Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications

Background The next generation magnetic nanoparticles (MNPs) with theranostic applications have attracted significant attention and will greatly improve nanomedicine in cancer therapeutics. Such novel MNP formulations must have ultra-low particle size, high inherent magnetic properties, effective imaging, drug targeting, and drug delivery properties. To achieve these characteristic properties, a curcumin-loaded MNP (MNP-CUR) formulation was developed. Methods MNPs were prepared by chemical precipitation method and loaded with curcumin (CUR) using diffusion method. The physicochemical properties of MNP-CUR were characterized using dynamic light scattering, transmission electron microscopy, and spectroscopy. The internalization of MNP-CUR was achieved after 6 hours incubation with MDA-MB-231 breast cancer cells. The anticancer potential was evaluated by a tetrazolium-based dye and colony formation assays. Further, to prove MNP-CUR results in superior therapeutic effects over CUR, the mitochondrial membrane potential integrity and reactive oxygen species generation were determined. Magnetic resonance imaging capability and magnetic targeting property were also evaluated. Results MNP-CUR exhibited individual particle grain size of ~9 nm and hydrodynamic average aggregative particle size of ~123 nm. Internalized MNP-CUR showed a preferential uptake in MDA-MB-231 cells in a concentration-dependent manner and demonstrated accumulation throughout the cell, which indicates that particles are not attached on the cell surface but internalized through endocytosis. MNP-CUR displayed strong anticancer properties compared to free CUR. MNP-CUR also amplified loss of potential integrity and generation of reactive oxygen species upon treatment compared to free CUR. Furthermore, MNP-CUR exhibited superior magnetic resonance imaging characteristics and significantly increased the targeting capability of CUR. Conclusion MNP-CUR exhibits potent anticancer activity along with imaging and magnetic targeting capabilities. This approach can be extended to preclinical and clinical use and may have importance in cancer treatment and cancer imaging in the future. Further, if these nanoparticles can functionalize with antibody/ligands, they will serve as novel platforms for multiple biomedical applications.

• Publication year

  2012

• Venue

  International Journal of Nanomedicine

• Publication date

  2012-04-17

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.2147/IJN.S29290PMID 22619526PMCID 3356199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• an update on

  2014cited by this paper
• Prevention and management of major side effects of targeted agents in breast cancer.

  2012cited by this paper
• Design of curcumin loaded cellulose nanoparticles for prostate cancer.

  2012cited by this paper
• Curcumin nanoformulations: a future nanomedicine for cancer.

  2012influential reference
• Fluorescent Magnetic Nanoparticles with Specific Targeting Functions for Combinded Targeting, Optical Imaging and Magnetic Resonance Imaging

  2012cited by this paper
• Targeting Glut1-overexpressing MDA-MB-231 cells with 2-deoxy-D-g1ucose modified SPIOs.

  2012cited by this paper
• Cancer theranostics: the rise of targeted magnetic nanoparticles.

  2011cited by this paper
• Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.

  2011cited by this paper
• Sustained targeting of Bcr-Abl + leukemia cells by synergistic action of dual drug loaded nanoparticles and its implication for leukemia therapy.

  2011cited by this paper
• Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles.

  2011cited by this paper
• Brain tumor targeting of magnetic nanoparticles for potential drug delivery: effect of administration route and magnetic field topography.

  2011cited by this paper
• Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy.

  2011influential reference
• Theranostic magnetic nanoparticles.

  2011influential reference
• Working together: the combined application of a magnetic field and penetratin for the delivery of magnetic nanoparticles to cells in 3D.

  2011cited by this paper
• Monodisperse magnetic nanoparticles for theranostic applications.

  2011cited by this paper
• Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention

  2011cited by this paper
• Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability.

  2011cited by this paper
• Cancer statistics, 2011

  2011influential reference
• Coformulation of doxorubicin and curcumin in poly(D,L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells.

  2011cited by this paper
• Synthesis and characterization of a cytotoxic cationic polyvinylpyrrolidone-curcumin conjugate.

  2011cited by this paper
• Interaction of curcumin nanoformulations with human plasma proteins and erythrocytes

  2011cited by this paper
• Interaction of curcumin and bixin with β-cyclodextrin: complexation methods, stability, and applications in food.

