p57Kip2 and Cancer: Time for a Critical Appraisal

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular Cancer Research

• Publication date

  2011-08-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-11-0220PMID 21816904
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNA-221 inhibits CDKN1C/p57 expression in human colorectal carcinoma

  2011cited by this paper
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  2011influential reference
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  2011cited by this paper
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  2011cited by this paper
• The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors.

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  2011cited by this paper
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  2011cited by this paper
• Aberrant DNA methylation of the p57KIP2 gene is a sensitive biomarker for detecting minimal residual disease in diffuse large B cell lymphoma.

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

  2010cited by this paper
• Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the Transcriptome

  2010cited by this paper
• CDKN1C Negatively Regulates RNA Polymerase II C-terminal Domain Phosphorylation in an E2F1-dependent Manner*

  2010cited by this paper
• Prognostic significance of co‐expression of nm23 and p57 protein in hepatocellular carcinoma

  2010cited by this paper
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  2010cited by this paper
• A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression

  2010cited by this paper
• Loss of ATRX in Chondrocytes Has Minimal Effects on Skeletal Development

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model

  2009influential reference
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  2009cited by this paper
• Imprinted CDKN1C Is a Tumor Suppressor in Rhabdoid Tumor and Activated by Restoration of SMARCB1 and Histone Deacetylase Inhibitors

  2009cited by this paper
• p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation

  2009cited by this paper
• p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells

  2009influential reference
• C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2

  2009cited by this paper
• Patterns of p57Kip2 expression in embryonic rat brain suggest roles in progenitor cell cycle exit and neuronal differentiation

  2009cited by this paper
• CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells

  2009cited by this paper
• The Cdk inhibitor p57Kip2 controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics

  2009cited by this paper
• MicroRNA 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells

  2009cited by this paper
• Regulation of p57(KIP2) during muscle differentiation: role of Egr1, Sp1 and DNA hypomethylation.

  2008cited by this paper
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  2008cited by this paper
• Histone deacetylase inhibitors as novel anticancer therapeutics

  2008cited by this paper
• Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57

  2008cited by this paper
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  2008influential reference
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  2008cited by this paper
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  2008cited by this paper
• The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination

  2008cited by this paper
• Significance of p57Kip2 Down-Regulation in Oncogenesis of Bladder Carcinoma: An Immunohistochemical Study

  2008cited by this paper
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  2008cited by this paper
• Significance of p 57 Kip 2 down-regulation in oncogenesis of bladder carcinoma : an immunohistochemical study

  2008cited by this paper
• CDKN1C/p57kip2 is a candidate tumor suppressor gene in human breast cancer

  2008cited by this paper
• MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma

  2008cited by this paper
• A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation

  2008cited by this paper
• p57 kip2's role beyond Schwann cell cycle control.

  2008influential reference
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  2008cited by this paper
• Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits.

  2008cited by this paper
• EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase.

  2007cited by this paper
• The Cyclin-dependent Kinase Inhibitors p57 and p27 Regulate Neuronal Migration in the Developing Mouse Neocortex*

  2007cited by this paper
• Cell Cycle Regulators Show Diagnostic and Prognostic Utility for Differentiated Thyroid Cancer

  2007cited by this paper
• BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.

  2007cited by this paper
• The Clinical Importance of Ki-67, p16, p14, and p57 Expression in Patients With Advanced Ovarian Carcinoma

  2007cited by this paper
• The cell cycle inhibitor p57Kip2 promotes cell death via the mitochondrial apoptotic pathway

  2007cited by this paper
• Histone deacetylase inhibitors upregulate p57Kip2 level by enhancing its expression through Sp1 transcription factor.

  2007cited by this paper
• A Crucial Role for p57Kip2 in the Intracellular Timer that Controls Oligodendrocyte Differentiation

  2007cited by this paper
• Immunohistochemical analysis of P57(kip2), p53 and hsp60 expressions in premalignant and malignant oral tissues.

  2006influential reference
• CTIP2 Associates with the NuRD Complex on the Promoter of p57KIP2, a Newly Identified CTIP2 Target Gene*

  2006cited by this paper
• EXPRESSION OF P57KIP2 IN GERM CELLS AND LEYDIG CELLS IN HUMAN TESTIS

  2006cited by this paper
• p57Kip2 is induced by MyoD through a p73-dependent pathway.

