A streamlined metabolic pathway for the biosynthesis of moenomycin A.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Chemistry and Biology

• Publication date

  2007-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.CHEMBIOL.2007.01.008PMID 17379141PMCID PMC1936435
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin.

  2007cited by this paper
• Isolation, Characterization, and Heterologous Expression of the Biosynthesis Gene Cluster for the Antitumor Anthracycline Steffimycin

  2006cited by this paper
• Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives.

  2006cited by this paper
• Occurrence of Two 5-Aminolevulinate Biosynthetic Pathways in Streptomyces nodosus subsp. asukaensis Is Linked with the Production of Asukamycin

  2006cited by this paper
• Characterization of moenomycin antibiotic complex by multistage MALDI-IT/RTOF-MS and ESI-IT-MS

  2006cited by this paper
• The Crystal Structure of (S)-3-O-Geranylgeranylglyceryl Phosphate Synthase Reveals an Ancient Fold for an Ancient Enzyme*

  2006cited by this paper
• Membrane lipids of mesophilic anaerobic bacteria thriving in peats have typical archaeal traits.

  2006cited by this paper
• Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus.

  2006cited by this paper
• Streptomyces inside-out: a new perspective on the bacteria that provide us with antibiotics

  2006influential reference
• Characterization of moenomycin antibiotics from medicated chicken feed by ion-trap mass spectrometry with electrospray ionization.

  2005cited by this paper
• A new family of glucose-1-phosphate/glucosamine-1-phosphate nucleotidylyltransferase in the biosynthetic pathways for antibiotics.

  2005cited by this paper
• Syntheses around the transglycosylation step in peptidoglycan biosynthesis.

  2005influential reference
• Bacterial transglycosylase inhibitors.

  2005influential reference
• Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

  2005cited by this paper
• Glycopeptide and lipoglycopeptide antibiotics.

  2005cited by this paper
• Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus.

  2004cited by this paper
• Exploiting the genetic potential of polyketide producing streptomycetes.

  2003cited by this paper
• Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases

  2003cited by this paper
• The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens

  2003cited by this paper
• PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

  2003cited by this paper
• Evidence for the Combined Participation of a C10 and a C15 Precursor in the Biosynthesis of Moenocinol, the Lipid Part of the Moenomycin Antibiotics

  2003cited by this paper
• A gene transfer system for the glycopeptide producer Nonomuraea sp. ATCC39727.

  2003cited by this paper
• Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum.

  2003cited by this paper
• The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS

  2002cited by this paper
• Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

  2002cited by this paper
• The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

  2002cited by this paper
• Remarkable structural similarities between diverse glycosyltransferases.

  2002cited by this paper
• AIDS Researcher Named CDC Chief

  2002cited by this paper
• Purification, Enzymatic Characterization, and Inhibition of theZ-Farnesyl Diphosphate Synthase from Mycobacterium tuberculosis *

  2001cited by this paper
• Rhamnose Biosynthesis Pathway Supplies Precursors for Primary and Secondary Metabolism in Saccharopolyspora spinosa

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• The role of ABC transporters in antibiotic-producing organisms: drug secretion and resistance mechanisms.

  2001cited by this paper
• The biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics

  2000cited by this paper
• The 1.9 Å crystal structure of Escherichia coli MurG, a membrane‐associated glycosyltransferase involved in peptidoglycan biosynthesis

  2000cited by this paper
• One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

  2000cited by this paper
• Studies on the Biosynthesis of the Antibiotic Moenomycin A

  2000cited by this paper
• Practical streptomyces genetics

  2000cited by this paper
• FramePlot: a new implementation of the frame analysis for predicting protein-coding regions in bacterial DNA with a high G + C content.

  1999cited by this paper
• High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes.

  1997cited by this paper
• Accumulation of bldA-specified tRNA is temporally regulated in Streptomyces coelicolor A3(2)

  1993cited by this paper
• Studies on the biosynthesis of bialaphos (SF-1293) 12. C-P bond formation mechanism of bialaphos: discovery of a P-methylation enzyme.

  1992cited by this paper
• Moenomycin A: A structural revision and new structure-activity reactions

  1990cited by this paper
• Moenomycin a: Minimum structural requirements for biological activity

  1987cited by this paper
• Moenomycin, a new antibiotic. I. Fermentation and isolation.

  1965cited by this paper

• Deciphering the O-Carbamoylation Modification Mechanism in Venturicidin A Biosynthesis.

  2026cites this paper
• Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity.

