Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute‐phase protein

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Molecular Microbiology

• Publication date

  1991-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2958.1991.tb00812.xPMID 1766369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo.

  1991cited by this paper
• CHAPTER 1 – Historical perspective

  1990cited by this paper
• The thiol-activated toxin streptolysin O does not require a thiol group for cytolytic activity

  1989cited by this paper
• Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae

  1989cited by this paper
• Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity

  1989cited by this paper
• Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological properties.

  1989cited by this paper
• Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin

  1988cited by this paper
• Expression in Escherichia coli and sequence analysis of the listeriolysin O determinant of Listeria monocytogenes

  1988cited by this paper
• Cloned streptococcal protein G genes

  1987cited by this paper
• Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae

  1987cited by this paper
• Nucleotide sequence of the streptolysin O (SLO) gene: structural homologies between SLO and other membrane-damaging, thiol-activated toxins

  1987cited by this paper
• Interaction between streptococcal IgG Fc receptors and human and rabbit IgG domains.

  1986cited by this paper
• Gene for an immunoglobulin-binding protein from a group G streptococcus

  1986cited by this paper
• Of urfs and orfs

  1986cited by this paper
• Human serum amyloid P component, a circulating lectin with specificity for the cyclic 4,6-pyruvate acetal of galactose. Interactions with various bacteria.

  1985cited by this paper
• Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1.

  1985cited by this paper
• Rapid and sensitive protein similarity searches.

  1985cited by this paper
• Complement activation and attack on autologous cell membranes induced by streptolysin-O

  1985cited by this paper
• "ATG vectors' for regulated high-level expression of cloned genes in Escherichia coli.

  1985cited by this paper
• Activation of human complement by the pneumococcal toxin pneumolysin

  1984cited by this paper
• A rapid technique for measuring leukocyte chemotaxis in vivo.

  1984cited by this paper
• Complement and the host's defense against the pneumococcus.

  1984cited by this paper
• The gene for staphylococcal protein A.

  1984cited by this paper
• Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin

  1984cited by this paper
• Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin

  1983cited by this paper
• Gene for staphylococcal protein A.

  1983cited by this paper
• Escherichia coli

  1983cited by this paper
• Biological effects of the interaction of staphylococcal alpha-toxin with human serum

  1982cited by this paper
• Fibronectin and C4-binding protein are selectively bound by aggregated amyloid P component

  1981cited by this paper
• Dimeric, trimeric and tetrameric complexes of immunoglobulin G fix complement.

  1980cited by this paper
• Binding of serum amyloid P-component (SAP) by amyloid fibrils.

  1979cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.

  1974cited by this paper
• Brief Definitive Report C-reactive Protein Is Protective against Streptococcus Pneumoniae Infection in Mice*

  year unknowncited by this paper

• Antibodies against polysaccharide type 3 and pneumococcal proteins demonstrate synergistic protective effect in a highly virulent type 3 invasive disease model in mice

  2025cites this paper
• The Role of Ficolins in Lung Injury

  2024cites this paper
• Pneumococcal pneumonia is driven by increased bacterial turnover due to bacteriocin-mediated intra-strain competition

  2024cites this paper
• Presenting Characteristics, Treatment, and Visual Outcomes in Streptococcal Compared to Non-Streptococcal Endophthalmitis

  2024cites this paper
• Necrotizing Pneumonia in Children: Early Recognition and Management

  2023cites this paper
• Eluding the immune system's frontline defense: Secreted complement evasion factors of pathogenic Gram-positive cocci.

  2023cites this paper
• C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

  2023cites this paper
• Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies

  2022cites this paper
• Immune response induced in mice by a hybrid rPotD-PdT pneumococcal protein

  2022cites this paper
• The Yin and Yang of Pneumolysin During Pneumococcal Infection

  2022cites this paper
• Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors

  2022cites this paper
• Streptococcus pneumoniae interactions with the complement system

  2022cites this paper
• Pneumolysin: Pathogenesis and Therapeutic Target

  2020cites this paper
• Interaction of Macrophages and Cholesterol-Dependent Cytolysins: The Impact on Immune Response and Cellular Survival

  2020cites this paper
• Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae

  2020cites this paper
• Streptococci and the complement system: interplay during infection, inflammation and autoimmunity.

