MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

No abstract is available for this paper.

• Publication year

  2017

• Venue

  EMBO Reports

• Publication date

  2017-02-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.15252/embr.201643068PMID 28219903PMCID PMC5376764
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

  2017cited by this paper
• Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors.

  2016influential reference
• A Metabolomic Study of Rats with Doxorubicin-Induced Cardiomyopathy and Shengmai Injection Treatment

  2015cited by this paper
• limma powers differential expression analyses for RNA-sequencing and microarray studies

  2015cited by this paper
• Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

  2015cited by this paper
• Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice

  2015cited by this paper
• Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.

  2015cited by this paper
• Taking on challenging targets: making MYC druggable.

  2014cited by this paper
• Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness

  2014cited by this paper
• Glutathione synthesis.

  2013cited by this paper
• A Re-Emerging Marker for Prognosis in Hepatocellular Carcinoma: The Add-Value of FISHing c-myc Gene for Early Relapse

  2013influential reference
• MicroRNA-494 Within an Oncogenic MicroRNA Megacluster Regulates G1/S Transition in Liver Tumorigenesis Through Suppression of Mutated in Colorectal Cancer

  2013influential reference
• MYC, metabolism, cell growth, and tumorigenesis.

  2013cited by this paper
• Molecular Pathways Molecular Pathways : Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

  2013cited by this paper
• The Metastasis Suppressor, N-myc Downregulated Gene 1 (NDRG1), Is a Prognostic Biomarker for Human Colorectal Cancer

  2013cited by this paper
• Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.

  2013cited by this paper
• Abstract 4992: A novel role of soluble E-selectin as a chemoatractant to human leukocytes through the PI3kinase signaling pathway in breast cancer.

  2013cited by this paper
• The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse

  2013cited by this paper
• Integrated Systems and Technologies Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics

  2013influential reference
• Global metabolic profiling of human osteoarthritic synovium.

  2012cited by this paper
• The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

  2012influential reference
• Serum miR-18a: A Potential Marker for Hepatitis B Virus-Related Hepatocellular Carcinoma Screening

  2012cited by this paper
• Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.

  2012influential reference
• MYC on the path to cancer.

  2012cited by this paper
• c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells

  2011cited by this paper
• 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.

  2011cited by this paper
• Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines

  2011cited by this paper
• Metabolic pathway alterations that support cell proliferation.

  2011cited by this paper
• MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase.

  2011cited by this paper
• Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.

  2011cited by this paper
• Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

  2010cited by this paper
• microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma

  2010influential reference
• C‐Myc is a Nrf2‐interacting protein that negatively regulates phase II genes through their electrophile responsive elements

  2010cited by this paper
• TPF: a rational choice for larynx preservation?

  2010cited by this paper
• Targeting c-Myc as a novel approach for hepatocellular carcinoma.

  2010cited by this paper
• HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

  2010influential reference
• Gain of Nrf2 Function in Non-Small-Cell Lung Cancer Cells Confers Radioresistance

  2010cited by this paper
• The etiology of hepatocellular carcinoma and consequences for treatment.

  2010cited by this paper
• c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism

  2009cited by this paper
• MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells.

  2009cited by this paper
• Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.

  2009cited by this paper
• Faculty Opinions recommendation of c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.

  2009influential reference
• Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

  2008cited by this paper
• The in vivo gene expression signature of oxidative stress.

  2008cited by this paper
• An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

  2008cited by this paper
• Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

  2008cited by this paper
• The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

  2007cited by this paper
• Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

  2007cited by this paper
• Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

  2007cited by this paper
• Etiology‐dependent molecular mechanisms in human hepatocarcinogenesis

  2007cited by this paper
• Bioinformatics and Computational Biology Solutions Using R and Bioconductor

  2007cited by this paper
• Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

  2006cited by this paper
• Bioinformatics and Computational Biology Solutions Using R and Bioconductor

  2006cited by this paper
• The thioredoxin system in cancer.

  2006cited by this paper
• c-Myc phosphorylation is required for cellular response to oxidative stress.

  2006cited by this paper
• limma: Linear Models for Microarray Data

  2005cited by this paper
• Using the KEGG Database Resource

  2005influential reference
• Genomic progression in mouse models for liver tumors.

  2005cited by this paper
• A microRNA polycistron as a potential human oncogene

  2005cited by this paper
• c-Myc-regulated microRNAs modulate E2F1 expression

  2005cited by this paper
• Glutathione metabolism and its implications for health.

  2004influential reference
• MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

  2004cited by this paper
• A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

  2002cited by this paper
• Imputing Missing Data for Gene Expression Arrays

  2001influential reference
• Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc*

  2000cited by this paper
• Amplification of c-myc in Hepatocellular Carcinoma: Correlation with Clinicopathologic Features, Proliferative Activity and p53 Overexpression

  1999cited by this paper
• Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process.

  1994cited by this paper
• Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance.

  1993cited by this paper
• Bioinformatics Applications Note Gene Expression the Sva Package for Removing Batch Effects and Other Unwanted Variation in High-throughput Experiments

  year unknowncited by this paper

• Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis

  2026cites this paper
• Hereditary cancer syndromes linked to oxidative phosphorylation insufficiency

  2025cites this paper
• Crosstalk between miRNAs and oxidative stress: implications for cancer pathogenesis and therapy

  2025cites this paper
• Inducing ferroptosis to impede metastasis by inhibiting the calcium channel TRPC6

  2025cites this paper
• Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer

  2025cites this paper
• Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

  2025cites this paper
• A Multi-Omics Framework for Decoding Disease Mechanisms: Insights From Methylmalonic Aciduria

  2025cites this paper
• The crosstalk between glutathione metabolism and non-coding RNAs in cancer progression and treatment resistance

  2025cites this paper
• Exploiting replication stress for synthetic lethality in MYC-driven cancers.

