A microsomal ATP‐binding protein involved in efficient protein transport into the mammalian endoplasmic reticulum.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  EMBO Journal

• Publication date

  1996-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/j.1460-2075.1996.tb01085.xPMID 9003769PMCID PMC452519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors.

  1996cited by this paper
• Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol.

  1996cited by this paper
• The 170 kDa glucose regulated stress protein is a large HSP70‐ HSP110‐like protein of the endoplasmic reticulum

  1996cited by this paper
• Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting

  1996cited by this paper
• Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae

  1995cited by this paper
• Sac1p mediates the adenosine triphosphate transport into yeast endoplasmic reticulum that is required for protein translocation

  1995cited by this paper
• Isolation of a mouse cDNA encoding MTJ1, a new murine member of the DnaJ family of proteins.

  1995cited by this paper
• Interaction of Calreticulin with Protein Disulfide Isomerase (*)

  1995cited by this paper
• BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.

  1995cited by this paper
• Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p.

  1995cited by this paper
• A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane.

  1995cited by this paper
• Functional characterization of the 180-kD ribosome receptor in vivo

  1995cited by this paper
• The membrane proteins TRAMp and sec61αp may be involved in post‐translational transport of presecretory proteins into mammalian microsomes

  1994cited by this paper
• Evolutionary conservation of components of the protein translocation complex

  1994cited by this paper
• Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70

  1993cited by this paper
• The role of molecular chaperones in protein transport into the endoplasmic reticulum.

  1993cited by this paper
• The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin.

  1993cited by this paper
• Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation.

  1993cited by this paper
• Components and mechanisms involved in transport of proteins into the endoplasmic reticulum.

  1993cited by this paper
• Hsc70, immunoglobulin heavy chain binding protein, and Hsp90 differ in their ability to stimulate transport of precursor proteins into mammalian microsomes.

  1993cited by this paper
• Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane.

  1993cited by this paper
• An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum.

  1993cited by this paper
• Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein.

  1993cited by this paper
• 180-kD ribosome receptor is essential for both ribosome binding and protein translocation

  1993cited by this paper
• Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation

  1992cited by this paper
• Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane.

  1992cited by this paper
• A protein of the endoplasmic reticulum involved early in polypeptide translocation

  1992cited by this paper
• Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein.

  1992cited by this paper
• A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.

  1992cited by this paper
• Transport of proteins across the endoplasmic reticulum membrane.

  1992cited by this paper
• Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor

  1992cited by this paper
• Sec61p and BiP directly facilitate polypeptide translocation into the ER.

  1992influential reference
• Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.

  1992cited by this paper
• Protein folding in the cell

  1992cited by this paper
• The signal recognition particle in S. cerevisiae.

  1991cited by this paper
• Photoaffinity labeling of dog pancreas microsomes with 8‐azido‐ATP inhibits association of nascent preprolactin with the signal sequence receptor complex

  1991cited by this paper
• The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER

  1991cited by this paper
• Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor

  1991cited by this paper
• An ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane.

  1991cited by this paper
• Protein translocation into the endoplasmic reticulum: a light at the end of the tunnel.

  1991cited by this paper
• A microsomal protein is involved in ATP‐dependent transport of presecretory proteins into mammalian microsomes.

  1991cited by this paper
• Protein export in prokaryotes and eukaryotes Theme with variations

  1991cited by this paper
• A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation

  1991cited by this paper
• Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

  1991cited by this paper
• ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein

  1991cited by this paper
• The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

  1991cited by this paper
• Binding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum in Saccharomyces cerevisiae.

  1991cited by this paper
• Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes.

  1990cited by this paper
• A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes.

  1990influential reference
• Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast

  1990cited by this paper
• Identification of a ribosome receptor in the rough endoplasmic reticulum

  1990cited by this paper
• Reconstitution of protein translocation activity from partially solubilized microsomal vesicles.

  1990cited by this paper
• Internal amino acid sequencing of proteins by in situ cyanogen bromide cleavage in polyacrylamide gels.

  1990cited by this paper
• Structural homology between the rat calreticulin gene product and the Onchocerca volvulus antigen Ral-1.

  1990cited by this paper
• Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth

  1989cited by this paper
• Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.

  1989cited by this paper
• The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide.

