Characterization of interactions among the Cef1p-Prp19p-associated splicing complex.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  RNA: A publication of the RNA Society

• Publication date

  2002-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1017/S1355838202025050PMID 12088152PMCID PMC1370298
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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• Pombe Cdc5-related Protein

  1997influential reference
• Systematic identification of mitotic phosphoproteins.

  1997cited by this paper
• Venous reconstruction using hybrid vascular tissue composed of vascular cells and collagen: tissue regeneration process.

  1996cited by this paper
• The structure and function of proteins involved in mammalian pre-mRNA splicing.

  1996cited by this paper
• Protein-RNA and protein-protein interactions of the Drosophila sex-lethal mediated by its RNA-binding domains.

  1996cited by this paper
• The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb.

  1996cited by this paper
• Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.

  1996cited by this paper
• Progressive alignment of amino acid sequences and construction of phylogenetic trees from them.

  1996cited by this paper
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  1996cited by this paper
• Multiple RNA binding domains (RBDs) just don't add up.

  1995cited by this paper
• Studies on the transformation of intact yeast cells by the LiAc/SS‐DNA/PEG procedure

  1995cited by this paper
• Heat-inducible degron: a method for constructing temperature-sensitive mutants.

  1994cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Functional association of essential splicing factor(s) with PRP19 in a protein complex.

  1994cited by this paper
• Yeast precursor mRNA processing protein PRP19 associates with the spliceosome concomitant with or just after dissociation of U4 small nuclear RNA.

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes.

  1991cited by this paper
• Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

  1991cited by this paper
• Guide to yeast genetics and molecular biology.

  1991cited by this paper
• Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae

  1990cited by this paper

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• Structure of the human activated spliceosome in three conformational states

  2018cites this paper
• Cryo-EM Studies of Pre-mRNA Splicing: From Sample Preparation to Model Visualization.

  2018influential citation
• Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

  2017cites this paper
• The U-box family genes in Medicago truncatula: Key elements in response to salt, cold, and drought stresses

  2017cites this paper
• Interaction profiling of RNA-binding ubiquitin ligases reveals a link between posttranscriptional regulation and the ubiquitin system

  2017cites this paper
• CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing.

  2017cites this paper
• Mechanistic insights into precursor messenger RNA splicing by the spliceosome

  2017cites this paper
• The Spliceosome: A Protein-Directed Metalloribozyme.

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• CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast

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• CryoEM structure of the spliceosome immediately after branching

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  2006cites this paper
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