  2025cites this paper
• Longitudinal multi-tracer imaging of hepatocellular carcinoma identifies novel stage- and oncogene-specific changes.

  2025cites this paper
• Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy

  2025cites this paper
• Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)

  2025cites this paper
• Ferroptosis and its relationship with cancer

  2025cites this paper
• Potential anticancer effect of free and nanoformulated Deferasirox for breast cancer treatment: in-vitro and in-vivo evaluation

  2024cites this paper
• Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities

  2024cites this paper
• MicroRNA-mediated regulation of Ferroptosis: Implications for disease pathogenesis and therapeutic interventions.

  2024cites this paper
• Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins

  2024cites this paper
• The Cancer Antioxidant Regulation System in Therapeutic Resistance

  2024cites this paper
• MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma

  2024cites this paper
• Glutathione metabolism-related gene signature predicts prognosis and treatment response in low-grade glioma

  2024cites this paper
• Roles of reactive oxygen species in inflammation and cancer

  2024cites this paper
• Myc upregulates Ggct, γ‐glutamylcyclotransferase to promote development of p53‐deficient osteosarcoma

  2024cites this paper
• Iron accumulation and lipid peroxidation: implication of ferroptosis in hepatocellular carcinoma

  2024cites this paper
• Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis

  2023cites this paper
• miRNA-Based Technologies in Cancer Therapy

  2023cites this paper
• Regulation of iron metabolism and ferroptosis in cancer stem cells

  2023cites this paper
• Emerging role of miRNAs in the regulation of ferroptosis

  2023cites this paper
• Metabolic reprogramming by miRNAs in the tumor microenvironment: Focused on immunometabolism

  2022cites this paper
• Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap

  2022cites this paper
• Ferroptosis in cancer and cancer immunotherapy

  2022influential citation
• The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma

  2022influential citation
• miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell adhesion/migration during solid tumor progression

  2022cites this paper
• Non-coding RNAs in ferroptotic cancer cell death pathway: meet the new masters

  2022cites this paper
• Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB

  2022cites this paper
• A Multi-Omics Approach to Evaluate the Toxicity Mechanisms Associated with Silver Nanoparticles Exposure

  2022influential citation
• MicroRNAs as Regulators of Cancer Cell Energy Metabolism

  2022cites this paper
• MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer

  2022cites this paper
• Ginsenosides in cancer: A focus on the regulation of cell metabolism.

  2022cites this paper
• MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype

  2021influential citation
• Metabolism-Associated Epigenetic and Immunoepigenetic Reprogramming in Liver Cancer

  2021cites this paper
• Managing GSH elevation and hypoxia to overcome resistance of cancer therapies using functionalized nanocarriers

  2021cites this paper
• Glutathione as Oxidative Stress Marker in Cancer

  2021cites this paper
• Oncogene-regulated release of extracellular vesicles.

  2021cites this paper
• Ferroptosis and Cancer: Complex Relationship and Potential Application of Exosomes

  2021cites this paper
• Potential Applications of NRF2 Modulators in Cancer Therapy

  2020cites this paper
• Astragaloside IV Synergizes with Ferulic Acid to Alleviate Hepatic Fibrosis in Bile Duct-Ligated Cirrhotic Rats

  2020cites this paper
• Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs

  2020cites this paper
• Glutathione Synthesis in Cancer Cells

  2020cites this paper
• Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression

  2020cites this paper
• The Application of Ferroptosis in Diseases.

  2020cites this paper
• Oncogene Regulated Release of Extracellular Vesicles

  2020cites this paper
• Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness

  2020cites this paper
• Charge transport through a water-assisted hydrogen bond in single-molecule glutathione disulfide junctions

  2020cites this paper
• The Impact of Diet on the Involvement of Non-Coding RNAs, Extracellular Vesicles, and Gut Microbiome-Virome in Colorectal Cancer Initiation and Progression

  2020cites this paper
• MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities.

  2020cites this paper
• Metabolomic profiling of mouse mammary tumor-derived cell lines reveals targeted therapy options for cancer subtypes

  2019cites this paper
• The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

  2019cites this paper
• miRNA Regulation of Glutathione Homeostasis in Cancer Initiation, Progression and Therapy Resistance

  2019cites this paper
• Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells

  2019cites this paper
• MicroRNAs in Tumor Cell Metabolism: Roles and Therapeutic Opportunities

  2019cites this paper
• Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure.

  2019cites this paper
• Identification of key gene modules and transcription factors for human osteoarthritis by weighted gene co-expression network analysis

  2019cites this paper
• Glutathione metabolism in cancer progression and treatment resistance

  2018cites this paper
• Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method.

  2018cites this paper
• Analysis of the Myc-induced pancreatic β cell islet tumor microenvironment using imaging ToF-SIMS.

  2018cites this paper
• Glutathione system in animal model of solid tumors: From regulation to therapeutic target.

  2018cites this paper
• MYC-induced metabolic stress and tumorigenesis.

  2018cites this paper
• MYC and tumor metabolism: chicken and egg

  2017cites this paper
• MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

  2017cites this paper
• Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs☆

  2017cites this paper
• In vivo Reprogramming of Cancer Metabolism by MYC

  2017influential citation