  2011influential reference
• Highly loaded, sustained-release microparticles of curcumin for chemoprevention.

  2011cited by this paper
• Curcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs

  2010cited by this paper
• Imaging and drug delivery using theranostic nanoparticles.

  2010cited by this paper
• beta-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells.

  2010influential reference
• The formulation, characterization and in vivo evaluation of a magnetic carrier for brain delivery of NIR dye

  2010cited by this paper
• Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis.

  2010cited by this paper
• PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications

  2010influential reference
• Novel drug delivery systems for sustained and targeted delivery of anti- cancer drugs: current status and future prospects.

  2010cited by this paper
• Multifunctional magnetoplasmonic nanoparticle assemblies for cancer therapy and diagnostics (theranostics).

  2010cited by this paper
• Poly(β-cyclodextrin)/curcumin self-assembly: a novel approach to improve curcumin delivery and its therapeutic efficacy in prostate cancer cells.

  2010cited by this paper
• Adjuvant radiotherapy of women with breast cancer - information, support and side-effects.

  2010cited by this paper
• Triple-negative breast cancer: disease entity or title of convenience?

  2010cited by this paper
• Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth

  2010cited by this paper
• Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells.

  2010influential reference
• Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

  2009cited by this paper
• Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

  2009cited by this paper
• Magnetic nanoparticles for theragnostics.

  2009influential reference
• Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.

  2009cited by this paper
• Cell toxicity of superparamagnetic iron oxide nanoparticles.

  2009cited by this paper
• Magnetic resonance imaging of multifunctional pluronic stabilized iron-oxide nanoparticles in tumor-bearing mice.

  2009influential reference
• N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging

  2008cited by this paper
• In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. XXXIII.

  2008influential reference
• The Chemopreventive Agent Curcumin Is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased Reactive Oxygen Species Production and Overactivation of the Mitogen-Activated Protein Kinase Pathway

  2008cited by this paper
• Cyclodextrin conjugated magnetic colloidal nanoparticles as a nanocarrier for targeted anticancer drug delivery

  2008cited by this paper
• Magnetic nanoparticles for drug delivery applications.

  2008influential reference
• Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging.

  2008cited by this paper
• Curcumin and cancer: an "old-age" disease with an "age-old" solution.

  2008cited by this paper
• Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.

  2007cited by this paper
• Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications.

  2007cited by this paper
• Bioavailability of curcumin: problems and promises.

  2007cited by this paper
• Managing treatment side effects in advanced breast cancer.

  2007cited by this paper
• Triple-negative (basal-like) breast cancer: a new entity

  2007cited by this paper
• Labeling Efficacy of Superparamagnetic Iron Oxide Nanoparticles to Human Neural Stem Cells: Comparison of Ferumoxides, Monocrystalline Iron Oxide, Cross-linked Iron Oxide (CLIO)-NH2 and tat-CLIO

  2007cited by this paper
• Tumor-targeted induction of oxystress for cancer therapy

  2007cited by this paper
• A comparison of dispersing media for various engineered carbon nanoparticles

  2007cited by this paper
• Information provision for patients by breast cancer teams about the side-effects of hormone treatments.

  2006cited by this paper
• Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice

  2005cited by this paper
• Iron oxide nanoparticles for sustained delivery of anticancer agents.

  2005cited by this paper
• ROS stress in cancer cells and therapeutic implications.

  2004cited by this paper
• The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update.

  2003cited by this paper
• Transverse relaxation of solvent protons induced by magnetized spheres: Application to ferritin, erythrocytes, and magnetite

  1987cited by this paper

• Formulation of folic acid-decorated β-cyclodextrin-based magnetic nanoparticles hybrid Nanotherapeutic for targeted delivery of chlorogenic acid

  2025cites this paper
• Targeted disruption of Biofilm-Associated MDR pathogens using Curcumin-Loaded mesoporous spions

  2025cites this paper
• Synergistic anticancer efficacy of optimized curcumin-piperine loaded magnetic nanoparticles for the treatment of colorectal cancer

  2025cites this paper
• Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy

  2025cites this paper
• Mycosynthesised iron oxide nanoparticles using Apiospora aurea: Mitigating somatic and germline toxicity for safer biomedical applications

