The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell Research

• Publication date

  2015-11-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/cr.2015.140PMID 26611634PMCID PMC4670996
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

  2016cited by this paper
• YAP1 and TAZ Activates mTORC1 Pathway by Regulating Amino Acid Transporters in hepatocellular carcinoma

  2016cited by this paper
• A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

  2015cited by this paper
• MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

  2015cited by this paper
• The emerging roles of YAP and TAZ in cancer

  2015cited by this paper
• Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

  2015cited by this paper
• Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness*♦

  2015cited by this paper
• Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.

  2015cited by this paper
• Nutrient-sensing mechanisms and pathways

  2015cited by this paper
• YAP and TAZ: a nexus for Hippo signaling and beyond.

  2015cited by this paper
• Differential regulation of mTORC1 by leucine and glutamine

  2015cited by this paper
• The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.

  2015cited by this paper
• Ubiquitylation of CD98 limits cell proliferation and clonal expansion

  2015cited by this paper
• LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

  2015cited by this paper
• The Hippo signal transduction pathway in soft tissue sarcomas.

  2015cited by this paper
• The biology of YAP/TAZ: hippo signaling and beyond.

  2014cited by this paper
• Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway

  2014cited by this paper
• The Catalytic Subunit of the System L1 Amino Acid Transporter (Slc7a5) Facilitates Nutrient Signalling in Mouse Skeletal Muscle

  2014cited by this paper
• CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction.

  2014cited by this paper
• Role of amino acid transporters in amino acid sensing.

  2014cited by this paper
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

  2014cited by this paper
• Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

  2014cited by this paper
• Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.

  2014cited by this paper
• Making new contacts: the mTOR network in metabolism and signalling crosstalk

  2014cited by this paper
• The Hippo signal transduction network in skeletal and cardiac muscle

  2014cited by this paper
• Regulation of mTORC1 by amino acids.

  2014cited by this paper
• Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

  2014cited by this paper
• Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

  2013cited by this paper
• Nutrient regulation of the mTOR Complex 1 signaling pathway

  2013cited by this paper
• The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

  2013cited by this paper
• Autophagy regulation by nutrient signaling

  2013cited by this paper
• Amino acid signalling upstream of mTOR

  2013cited by this paper
• Regulation of the Hippo pathway and implications for anticancer drug development.

  2013cited by this paper
• DNASU plasmid and PSI:Biology-Materials repositories: resources to accelerate biological research

  2013cited by this paper
• The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

  2012cited by this paper
• YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

  2012cited by this paper
• The role of amino acid transporters in inherited and acquired diseases.

  2011cited by this paper
• Regulation of mTORC1 by the Rab and Arf GTPases*

  2010cited by this paper
• Structural insights into the YAP and TEAD complex.

  2010cited by this paper
• Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

  2009cited by this paper
• Bidirectional transport of amino acids regulates mTOR and autophagy.

  2009cited by this paper
• A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.

  2008cited by this paper
• Regulation of TORC1 by Rag GTPases in nutrient response

  2008cited by this paper
• Expression of Yes-associated protein in common solid tumors.

  2008cited by this paper
• The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

  2008cited by this paper
• Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

  2008cited by this paper
• TEAD mediates YAP-dependent gene induction and growth control.

  2008cited by this paper
• YAP1 increases organ size and expands undifferentiated progenitor cells.

  2007cited by this paper
• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

  2007cited by this paper
• Elucidation of a universal size-control mechanism in Drosophila and mammals.

  2007cited by this paper
• CD98hc (SLC3A2) mediates integrin signaling.

  2005cited by this paper
• CD98hc (SLC3A2) Interaction with β1 Integrins Is Required for Transformation*

  2004cited by this paper
• Activation of system L heterodimeric amino acid exchangers by intracellular substrates

  2002cited by this paper
• Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.

  2002cited by this paper
• Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake.

  2002cited by this paper
• mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

  2002cited by this paper
• Intracellular Sensing of Amino Acids in Xenopus laevis Oocytes Stimulates p70 S6 Kinase in a Target of Rapamycin-dependent Manner*

  2002cited by this paper
• TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.

  2001cited by this paper
• Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism*

  1998cited by this paper
• Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

  1998cited by this paper
• Amino acid availability regulates p70 S6 kinase and multiple translation factors.

  1998cited by this paper

• The Role of the Hippo Signaling Pathway in 7,12‐Dimethylbenz(a)anthracene (DMBA)‐Induced Follicular Depletion

  2026cites this paper
• Dexmedetomidine suppresses ferritinophagy-mediated ferroptosis in myocardial ischemia-reperfusion injury via the YAP1/NCOA4 pathway.

