Deubiquitylases from genes to organism.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Physiological Reviews

• Publication date

  2013-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/physrev.00002.2013PMID 23899565
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation

  2013cited by this paper
• Assembly, analysis and architecture of atypical ubiquitin chains

  2013cited by this paper
• Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.

  2013cited by this paper
• Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells

  2013cited by this paper
• USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

  2013influential reference
• Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration

  2013cited by this paper
• Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs*

  2013cited by this paper
• Regulation of A20 and other OTU deubiquitinases by reversible oxidation

  2013cited by this paper
• Why do cellular proteins linked to K63‐polyubiquitin chains not associate with proteasomes?

  2013cited by this paper
• Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development

  2012cited by this paper
• OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.

  2012influential reference
• USP11 augments TGFβ signalling by deubiquitylating ALK5

  2012cited by this paper
• Ubiquitin removal in the TGF-β pathway

  2012cited by this paper
• USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

  2012cited by this paper
• Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes

  2012cited by this paper
• A20: linking a complex regulator of ubiquitylation to immunity and human disease

  2012cited by this paper
• Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14.

  2012cited by this paper
• Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins*

  2012cited by this paper
• CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

  2012cited by this paper
• A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.

  2012influential reference
• Negative regulation of IL-17-mediated signaling and inflammation by ubiquitin-specific protease 25

  2012cited by this paper
• The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases

  2012cited by this paper
• Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

  2012cited by this paper
• The RCSB Protein Data Bank: new resources for research and education

  2012cited by this paper
• A Tight Link between Orthologs and Bidirectional Best Hits in Bacterial and Archaeal Genomes

  2012cited by this paper
• Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15

  2012cited by this paper
• Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains.

  2012cited by this paper
• New and continuing developments at PROSITE

  2012cited by this paper
• Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions

  2012cited by this paper
• Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13*

  2012cited by this paper
• Cellular functions of the DUBs

  2012cited by this paper
• Ubiquitin-Specific Peptidase 46 (Usp46) Regulates Mouse Immobile Behavior in the Tail Suspension Test through the GABAergic System

  2012cited by this paper
• USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

  2012cited by this paper
• O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.

  2012cited by this paper
• Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.

  2012cited by this paper
• USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.

  2012cited by this paper
• Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

  2012cited by this paper
• USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.

  2012cited by this paper
• Basal and stress-induced Hsp70 are modulated by ataxin-3

  2012cited by this paper
• Selectivity of the ubiquitin‐binding modules

  2012cited by this paper
• Transient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate.

  2012cited by this paper
• Deubiquitinases as a signaling target of oxidative stress

  2012cited by this paper
• Governance of endocytic trafficking and signaling by reversible ubiquitylation.

  2012cited by this paper
• Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

  2012cited by this paper
• CDD: conserved domains and protein three-dimensional structure

  2012cited by this paper
• Near-atomic resolution structural model of the yeast 26S proteasome

  2012cited by this paper
• Faculty Opinions recommendation of The mechanism of OTUB1-mediated inhibition of ubiquitination.

  2012cited by this paper
• Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.

  2012cited by this paper
• The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.

  2012cited by this paper
• Molecular model of the human 26S proteasome.

  2012cited by this paper
• The ubiquitin code.

  2012cited by this paper
• The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response

  2012cited by this paper
• Deciphering a global network of functionally associated post-translational modifications

  2012cited by this paper
• Ubiquitin chain conformation regulates recognition and activity of interacting proteins

  2012cited by this paper
• USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

  2012cited by this paper
• Regulation of the transforming growth factor β pathway by reversible ubiquitylation

  2012cited by this paper
• Ubiquitin‐specific protease‐like 1 (USPL1) is a SUMO isopeptidase with essential, non‐catalytic functions

  2012cited by this paper
• The mechanism of OTUB1 inhibition of ubiquitination

  2012cited by this paper
• Regulation of NF-κB signaling by the A20 deubiquitinase

  2012cited by this paper
• Generation and physiological roles of linear ubiquitin chains

  2012cited by this paper
• Phosphorylation-dependent activity of the deubiquitinase DUBA

  2012cited by this paper
• INAUGURAL ARTICLE by a Recently Elected Academy Member:Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

  2012cited by this paper
• Faculty Opinions recommendation of Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.