  2025cites this paper
• Revolution in Cancer Treatment Methods: Perspective Review of Factors Affecting the Final Results of Nanoparticles Used in Magnetic Fluid Hyperthermia

  2025cites this paper
• Development and characterization of ethosomes of Acacia senegal for improved topical treatment of breast cancer

  2025cites this paper
• Developing a Localized Delivery of Polymer-Based Targeted Nanoparticles Through Paclitaxel-Loaded Transdermal Patches for Breast Cancer Therapy: A Proof-of-Concept

  2025cites this paper
• Sub-15 nm Nanoparticles for Drug Delivery: Emerging Frontiers and Therapeutic Potential

  2025cites this paper
• Development and Evaluation of Tumor-Targeting Curcumin-Loaded Magnetic Nanoparticles Based on PEG-PLGA and Transferrin for Anti-Lung Cancer Therapy

  2025cites this paper
• Docetaxel‐Loaded, Dipeptide‐Functionalized γ‐Fe2O3 Magnetic Nanoparticles: Synthesis, Characterization, and Targeting to Prostate Cancer

  2025cites this paper
• Phytoactive Molecules and Nanodelivery Approaches for Breast Cancer Treatment: Current and Future Perspectives.

  2024cites this paper
• Enhanced Biocompatibility by Evaluating the Cytotoxic and Genotoxic Effects of Magnetic Iron Oxide Nanoparticles and Chitosan on Hepatocellular Carcinoma Cells (HCC)

  2024cites this paper
• Potential magnetic drug targeting with magnetite nanoparticles in cancer treatment by enhancer-modifier natural herb and loaded drug

  2024cites this paper
• Transforming cancer treatment: The potential of nanonutraceuticals.

  2024cites this paper
• Curcumin- and quercetin-functionalized polypropylene membranes as active food packaging material.

  2024cites this paper
• Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting

  2024cites this paper
• Characterization and investigating the potential therapeutic effects of phyto-assisted CuO and Zn-doped CuO nanoparticles from Calophyllum apetalum (Willd) leaf extract

  2024cites this paper
• The Emerging Role of Natural Products in Cancer Treatment

  2024cites this paper
• Cell-Penetrating Peptidic GRP78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging.

  2023cites this paper
• Biosynthesis of Zinc Oxide-Zerumbone (ZnO-Zer) Nanoflakes Towards Evaluating Its Antibacterial and Reactive Oxygen Species (ROS)-Dependent Cytotoxic Activity

  2023influential citation
• Curcumin capped magnetic nanoparticles. Synthesis, Characterization and Photoinactivation activity against S. Aureus

  2023cites this paper
• Iron oxide-Silver-Curcumin Nanocomposite Acts against HPV16 Positive Cervical Cancer Cell SiHa by Triggering Crosstalk between Autophagy and Apoptosis Primarily via Breach in Cellular Redox Equilibrium

  2023cites this paper
• A comprehensive review of the biomaterial-based multifunctional nanocarriers for therapeutic applications in breast cancer

  2023cites this paper
• Hybrid nanomaterial composed of chitosan, curcumin, ZnO and TiO2 for antibacterial therapies.

  2023cites this paper
• Emerging application of magnetic nanoparticles for breast cancer therapy

  2023cites this paper
• Naturally Occurring Phytochemicals to Target Breast Cancer Cell Signaling

  2023cites this paper
• Nano-drug delivery system: a promising approach against breast cancer.

  2023cites this paper
• Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers

  2023cites this paper
• Fe3O4/HA nanocarriers of Curcumin to evaluate the anti-cancer effect in MCF-7

  2023cites this paper
• Glutathione-Responsive Tannic Acid-Assisted FRET Nanomedicine for Cancer Therapy

  2023cites this paper
• (Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

  2023cites this paper
• Stimuli-responsive (nano)architectures for phytochemical delivery in cancer therapy.

  2023cites this paper
• Therapeutic potential of curcumin and its nanoformulations for treating oral cancer

  2023cites this paper
• Lutein-loaded chitosan/alginate-coated Fe3O4 nanoparticles as effective targeted carriers for breast cancer treatment.

