED EXTRACT ON CISPLATIN INDUCED NEPHROTOXICITY IN RATS

  2021cites this paper
• Toxicological effects of thimerosal on rat kidney: a histological and biochemical study.

  2021cites this paper
• Protective roles of thymoquinone and vildagliptin in manganese-induced nephrotoxicity in adult albino rats

  2021cites this paper
• Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression

  2021cites this paper
• Protection by ginseng saponins against cyclophosphamide‐induced liver injuries in rats by induction of cytochrome P450 expression and mediation of the l‐arginine/nitric oxide pathway based on metabolomics

  2021cites this paper
• Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson’s Disease

  2021cites this paper
• The Protective Effect of Rutin Against Methotrexate- Induced Nephrotoxicity in Rats

  2021cites this paper
• Effects of catechin hydrate in benzo[a]pyrene-induced lung toxicity: roles of oxidative stress, apoptosis, and DNA damage

  2021influential citation
• Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation

  2021cites this paper
• Slower Elimination of Tofacitinib in Acute Renal Failure Rat Models: Contribution of Hepatic Metabolism and Renal Excretion

  2020cites this paper
• Effects of tramadol administration on male reproductive toxicity in Wistar rats The role of oxidative stress, mitochondrial dysfunction, apoptosis-related gene expression, and nuclear factor kappa B signalling.

  2020cites this paper
• Chlorogenic acid prevents vancomycin‐induced nephrotoxicity without compromising vancomycin antibacterial properties

  2020cites this paper
• Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities

  2020cites this paper
• 6-Methoxyflavanone abate cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: A behavioral and molecular simulation study.

  2020cites this paper
• Protection against chemotherapy- and radiotherapy-induced side effects: A review based on the mechanisms and therapeutic opportunities of phytochemicals.

  2020cites this paper
• Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats

  2020cites this paper
• Isoquercitrin Ameliorates Cisplatin-Induced Nephrotoxicity Via the Inhibition of Apoptosis, Inflammation, and Oxidative Stress

  2020cites this paper
• LncRNA miR503HG Regulates the Drug Resistance of Recurrent Cervical Squamous Cell Carcinoma Cells by Regulating miR-155/Caspase-3

  2020cites this paper
• THE POTENTIAL MODULATORY EFFECT OF RUTIN ON TITANIUM DIOXIDE NANOPARTICLES-INDUCED RENAL INJURY IN MALE MICE

  2020influential citation
• A meta-analysis of preclinical studies using antioxidants for the prevention of cisplatin nephrotoxicity: implications for clinical application

  2020cites this paper
• Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-κB and MAPK mediated apoptosis signaling pathways in mice.

  2020cites this paper
• Protective effect of Barringtonia racemosa Ethyl Acetate Fraction against Cisplatin-induced Nephrotoxicity in Rats

  2020cites this paper
• Rutin trihydrate attenuated cisplatin- induced cardiac toxicity in isolated perfused rat’s hearts

  2020cites this paper
• Therapeutic benefits of rutin and its nanoformulations

  2020cites this paper
• The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

  2020cites this paper
• Rutin protects boar sperm from cryodamage via enhancing the antioxidative defense.

  2020cites this paper
• Inhibition of Histone H3K27 Acetylation Orchestrates Interleukin-9-Mediated and Plays an Anti-Inflammatory Role in Cisplatin-Induced Acute Kidney Injury

  2020cites this paper
• The Effects of Urtica dioica and Lamium album Extracts on the Expression Level of Cyclooxygenase-2 and Caspase-3 in the Liver and Kidney of Streptozotocin-Induced Diabetic Rats

  2019cites this paper
• Ellagic acid ameliorates cisplatin induced hepatotoxicity in colon carcinogenesis

  2019cites this paper
• Rutin protects human periodontal ligament stem cells from TNF-α induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environment.

  2019cites this paper
• Synergistic effect of cranberry extract and losartan against aluminium chloride-induced hepatorenal damage associated cardiomyopathy in rats

  2019cites this paper
• A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

  2019cites this paper
• Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

  2019cites this paper
• Ambroxol attenuates cisplatin-induced hepatotoxicity and nephrotoxicity via inhibition of p-JNK/p-ERK.

  2019cites this paper
• Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats.

  2019cites this paper
• Peripheral neurotoxic effects of cisplatin on rats and treatment with rutin.

  2019cites this paper
• The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review.

  2019cites this paper
• Antigenotoxic effects of rutin against methotrexate genotoxicity in Swiss albino mice

  2019cites this paper
• RUTIN: A PHARMACOLOGICAL REVIEW

  2018cites this paper
• Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review.

  2018cites this paper
• Protective effect of rutin against carbon tetrachloride-induced oxidative stress, inflammation and apoptosis in mouse kidney associated with the ceramide, MAPKs, p53 and calpain activities.

  2018cites this paper
• Anti-inflammatory and Antioxidant Properties of Probiotic Bacterium Lactobacillus mucosae AN1 and Lactobacillus fermentum SNR1 in Wistar Albino Rats

  2018cites this paper
• Curcumin as an anti‐inflammatory agent: Implications to radiotherapy and chemotherapy

  2018cites this paper
• Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats

  2018cites this paper
• Amelioration of oxidative stress in differentiated neuronal cells by rutin regulated by a concentration switch.

  2018cites this paper
• The protective role of melatonin in chemotherapy‐induced nephrotoxicity: a systematic review of non-clinical studies

  2018cites this paper
• Renoprotective Effects of Fermented Black Ginseng through Ameliorating Oxidative Stress Associated with Cisplatin-Induced Acute Nephrotoxicity in Mice

  2018influential citation
• Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up‐regulation of antioxidants and SIRT1

  2018cites this paper
• Xanthohumol attenuates cisplatin‐induced nephrotoxicity through inhibiting NF‐&kgr;B and activating Nrf2 signaling pathways

  2018cites this paper
• Venlafaxine mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats.

  2018cites this paper
• Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity

  2018cites this paper