  2012cited by this paper
• Structural characterization of human Uch37

  2012cited by this paper
• A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

  2011cited by this paper
• The ESCRT pathway.

  2011cited by this paper
• Ubiquitin Chain Trimming Recycles the Substrate Binding Sites of the 26 S Proteasome and Promotes Degradation of Lysine 48-linked Polyubiquitin Conjugates*

  2011cited by this paper
• MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.

  2011cited by this paper
• Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.

  2011cited by this paper
• USP15 is a deubiquitylating enzyme for receptor-activated SMADs

  2011cited by this paper
• Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

  2011cited by this paper
• The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse

  2011cited by this paper
• Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease.

  2011cited by this paper
• SMART 7: recent updates to the protein domain annotation resource

  2011cited by this paper
• An Ankyrin-repeat ubiquitin binding domain determines TRABID’s specificity for atypical ubiquitin chains

  2011cited by this paper
• The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

  2011cited by this paper
• Structural basis for ESCRT-III CHMP3 recruitment of AMSH.

  2011cited by this paper
• Roles of HAUSP-mediated p53 regulation in central nervous system development

  2011cited by this paper
• Dendritic cell expression of A20 preserves immune homeostasis and prevents colitis and spondyloarthritis

  2011cited by this paper
• USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.

  2011cited by this paper
• Positive regulation of p 53 stability and activity by the deubiquitinating enzyme

  2011cited by this paper
• The Deubiquitinating Enzyme USP-46 Negatively Regulates the Degradation of Glutamate Receptors to Control Their Abundance in the Ventral Nerve Cord of Caenorhabditis elegans

  2011cited by this paper
• Complete subunit architecture of the proteasome regulatory particle

  2011cited by this paper
• A Perturbed Ubiquitin Landscape Distinguishes Between Ubiquitin in Trafficking and in Proteolysis

  2011cited by this paper
• Mice Lacking the USP2 Deubiquitinating Enzyme Have Severe Male Subfertility Associated with Defects in Fertilization and Sperm Motility1

  2011cited by this paper
• Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

  2011cited by this paper
• Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

  2011cited by this paper
• Structural and thermodynamic comparison of the catalytic domain of AMSH and AMSH-LP: nearly identical fold but different stability.

  2011cited by this paper
• Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degeneration.

  2011cited by this paper
• Germline BAP1 mutations predispose to malignant mesothelioma

  2011cited by this paper
• Structure and recognition of polyubiquitin chains of different lengths and linkage

  2011cited by this paper
• Systematic and quantitative assessment of the ubiquitin-modified proteome.

  2011cited by this paper
• Molecular mechanisms of ubiquitin-dependent membrane traffic.

  2011cited by this paper
• USP4 inhibits p53 through deubiquitinating and stabilizing ARF‐BP1

  2011cited by this paper
• Direct, noncatalytic mechanism of IKK inhibition by A20.

  2011cited by this paper
• Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

  2011cited by this paper
• Ubiquitin Homeostasis Is Critical for Synaptic Development and Function

  2011cited by this paper
• AMSH is required to degrade ubiquitinated proteins in the central nervous system.

  2011cited by this paper
• Polyubiquitin binding and cross‐reactivity in the USP domain deubiquitinase USP21

  2011cited by this paper
• A20 deficiency in B cells enhances B‐cell proliferation and results in the development of autoantibodies

  2011cited by this paper

• Regulatory mechanisms for Snail protein stability: ubiquitin-proteasome system and chaperone-mediated autophagy.

  2026cites this paper
• Spotlights on ubiquitin-specific proteases in lung cancer: from multifaceted pathophysiological mechanisms to potential therapeutic targets

  2026cites this paper
• Ubiquitin-Specific Protease 10: A New Target in Tumor Immune Escape.

  2026cites this paper
• Mouse mesenchymal stem cell-derived exosomal miR-205-5p modulates LPS-induced macrophage polarization and alleviates lung injury by regulating the USP7/FOXM1 axis.

  2025cites this paper
• Mechanisms of action of ubiquitin-specific proteases, particularly ubiquitin-specific proteases 7, 8, and 25, in depression treatment.

