Regulatory miRNAs in Colorectal Carcinogenesis and Metastasis

Colorectal cancer is one of the most common malignancies and is the second-leading cause of cancer-related death world-wide, which is linked to genetic mutations, epigenetic alterations, and oncogenic signaling activation. MicroRNAs, one of the categories of epigenetics, have been demonstrated significant roles in carcinogenesis and progression through regulating of oncogenic signaling pathways, stem cells, epithelial-mesenchymal transition, and metastasis. This review summarizes the roles of microRNAs in the regulating of Wnt, Ras, TGF-β, and inflammatory signaling pathways, stemness, and epithelial-mesenchymal transition, for carcinogenesis and metastasis in colorectal cancer. Improving our understanding of the mechanisms of regulatory interactions of microRNAs with signaling pathways in colorectal cancer formation and progression will aid in determining the genes responsible for colorectal cancer initiation, progression, metastasis, and recurrence and, finally, in developing personalized approaches for cancer prevention and therapy.

• Publication year

  2017

• Venue

  International Journal of Molecular Sciences

• Publication date

  2017-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms18040890PMID 28441730PMCID 5412469
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNAs: Potential candidates for diagnosis and treatment of colorectal cancer

  2018cited by this paper
• Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer

  2017cited by this paper
• Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

  2017cited by this paper
• Blood-based microRNAs as biomarkers for the diagnosis of colorectal cancer: a systematic review and meta-analysis

  2017cited by this paper
• From tumour heterogeneity to advances in precision treatment of colorectal cancer

  2017cited by this paper
• MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications

  2017cited by this paper
• Expression analysis of microRNA as prognostic biomarkers in colorectal cancer.

  2017cited by this paper
• [The Role of MicroRNAs in Colorectal Cancer].

  2017cited by this paper
• Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract

  2016cited by this paper
• Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1

  2016cited by this paper
• Expression analysis of microRNA as prognostic biomarkers in colorectal cancer

  2016cited by this paper
• Cancer statistics, 2016

  2016cited by this paper
• The role of microRNAs in colorectal cancer.

  2016cited by this paper
• Inflammatory networks underlying colorectal cancer

  2016cited by this paper
• Rnd3 in Cancer: A Review of the Evidence for Tumor Promoter or Suppressor

  2016cited by this paper
• Modulatory roles of microRNAs in the regulation of different signalling pathways in large bowel cancer stem cells

  2016cited by this paper
• MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer

  2015cited by this paper
• Matters of context guide future research in TGFβ superfamily signaling

  2015cited by this paper
• Epithelial–mesenchymal transition: Untangling EMT's functions

  2015cited by this paper
• MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer.

  2015cited by this paper
• MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity.

  2015cited by this paper
• The Effects of miR‐20a on p21: Two Mechanisms Blocking Growth Arrest in TGF‐β‐Responsive Colon Carcinoma

  2015cited by this paper
• Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer

  2015cited by this paper
• MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer

  2015cited by this paper
• Notch‐1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer

  2015cited by this paper
• Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers.

  2015cited by this paper
• RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.

  2015cited by this paper
• Down-regualtion of miR-106b induces epithelial-mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer.

  2015cited by this paper
• Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice

  2015cited by this paper
• MiR‐29b Downregulates Canonical Wnt Signaling by Suppressing Coactivators of β‐Catenin in Human Colorectal Cancer Cells

  2014cited by this paper
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

  2014cited by this paper
• Colorectal carcinogenesis--update and perspectives.

  2014cited by this paper
• p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer.

  2014cited by this paper
• Tumor Suppressor MicroRNA-27a in Colorectal Carcinogenesis and Progression by Targeting SGPP1 and Smad2

  2014cited by this paper
• MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression

  2014cited by this paper
• A let-7 microRNA-Binding Site Polymorphism in KRAS Predicts Improved Outcome in Patients with Metastatic Colorectal Cancer Treated with Salvage Cetuximab/Panitumumab Monotherapy

  2014cited by this paper
• MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling.

  2014cited by this paper
• Inflammation and MiR-21 Pathways Functionally Interact to Downregulate PDCD4 in Colorectal Cancer

  2014cited by this paper
• Original ResearchFull Report: Basic and Translational—Alimentary TractA microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFκB and STAT3 in Colorectal Cancer Cells

  2014influential reference
• MicroRNA Profiling in Muc2 Knockout Mice of Colitis-Associated Cancer Model Reveals Epigenetic Alterations during Chronic Colitis Malignant Transformation

  2014cited by this paper
• MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

  2014cited by this paper
• MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of β-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer.

  2014cited by this paper
• microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS.