  2020cites this paper
• Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity

  2020cites this paper
• Next-Generation Whole-Cell Pneumococcal Vaccine

  2019cites this paper
• Pneumolysin Induces 12-Lipoxygenase–Dependent Neutrophil Migration during Streptococcus pneumoniae Infection

  2019cites this paper
• Streptococcus pneumoniae: Invasion and Inflammation

  2019cites this paper
• Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection

  2019cites this paper
• Pneumococcal Vaccines

  2019cites this paper
• Functional Characterisation of TprA/PhrA Quorum Sensing System in Streptococcus pneumoniae

  2018cites this paper
• The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases

  2018cites this paper
• Purification of Capsular Polysaccharides of Streptococcus pneumoniae: Traditional and New Methods

  2018cites this paper
• Modulation of neutrophil migration by the pneumococcal toxin, pneumolysin

  2018cites this paper
• A visual review of the human pathogen Streptococcus pneumoniae.

  2017cites this paper
• The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation

  2017cites this paper
• Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

  2017cites this paper
• Pneumolysin as a vaccine and study of structure and function

  2017influential citation
• Characterization of the interactions of the Streptococcus pneumoniae toxin, Pneumolysin, with soluble molecules of the immune system

  2017cites this paper
• Streptococcus pneumoniae and lytic antibiotic therapy: are we adding insult to injury during invasive pneumococcal disease and sepsis?

  2017cites this paper
• Red Blood Cell Susceptibility to Pneumolysin

  2016cites this paper
• hBD-2 and hBD-3 are induced in S. pneumoniae infected human macrophages via distinct signaling pathways but exhibit similar immune modulatory functions

  2016cites this paper
• Streptococcus pneumoniae Neutrophil transendothelial migration in vitro to

  2016cites this paper
• Red Blood Cell Susceptibility to Pneumolysin: Correlation with Membrane Biochemical and Physical Properties

  2016cites this paper
• Anatomical site-specific contributions of pneumococcal virulence determinants

  2016cites this paper
• Inflammasome Signaling and Bacterial Infections

  2016cites this paper
• University of Birmingham Red Blood Cell Susceptibility to Pneumolysin

  2016cites this paper
• Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

  2016cites this paper
• Streptococcal toxins: role in pathogenesis and disease

  2015cites this paper
• Chapter 14 – Pneumolysin

  2015cites this paper
• Deciphering the molecular composition of two independent activation cascades of the lectin pathway of complement

  2015cites this paper
• Studies on transcriptional regulation of pyruvate formate lyase in Streptococcus pneumoniae

  2015cites this paper
• Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines.

  2015cites this paper
• The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex

  2015cites this paper
• Genetic basis of susceptibility to invasive pneumococcal disease

  2015cites this paper
• Roles of Complement C1q in Pneumococcus-Host Interactions.

  2015cites this paper
• Streptococcus pneumoniae Interactions with Macrophages and Mechanisms of Immune Evasion

  2015cites this paper
• The role of the complement system in the hemolytic uremic syndrome

  2015cites this paper
• Microreview Streptococcal toxins : role in pathogenesis and disease

  2015cites this paper
• Defying death: Cellular survival strategies following plasmalemmal injury by bacterial toxins.

  2015cites this paper
• The biology of pneumolysin.

  2014cites this paper
• Identification and Characterization of Inerolysin, the Cholesterol Dependent Cytolysin produced by Lactobacillus iners

  2014cites this paper
• Distinct Mechanisms without Membrane Pore Formation Membrane Permeabilization and Executes Apoptosis by Pneumolysin Activates Macrophage Lysosomal 2014

  2014cites this paper
• Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

  2014cites this paper
• Mouse, but Not Human, ApoB-100 Lipoprotein Cholesterol Is a Potent Innate Inhibitor of Streptococcus pneumoniae Pneumolysin

  2014cites this paper
• The role of autophagy in infection with S. pneumoniae

  2014cites this paper
• Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein.

  2014cites this paper
• Detoxified pneumolysin derivative plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines

  2014cites this paper
• Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae

  2014cites this paper
• Type II Toxin-Antitoxin Loci: The Epsilon/zeta Family

  2013cites this paper
• La glycéraldéhyde-3-phosphate déshydrogénase, une protéine de la glycolyse présente à la surface cellulaire, est impliquée dans la reconnaissance par le système du complément chez Streptococcus pneumoniae

  2013cites this paper
• Identification of B-cell epitopes in an antigen for inducing specific class of antibodies

  2013cites this paper
• Development of improved diagnostic testing methods for invasive pneumococcal disease

  2013cites this paper
• Human L-ficolin, a Recognition Molecule of the Lectin Activation Pathway of Complement, Activates Complement by Binding to Pneumolysin, the Major Toxin of Streptococcus pneumoniae

