Fluoxetine affords robust neuroprotection in the postischemic brain via its anti‐inflammatory effect

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Neuroscience Research

• Publication date

  2009-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jnr.21899PMID 18855941
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  2002influential reference
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Ischemic cell death in brain neurons.

  1999cited by this paper
• Pathobiology of ischaemic stroke: an integrated view.

  1999cited by this paper
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  1996cited by this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper