Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Immunity

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1074-7613(00)80465-3PMID 9462518
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The transcription factor NF-ATc is essential for cardiac valve formation

  1998cited by this paper
• Transcription factors of the NFAT family: regulation and function.

  1997cited by this paper
• Redundant expression but selective utilization of nuclear factor of activated T cells family members.

  1997cited by this paper
• Differential activation of transcription factors induced by Ca2+ response amplitude and duration

  1997cited by this paper
• Expression of NFAT-family proteins in normal human T cells

  1997cited by this paper
• c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation.

  1997cited by this paper
• Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

  1997cited by this paper
• Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

  1996cited by this paper
• Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.

  1996cited by this paper
• An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

  1996cited by this paper
• Characterization of a New Isoform of the NFAT (Nuclear Factor of Activated T Cells) Gene Family Member NFATc*

  1996cited by this paper
• High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters.

  1996cited by this paper
• Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.

  1995cited by this paper
• Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c

  1995cited by this paper
• Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation

  1995cited by this paper
• NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus

  1995cited by this paper
• Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency.

  1995cited by this paper
• Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

  1995cited by this paper
• Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene.

  1995cited by this paper
• The Ca2+/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene.

  1994cited by this paper
• NF-AT components define a family of transcription factors targeted in T-cell activation

  1994cited by this paper
• A common factor regulates both Th1‐ and Th2‐specific cytokine gene expression.

  1994cited by this paper
• Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4.

  1994cited by this paper
• Cyclosporin-A sensitive induction of NF-AT in murine B cells.

  1994cited by this paper
• RAG-2-Deficient Blastocyst Complementation

  1994cited by this paper
• Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter

  1993cited by this paper
• B lymphocyte development and activation independent of MHC class II expression.

  1993cited by this paper
• The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

  1993cited by this paper
• The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB

  1993cited by this paper
• RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

  1993cited by this paper
• Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter.

  1993cited by this paper
• The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT

  1993cited by this paper
• Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.

  1993cited by this paper
• Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc

  1993cited by this paper
• Nuclear factor of activated T cells contains Fos and Jun

  1992cited by this paper
• Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

  1992cited by this paper
• Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

  1991cited by this paper
• Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

  1991cited by this paper
• Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5

  1991cited by this paper
• Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.

  1990cited by this paper
• The ideal scientist described.

  1990cited by this paper
• Contingent genetic regulatory events in T lymphocyte activation.

  1989cited by this paper
• Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.

  1989cited by this paper
• Characterization of antigen receptor response elements within the interleukin-2 enhancer

  1988cited by this paper
• Identification of a putative regulator of early T cell activation genes.

  1988cited by this paper
• Differential regulation of IgG1 and IgE synthesis by interleukin 4

  1988cited by this paper
• Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production.

  1987cited by this paper

• Lipid metabolism in homeostasis and disease

  2026cites this paper
• Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells.

  2025cites this paper
• Multifaceted control of T cell differentiation by STIM1.

  2023cites this paper
• The Role of Airway Epithelial Cell Alarmins in Asthma

  2022cites this paper
• Formaldehyde exposure induces differentiation of regulatory T cells via the NFAT-mediated T cell receptor signalling pathway in Yucatan minipigs

  2021cites this paper
• Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development

  2021cites this paper
• Alcohol consumption induces murine osteoporosis by downregulation of natural killer T‐like cell activity

  2021cites this paper
• Role of NFAT in Chronic Lymphocytic Leukemia and Other B-Cell Malignancies

  2021cites this paper
• Genetic Inhibition of Nfatc2 Attenuates Asparaginase Hypersensitivity in Mice

  2020cites this paper
• Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma

  2020influential citation
• TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8+ T Cell Activation Setpoint

  2020influential citation
• Identification of novel interacting regions involving calcineurin and nuclear factor of activated T cells

  2020cites this paper
• Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway

  2020cites this paper
• Enhancer jungles establish robust tissue-specific regulatory control in the human genome.

  2019cites this paper
• Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2)

  2019cites this paper
• Opening the Black Box of Immunosuppression

  2018cites this paper
• STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes.

