Erratum: CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature Network Boston

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/NM1004-1139APMID 15334074
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

  2004cited by this paper
• The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.

  2003cited by this paper
• RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

  2003cited by this paper
• Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets.

  2003cited by this paper
• Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.

  2003cited by this paper
• Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets.

  2003cited by this paper
• Activation of Rap1B by Gi Family Members in Platelets*

  2002cited by this paper
• Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody.

  2002cited by this paper
• RasGRP4, a New Mast Cell-restricted Ras Guanine Nucleotide-releasing Protein with Calcium- and Diacylglycerol-binding Motifs

  2002cited by this paper
• Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton.

  2002cited by this paper
• Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling

  2002cited by this paper
• Flow cytometric detection of activated mouse integrin αIIbβ3 with a novel monoclonal antibody

  2002cited by this paper
• A Gi-dependent Pathway Is Required for Activation of the Small GTPase Rap1B in Human Platelets*

  2002cited by this paper
• Relationships between Rap1b, Affinity Modulation of Integrin αIIbβ3, and the Actin Cytoskeleton*

  2002cited by this paper
• Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen

  2001cited by this paper
• The role of Rap1 in integrin-mediated cell adhesion.

  2001cited by this paper
• A CalDAG-GEFI/Rap1/B-Raf Cassette Couples M1Muscarinic Acetylcholine Receptors to the Activation of ERK1/2*

  2001cited by this paper
• Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.

  2001cited by this paper
• RasGRP links T-cell receptor signaling to Ras.

  2000cited by this paper
• Sequential Regulation of the Small GTPase Rap1 in Human Platelets

  2000cited by this paper
• CalDAG-GEFIII Activation of Ras, R-Ras, and Rap1*

  2000cited by this paper
• Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

  1999cited by this paper
• RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.

  1998cited by this paper
• A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.

  1998cited by this paper
• Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.

  1998cited by this paper
• Localization of megakaryocytes in normal mice and following administration of platelet antiserum, 5-fluorouracil, or radiostrontium: evidence for the site of platelet production.

  1997cited by this paper
• Rapid Ca2+‐mediated activation of Rap1 in human platelets

  1997cited by this paper
• Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

  1996cited by this paper
• The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel.

  1991cited by this paper

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• RAP1-RHO small GTPase cross-talk mediates integrin-dependent and -independent platelet procoagulant response

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• Platelet Membrane Receptors and Signalling Pathways.

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• Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits.

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• Therapeutic effects and molecular mechanisms of natural products in thrombosis

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• Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors

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• Roles of G proteins and their GTPase-activating proteins in platelets

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• The Perspectives of Platelet Proteomics in Health and Disease

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• Utility of thromboelastography with platelet mapping (TEG-PM) for monitoring platelet transfusion in qualitative platelet disorders.

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• Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

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• High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis

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• The CalDAG-GEFI/Rap1/αIIbβ3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry

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• The rate of platelet activation determines thrombus size and structure at arterial shear.

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• Protease activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.

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• Loss of P2Y1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro.

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• The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes

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• RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma

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• Molecular Mechanisms of Leukocyte β2 Integrin Activation.

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• Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets

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• ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor‐induced leak

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• LFA1 Activation: Insights from a Single-Molecule Approach

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• Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms

  2022cites this paper
• Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance

  2022cites this paper
• The novel antitumor compound clinopodiside A induces cytotoxicity via autophagy mediated by the signaling of BLK and RasGRP2 in T24 bladder cancer cells

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• Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability

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• The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells

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• Mutations in RASGRP2 gene identified in patients misdiagnosed as Glanzmann thrombasthenia patients.

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• Influence of genetic polymorphisms in P2Y12 receptor signaling pathway on antiplatelet response to clopidogrel in coronary heart disease

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  2021cites this paper
• Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin.

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• The Many Faces of Rap1 GTPase

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• Platelet Signaling Pathways and New Inhibitors.

  2018cites this paper
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  2018cites this paper
• The role of kindlin in neutrophil recruitment to inflammatory sites

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• Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis

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  2017cites this paper
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  2017cites this paper
• New Concepts and Mechanisms of Platelet Activation Signaling.

  2017cites this paper
• Platelets at the vascular interface

  2017cites this paper
• [Inherited thrombopathia in Simmental cattle].

  2016cites this paper
• The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling

  2016cites this paper
• Losing your GRP on platelet activation.

  2016cites this paper
• Inherited CalDAG-GEFI deficiency.

  2016cites this paper
• The Rap1-RIAM-talin axis of integrin activation and blood cell function.

  2016cites this paper
• Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis

  2016cites this paper
• CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice

  2016cites this paper
• Differential proteomic analysis of platelets suggested target-related proteins in rabbit platelets treated with Rhizoma Corydalis

  2016cites this paper
• Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra

  2016cites this paper
• A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation.

  2016cites this paper
• Regulation of Rap GTPases in mammalian neurons

  2016cites this paper
• Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation.

  2016cites this paper
• Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis

  2016cites this paper
• [Thromboxane A2: Mechanisms of Synthesis and Intracellular Signaling System of Realization].

  2016cites this paper
• Regulation of Platelet Function by Orai, STIM and TRP.

  2016cites this paper
• GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.

  2016cites this paper
• Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.

  2016cites this paper
• Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils

  2016cites this paper
• Platelets and hemostasis: a new perspective on an old subject.

  2016cites this paper