Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1998-09-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/BBRC.1998.9394PMID 9784422
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

  1998cited by this paper
• TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption

  1998cited by this paper
• Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.

  1998cited by this paper
• Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.

  1998cited by this paper
• Regulation of osteoprotegerin mRNA levels by prostaglandin E2 in human bone marrow stroma cells.

  1998cited by this paper
• Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

  1998cited by this paper
• Development and Characterization of Conditionally Immortalized Osteoblast Precursor Cell Lines from Human Bone Marrow Stroma

  1998cited by this paper
• Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.

  1998cited by this paper
• Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.

  1997cited by this paper
• A Preliminary Evaluation of the Lunar Expert‐XL for Bone Densitometry and Vertebral Morphometry

  1997cited by this paper
• Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.

  1997cited by this paper
• Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells.

  1997cited by this paper
• Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

  1997cited by this paper
• Advances in bone biology: the osteoclast.

  1996cited by this paper
• Stimulatory effect of bone morphogenetic protein‐2 on osteoclast‐like cell formation and bone‐resorbing activity

  1995cited by this paper
• Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.

  1995cited by this paper
• Fast hybridization solution for the detection of immobilized nucleic acids.

  1995cited by this paper
• Development and characterization of a conditionally immortalized human fetal osteoblastic cell line

  1995cited by this paper
• Interleukin-1 alpha upregulates tumor necrosis factor receptors expressed by a human bone marrow stromal cell strain: implications for cytokine redundancy and synergy.

  1995cited by this paper
• Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4.

  1995cited by this paper
• Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period.

  1995cited by this paper
• Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.

  1995cited by this paper
• Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-beta superfamily.

  1995cited by this paper
• Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.

  1995cited by this paper
• Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

  1994cited by this paper
• Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype.

  1993cited by this paper
• Cytokines and estrogen in bone: anti-osteoporotic effects.

  1993cited by this paper
• Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia.

  1992cited by this paper
• Novel regulators of bone formation: molecular clones and activities.

  1988cited by this paper
• Rapid, reversible staining of northern blots prior to hybridization.

  1988cited by this paper
• Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

  1986cited by this paper
• Human bone cellsin vitro

  1985cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

  1980cited by this paper
• RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.

  1977cited by this paper

• Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV

  2025cites this paper
• Effects of Epigallocatechin-3-O-Gallate on Bone Health

  2025cites this paper
• The effect of Schizophyllan on the differentiation of osteoclasts and osteoblasts.

  2024cites this paper
• Convergence of Calcium Channel Regulation and Mechanotransduction in Skeletal Regenerative Biomaterial Design

  2023cites this paper
• Correlates of circulating osteoprotegerin in women with a pathogenic or likely pathogenic variant in the BRCA1 gene.

  2023cites this paper
• An unbiased proteomics approach to identify the senescence-associated secretory phenotype of human bone marrow-derived mesenchymal stem cells

  2023cites this paper
• Delineating the role of osteoprotegerin as a marker of breast cancer risk among women with a BRCA1 mutation

  2022cites this paper
• Mineralizing Gelatin Microparticles as Cell Carrier and Drug Delivery System for siRNA for Bone Tissue Engineering

  2022cites this paper
• Chi3L1 is a therapeutic target in bone metabolism and a potential clinical marker in patients with osteoporosis.

  2022cites this paper
• Femoral µCT Analysis, Mechanical Testing and Immunolocalization of Bone Proteins in β-Hydroxy β-Methylbutyrate (HMB) Supplemented Spiny Mouse in a Model of Pregnancy and Lactation-Associated Osteoporosis

  2021cites this paper
• Bone Deleterious Effects of Different NRTIs in Treatment-naïve HIV Patients After 12 and 48 Weeks of Treatment

  2021cites this paper
• Bone responsiveness to parathyroid hormone is negatively associated with parathyroid hormone-lowering drug use in patients undergoing hemodialysis: a cross-sectional study

