The sequence of a peptide containing the active site phosphohistidine residue of phosphoglycerate mutase from chicken breast muscle.

Phosphoglycerate mutase is phosphorylated on a histidine residue by the cofactor of the reaction, 2,3-bisphosphoglycerate (Rose, Z. B. (1970) Arch. Biochem. Biophys. 140, 508-513). The phosphoryl group is readily transferred to the normal acceptors, 3-phosphoglycerate and 2-phosphoglycerate, or to water in the presence of glycolate-2-P. An acid-labile phosphorylated decapeptide has been purified from a tryptic digest of the phosphoenzyme. The amino acid sequence of the peptide has been determined to be: Aal-Gly-Gln-Leu-Asp-Glu-Ser-His-Arg. This sequence bears a striking analogy to part of a highly conserved region of lactate dehydrogenase (residues 100 to 109) (Taylor, S. S., Oxley, S. S., Allison, W. S., and Kaplan, N. O. (1973) Proc. Natl. Acad. Sci. U. S. A. 70, 1970-1974). Evidence from x-ray crystallographic studies indicates that the two enzymes are similar in tertiary structure (Campbell, J. W., Watson, H. C. and Hodgson, G. I. (1974) Nature 250, 301-303).

• Publication year

  1975

• Venue

  Journal of Biological Chemistry

• Publication date

  1975-10-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0021-9258(19)40907-1PMID 170278
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Blue dextran-sepharose: an affinity column for the dinucleotide fold in proteins.

  1975cited by this paper
• Chemical and biological evolution of a nucleotide-binding protein

  1974cited by this paper
• Structure of yeast phosphoglycerate mutase

  1974cited by this paper
• Structure-function relationships in lactate dehydrogenase.

  1973cited by this paper
• Comparison of super-secondary structures in proteins.

  1973cited by this paper
• Thin-layer chromatography of sub-nanomole amounts of phenylthiohydantoin (PTH) amino acids on polyamide sheets.

  1973cited by this paper
• Aminoacid sequence of dogfish M4 lactate dehydrogenase.

  1973cited by this paper
• Multiple forms of phosphoglyceromutase from chicken breast muscle.

  1972cited by this paper
• Succinyl coenzyme A synthetase of Escherichia coli. Sequence of a peptide containing the active-site phosphohistidine residue.

  1972cited by this paper
• Studies on a role of the 2,3-diphosphoglycerate phosphatase activity in the yeast phosphoglycerate mutase reaction.

  1971cited by this paper
• The phosphorylation of yeast phosphoglycerate mutase.

  1971cited by this paper
• 2,3-diphosphoglycerate phosphatase from human erythrocytes. General properties and activation by anions.

  1970cited by this paper
• Evidence for a phosphohistidine protein intermediate in the phosphoglycerate mutase reaction.

  1970cited by this paper
• Direct determination of 2,3-diphosphoglycerate.

  1970cited by this paper
• The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

  1969cited by this paper
• The preparation, properties, and reactions of succinyl coenzyme A synthetase and its phosphorylated form.

  1967cited by this paper
• The preparation and characterization of 1-phosphohistidine and 3-phosphohistidine.

  1966cited by this paper
• Phosphate transfer from adenosine diphosphate phosphoglycerate and 2,3-diphosphoglycerate.

  1965cited by this paper
• ENZYMIC DEPHOSPHORYLATION OF ADENOSINE DIPHOSPHATE PHOSPHOGLYCERIC ACID.

  1964cited by this paper
• The presence of adenylyl 2, 3-diphosphoglyceric acid in pig blood.

  1961cited by this paper
• The molecular properties of yeast and muscle phosphoglyceric acid mutase.

  1957cited by this paper
• The kinetic properties of yeast and muscle phosphoglyceric acid mutase.

  1957cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• Mechanism of the phosphoglyceric mutase reaction.

  1949cited by this paper
• An improved method for the colorimetric determination of phosphate.

  1938cited by this paper

• Targeting PGAM1 in cancer: An emerging therapeutic opportunity.

  2022cites this paper
• Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1

  2017cites this paper
• Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease

  2015cites this paper
• The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications

  2014cites this paper
• Post-translational modifications and the Warburg effect

  2013cites this paper
• Metabolic Signaling and Therapy of Lung Cancer

  2013cites this paper
• Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

  2013cites this paper
• Mammalian histidine kinases: do they REALLY exist?

  2002cites this paper
• Inhibition of branched-chain alpha-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol.

  2002cites this paper
• Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping.

  2001cites this paper
• The histidine protein kinase superfamily.

  1999cites this paper
• Chapter 1 The covalent structure of proteins

  1997cites this paper
• Chemical Information: How Do We Get It and What Do We Do With It?

  1995cites this paper
• Post-translational chemical modifications of proteins--III. Current developments in analytical procedures of identification and quantitation of post-translational chemically modified amino acid(s) and its derivatives.