  2025cites this paper
• Genome mining of Streptomyces bambergiensis AC-800 unravels the biosynthetic gene cluster for inhibitors of prolyl hydroxylase fibrostatins

  2025cites this paper
• Genomic and Metabolite Profiling Reveal a Novel Streptomyces Strain, QHH-9511, from the Qinghai-Tibet Plateau

  2023cites this paper
• Regulatory Control of Rishirilide(s) Biosynthesis in Streptomyces bottropensis

  2021cites this paper
• Genetic Engineering of Streptomyces ghanaensis ATCC14672 for Improved Production of Moenomycins

  2021influential citation
• Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study

  2021cites this paper
• Genetically engineered rpsL merodiploidy impacts secondary metabolism and antibiotic resistance in Streptomyces

  2021cites this paper
• Identification and Characterization of Four c-di-GMP-Metabolizing Enzymes from Streptomyces ghanaensis ATCC14672 Involved in the Regulation of Morphogenesis and Moenomycin A Biosynthesis

  2021cites this paper
• Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes

  2020cites this paper
• Bacterial terpenome.

  2020cites this paper
• Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI‐MS‐Guided High‐Throughput Elicitor Screening

  2020cites this paper
• Radical S-Adenosylmethionine Methylases

  2020cites this paper
• Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction

  2020cites this paper
• Cyclic di-GMP cyclase SSFG_02181 from Streptomyces ghanaensis ATCC14672 regulates antibiotic biosynthesis and morphological differentiation in streptomycetes

  2020cites this paper
• Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening.

  2020cites this paper
• Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria

  2019cites this paper
• MICROBE-PLANT INTERACTIONS BETWEEN STREPTOMYCES AND MODEL AGRICULTURAL PLANTS – HORDEUM VULGARE AND LYCOPERSICON ESCULENTUM (MICROTOM)

  2019cites this paper
• Recent Progress in Unusual Carbohydrate-Containing Natural Products Biosynthesis

  2019cites this paper
• Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products.

  2019cites this paper
• Perquinoline A–C: neuartige bakterielle Tetrahydroisochinoline mit einer bemerkenswerten Biosynthese

  2019cites this paper
• Heterologous production of small molecules in the optimized Streptomyces hosts.

  2019cites this paper
• Perquinolines A-C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing Biosynthesis.

  2019cites this paper
• Gene ssfg_01967 (miaB) for tRNA modification influences morphogenesis and moenomycin biosynthesis in Streptomyces ghanaensis ATCC14672.

  2019cites this paper
• Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters.

  2018cites this paper
• Enhanced Solubilization of Class B Radical S-Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli.

  2018cites this paper
• Entwicklung und Anwendungen eines SPR-Biosensor-Assays für Moenomycine und andere Glykosyltransferase-Inhibitoren

  2018cites this paper
• Biochemical and genetic insights into asukamycin biosynthesis

  2018cites this paper
• Analysis of Streptomyces ghanaensis ATCC14672 gene SSFG_07725 for putative γ-butyrolactone synthase

  2018cites this paper
• An Unusual Protector-Protégé Strategy for the Biosynthesis of Purine Nucleoside Antibiotics.

  2017cites this paper
• nEgativE rEgulation of MoEnoMyCin a BiosynthEsis in sTREPTOMyCEs GHANAENsIs ATCC 14672

  2017cites this paper
• Genomic data mining of the marine actinobacteria Streptomyces sp. H-KF8 unveils insights into multi-stress related genes and metabolic pathways involved in antimicrobial synthesis

  2017cites this paper
• A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology.

  2017cites this paper
• TsrM as a Model for Purifying and Characterizing Cobalamin-Dependent Radical S-Adenosylmethionine Methylases.

  2017cites this paper
• Identification and characterization of the ficellomycin biosynthesis gene cluster from Streptomyces ficellus

  2017cites this paper
• Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase.

  2016cites this paper
• A gene cluster for the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producer Actinoplanes teichomyceticus

  2016influential citation
• Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus

  2016cites this paper
• Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: outcomes for genetic screening techniques

  2015influential citation
• Applications of Natural Products from Soil Microbes

  2015cites this paper
• Testing the utility of site-specific recombinases for manipulations of genome of moenomycin producer Streptomyces ghanaensis ATCC14672

  2015cites this paper
• Bacterial Cell Wall

  2015cites this paper
• Generation and study of the strains of streptomycetes-heterologous hosts for the production of moenomycin

  2014cites this paper
• Bioactive oligosaccharide natural products.