  2023cites this paper
• Synthesis and in vitro antibacterial behavior of curcumin-conjugated gold nanoparticles.

  2023cites this paper
• Recent trends in macromolecule-conjugated hybrid quantum dots for cancer theranostic applications

  2023cites this paper
• Nanocarriers based novel and effective drug delivery system.

  2022cites this paper
• Magnetic Nanoseparation Technology for Efficient Control of Microorganisms and Toxins in Foods: A Review.

  2022cites this paper
• Fabrication of Curcumin Diethyl γ-Aminobutyrate-Loaded Chitosan-Coated Magnetic Nanocarriers for Improvement of Cytotoxicity against Breast Cancer Cells

  2022cites this paper
• Uniaxial and Coaxial Nanofibers PCL/Alginate or PCL/Gelatine Transport and Release Tamoxifen and Curcumin Affecting the Viability of MCF7 Cell Line

  2022cites this paper
• Novel MR imaging nanoprobe for hepatocellular carcinoma detection based on manganese–zinc ferrite nanoparticles: in vitro and in vivo assessments

  2022cites this paper
• Cinchona officinalis Phytochemicals-Loaded Iron Oxide Nanoparticles Induce Cytotoxicity and Stimulate Apoptosis in MCF-7 Human Breast Cancer Cells

  2022cites this paper
• Advances with metal oxide-based nanoparticles as MDR metastatic breast cancer therapeutics and diagnostics

  2022cites this paper
• Recent advances in phytochemical based nano-drug delivery systems to combat breast cancer: A review

  2022cites this paper
• Construction of targeted delivery system for curcumin loaded on magnetic α-Fe2O3/Fe3O4 heterogeneous nanotubes and its apoptosis mechanism on MCF-7 cell.

  2022cites this paper
• Nanocurcumin in Oral Squamous Cancer Cells and Its Efficacy as a Chemo-Adjuvant

  2022cites this paper
• A comparative study on biopharmaceutical function of curcumin and miR-34a by multistimuli-responsive nanoniosome carrier: In-vitro and in-vivo

  2022cites this paper
• A zinc ferrite nanodrug carrier for delivery of docetaxel: synthesis, characterization, and in vitro tests on C6 glioma cells

  2022cites this paper
• Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment

  2022cites this paper
• Anticancer potential of curcumin-cyclodextrin complexes and their pharmacokinetic properties.

  2022cites this paper
• Curcumin Nanoformulations with Metal Oxide Nanomaterials for Biomedical Applications

  2021influential citation
• Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers

  2021cites this paper
• Curcumin loaded chitosan-protamine nanoparticles revealed antitumor activity via suppression of NF-κB, proinflammatory cytokines and Bcl-2 gene expression in the breast cancer cells.

  2021cites this paper
• Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo

  2021cites this paper
• Theranostic Applications of Magnetic Nanoparticles in Breast Cancer

  2021cites this paper
• Current and future perspectives of multifunctional magnetic nanoparticles based controlled drug delivery systems

  2021cites this paper
• Natural products: A lead for drug discovery and development

  2021cites this paper
• Inulin-Coated Iron Oxide Nanoparticles: A Theranostic Platform for Contrast-Enhanced MR Imaging of Acute Hepatic Failure.

  2021cites this paper
• Chemopreventive and Therapeutic Potential of Natural Agents and Their Combinations for Breast Cancer

  2021cites this paper
• Curcumin-Loaded Micelles Dispersed in Ureasil-Polyether Materials for a Novel Sustained-Release Formulation

  2021cites this paper
• Toxicity and biodistribution assessment of curcumin-coated iron oxide nanoparticles: Multidose administration.

  2021cites this paper
• GRGDS-conjugated and curcumin-loaded magnetic polymeric nanoparticles for the hyperthermia treatment of glioblastoma cells

  2021cites this paper
• Magnetically responsive delivery into tumor environment

  2021cites this paper
• Nanoparticles for Delivering Natural Product Chemotherapeutics to Breast Cancer Cells

  2021cites this paper
• Theranostic nanoparticles engineered for clinic and pharmaceutics

  2021cites this paper
• Use of nanosystems to improve the anticancer effects of curcumin

  2021cites this paper
• Nano Metal based Herbal theranostics for Cancer management: coalescing nature's boon with nanotechnological advancement.