  2013cites this paper
• Enolase of Streptococcus pneumoniae Binds Human Complement Inhibitor C4b-Binding Protein and Contributes to Complement Evasion

  2012cites this paper
• A Streptococcus pneumoniae infection model in larvae of the wax moth Galleria mellonella

  2012cites this paper
• Alterations of brain dendrite and synapse structure by the Streptococcus pneumoniae neurotoxin pneumolysin - Insights and pharmacological modulation Morphologische Veränderungen von Dendriten und Synapsen durch das Neurotoxin Pneumolysin - Einblicke und pharmakologischer Ansatz

  2012cites this paper
• Genetic variation and virulence of Streptococcus pneumoniae

  2012cites this paper
• Export Requirements of Pneumolysin in Streptococcus pneumoniae

  2012cites this paper
• EvasionProtein and Contributes to Complement Human Complement Inhibitor C4b-Binding Binds Streptococcus pneumoniae Enolase of

  2012cites this paper
• Role of the Lectin Pathway Recognition Molecule Ficolin A in Fighting Pneumococcal Infection

  2012cites this paper
• Protease-dependent mechanisms of complement evasion by bacterial pathogens

  2012cites this paper
• New approach for the treatment of pneumococcal diseases

  2011cites this paper
• Colonisation-induced protection against Streptococcus pneumoniae disease

  2011cites this paper
• Pathogenesis of A Clinical Ocular Strain of Streptococcus pneumoniae and the Interaction of Pneumolysin with Corneal Cells.

  2011cites this paper
• Screening of streptococcus pneumoniae ABC transporters for their role in virulence and investigation of their lipoprotein components as vaccine candidates

  2011cites this paper
• Pulmonale Expression und Regulation von IL-15 und den Rezeptoruntereinheiten IL-15Ra, IL 15Rb und gc in der durch Streptococcus pneumoniae induzierten Mauspneumonie

  2011cites this paper
• University of Birmingham Development of a multiplexed bead-based immunoassay for the simultaneous detection of antibodies to 17 pneumococcal proteins

  2011cites this paper
• ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development

  2011cites this paper
• Pneumolysin with Low Hemolytic Activity Confers an Early Growth Advantage to Streptococcus pneumoniae in the Blood

  2011cites this paper
• Alcohol abuse and Streptococcus pneumoniae infections: consideration of virulence factors and impaired immune responses.

  2011cites this paper
• Investigations on the Oligomerization of Pyolysin, a Cholesterol-Dependent Cytolysin

  2011cites this paper
• Etudes structurale et fonctionnelle de protéines impliquées dans la virulence chez S. pneumoniae et P. aeruginosa

  2011cites this paper
• Prise en charge des pneumonies graves à pneumocoque — Pneumonies communautaires aiguës sévères à Streptococcus pneumoniae (PAC Sp): rôle de l’hôte et des facteurs de virulence bactérienne

  2011cites this paper
• Prise en charge des pneumonies graves à pneumocoque — Pneumonies communautaires aiguës sévères à Streptococcus pneumoniae (PAC Sp) : rôle de l’hôte et des facteurs de virulence bactérienne Management of severe pneumococcal pneumonia — Severe acute community-acquired Streptococcus pneumoniae

  2010cites this paper
• The Effect of Bacterial Toxins on Platelet Function

  2010cites this paper
• Genetic characterisation of Streptococcus pneumoniae serotype 1 isolates in relation to invasiveness.

  2010cites this paper
• Novel strategies to prevent and treat experimental pneumococcal disease

  2010cites this paper
• Mécanismes moléculaires de la biogenèse du pilus chez Streptococcus pneumoniae

  2010cites this paper
• Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

  2010cites this paper
• Studies on emergence and spread of antibiotic resistant Streptococcus pneumoniae

  2010cites this paper
• INNATE IMMUNE SENSING OF A BACTERIAL PORE-FORMING TOXIN: THE ROLE OF THE NLRP3 INFLAMMASOME

  2010cites this paper
• MKP1 regulates the induction of inflammatory response by pneumococcal pneumolysin in human epithelial cells.

  2010cites this paper
• Human Lung Mast Cells Mediate Pneumococcal Cell Death in Response to Activation by Pneumolysin

  2010cites this paper
• S ON D SP IOTIC EPT NEUM

  2010cites this paper
• Pneumococci: immunology of the innate host response

  2010cites this paper
• Streptococcus pneumoniae: virulence factors and variation.

  2010cites this paper
• This information is current as Activation by Pneumolysin Pneumococcal Cell Death in Response to Human Lung Mast Cells Mediate

  2010cites this paper