HDL, lipid peroxidation, and atherosclerosis11 See referenced article, J. Lipid Res. 2009, 50: 716–722.

Genetic, clinical, and pharmacological studies implicate elevated levels of LDL in the pathogenesis of atherosclerotic vascular disease, the leading cause of death in industrialized societies (1). Paradoxically, native LDL fails to exert potentially atherogenic effects in vitro, suggesting that it must be modified to promote vascular disease. Indeed, many lines of evidence support the LDL oxidation hypothesis, which suggests that oxidative damage to LDL is one important mechanism for rendering lipoproteins atherogenic (as reviewed in Refs. 2, 3).

• Publication year

  2009

• Venue

  Journal of Lipid Research

• Publication date

  2009-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1194/jlr.E900001-JLR200PMID 19141435PMCID PMC2656652
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HDL is the major lipoprotein carrier of plasma F2-isoprostanes This work was supported by grants from the National Heart Foundation of Australia and the National Health and Medical Research Council of Australia. Published, JLR Papers in Press, December 2, 2008.

  2009cited by this paper
• ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet.

  2008cited by this paper
• High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1

  2007cited by this paper
• Release of Free F2-isoprostanes from Esterified Phospholipids Is Catalyzed by Intracellular and Plasma Platelet-activating Factor Acetylhydrolases*

  2006cited by this paper
• Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis

  2006cited by this paper
• Acrolein Impairs ATP Binding Cassette Transporter A1-dependent Cholesterol Export from Cells through Site-specific Modification of Apolipoprotein A-I*

  2005cited by this paper
• Tyrosine 192 in Apolipoprotein A-I Is the Major Site of Nitration and Chlorination by Myeloperoxidase, but Only Chlorination Markedly Impairs ABCA1-dependent Cholesterol Transport*

  2005cited by this paper
• Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell?

  2005cited by this paper
• Lipoprotein-associated phospholipase A2 as a target of therapy

  2005cited by this paper
• Reconstituted High-Density Lipoproteins Inhibit the Acute Pro-Oxidant and Proinflammatory Vascular Changes Induced by a Periarterial Collar in Normocholesterolemic Rabbits

  2005cited by this paper
• ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease.

  2005cited by this paper
• Increased Atherosclerosis in Mice Lacking Apolipoprotein A-I Attributable to Both Impaired Reverse Cholesterol Transport and Increased Inflammation

  2005cited by this paper
• Antiinflammatory Properties of HDL

  2004cited by this paper
• The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.

  2004cited by this paper
• Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.

  2004cited by this paper
• Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol.

  2003cited by this paper
• 2,3-Dinor-5,6-dihydro-15-F(2t)-isoprostane: a bioactive prostanoid metabolite.

  2001cited by this paper
• Is the emperor wearing clothes? Clinical trials of vitamin E and the LDL oxidation hypothesis.

  2001cited by this paper
• The role of high-density lipoproteins in oxidation and inflammation.

  2001cited by this paper
• Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

  2001cited by this paper
• Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo.

  2000cited by this paper
• Isoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo *

  1999cited by this paper
• Measurement of Lipid Peroxidation

  1999cited by this paper
• A novel lecithin-cholesterol acyltransferase antioxidant activity prevents the formation of oxidized lipids during lipoprotein oxidation.

  1999cited by this paper
• Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis.

  1998cited by this paper
• Measurement of lipid peroxidation.

  1998cited by this paper
• Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

  1994cited by this paper
• Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.

  1994cited by this paper
• Role of oxidised low density lipoprotein in atherogenesis.

  1993cited by this paper
• Koch's postulates for cholesterol.

  1992cited by this paper
• High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.

  1992influential reference
• Role of oxidized low density lipoprotein in atherogenesis.

  1991cited by this paper
• High-density lipoprotein--the clinical implications of recent studies.

  1989cited by this paper
• The plasma lecithins:cholesterol acyltransferase reaction.

  1968cited by this paper

• Exploiting Hydrogen Cyanide Producing Rhizobacteria to Combat Fusarium equiseti and Improve Sugar Beet Performance

  2025cites this paper
• Sustained Activation of Myeloperoxidase Is Associated with Oxidative Stress and Inflammation in People Living with the Human Immunodeficiency Virus at Risk of Cardiovascular Disease

  2025cites this paper
• Association between vitamin D deficiency, low high density lipoprote in cholesterol and higher risk of activities of daily living disability and dementia in Chinese adults aged over 65 years.