  2014cites this paper
• Prospects for novel inhibitors of peptidoglycan transglycosylases

  2014cites this paper
• Recently published Streptomyces genome sequences

  2014cites this paper
• Generation and study of the strains of streptomycetes-heterologous hosts for the production of moenomycin

  2014cites this paper
• Discovery of novel bioactive compounds: Molecular awakening of silent clusters in Streptomyces natalensis

  2014cites this paper
• Genome engineering in actinomycetes using site-specific recombinases

  2013influential citation
• Peptidoglycan Glycosyltransferase Substrate Mimics as Templates for the Design of New Antibacterial Drugs

  2013cites this paper
• Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin

  2013cites this paper
• MoeH5: a natural glycorandomizer from the moenomycin biosynthetic pathway

  2013influential citation
• Viable screening targets related to the bacterial cell wall

  2013cites this paper
• Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

  2013cites this paper
• Characterization of the Bafilomycin Biosynthetic Gene Cluster from Streptomyces lohii

  2013cites this paper
• Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants.

  2012cites this paper
• Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes.

  2012cites this paper
• Identification of phoslactomycin biosynthetic gene clusters from Streptomyces platensis SAM-0654 and characterization of PnR1 and PnR2 as positive transcriptional regulators.

  2012cites this paper
• Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism

  2012cites this paper
• Structural perspective of peptidoglycan biosynthesis and assembly.

  2012cites this paper
• Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production.

  2011cites this paper
• The missing C-17 O-methyltransferase in geldanamycin biosynthesis.

  2011cites this paper
• Two distinct mechanisms for TIM barrel prenyltransferases in bacteria.

  2011cites this paper
• The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases

  2010influential citation
• A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis.

  2010cites this paper
• Genetic factors that influence moenomycin production in streptomycetes

  2010influential citation
• Mechanistic and functional versatility of radical SAM enzymes

  2010cites this paper
• Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products.

  2010cites this paper
• Formation and Attachment of the Deoxysugar Moiety and Assembly of the Gene Cluster for Caprazamycin Biosynthesis

  2010cites this paper
• Biochemical and Genetic Insights into Asukamycin Biosynthesis*

  2010cites this paper
• Recent advances in thiopeptide antibiotic biosynthesis.

  2010cites this paper
• Isoprenoid in Actinomycetes

  2010cites this paper
• Cell Wall Targeted Antibiotics

  2010cites this paper
• Biosynthesis of liponucleoside antibiotics in Streptomyces : Molecular and biochemical investigations of the caprazamycin and the liposidomycin gene cluster

  2010cites this paper
• 1.22 – Isoprenoid in Actinomycetes

  2010cites this paper
• Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis

  2010cites this paper
• The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways

  2010cites this paper
• Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. II: Structure elucidation

  2010cites this paper
• Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification

  2010cites this paper
• Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity.

  2010cites this paper
• Genomic basis for natural product biosynthetic diversity in the actinomycetes.

  2009cites this paper
• Genes and enzymes involved in bacterial isoprenoid biosynthesis.

  2009cites this paper
• 13 Bacterial Cell Wall Morphology and Biochemistry

  2009cites this paper
• Complete characterization of the seventeen step moenomycin biosynthetic pathway.

  2009influential citation
• Identification and characterization of Streptomyces ghanaensis ATCC14672 integration sites for three actinophage-based plasmids.

  2009influential citation
• A brief tour of myxobacterial secondary metabolism.

  2009cites this paper
• Characterization of the Polyoxin Biosynthetic Gene Cluster from Streptomyces cacaoi and Engineered Production of Polyoxin H*

  2009cites this paper
• Exploring the Substrate Promiscuity of Drug‐Modifying Enzymes for the Chemoenzymatic Generation of N‐Acylated Aminoglycosides

  2009cites this paper
• Intramolecular cyclizations of polyketide biosynthesis: mining for a "Diels-Alderase"?

  2008cites this paper
• Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design.

  2008cites this paper
• Structural details of the glycosyltransferase step of peptidoglycan assembly.

  2008cites this paper
• Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics

  2008cites this paper
• The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710.

  2008cites this paper
• Natural-product sugar biosynthesis and enzymatic glycodiversification.

  2008cites this paper
• Thebiosyntheticgenes encoding for theproductionofthe dynemicin enediyne core inMicromonospora chersina ATCC 53710

  2008cites this paper
• Bacterial Cell Wall Components

  2008cites this paper
• tmRNA of Streptomyces collinus and Streptomyces griseus during the growth and in the presence of antibiotics

  2008cites this paper
• Biosynthese von Naturstoffzuckern und enzymatische Glycodiversifizierung

  2008cites this paper
• Der lange Weg zur ersten Totalsynthese von Moenomycin A

  2007cites this paper
• Mining and engineering natural-product biosynthetic pathways.

  2007cites this paper