  2021cites this paper
• Bones and Rheumatology

  2021cites this paper
• The Effects of TGF-ß3, 17-ß Estradiol and Bisphenol A on Osteoprotegerin Production in Osteoblasts

  2021cites this paper
• The Role of BMP Signaling in Osteoclast Regulation

  2021cites this paper
• Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology

  2020cites this paper
• The Bone Morphogenetic Protein Pathway: The Osteoclastic Perspective

  2020cites this paper
• Basic Aspects of Osteoclast Differentiation and Function

  2020cites this paper
• Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice

  2020cites this paper
• Molecular mechanisms underlying the inhibitory effects of bovine lactoferrin on osteosarcoma.

  2019cites this paper
• Title Interleukin-1 β and 6-induced calcium channel current modulation in MC 3 T 3E 1 cells

  2019cites this paper
• Bone morphogenetic proteins: Their role in regulating osteoclast differentiation

  2019cites this paper
• The genetic association between osteoprotegerin gene polymorphisms and fracture risk in Chinese Han population

  2019cites this paper
• Histomorphometrische und molekularbiologische Untersuchungen zur Osseointegration von dentalen Implantaten am mit Zoledronat behandelten Tiermodell des Göttinger Minipigs

  2019cites this paper
• Interleukin-1β and 6-induced calcium channel current modulation in MC3T3-E1 cells

  2019cites this paper
• Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

  2019cites this paper
• The Role of Osteocytes in Inflammatory Bone Loss

  2019cites this paper
• Osteoporosis, Inflammation, and Aging

  2019cites this paper
• Inflammation‐induced lymphatic architecture and bone turnover changes are ameliorated by irisin treatment in chronic inflammatory bowel disease

  2018cites this paper
• Title Interleukin-1 β and 6-Induced Calcium Channel Current Modulation in MC 3 T 3E 1 Osteoblast Cell Line

  2018cites this paper
• In silico estrogen-like activity and in vivo osteoclastogenesis inhibitory effect of Cicer arietinum extract.

  2018cites this paper
• Decreased JMJD3 expression in mesenchymal stem cells contributes to longterm suppression of osteoblast differentiation in multiple myeloma

  2018cites this paper
• Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review

  2018cites this paper
• Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats

  2018cites this paper
• Steroidogenic effect of Erxian decoction for relieving menopause via the p-Akt/PKB pathway in vitro and in vivo.

  2017cites this paper
• Inflammatory Bowel Disease in a Rodent Model Alters Osteocyte Protein Levels Controlling Bone Turnover

  2017influential citation
• Protective effect of Rhus verniciflua Stokes extract in an experimental model of post-menopausal osteoporosis

  2017cites this paper
• Loss of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetry in fracture healing

  2017cites this paper
• Immunopathology of the Musculoskeletal System

  2017cites this paper
• Effects of Single Vitamin D3 Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency

  2017cites this paper
• TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.

  2017cites this paper
• Suppression by HSP90 inhibitors of BMP‑4‑stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase.

  2017cites this paper
• RANK and RANKL of Bones, T Cells, and the Mammary Glands

  2016cites this paper
• 25-Hydroxy- and 1α,25-Dihydroxycholecalciferol Have Greater Potencies than 25-Hydroxy- and 1α,25-Dihydroxyergocalciferol in Modulating Cultured Human and Mouse Osteoblast Activities

  2016cites this paper
• Is Heparin Effective for the Controlled Delivery of High-Dose Bone Morphogenetic Protein-2?

  2016cites this paper
• Role of bacterial γ-glutamyltranspeptidase as a novel virulence factor in bone-resorbing pathogenesis

  2016cites this paper
• Osteoporosis Recovery by Antrodia camphorata Alcohol Extracts through Bone Regeneration in SAMP8 Mice

  2016cites this paper
• Effects of Roughly Focused Extracorporeal Shock Waves Therapy on the Expressions of Bone Morphogenetic Protein-2 and Osteoprotegerin in Osteoporotic Fracture in Rats

  2016cites this paper
• Inhibitory Mechanism of TiO2 Nanotubular Structures in Osteoclast Formation Via Coculture

  2016cites this paper
• Facilitation of bone resorption activities in synovial lavage fluid patients with mandibular condyle fractures.

