Key signaling nodes in mammary gland development and cancer: β-catenin

Abstractβ-Catenin plays important roles in mammary development and tumorigenesis through its functions in cell adhesion, signal transduction and regulation of cell-context-specific gene expression. Studies in mice have highlighted the critical role of β-catenin signaling for stem cell biology at multiple stages of mammary development. Deregulated β-catenin signaling disturbs stem and progenitor cell dynamics and induces mammary tumors in mice. Recent data showing deregulated β-catenin signaling in metaplastic and basal-type tumors suggest a similar link to reactivated developmental pathways and human breast cancer. The present review will discuss β-catenin as a central transducer of numerous signaling pathways and its role in mammary development and breast cancer.

• Publication year

  2010

• Venue

  Breast Cancer Research

• Publication date

  2010-11-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/bcr2723PMID 21067528PMCID 3046427
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010influential reference
• Molecular mechanisms guiding embryonic mammary gland development.

  2010cited by this paper
• Cowden syndrome

  2010cited by this paper
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• β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling

  2010cited by this paper
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  2010cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2009cited by this paper
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