  2025cites this paper
• The effect of ubiquitination and deubiquitination to imatinib resistance in gastrointestinal stromal tumors

  2025cites this paper
• The Deubiquitinase USP36 Regulates Growth and Spermatogenesis Through Catalytic-Dependent and -Independent Mechanisms in Drosophila

  2025cites this paper
• The Deubiquitinase USP28 Maintains the Expression of PPARγ and Its Inactivation Protects Mice from Diet-Induced MASH and Hepatocarcinoma.

  2025cites this paper
• USP5 deubiquitinates and stabilizes IMPDH2, to promote hepatocellular carcinoma progression

  2025cites this paper
• Rational DESIGN and Structure-activity relationship study of novel JOSD2 inhibitor against colorectal cancer.

  2025cites this paper
• The deubiquitinase USP36 funtions through catalytic-dependent and catalytic-independent mechanisms in Drosophila

  2025cites this paper
• USP41 regulates glioma malignancy through Notch1 activation: Insights from in vitro and in vivo studies.

  2025cites this paper
• The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes

  2025cites this paper
• OTUB2/NR4A1 restrains the development of preeclampsia by suppressing macrophage M1 polarization

  2025cites this paper
• The deubiquitinase YOD1 suppresses tumor progression by stabilizing ZNF24 in clear cell renal carcinoma

  2025cites this paper
• Ubiquitin-specific protease 34 serves as a novel prognostic biomarker through correlating with immune responses and cell proliferation in acute myeloid leukemia

  2025cites this paper
• Deciphering deubiquitinating enzyme Ataxin-3 as an emerging target for cancer intervention.

  2025cites this paper
• The Molecular Toolbox for Linkage Type‐Specific Analysis of Ubiquitin Signaling

  2025cites this paper
• Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism

  2025cites this paper
• Deubiquitinating enzyme USP2 regulates brown adipose tissue thermogenesis via controlling EBF2 stabilization

  2025cites this paper
• Recent advances in small molecule inhibitors of deubiquitinating enzymes.

  2025cites this paper
• Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus.

  2025cites this paper
• USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis

  2025cites this paper
• Regulation of disease signaling by YOD1: potential implications for therapeutic strategies

  2025cites this paper
• OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

  2025cites this paper
• Interpretable bioinformatics approaches for pheochromocytoma bioactivity and protein interaction analysis

  2025cites this paper
• Physiological roles and therapeutic implications of USP6

  2025cites this paper
• USP25 maintains KRAS expression and inhibiting the deubiquitinase suppresses KRAS signaling in human cancer

  2025cites this paper
• Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages

  2024cites this paper
• Regulation of the Inflammasome Activation by Ubiquitination Machinery.

  2024cites this paper
• Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

  2024cites this paper
• Dysregulation of deubiquitination in breast cancer.

  2024cites this paper
• Germline USP36 mutation confers resistance to EGFR-TKIs by upregulating MLLT3 expression in non-small cell lung cancer patients.

  2024cites this paper
• Molecular mechanisms of ubiquitination in wound healing.

  2024cites this paper
• E2F1-regulated USP5 contributes to the tumorigenic capacity of glioma stem cells through the maintenance of OCT4 stability.

  2024cites this paper
• Targeting the ubiquitin pathway in lymphoid malignancies.

  2024cites this paper
• Linear ubiquitin chains remodel the proteome and influence the levels of hundreds of regulators in Drosophila

  2024cites this paper
• Regulation of ubiquitination in sepsis: from PAMP versus DAMP to peripheral inflammation and cell death

  2024cites this paper
• Comparison of two UPS regulators: the 26S proteasome LID and the COP9 signalosome

  2024cites this paper
• The role of ubiquitination in health and disease

  2024influential citation
• Linear poly-ubiquitin remodels the proteome and influences hundreds of regulators in Drosophila

  2024cites this paper
• Research progress of the Otubains subfamily in hepatocellular carcinoma.

  2024cites this paper
• An insight into the roles of ubiquitin-specific proteases in plants: development and growth, morphogenesis, and stress response

  2024cites this paper
• The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation

  2024cites this paper
• PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation.

  2024cites this paper
• Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1

  2024cites this paper
• Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates.

  2024cites this paper
• The role of deubiquitinases in cardiac disease

  2024cites this paper
• The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer.

  2024cites this paper
• Profiling of deubiquitinases that control virulence in the pathogenic plant fungus Fusarium graminearum.