  2014cited by this paper
• MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells

  2014influential reference
• Colorectal cancer

  2014cited by this paper
• Association Study of the let-7 miRNA-Complementary Site Variant in the 3′ Untranslated Region of the KRAS Gene in Stage III Colon Cancer (NCCTG N0147 Clinical Trial)

  2014cited by this paper
• Induction of microRNA‐138 by pro‐inflammatory cytokines causes endothelial cell dysfunction

  2014cited by this paper
• MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation

  2013cited by this paper
• Chemokines in colitis: microRNA control

  2013cited by this paper
• MicroRNA-31 Activates the RAS Pathway and Functions as an Oncogenic MicroRNA in Human Colorectal Cancer by Repressing RAS p21 GTPase Activating Protein 1 (RASA1)*

  2013cited by this paper
• Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

  2013cited by this paper
• Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis.

  2013cited by this paper
• Downregulation of miR-138 Sustains NF-κB Activation and Promotes Lipid Raft Formation in Esophageal Squamous Cell Carcinoma

  2013cited by this paper
• Regulation of intestinal cancer stem cells.

  2013cited by this paper
• AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer

  2013cited by this paper
• TRAIL‐induced miR‐146a expression suppresses CXCR4‐mediated human breast cancer migration

  2013cited by this paper
• miR145 targets the SOX9/ADAM17 axis to inhibit tumor-initiating cells and IL-6-mediated paracrine effects in head and neck cancer.

  2013cited by this paper
• MiR-20a triggers metastasis of gallbladder carcinoma.

  2013cited by this paper
• A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.

  2013cited by this paper
• NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.

  2012cited by this paper
• Inflammation and colorectal cancer: colitis-associated neoplasia

  2012cited by this paper
• Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer

  2012cited by this paper
• Signaling in colon cancer stem cells

  2012cited by this paper
• MiR-27a Functions as a Tumor Suppressor in Acute Leukemia by Regulating 14-3-3θ

  2012cited by this paper
• MicroRNA miR-150 Is Involved in Vα14 Invariant NKT Cell Development and Function

  2012cited by this paper
• Up-regulated miR-17 promotes cell proliferation, tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma.

  2012cited by this paper
• Understanding cancer stem cell heterogeneity and plasticity

  2012cited by this paper
• Targeting MET in cancer: rationale and progress

  2012cited by this paper
• MicroRNA expression profiling identifies miR-328 regulates cancer stem cell-like SP cells in colorectal cancer

  2012cited by this paper
• Notch signaling and intestinal cancer.

  2012cited by this paper
• Targeting MET in cancer: rationale and progress

  2012cited by this paper
• The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models

  2012cited by this paper
• MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1.

  2011cited by this paper
• Innate immune mechanisms of colitis and colitis-associated colorectal cancer

  2011cited by this paper
• Stem cells and their implications for colorectal cancer

  2011cited by this paper
• MicroRNA‐451 Is Involved in the Self‐renewal, Tumorigenicity, and Chemoresistance of Colorectal Cancer Stem Cells

  2011cited by this paper
• A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

  2011cited by this paper
• MicroRNA in colorectal cancer: from benchtop to bedside.

  2011cited by this paper
• p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

  2011cited by this paper
• Alterations of microRNAs contribute to colon carcinogenesis.

  2011cited by this paper
• miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

  2011cited by this paper
• MicroRNAs in colorectal cancer metastasis

  2011cited by this paper
• LIN28B promotes colon cancer progression and metastasis.

  2011cited by this paper
• The cancer stem cell: premises, promises and challenges

  2011cited by this paper
• Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer.

  2011cited by this paper
• HMGB factors are required for posterior digit development through integrating signaling pathway activities

  2011cited by this paper
• Inflammation and colon cancer.

  2010cited by this paper
• The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma.

  2010cited by this paper
• MicroRNA control of signal transduction

  2010cited by this paper
• microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells.

  2010cited by this paper
• Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening

  2010cited by this paper
• The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.

  2010cited by this paper
• miR-21 and miR-31 Converge on TIAM1 to Regulate Migration and Invasion of Colon Carcinoma Cells*

  2010cited by this paper
• The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?

  2010cited by this paper
• Oncogenic microRNA‐27a is a target for anticancer agent methyl 2‐cyano‐3,11‐dioxo‐18β‐olean‐1,12‐dien‐30‐oate in colon cancer cells

  2009cited by this paper
• Role of miR-143 targeting KRAS in colorectal tumorigenesis

  2009influential reference
• Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression

  2009cited by this paper
• Inflammation and cancer: IL-6 and STAT3 complete the link.

  2009cited by this paper
• MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.

  2009cited by this paper
• Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling.

  2008cited by this paper

• Evaluating MiRNAs in Blood-Based Liquid Biopsy for Early-Onset Colorectal Cancer Detection: A Systematic Review and Meta-Analysis

  2026cites this paper
• Non-coding RNAs as mediators of epithelial - Mesenchymal transition (EMT) in metastatic colorectal cancers.