  2025cites this paper
• Gene Therapy Approaches for Atherosclerosis Focusing on Targeting Lipid Metabolism and Inflammation

  2025cites this paper
• The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis

  2024cites this paper
• Protective Role of High-Density Lipoprotein in Multiple Sclerosis

  2024cites this paper
• Cucurbita Pepo L. Seed Oil Modulates Dyslipidemia and Neuronal Dysfunction in Tramadol-Induced Toxicity in Wistar Albino Rats

  2024cites this paper
• Lipid Oxidation Products and the Risk of Cardiovascular Diseases: Role of Lipoprotein Transport

  2024cites this paper
• The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway.

  2024cites this paper
• Isoform‐specific modification of apolipoprotein E by 4‐hydroxynonenal: protective role of apolipoprotein E3 against oxidative species

  2023cites this paper
• Outlook of Ferroptosis-Targeted Lipid Peroxidation in Cardiovascular Disease.

  2022cites this paper
• Increased high‑density lipoprotein‑oxidant index in ischemic stroke patients.

  2022cites this paper
• Plasma Vitamin C and Risk of Late Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study

  2021cites this paper
• Trelagliptin ameliorates oxygen–glucose deprivation/reperfusion (OGD/R)-induced mitochondrial dysfunction and metabolic disturbance of endothelial cells

  2021cites this paper
• Ferulago Angulata as a Good Radioprotector against Genotoxicity.

  2021cites this paper
• Association Analysis of Hyperlipidemia with the 28-Day All-Cause Mortality of COVID-19 in Hospitalized Patients

  2021cites this paper
• Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

  2021cites this paper
• Small Molecule and Macrocyclic Pyrazole Derived Inhibitors of Myeloperoxidase (MPO).

  2021cites this paper
• Lipid Oxidation: New Perspectives on an Old Reaction

  2020cites this paper
• Sphingomyelins Prevent Propagation of Lipid Peroxidation—LC-MS/MS Evaluation of Inhibition Mechanisms

  2020cites this paper
• Inhibition of Myeloperoxidase.

  2020cites this paper
• Fibrillar conformation of an apolipoprotein A-I variant involved in amyloidosis and atherosclerosis.

  2020cites this paper
• Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell–Dependent Endothelial Cell Apoptosis

  2020cites this paper
• INFLUENCE OF THE BURDEN BY VARIOUS LEVELS OF PROFESSIONAL STRESS ON SERUM LIPIDS CONCENTRATION IN SECURITY OFFICERS

  2019cites this paper
• Investigation of dysfunctional HDL using myeloperoxidase / paraoxonase ratio in lymphoma

  2019cites this paper
• Altered HDL particle in sickle cell disease: decreased cholesterol content is associated with hemolysis, whereas decreased Apolipoprotein A1 is linked to inflammation

  2019cites this paper
• Humic acid as a feed additive in poultry diets: a review.

  2019cites this paper
• An analysis of isolated and intact RBC membranes - a comparison of a semiquantitative approach by means of FTIR, nano-FTIR and Raman spectroscopies.

  2019cites this paper
• Study of angiotensin-converting enzyme insertion/deletion polymorphism, enzyme activity and oxidized low density lipoprotein in Western Iranians with atherosclerosis: a case-control study

  2019cites this paper
• Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells.

  2018cites this paper
• Associations of the ABCA1 and LPL Gene Polymorphisms With Lipid Levels in a Hyperlipidemic Population

  2018cites this paper
• Lipid Profile and Coronary Heart Disease

  2018cites this paper
• Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies

  2018cites this paper
• Oxidant and antioxidant status in coronary artery disease.

  2018cites this paper
• Risk Factors of Atherosclerosis

  2018cites this paper
• Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension

  2017cites this paper
• Urinary Isoprostane Levels and Age-Related Macular Degeneration.

  2017cites this paper
• [DESIALATED LOW DENSITY LIPOPROTEINS IN HUMAN BLOOD].

  2017cites this paper
• Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.

  2017cites this paper
• Oxidized lipoprotein lipids and atherosclerosis

  2017cites this paper
• Studies on Antiobesity-related Compound in Okinawan Medicinal Plant Peucedanum japonicum Thunb: Identification and its Mechanisms of Action

  2016cites this paper
• Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease

  2016cites this paper
• Effect of Continuous and Intermittent Exercises on Oxidised HDL and LDL Lipids in Runners

  2016cites this paper
• Biomolecules damage and redox status abnormalities in Fabry patients before and during enzyme replacement therapy.

  2016cites this paper
• Strenuous physical exercise accelerates the lipid peroxide clearing transport by HDL

  2016cites this paper
• Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux[S]

  2016cites this paper
• Effects of salts on oxidative stability of lipids in Tween-20 stabilized oil-in-water emulsions.