  1989cited by this paper
• A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein

  1989cited by this paper
• Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel

  1989cited by this paper
• Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast

  1989cited by this paper
• Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

  1989cited by this paper
• Four intracisternal calcium-binding glycoproteins from rat liver microsomes with high affinity for calcium. No indication for calsequestrin-like proteins in inositol 1,4,5-trisphosphate-sensitive calcium sequestering rat liver vesicles.

  1989cited by this paper
• Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains

  1989cited by this paper
• Defective co-translational formation of disulphide bonds in protein disulphide-isomerase-deficient microsomes

  1988cited by this paper
• Improved tools for biological sequence comparison.

  1988cited by this paper
• 70K heat shock related proteins stimulate protein translocation into microsomes

  1988cited by this paper
• In vivo and in vitro analysis of ptl1, a yeast ts mutant with a membrane‐associated defect in protein translocation.

  1988cited by this paper
• Seventy‐kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M13 procoat protein into microsomes.

  1988cited by this paper
• A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

  1988cited by this paper
• A signal sequence receptor in the endoplasmic reticulum membrane

  1987cited by this paper
• The ATP requiring step in assembly of M13 procoat protein into microsomes is related to preservation of transport competence of the precursor protein.

  1987cited by this paper
• Isolation and characterization of cDNA clones for rat ribophorin I: complete coding sequence and in vitro synthesis and insertion of the encoded product into endoplasmic reticulum membranes

  1987cited by this paper
• ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

  1987cited by this paper
• Proteins as molecular chaperones

  1987cited by this paper
• The primary structure of rat ribosomal protein L5. A comparison of the sequence of amino acids in the proteins that interact with 5 S rRNA.

  1987cited by this paper
• Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum‐specific glycoproteins.

  1987cited by this paper
• Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking

  1987cited by this paper
• Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein

  1986cited by this paper
• Uncoupling translocation from translation: implications for transport of proteins across membranes.

  1986cited by this paper
• 1986: A year of new insights into how proteins cross membranes

  1986cited by this paper
• Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.

  1986cited by this paper
• Phase separation of rat intestinal brush border membrane proteins using Triton X-114.

  1986cited by this paper
• Speculations on the functions of the major heat shock and glucose-regulated proteins.

  1986cited by this paper
• An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein.

  1986cited by this paper
• The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle

  1986cited by this paper
• The signal recognition particle receptor is a complex that contains two distinct polypeptide chains

  1986cited by this paper
• Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin

  1985cited by this paper
• Topology of signal recognition particle receptor in endoplasmic reticulum membrane

  1985cited by this paper
• Silver staining of proteins in polyacrylamide gels: increased sensitivity through a combined Coomassie blue-silver stain procedure.

  1985cited by this paper
• The latency of rat liver microsomal protein disulphide-isomerase.

  1985cited by this paper
• A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.

  1984cited by this paper
• Preparation of microsomal membranes for cotranslational protein translocation.

  1983cited by this paper
• Structural properties of homogeneous protein disulphide-isomerase from bovine liver purified by a rapid high-yielding procedure.

  1983cited by this paper
• M13 procoat and a pre-immunoglobulin share processing specificity but use different membrane receptor mechanisms.

  1983cited by this paper
• Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor

  1982cited by this paper
• Secretory protein translocation across membranes—the role of the ‘docking protein’

  1982cited by this paper
• Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle

  1982cited by this paper
• Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein

  1981cited by this paper
• Silver staining of proteins in polyacrylamide gels.

  1981cited by this paper
• Phase separation of integral membrane proteins in Triton X-114 solution.

  1981cited by this paper

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  2023cites this paper
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  2023cites this paper
• Signal Peptide Features Determining the Substrate Specificities of Targeting and Translocation Components in Human ER Protein Import

  2022cites this paper
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• ER import of small human presecretory proteins: components and mechanisms

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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• BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions.

  2015cites this paper
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  2014cites this paper
• The Sec translocon mediated protein transport in prokaryotes and eukaryotes

  2014cites this paper
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  2014cites this paper
• BiP Clustering Facilitates Protein Folding in the Endoplasmic Reticulum

  2014cites this paper
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  2013cites this paper
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  2011cites this paper
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  2011cites this paper
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  2007cites this paper
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  2005cites this paper
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  2004cites this paper
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