  2024cites this paper
• K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment.

  2024cites this paper
• Programmed Death Ligand 1 Regulatory Crosstalk with Ubiquitination and Deubiquitination: Implications in Cancer Immunotherapy

  2024cites this paper
• Functional dynamics of human ubiquitin C-terminal hydrolases

  2024cites this paper
• Exploring the Role of Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease

  2024cites this paper
• Phylogenomics of Life Kingdom's Deubiquitinases

  2023cites this paper
• Deubiquitylating Enzymes in Cancer and Immunity

  2023cites this paper
• Protein ubiquitination in ovarian cancer immunotherapy: The progress and therapeutic strategy

  2023cites this paper
• Method to Measure Ubiquitination of NLRs.

  2023cites this paper
• Molecular and biological factors in the prognosis of head and neck squamous cell cancer

  2023cites this paper
• Autophagy in Intracerebral Hemorrhage: From Mechanism to Regulation.

  2023cites this paper
• USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway

  2023cites this paper
• USP18 regulates the malignant phenotypes of glioblastoma stem cells.

  2023cites this paper
• Targeted therapy based on ubiquitin-specific proteases, signalling pathways and E3 ligases in non-small-cell lung cancer

  2023cites this paper
• USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

  2023cites this paper
• Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3

  2023cites this paper
• Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice

  2023cites this paper
• The Involvement of Ubiquitination and SUMOylation in Retroviruses Infection and Latency

  2023cites this paper
• High-Throughput MALDI-TOF Mass Spectrometry-Based Deubiquitylating Enzyme Assay for Drug Discovery.

  2023cites this paper
• Acyl azide modification of the ubiquitin C-terminus enables DUB capture.

  2023cites this paper
• K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ)

  2023cites this paper
• Identification of Deubiquitinase Substrates in Xenopus Egg Extract.

  2023cites this paper
• Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells

  2023cites this paper
• In silico screening and computational evaluation of novel promising USP14 inhibitors targeting the palm-thumb pocket.

  2023cites this paper
• Deubiquitinases (DUBs): A Sub - Family of Master Regulators in Modulating Inflammatory Response through Toll Like Receptor (TLR) Signalling

  2023cites this paper
• The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma

  2023cites this paper
• Observation of Arginine Side-Chain Motions Coupled to the Global Conformational Exchange Process in Deubiquitinase A

  2022cites this paper
• Novel biallelic variants affecting the OTU domain of the gene OTUD6B associate with severe intellectual disability syndrome and molecular dynamics simulations.

  2022cites this paper
• The role of K63-linked polyubiquitin in several types of autophagy

  2022cites this paper
• USP10 as a Potential Therapeutic Target in Human Cancers

  2022cites this paper
• The Role of Deubiquitinases in Virus Replication and Host Innate Immune Response

  2022cites this paper
• The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function

  2022cites this paper
• The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

  2022cites this paper
• Deubiquitinases in Neurodegeneration

  2022cites this paper
• USP15 in Cancer and Other Diseases: From Diverse Functionsto Therapeutic Targets

  2022cites this paper
• A Synthetically Accessible Small-Molecule Inhibitor of USP5-Cav3.2 Calcium Channel Interactions with Analgesic Properties.

  2022cites this paper
• Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3

  2022cites this paper
• On the Study of Deubiquitinases: Using the Right Tools for the Job

  2022cites this paper
• OsLMP1, Encoding a Deubiquitinase, Regulates the Immune Response in Rice

  2022cites this paper
• Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery

  2022cites this paper
• The equilibrium of tumor suppression: DUBs as active regulators of PTEN

  2022cites this paper
• N^6-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors

  2022cites this paper
• Plant deubiquitinases: from structure and activity to biological functions

  2022cites this paper
• USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma

  2022cites this paper
• Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1‐mediated glycolysis

  2022influential citation
• The deubiquitylase USP31 controls the Chromosomal Passenger Complex and spindle dynamics

  2022cites this paper
• Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5

  2022cites this paper
• X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.

  2022cites this paper
• USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1

  2022cites this paper
• The Ubiquitin-Proteasome System in Apoptosis and Apoptotic Cell Clearance

  2022cites this paper
• TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability

  2022cites this paper