  2026cites this paper
• Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions

  2026cites this paper
• Network-based analysis reveals microRNA regulation of oncogenic pathways in SOX10-depleted uveal melanoma

  2025cites this paper
• Load-induced human skeletal muscle hypertrophy: Mechanisms, myths, and misconceptions.

  2025cites this paper
• Targeting emerging amino acid dependencies and transporters in cancer therapy

  2025cites this paper
• TRANSLATING MOLECULAR MECHANISMS OF EPITHELIOID HEMANGIOENDOTHELIOMA TO IMPROVE PATIENT OUTCOME.

  2025cites this paper
• Spindle localization of YAP/TAZ maintains even distribution of YAP/TAZ in daughter cells

  2025cites this paper
• TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence

  2025cites this paper
• Tissue stiffness heterogeneity in the jaw and temporomandibular joint: its impact on tumor metabolism and considerations for in vitro model development

  2025cites this paper
• Disulfidptosis mechanisms and therapeutic implications in cancer metabolic reprogramming and future perspectives

  2025cites this paper
• Engineering stem cell metabolism using biomaterial-induced mechanotransduction

  2025cites this paper
• Liver regeneration–associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition

  2025cites this paper
• Pipeline to evaluate YAP-TEAD inhibitors indicates TEAD inhibition represses NF2-mutant mesothelioma

  2025cites this paper
• Exploring YAP1-TEAD interaction in multi-pathway regulation: potential repairing efficacy for bone defect

  2025cites this paper
• The Role of Collagen Matrix in the Development and Progression of Heterotopic Ossification in Tendon and Its Biological Mechanisms

  2025cites this paper
• Hippo/YAP signaling’s multifaceted crosstalk in cancer

  2025cites this paper
• Epithelioid Hemangioendothelioma: Treatment Landscape and Innovations for an Ultra-Rare Sarcoma

  2025cites this paper
• YAP-activated NAT10 promotes hepatoblastoma progression by activating the pentose phosphate pathway

  2025cites this paper
• The effects and post-exercise energy metabolism characteristics of different high-intensity interval training in obese adults

  2025cites this paper
• Enlarging Scalp Lesion in Pediatric Patient

  2025cites this paper
• Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: a review

  2025cites this paper
• Peripheral nerves modulate the peri-implant osteogenesis under type 2 diabetes through exosomes derived from schwann cells via miR-15b-5p/Txnip signaling axis

  2025cites this paper
• Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance

  2025cites this paper
• A feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration

  2025cites this paper
• In vivo screen reveals specific roles of Hippo pathway components in development and regeneration

  2025cites this paper
• First-in-Class SAM-Competitive G9a Inhibitor FLAV-27 as a Disease-Modifying Therapy for Alzheimer's Disease.

  2025cites this paper
• Insights into Metabolic Reprogramming in Tumor Evolution and Therapy

  2024cites this paper
• What are the potential mechanisms of fatigue-induced skeletal muscle hypertrophy with low-load resistance exercise training?

  2024cites this paper
• YAP/TAZ mediates resistance to KRAS inhibitors through inhibiting proapoptosis and activating the SLC7A5/mTOR axis

  2024cites this paper
• Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways

  2024cites this paper
• mTORC1, the maestro of cell metabolism and growth

  2024cites this paper
• Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish.

  2024cites this paper
• YAP promotes global mRNA translation to fuel oncogenic growth despite starvation

  2024cites this paper
• LAT1 supports mitotic progression through Golgi unlinking in an amino acid transport activity-independent manner

  2024cites this paper
• ITCH inhibits alkaliptosis in human pancreatic cancer cells through YAP1-dependent SLC16A1 activation.

  2024cites this paper
• Exercise-Specific Adaptations in Human Skeletal Muscle: Molecular Mechanisms of Making Muscles Fit and Mighty.

  2024cites this paper
• The effect of genetics and biochemistry on the pathogenesis of cholangiocarcinoma

  2024cites this paper
• Promoting Biological Similarity by Collagen Microfibers in 3D Colorectal Cancer-Stromal Tissue: Replicating Mechanical Properties and Cancer Stem Cell Markers.

  2024cites this paper
• Mitigation of Breast Cancer Cells’ Invasiveness via Down Regulation of ETV7, Hippo, and PI3K/mTOR Pathways by Vitamin D3 Gold-Nanoparticles

  2024cites this paper
• Protein expression of the amino acid transporter SLC7A5 in tumor tissue is prognostic in early-stage colorectal cancer

  2024cites this paper
• L-type Amino Acid Transporter 1 as a Therapeutic Target in Pancreatic Cancer

  2024cites this paper
• Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells.

