Gap Junctions and Cancer: New Functions for an Old Story

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2008.2153PMID 18834328
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Implications and challenges of connexin connections to cancer

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• Cytoplasmic accumulation of connexin32 protein enhances motility and metastatic ability of human hepatoma cells in vitro and in vivo

  2007cited by this paper
• The role of connexins in controlling cell growth and gene expression.

  2007cited by this paper
• A role for connexin 26 in metastasis of human malignant melanoma : communication between melanoma and endothelial cells via connexin 26

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• Role for connexin 26 in metastasis of human malignant melanoma

  2007cited by this paper
• The Gap Junction Protein Connexin32 Interacts with the Src Homology 3/Hook Domain of Discs Large Homolog 1*

  2007cited by this paper
• Gap junction adhesion is necessary for radial migration in the neocortex

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• Connexin43 enhances glioma invasion by a mechanism involving the carboxy terminus

  2007cited by this paper
• Pathological Significance of Intracytoplasmic Connexin Proteins: Implication in Tumor Progression

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• Changes in gap junctional connexin isoforms during prostate cancer progression

  2006cited by this paper
• The role of the MAGUK protein CASK in neural development and synaptic function.

  2006cited by this paper
• Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

  2006cited by this paper
• Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer

  2006cited by this paper
• Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells

  2006cited by this paper
• Regulation of Connexin-43-Mediated Growth Inhibition by a Phosphorylatable Amino-Acid is Independent of Gap Junction-Forming Ability

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• Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis.

  2006cited by this paper
• Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism.

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• Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: significant correlation with poor prognosis.

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  2005cited by this paper
• Cell-to-cell interactions in bone.

  2005cited by this paper
• Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture

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• Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas

  2005cited by this paper
• Connexin-based gap junction hemichannels: gating mechanisms.

  2005cited by this paper
• Alterations in Connexin26 Expression during Colorectal Carcinogenesis

  2005cited by this paper
• Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype.

  2005cited by this paper
• Contact stimulation of prostate cancer cell migration: the role of gap junctional coupling and migration stimulated by heterotypic cell‐to‐cell contacts in determination of the metastatic phenotype of Dunning rat prostate cancer cells

  2005cited by this paper
• Involvement of gap junctions in placental functions and development.

  2005cited by this paper
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• Connexin43 Interacts with NOV

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  2004cited by this paper
• A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells.

  2004cited by this paper
• The effects of connexin phosphorylation on gap junctional communication.

  2004cited by this paper
• Negative growth control of renal cell carcinoma cell by connexin 32: Possible involvement of Her‐2

  2004cited by this paper
• Breast cancer metastatic potential: Correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells

  2004cited by this paper
• Gap junctions are required for trophoblast proliferation in early human placental development.

  2004cited by this paper
• Faculty Opinions recommendation of CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression.

  2004influential reference
• Gene expression alterations in connexin null mice extend beyond the gap junction.

  2004cited by this paper
• Diversity in protein-protein interactions of connexins: emerging roles.

  2004cited by this paper
• Connexin26 Regulates the Expression of Angiogenesis-Related Genes in Human Breast Tumor Cells by Both GJIC-Dependent and -Independent Mechanisms

  2003influential reference
• Mutations in the second extracellular region of connexin 43 prevent localization to the plasma membrane, but do not affect its ability to suppress cell growth.

  2003cited by this paper
• The Gap Junction-independent Tumor-suppressing Effect of Connexin 43*

  2003cited by this paper
• Array analysis of gene expression in connexin-43 null astrocytes.

  2003cited by this paper
• Changes in Neuronal Migration in Neocortex of Connexin43 Null Mutant Mice

  2003cited by this paper
• Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant‐negative connexin 43

  2003cited by this paper
• Communication between malignant glioma cells and vascular endothelial cells through gap junctions.

  2003influential reference
• Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation.

  2003cited by this paper
• A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2).

  2003cited by this paper
• Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation

  2003cited by this paper
• Increased invasive capacity of connexin43-overexpressing malignant glioma cells.

  2003cited by this paper
• Thyroid cell proliferation in response to forced expression of gap junction proteins.

  2002cited by this paper
• Connexin expression and gap junctional intercellular communication in human first trimester trophoblast.

  2002cited by this paper
• Autocrine Regulation of Myocyte Cx43 Expression by VEGF

  2002cited by this paper
• Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology.

  2002cited by this paper
• Connexin 43 Enhances the Adhesivity and Mediates the Invasion of Malignant Glioma Cells

  2002cited by this paper
• Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome

  2002cited by this paper
• Gap Junctions between Cells Expressing Connexin 43 or 32 Show Inverse Permselectivity to Adenosine and ATP*

  2002cited by this paper
• Gap junctions as targets for cancer chemoprevention and chemotherapy.

  2002cited by this paper
• Gap junctions and tumour progression.

  2002influential reference
• VEGF transiently disrupts gap junctional communication in endothelial cells.

  2001cited by this paper
• N-Cadherin and Cx43α1 Gap Junctions Modulates Mouse Neural Crest Cell Motility via Distinct Pathways

  2001influential reference
• Dual functions for connexins: Cx43 regulates growth independently of gap junction formation.

  2001cited by this paper
• Rat gap junction connexin-30 inhibits proliferation of glioma cell lines.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000influential reference
• Wnt-1 regulation of connexin43 in cardiac myocytes.

  2000cited by this paper
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• Identification of genes differentially expressed in C6 glioma cells transfected with connexin43.

  2000cited by this paper
• Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo

  2000cited by this paper
• Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells

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• Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells.

  2000influential reference
• Direct gap junction communication between malignant glioma cells and astrocytes.

  1999cited by this paper
• Selective transfer of endogenous metabolites through gap junctions composed of different connexins

  1999cited by this paper
• Defects in the germ line and gonads of mice lacking connexin43.

  1999cited by this paper
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  1999cited by this paper
• Suppression of human prostate cancer cell growth by forced expression of connexin genes.

  1999cited by this paper
• Cell-cell communication in carcinogenesis.

  1998cited by this paper
• Cx43 gap junctions in cardiac development.

  1998cited by this paper
• Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.

  1998cited by this paper
• Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase.

  1998cited by this paper
• Connexin transfection induces invasive properties in HeLa cells.

  1998cited by this paper
• Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development.

  1998cited by this paper
• Gap Junction–mediated Cell–Cell Communication Modulates Mouse Neural Crest Migration

  1998cited by this paper
• Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43).

  1998influential reference
• Inhibition of tumor promoter activity toward mouse fibroblasts and their in vitro transformation by tissue inhibitor of metalloproteinases-1 (TIMP-1).

  1997cited by this paper
• Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation.

  1997cited by this paper
• Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes

  1997cited by this paper

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• Connexin Expression in Pituitary Adenomas and the Effects of Overexpression of Connexin 43 in Pituitary Tumor Cell Lines

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