  1993cites this paper
• Structural modeling of the human erythrocyte bisphosphoglycerate mutase.

  1992cites this paper
• cDNA encoding type B subunit of rat phosphoglycerate mutase: its isolation and nucleotide sequence.

  1991cites this paper
• A histidine residue at the active site of avian liver phosphoenolpyruvate carboxykinase.

  1989cites this paper
• Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria.

  1989cites this paper
• Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene family.

  1988cites this paper
• Isolation of a cDNA encoding the muscle-specific subunit of human phosphoglycerate mutase.

  1987cites this paper
• Metabolism of glycerate 2,3-P2--XII. Characterization of the 2,3-bisphosphoglycerate synthase-phosphatase and of the hybrid phosphoglycerate mutase/2,3-bisphosphoglycerate synthase-phosphatase from pig brain.

  1987cites this paper
• Metabolism of glycerate 2,3-P2--XI. Essential amino acids of pig phosphoglycerate mutase isozymes.

  1987cites this paper
• Vit C.Fe(III) induced loss of the covalently bound phosphate and enzyme activity of phosphoglucomutase.

  1985cites this paper
• Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia.

  1985cites this paper
• Metabolism of glycerate-2,3-P2--V. Histidine-specific reagents inactivate the phosphoglycerate mutase, glycerate-2,3-P2 synthase and glycerate-2,3-P2 phosphatase activities of rabbit muscle phosphoglycerate mutase.

  1983cites this paper
• Phylogeny and ontogeny of the phosphoglycerate mutases.--V. Inactivation of phosphoglycerate mutase isozymes by histidine-specific reagents.

  1982cites this paper
• Phylogeny and ontogeny of the phosphoglycerate mutases--IV. Distribution of glycerate-2,3-P2 dependent and independent phosphoglycerate mutases in algae, fungi, plants and animals.

  1982cites this paper
• Human erythrocyte phosphoglycerate mutase: evidence for normal catalysis in the absence of added 2,3-bisphospho-D-glycerate.

  1980cites this paper
• Amino acid sequences of active‐site histidine peptides from rabbit muscle phosphoglycerate mutase

  1980cites this paper
• Pyruvate phosphate dikinase: sequence of the histidyl peptide, the pyrophosphoryl and phosphoryl carrier.

  1980cites this paper
• Vanadate inhibits 2,3-bisphosphoglycerate dependent phosphoglycerate mutases but does not affect the 2,3-bisphosphoglycerate independent phosphoglycerate mutases.

  1980cites this paper
• Enzyme-catalyzed phosphoryl transfer reactions.

  1980cites this paper
• Phosphoglycerate mutases: stereochemical course of the phosphoryl group transfers catalyzed by the cofactor-dependent enzyme from rabbit muscle and the cofactor-independent enzyme from wheat germ.

  1980cites this paper
• Identification of histidine-119 as the target in the site-specific inactivation of ribonuclease A by ferrate ion.

  1979cites this paper
• Active site phosphohistidine peptides from red cell bisphosphoglycerate synthase and yeast phosphoglycerate mutase.

  1979cites this paper
• Histidin im aktiven Zentrum von Enzymen

  1978cites this paper
• Histidine in enzyme active centers.

  1978cites this paper
• Phosphoglycerate mutase. Kinetics and effects of salts on the mutase and bisphosphoglycerate phosphatase activities of the enzyme from chicken breast muscle.

  1978cites this paper
• Phosphoenolypyruvate synthetase of Escherichia coli: molecular weight, subunit composition, and identification of phosphohistidine in phosphoenzyme intermediate.

  1977cites this paper
• Studies on the mechanism of action of histone kinase dependent on adenosine 3':5'-monophosphate. Evidence for involvement of histidine and lysine residues in the phosphotransferase reaction.

  1977cites this paper
• Studies on phosphoglyceromutase from chicken breast muscle: chemical modification of lysyl residues.

  1977cites this paper
• The active site of yeast phosphoglycerate mutase.

  1977cites this paper
• Phosphoglycerate mutase from wheat germ: studies with 18O-labeled substrate, investigations of the phosphatase and phosphoryl transfer activities, and evidence for a phosphoryl-enzyme intermediate.

  1977cites this paper
• Phosphohistidine as a stoichiometric intermediate in reactions catalyzed by isoenzymes of wheat germ acid phosphatase.

  1977cites this paper
• Membrane mediated link between ion transport and metabolism in human red cells.

  1977cites this paper
• Phosphoglycerate mutase has essential arginyl residues.

  1976cites this paper
• Detection of an essential sulfhydryl group in phosphoglycerate mutase with an affinity-labeling reagent.

  1976cites this paper
• Rates of phosphorylation and dephosphorylation of phosphoglycerate mutase and bisphosphoglycerate synthase.

  1976cites this paper
• The amino acid sequence of yeast phosphoglycerate mutase

  1975cites this paper