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Systems for the delivery of chemotherapeutic drugs, new approaches and perspective

А. Д. Халахакун

Published 2017 in Russian Open Medical Journal

ABSTRACT

Great perspectives in the field of drug therapy are currently associated with the targeted delivery of drugs to the organ, tissue or cells. Drug delivery systems (DDS) play a key role in enhancing the quality of chemotherapy in cancer disease. The intense interest in the topic of chemotherapy is the development of novel methods of drug delivery. The success of anti-tumor chemotherapy significantly dependends on the ability of therapeutic substances to achieve its target as well as minimal accumulation in non-specific sites (healthy organs and tissues). According to that, splendid perspectives in the field of chemotherapy are currently associated with the targeted delivery of drugs to the organs, tissues or cells. The essence of targeted delivery is that the drug itself, but more often a means of delivery systems (the vector, containers, and others.) modified by molecules, which can be identified by a unique receptor on cells or target sites. Then they are called “targeted drug delivery systems”. At the same time, the engineering of multifunctional nanocarriers with several useful properties in one carrier (nanoparticles, liposomes, micelles, dendrimers, and others.) can significantly enhance the efficacy of many therapeutic and diagnostic protocols. In this article, summarize the accumulated information about potential possibilities of DDS, and the practical applications in cancer chemotherapy.

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