  2018cites this paper
• Identification of a Novel Alternatively Spliced Form of Inflammatory Regulator SWAP-70-Like Adapter of T Cells

  2017cites this paper
• Phospholipase Cγ1 is required for pre‐TCR signal transduction and pre‐T cell development

  2017cites this paper
• CD28 Costimulation in T Cells to Mediate IL-4 Gene Expression in Response to Θ Vav Synergizes with Protein Kinase C

  2017cites this paper
• Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy

  2016cites this paper
• Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player

  2016cites this paper
• Repository of the Max Delbrück Center for Molecular Medicine ( MDC ) in the Helmholtz Association

  2016cites this paper
• NFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytes

  2016cites this paper
• Nuclear Factor of Activated T Cells and Tolerance

  2016cites this paper
• NFAT2 Regulates Generation of Innate-Like CD8+ T Lymphocytes and CD8+ T Lymphocytes Responses

  2016cites this paper
• NFATC3 promotes IRF7 transcriptional activity in plasmacytoid dendritic cells

  2016cites this paper
• Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4

  2016cites this paper
• Analyse des Transkriptionsfaktors NFAT2 in der Pathogenese der CLL

  2015cites this paper
• NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms

  2015cites this paper
• Role of IL-25 in Immunity.

  2015cites this paper
• Consequences of chromsome18q deletions

  2015cites this paper
• Transcription factors and target genes of pre-TCR signaling

  2015cites this paper
• NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis

  2015cites this paper
• NFATc1 deletion in T lymphocytes inhibits the allergic trait in a murine model of asthma

  2015cites this paper
• Impact on antibody responses of B-cell-restricted transgenic expression of a viral gene inhibiting activation of NF-κB and NFAT

  2015cites this paper
• Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4

  2015cites this paper
• Differentiation of Effector CD 4 T Cell Populations ∗

  2014cites this paper
• Pontin is required for pre-TCR signaling at the β-selection checkpoint in T cell development.

  2014cites this paper
• Role of Ca/CaN/NFAT signaling in IL-4 expression by splenic lymphocytes exposed to phthalate (2-ethylhexyl) ester in spleen lymphocytes

  2014cites this paper
• Regulation of NFATc1 in Osteoclast Differentiation

  2014cites this paper
• Pathophysiology of tobacco smoke exposure: recent insights from comparative and redox proteomics.

  2014cites this paper
• Transcriptional regulatory networks for CD4 T cell differentiation.

  2014cites this paper
• Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

  2014cites this paper
• Regulation of lymphocyte response in vitro and in vivo

  2013cites this paper
• Cell Differentiation Time-Restricted Instruction Switch for Th2 IL-4-Induced GATA-3 Expression Is a

  2013cites this paper
• Nfatc1 directs the endocardial progenitor cells to make heart valve primordium.

  2013influential citation
• Inhibition of Th2 cytokine production in T cells by monascin via PPAR-γ activation.

  2013cites this paper
• with classical Hodgkin lymphoma from that of other diffuse large B-cell lymphomas and shares features The molecular signature of mediastinal large B-cell lymphoma differs

  2013cites this paper
• ‘All things considered’: transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation

  2013cites this paper
• Coactivators to Ensure Thymocyte Survival t Recruits Steroid Receptor γ ROR

  2013cites this paper
• cDNA Microarray Analyse und Genexpressionprofil von sporadischen Vestibularisschwannomen verglichen mit gesundem Autopsiegewebe : eine Betrachtungsweise auf molekularer Ebene unter Verwendung der Ingenuity Pathway Analysis Software

  2013cites this paper
• Noncanonical NFATc1 activation in DN thymocytes

  2013cites this paper
• The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression

  2013cites this paper
• NFAT5 induction by the pre–T-cell receptor serves as a selective survival signal in T-lymphocyte development

  2013cites this paper
• “ All Things Considered ” : Transcriptional Regulation of Th 2 Differentiation from Precursor to Effector Activation

  2013cites this paper
• Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T‐helper cell subsets

  2013cites this paper
• Transcription in Naive CD4+ T Cells Regulates NFATc/p Activity and Early IL-4 The Potency of TCR Signaling Differentially

  2013cites this paper
• Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells.