  2016cites this paper
• Petri Kresanov – Oxidized HDL lipids and the risk for atherosclerosis

  2016cites this paper
• Acrolein Impairs the Cholesterol Transport Functions of High Density Lipoproteins

  2015cites this paper
• Identification of carbonylated lipids from different phospholipid classes by shotgun and LC-MS lipidomics

  2015cites this paper
• articleHigh-density lipoproteins downregulate CCL 2 production in human fibroblast-like synoviocytes stimulated by urate crystals

  2015cites this paper
• Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study

  2015cites this paper
• Valoración del estado nutricional en los diferentes estadios de la enfermedad renal crónica y su relación con el estrés oxidativo y la inflamación

  2015cites this paper
• Phytoestrogens: Health benefits and possible adverse effect

  2015cites this paper
• Lipid-Mediated Mechanisms in Atherosclerosis

  2014cites this paper
• Prevalence of dyslipidemia and its association with insomnia in a community based population in China

  2014cites this paper
• Mecanismos celulares y moleculares de la aterotrombosis

  2014cites this paper
• Investigating Changes in the Composition and the Function of High Density Lipoprotein after Roux-n-Y Bariatric Surgery

  2014influential citation
• Control glucémico y daño oxidativo a biomoléculas en diabéticos tipo 2

  2014cites this paper
• Dysfunctional HDL: the journey from savior to slayer

  2014cites this paper
• Effects of high-fat diets from different sources on serum and thymus lipid profile: study in an experimental model.

  2014cites this paper
• Assay of Protein and Peptide Adducts of Cholesterol Ozonolysis Products by Hydrophobic and Click Enrichment Methods

  2014cites this paper
• Thrombocyte adhesion and release of extracellular microvesicles correlate with surface morphology of adsorbent polymers for lipid apheresis.

  2014cites this paper
• Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats

  2014cites this paper
• Low Density Lipoprotein-Containing Circulating Immune Complexes: Role in Atherosclerosis and Diagnostic Value

  2014cites this paper
• Effects of Ferulago angulata Extract on Serum Lipids and Lipid Peroxidation

  2014cites this paper
• ApoD Mediates Binding of HDL to LDL and to Growing T24 Carcinoma

  2014cites this paper
• Dysfunctional HDL: the journey from savior

  2014cites this paper
• The associations of oxidized high-density lipoprotein lipids with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study.

  2013cites this paper
• Fatty acids as determinants of in-vivo lipid peroxidation: The EFFGE study in Eastern Finnish hypertensive and non-hypertensive subjects

  2013cites this paper
• 4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase Activation-Dependent Phosphatidylserine Exposure

  2013cites this paper
• Increased Small Dense LDL and Decreased Paraoxonase Enzyme Activity Reveals Formation of an Atherogenic Risk in Streptozotocin-Induced Diabetic Guinea Pigs

  2013cites this paper
• Molecular Studies on Coronary Artery Disease—A Review

  2013cites this paper
• Atherogenesis, the oxidative LDL modification hypothesis revisited

  2013cites this paper
• Why Targeting HDL Should Work as a Therapeutic Tool, but Has Not

  2013cites this paper
• Oxidized-phospholipids in reconstituted high density lipoprotein particles affect structure and function of recombinant paraoxonase 1.

  2013cites this paper
• Coronary Heart Disease: Lipid Theory

  2013cites this paper
• Lipoprotein and Lipid Metabolism

  2013cites this paper
• High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease1

  2013cites this paper
• Systematic review on the association between F2-isoprostanes and cardiovascular disease

  2013cites this paper
• Evaluation of para oxonase 1 arylesterase activity and lipid peroxide levels in patients with type 1 diabetes

  2012cites this paper
• Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease

  2012cites this paper
• Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

  2012cites this paper
• Cardiovascular disease in women.

  2012cites this paper
• Improvements of atherosclerosis and hepatic oxidative stress are independent of exercise intensity in LDLr(-/-) mice.

  2012cites this paper
• The innate immune response to products of phospholipid peroxidation

  2012cites this paper
• New insights into the role of iron in the promotion of lipid oxidation in bulk oils containing reverse micelles.

  2012cites this paper
• HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms

  2011cites this paper
• Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

  2011cites this paper
• Evaluation of paraoxonase 1 arylesterase activity and lipid peroxide levels in patients with type 1 diabetes.

  2011cites this paper
• History of discovery: platelet-derived growth factor.

  2011cites this paper
• 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E‐null mice

  2011cites this paper
• The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established.

  2011cites this paper
• Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited

  2010cites this paper
• Polimorfismo da Ala16Val MnSOD na hipercolesterolemia e sua associação com biomarcadores de inflamação e estresse oxidativo

  2010cites this paper
• The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)

  2010cites this paper
• NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology

  2010cites this paper
• Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization.

  2010cites this paper
• High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals

  2010cites this paper
• Interaction of HDL cholesterol concentrations on the relationship between physical function and inflammation in community-dwelling older persons.

  2010cites this paper