  2006cited by this paper
• Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia.

  2006cited by this paper
• Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor in chronic lymphocytic leukaemia in Chinese patients

  2006cited by this paper
• Downregulation of the KIP family members p27KIP1 and p57KIP2 by SKP2 and the role of methylation in p57KIP2 inactivation in nonsmall cell lung cancer

  2006cited by this paper
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  2006cited by this paper
• p57kip2 expression is related to carcinogenesis and tumor progression in laryngeal tissues

  2006cited by this paper
• Differential expression of cyclin-dependent kinase inhibitors, p27Kip1 and p57Kip2, by corticotropin in rat adrenal cortex.

  2006cited by this paper
• p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors.

  2006cited by this paper
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  2006cited by this paper
• Absence of p21CIP1, p27KIP1 and p57KIP2 methylation in MDS and AML

  2005cited by this paper
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  2005cited by this paper
• Multiple mechanisms downregulate CDKN1C in human bladder cancer

  2005cited by this paper
• Absence of p21(CIP 1), p27(KIP 1) and p 57(KIP 2) methylation in MDS and AML.

  2005cited by this paper
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  2005influential reference
• Epigenetic Down-Regulation of CDKN1C/p57KIP2 in Pancreatic Ductal Neoplasms Identified by Gene Expression Profiling

  2005cited by this paper
• ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith–Wiedemann syndrome

  2005cited by this paper
• Regulation of the Cyclin-Dependent Kinase Inhibitor p57Kip2 Expression by p63

  2005cited by this paper
• Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia.

  2005cited by this paper
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  2005cited by this paper
• Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.

  2005cited by this paper
• Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status.

  2005influential reference
• p57Kip2 is expressed in quiescent mouse bone marrow side population cells.

  2005cited by this paper
• p73beta-Mediated apoptosis requires p57kip2 induction and IEX-1 inhibition.

  2005cited by this paper
• Results of a phase I/II study of the combination of 5-aza-2’-deoxycytidine and valproic acid in patients with acute myeloid leukemia and myelodysplastic syndrome

  2005cited by this paper
• Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation.

  2005cited by this paper
• Identification of Multiple Cell Cycle Regulatory Functions of p57Kip2 in Human T Lymphocytes1

  2004cited by this paper
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  2004cited by this paper
• Expression of p57 in mouse and human testes.

  2004cited by this paper
• p27 binds cyclin–CDK complexes through a sequential mechanism involving binding-induced protein folding

  2004cited by this paper
• p53‐independent anti‐tumor effects of the nitrogen‐containing bisphosphonate zoledronic acid

  2004cited by this paper
• Expression of the Components of the Cip/Kip Family in Malignant Lymphoma of the Thyroid

  2004cited by this paper
• Expression of p57kip2 in mouse and human testes

  2004cited by this paper
• Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas.

  2004cited by this paper
• Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation

  2004cited by this paper
• Signal‐induced ubiquitination of p57Kip2 is independent of the C‐terminal consensus Cdk phosphorylation site

  2003cited by this paper
• Expressions of cyclin E, cyclin dependent kinase 2 and p57(KIP2) in human gastric cancer.

  2003cited by this paper
• Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia.

  2003cited by this paper
• p57KIP2 Modulates Stress-activated Signaling by Inhibiting c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase*

  2003cited by this paper
• Alterations in Cell Cycle Genes in Early Stage Lung Adenocarcinoma Identified by Expression Profiling

  2003cited by this paper
• Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

  2003cited by this paper
• Loss of p57KIP2 is associated with colorectal carcinogenesis.

  2003cited by this paper

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• p57Kip2 Phosphorylation Modulates Its Localization, Stability, and Interactions

  2024cites this paper
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  2023cites this paper
• Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells

  2023cites this paper
• p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms

  2023cites this paper
• Promoter methylation and enhanced SKP2 are associated with the downregulation of CDKN1C in cervical squamous cell carcinoma.

  2023cites this paper
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• The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer

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• Regulation of p27Kip1 and p57Kip2 Functions by Natural Polyphenols

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