Decorin‐mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers

Currently, the multifaceted role of the extracellular matrix (ECM) in tumourigenesis has been realized. One ECM macromolecule exhibiting potent oncosuppressive actions in tumourigenesis is decorin, the prototype of the small leucine‐rich proteoglycan gene family. The actions of decorin include its ability to function as an endogenous pan‐receptor tyrosine kinase inhibitor, a regulator of both autophagy and mitophagy, as well as a modulator of the immune system. In this review, we will discuss these topics in more detail. We also provide a summary of preclinical studies exploring the value of decorin‐mediated oncosuppression, as a potential future adjuvant therapy for epithelial cancers.

• Publication year

  2018

• Venue

  British Journal of Pharmacology

• Publication date

  2018-04-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/bph.14180PMID 29488209PMCID 6284329
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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