  2024cites this paper
• Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.

  2024cites this paper
• JCAD deficiency delayed liver regenerative repair through the Hippo–YAP signalling pathway

  2024cites this paper
• The molecular crosstalk of the hippo cascade in breast cancer: A potential central susceptibility.

  2024cites this paper
• Targeting YAP1 to improve the efficacy of immune checkpoint inhibitors in liver cancer: mechanism and strategy

  2024cites this paper
• Alpha-fetoprotein upregulates hepatocellular carcinoma cell-intrinsic PD-1 expression through the LATS2/YAP/TEAD1 pathway.

  2024cites this paper
• Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease

  2024cites this paper
• Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis.

  2024cites this paper
• KLF15 transcriptionally activates LINC00689 to inhibit colorectal cancer development

  2024cites this paper
• The LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway

  2024cites this paper
• SLC3A2 promotes tumor‐associated macrophage polarization through metabolic reprogramming in lung cancer

  2023cites this paper
• Vasculature is getting Hip(po): Hippo signaling in vascular development and disease.

  2023cites this paper
• YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations

  2023cites this paper
• The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis

  2023cites this paper
• TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression

  2023cites this paper
• Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential

  2023cites this paper
• Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis.

  2023cites this paper
• TOR complex 1 negatively regulates NDR kinase Cbk1 to control cell separation in budding yeast

  2023cites this paper
• A covalent inhibitor of the YAP–TEAD transcriptional complex identified by high-throughput screening

  2023cites this paper
• P4HA2-induced prolyl hydroxylation of YAP1 restricts vascular smooth muscle cell proliferation and neointima formation.

  2023cites this paper
• AR activates YAP/TAZ differentially in prostate cancer

  2023cites this paper
• Crosstalk between the mTOR and Hippo pathways

  2023cites this paper
• Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming

  2023cites this paper
• Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

  2023cites this paper
• The Hippo signaling pathway: from multiple signals to the hallmarks of cancers

  2023cites this paper
• Hippo pathway in intestinal diseases: focusing on ferroptosis

  2023influential citation
• The functional relationship of Yap/Taz with autophagy functions in sarcopenia associated with aging

  2023cites this paper
• Research Progress of Hippo-Yap/Taz Signaling in Skeletal Muscle Hypertrophy

  2023cites this paper
• Airway secretory cell fate conversion via YAP‐mTORC1‐dependent essential amino acid metabolism

  2022cites this paper
• Abnormal activation of yap/Taz contributes to the pathogenesis of tuberous sclerosis complex.

  2022cites this paper
• mTOR Signaling Components in Tumor Mechanobiology

  2022cites this paper
• The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

  2022cites this paper
• The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: Physiological and pathophysiological implications

  2022cites this paper
• Extracellular-matrix mechanics regulate cellular metabolism: A ninja warrior behind mechano-chemo signaling crosstalk

  2022cites this paper
• Inter-set stretch: A potential time-efficient strategy for enhancing skeletal muscle adaptations

  2022cites this paper
• Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis

  2022cites this paper
• Crosstalk between Hypoxia and Extracellular Matrix in the Tumor Microenvironment in Breast Cancer

  2022cites this paper
• A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

  2022cites this paper
• The Hippo pathway drives the cellular response to hydrostatic pressure

  2022influential citation
• RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling

  2022cites this paper
• Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.

  2022cites this paper
• An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

  2022cites this paper
• Current Advances in 3D Bioprinting for Cancer Modeling and Personalized Medicine

  2022cites this paper
• Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients

  2022cites this paper
• Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

  2021cites this paper
• The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development

  2021cites this paper
• High-Intensity Functional Training: Molecular Mechanisms and Benefits

  2021cites this paper
• YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance.

  2021cites this paper
• Mechanical Stiffness Controls Dendritic Cell Metabolism and Function.

  2021cites this paper
• Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing

  2021cites this paper
• β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling.

  2021cites this paper
• A specific tRNA half, 5’tiRNA-His-GTG, responds to hypoxia via the HIF1α/ANG axis and promotes colorectal cancer progression by regulating LATS2

  2021cites this paper
• WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma

  2021cites this paper
• YAP and TAZ Mediators at the Crossroad between Metabolic and Cellular Reprogramming

  2021cites this paper
• In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives

  2021cites this paper
• The Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes

  2021cites this paper
• New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges

  2021cites this paper
• Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1

  2021cites this paper