Pharmacological Interventions to Enhance Stroke Recovery

Abstract Neuropharmacological management after stroke focuses on augmenting the recovery process during rehabilitation, with the goal of improving function and independence. It is hypothesized that neuropharmacological agents affect central nervous system neurotransmitters, neurogenesis, and synaptogenesis. This chapter reviews the literature of these medications and their effect on motor, aphasia, and cognitive recovery. Animal and human evidence support the beneficial effect of selective serotonin reuptake inhibitors (SSRIs) on motor recovery post stroke. There is no definitive conclusion for the use of amphetamines or dopamine to promote motor recovery post stroke. There is no definitive conclusion for the use of dopamine, amphetamines and bromocriptine in aphasia recovery post stroke. Acetylcholine has literature support for use in aphasia recovery post stroke, while memantine also has some support. In cognitive recovery, there is not a unified recommendation for using SSRIs, and cholinergic or dopaminergic agents. More literature is needed in determining guidelines for administering these medications after stroke.

• Publication year

  2019

• Venue

  Stroke Rehabilitation

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/B978-0-323-55381-0.00013-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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