Low-affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection

Atomic force microscopy is used to establish that low-affinity integrins bind in cis to P2Y2R. Integrin activation is initiated by a membrane-normal switchblade motion triggered by integrin priming after the virus binds to the integrin PSI domain. Tensile force between the P2Y2R and unbending integrin stimulates outside-in signaling.

• Publication year

  2017

• Venue

  Molecular Biology of the Cell

• Publication date

  2017-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E17-01-0082PMID 28835374PMCID 5638590
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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