  2025cites this paper
• Targeting the CCL2/CCR2 Axis in Colorectal Cancer; Immunopharmacological Perspectives and Therapeutic Strategies.

  2025cites this paper
• NanoMarine therapeutics: a new wave in drug delivery from oceanic bioresources targeting colon cancer via miRNA modulation

  2025cites this paper
• The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications

  2025cites this paper
• The role of miRNAs in the pathogenesis, diagnosis, and treatment of colorectal cancer and colitis-associated cancer

  2025cites this paper
• Gene Coexpression and miRNA Regulation: A Path to Early Intervention in Colorectal Cancer

  2024cites this paper
• Tamizaje de cáncer colorrectal: pruebas emergentes no invasivas

  2024cites this paper
• Molecular Landscape of Small Bowel Adenocarcinoma

  2022cites this paper
• Differentially Deregulated MicroRNAs as Novel Biomarkers for Neoplastic Progression in Ulcerative Colitis

  2022cites this paper
• Essential role of aerobic glycolysis in epithelial-to-mesenchymal transition during carcinogenesis

  2022influential citation
• Genomic, Microbial and Immunological Microenvironment of Colorectal Polyps

  2021cites this paper
• EMT‐associated microRNAs and their roles in cancer stemness and drug resistance

  2021cites this paper
• Predictive Efficacy of MiR-125b-5p, MiR-17-5p, and MiR-185-5p in Liver Metastasis and Chemotherapy Response Among Advanced Stage Colorectal Cancer Patients

  2021cites this paper
• Regulatory effect between HMGA2 and the Wnt/β-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma

  2021cites this paper
• The long non-coding RNA HOXA11-AS promotes epithelial mesenchymal transition by sponging miR-149-3p in Colorectal Cancer

  2020cites this paper
• Analysis of microRNA-34a expression profile and rs2666433 variant in colorectal cancer: a pilot study

  2020cites this paper
• Function and mechanisms of microRNA-20a in colorectal cancer

  2020cites this paper
• A Review on AEG-1 oncogene regulating MicroRNA expression in Colon Cancer progression.

  2020cites this paper
• KRAS-associated microRNAs in colorectal cancer

  2020cites this paper
• PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation

  2020cites this paper
• Construction of prognostic predictor by comprehensive analyzing alternative splicing events for colon adenocarcinoma

  2020cites this paper
• Downregulation of miR-654-3p in Colorectal Cancer Indicates Poor Prognosis and Promotes Cell Proliferation and Invasion by Targeting SRC

  2020cites this paper
• Screening of colorectal cancer associated lncRNA, miRNA and mRNA based on bioinformatics technology and analysis of their biological functions

  2019cites this paper
• Small non‐coding RNA and colorectal cancer

  2019cites this paper
• Focused screening reveals functional effects of microRNAs differentially expressed in colorectal cancer

  2019cites this paper
• Expression Profiling Reveals Involvement of WNT Pathway in the Malignant Progression of Sessile Serrated Adenomas.

  2019cites this paper
• Plasma microRNA Levels Combined with CEA and CA19-9 in the Follow-Up of Colorectal Cancer Patients

  2019cites this paper
• Ursolic acid suppresses the invasive potential of colorectal cancer cells by regulating the TGF-β1/ZEB1/miR-200c signaling pathway

  2019cites this paper
• Up-regulation of microRNA-497-5p inhibits colorectal cancer cell proliferation and invasion via targeting PTPN3

  2019cites this paper
• Liquid biopsies in gastrointestinal malignancies: when is the big day?

  2018cites this paper
• The Promising Role of Let-7 Microrna in Colorectal Cancer: Practical Points for Clinicians

  2018cites this paper
• THE ROLE OF THE EPITHELIALLY-MESENCHIMAL TRANSITION IN THE DEVELOPMENT OF COLORECTAL CANCER (review)

  2018cites this paper
• Nicotine downregulates microRNA‐200c to promote metastasis and the epithelial–mesenchymal transition in human colorectal cancer cells

  2018cites this paper
• Inflammatory Markers and MicroRNAs: The Backstage Actors Influencing Prognosis in Colorectal Cancer Patients

  2018cites this paper
• Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma

  2018cites this paper
• SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.

  2017cites this paper
• Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer

  2017cites this paper
• Plasma microRNAs – novel markers for the detection of colonic polyps and their progression to colorectal cancer

  2017cites this paper
• MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis.

  2017cites this paper
• mRNA-miRNA bipartite network reconstruction to predict prognostic module biomarkers in colorectal cancer stage differentiation.

  2017cites this paper