  2012cites this paper
• NFATc1/αA: The other Face of NFAT Factors in Lymphocytes

  2012cites this paper
• Host Factor Transcriptional Regulation Contributes to Preferential Expression of HIV Type 1 in IL-4–Producing CD4 T Cells

  2012cites this paper
• NFAT1 C-Terminal Domains Are Necessary but Not Sufficient for Inducing Cell Death

  2012cites this paper
• Buckwheat extracts (Fagopyrum tataricum) and rutin attenuate Th2 cytokines production and cellular allergic effects in vitro and in vivo

  2012cites this paper
• Thy-1 Signaling in T cells is Weaker and Has Delayed Signaling Kinetics, Promotes Delayed Acquisition and Triggering of Cytotoxic Effector Function, and Preferentially Promotes IL-17A and IL-4 Production in Comparison to TcR Signaling

  2012cites this paper
• Immune responses in cystic fibrosis: are they intrinsically defective?

  2012cites this paper
• Mecanismo molecular de la activación del enhancer del locus de la cadena alfa del receptor de linfocitos T (Tcra)

  2011influential citation
• Role of nuclear factor of activated T cell (NFAT) transcription factors in skin and vascularized cardiac allograft rejection.

  2011cites this paper
• The role of the IL23/IL17 pathway in inflammatory bowel disease

  2011influential citation
• Molecular regulation and endogenous expression of CRTh2 in in vitro differentiated CRTh2+ Th2 cells

  2011cites this paper
• CD4+ T cell interactions through CD28/B7 molecules affects their Th1/Th2 phenotype

  2011cites this paper
• Transplantation osteoporosis.

  2011cites this paper
• Interferon Regulatory Factor 2 Binding Protein 2 Is a New NFAT1 Partner and Represses Its Transcriptional Activity

  2011cites this paper
• Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation

  2011cites this paper
• [Calcineurin inhibitors and calcineurin-NFAT system].

  2010cites this paper
• CRACking the Code without Rosetta: Molecular Regulation of Calcium-Stimulated Gene Transcription after T Cell Activation

  2010cites this paper
• Critical role of NFATc1 in periapical lesions.

  2010cites this paper
• New mechanisms regulating human Th1 and Th2 cell differentiation

  2010cites this paper
• NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo

  2010cites this paper
• Novel Ribbon-Type Nuclear Factor of Activated T Cells Decoy Oligodeoxynucleotides Preclude Airways Hyperreactivity and Th2 Cytokine Expression in Experimental Asthma

  2010cites this paper
• Advances in immunosuppression for renal transplantation

  2010cites this paper
• Transcriptional control of the TNF gene.

  2010cites this paper
• UNTERSUCHUNG DER EXPRESSION UND TRANSLOKATION VON TRANSKRIPTIONSFAKTOREN BEI DER AKTIVIERUNG VON T-HELFER- UND REGULATORISCHEN T-ZELLEN

  2010cites this paper
• Differentiation of effector CD4 T cell populations (*).

  2010cites this paper
• Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

  2010cites this paper
• NFATc1 in inflammatory and musculoskeletal conditions.

  2010cites this paper
• NIP45 controls the magnitude of the type 2 T helper cell response

  2010cites this paper
• Immunosuppressive and antiproteolytic therapy in vascular diseases

  2010cites this paper
• Targeting allergic airway diseases by siRNA: an option for the future?

  2009cites this paper
• Transactivation Domain Defective Phosphorylation of NFAT Antigen-Stimulated CD 8 T Cells Linked to Impaired NFAT Transcriptional Activity in Guerder

  2009cites this paper
• Regulation of T‐cell tolerance by calcium/NFAT signaling

  2009cites this paper
• The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells

  2009cites this paper
• The significance of OX40 and OX40L to T‐cell biology and immune disease

  2009cites this paper
• Probing lymphocyte responses to modulation of the F0F1-ATPase by BZ-423

  2009cites this paper
• Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase*

  2009cites this paper
• Calcium signaling in the development and function of T‐lineage cells

  2009cites this paper
• NFAT1 transcription factor regulates pulmonary allergic inflammation and airway responsiveness.

  2009cites this paper
• Impaired NFAT Transcriptional Activity in Antigen-Stimulated CD8 T Cells Linked to Defective Phosphorylation of NFAT Transactivation Domain1

  2009cites this paper
• Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes.

  2009cites this paper
• MKP-1 Is Necessary for T Cell Activation and Function*

  2009cites this paper
• Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

  2009cites this paper