  2021cites this paper
• Nanocarrier based precise approaches for anticancer agents in treatment of breast cancer.

  2021cites this paper
• Dendrimer-Based Nanomedicine (Paramagnetic Nanoparticle, Nanocombretastatin, Nanocurcumin) for Glioblastoma Multiforme Imaging and Therapy

  2021cites this paper
• Phyto-drug conjugated nanomaterials enhance apoptotic activity in cancer.

  2021cites this paper
• Potential Therapeutic Approaches for SARS CoV2 Infection

  2021cites this paper
• Enhanced Photodynamic Suppression of Enterococcus faecalis Using Curcumin-Loaded Zeolite

  2021cites this paper
• Nanocurcumin: A Promising Candidate for Therapeutic Applications

  2020cites this paper
• Theranostic Nanoparticles for Pancreatic Cancer Treatment.

  2020cites this paper
• Micellar assisted aqueous stabilization of iron oxide nanoparticles for curcumin encapsulation and hyperthermia application

  2020cites this paper
• Efficacy of Nano-phytochemicals Over Pure Phytochemicals Against Various Cancers: Current Trends and Future Prospects

  2020cites this paper
• Novel hybrid nanostructure for breast cancer application

  2020cites this paper
• Sustainable Agriculture Reviews 44: Pharmaceutical Technology for Natural Products Delivery Vol. 2 Impact of Nanotechnology

  2020cites this paper
• A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo studies.

  2020cites this paper
• Hydrophobically modified sodium alginate conjugated plasmonic magnetic nanocomposites for drug delivery & magnetic resonance imaging

  2020cites this paper
• A Novel Elvitegravir Nanoformulation for Drug Delivery Across the Blood-Brain Barrier to Suppress HIV-1 in Macrophages and Microglia

  2020cites this paper
• Herbal Nanocarriers for Cancer Therapy

  2020cites this paper
• EFFECT OF SONICATION TIME AND PARTICLE SIZE FOR SYNTHESIS OF MAGNETIC NANOPARTICLE FROM LOCAL IRON SAND

  2020cites this paper
• Miscellaneous Approaches of Chemoprevention

  2020cites this paper
• Enhancement of Curcumin Solubility Using a Novel Solubilizing Polymer Soluplus®

  2020cites this paper
• Review of Curcumin Physicochemical Targeting Delivery System

  2020cites this paper
• Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid

  2020influential citation
• Inorganic Particles for Delivering Natural Products

  2020cites this paper
• Antioxidant, antimicrobial and cytotoxic activity of Curkolin® (Curcuma longa and Coleus forskohlii formulation)

  2020cites this paper
• One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications

  2020cites this paper
• 3D-QSAR and Molecular Docking Studies on Design Anti-prostate Cancer Curcumin Analogues.

  2020cites this paper
• Folic acid decorated magnetic nanosponge: An efficient nanosystem for targeted curcumin delivery and magnetic resonance imaging.

  2019cites this paper
• Fabrication and evaluation of novel quercetin-conjugated Fe3O4–β-cyclodextrin nanoparticles for potential use in epilepsy disorder

  2019influential citation
• Review on Nanoformulations of Curcumin (Curcuma longa Linn.): Special Emphasis on Nanocurcumin®

  2019cites this paper
• Curcumin-Loaded Nanoparticles and Their Potential as Anticancer Agents in Breast Cancer

  2019cites this paper
• Flower-like curcumin-loaded folic acid-conjugated ZnO-MPA- βcyclodextrin nanostructures enhanced anticancer activity and cellular uptake of curcumin in breast cancer cells.

  2019influential citation
• In vitro and in vivo characteristics of doxorubicin-loaded cyclodextrine-based polyester modified gadolinium oxide nanoparticles: a versatile targeted theranostic system for tumour chemotherapy and molecular resonance imaging

  2019cites this paper
• Purification of transferrin by magnetic nanoparticles and conjugation with cysteine capped gold nanoparticles for targeting diagnostic probes

  2019cites this paper
• Engineered polymeric iron oxide nanoparticles as potential drug carrier for targeted delivery of docetaxel to breast cancer cells

  2019cites this paper