  2016cites this paper
• Resveratrol amplifies BMP-4-stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts.

  2015cites this paper
• "This is the pre-peer reviewed version of the following article: Review article: the effects of antitumour necrosis factor-α on bone metabolism in inflammatory bowel

  2015cites this paper
• Experimental techniques for screening of antiosteoporotic activity in postmenopausal osteoporosis

  2015cites this paper
• The genetics of osteoporosis.

  2015cites this paper
• Dual Role of Cyanidin-3-glucoside on the Differentiation of Bone Cells

  2015cites this paper
• : the effects of antitumour necrosis factor-α on bone metabolism in inflammatory bowel disease

  2015cites this paper
• Systemic MSC Transplantation Restores Functional Bone in a Mouse Model of Age-related Osteoporosis

  2015cites this paper
• Regulation of OPG and RANKL expressed by human dental follicle cells in osteoclastogenesis

  2015cites this paper
• Interleukin-1β and 6-Induced Calcium Channel Current Modulation in MC3T3-E1 Osteoblast Cell Line

  2015cites this paper
• The relationship between aortic calcification and osteoporosis in postmenopausal women

  2015influential citation
• Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H

  2014cites this paper
• Interleukin-1β and 6-induced calcium channel current modulation in MC3T3-E1 cells

  2014cites this paper
• Novel serum biomarkers in pulmonary arterial hypertension.

  2014cites this paper
• Treatment with N- and C-Terminal Peptides of Parathyroid Hormone-Related Protein Partly Compensate the Skeletal Abnormalities in IGF-I Deficient Mice

  2014cites this paper
• 活性型ビタミンD存在下でのBMP-2刺激が骨芽細胞様細胞MC3T3-E1細胞のビタミンD受容体発現に及ぼす影響

  2014cites this paper
• Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

  2014cites this paper
• Essential roles of Pdia3/PLAA receptor complex and CaMKII IN 1α,25(OH)₂D₃ and Wnt5a calcium-dependent signaling pathways in osteoblasts and chondrocytes

  2014cites this paper
• Inflammatory and bone turnover markers in relation to PTH and vitamin D status among saudi postmenopausal women with and without osteoporosis.

  2014cites this paper
• Re-evaluating the role of vitamin D in the periodontium.

  2014cites this paper
• The clinical use of bone morphogenetic proteins revisited: a novel biocompatible carrier device OSTEOGROW for bone healing

  2014cites this paper
• Effect of combineduse of daidzein andraloxifene on osteoblast-like cells

  2014cites this paper
• Inflammatory and bone turnover markers in relation to PTH and vitamin D status among Saudi postmenopausal women with and without osteoporosis.

  2014cites this paper
• Experimental fracture protocols in assessments of potential agents for osteoporotic fracture healing using rodent models.

  2013cites this paper
• Osteoprotegerin Enhances Osteogenesis of Human Mesenchymal Stem Cells

  2013cites this paper
• osteosclerosis induced by high thrombopoietin levels in mice Proteasome inhibitor bortezomib impairs both myelofibrosis and

  2013cites this paper
• Cyclic variations of bone resorption mediators and markers in the different phases of the menstrual cycle

  2013cites this paper
• L’ostéoprotégérine, nouvel acteur dans l’angiogenèse : Rôle dans la formation de nouveaux vaisseaux et mécanisme d’action

  2013cites this paper
• Severe Vitamin D-Deficiency and Increased Bone Turnover in Patients with Hepatitis B from Northeastern China

  2013cites this paper
• Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

  2012cites this paper
• “ Expression of Bone Resorption Markers in Gingival Crevicular Fluid of Rheumatoid Arthritis Patients with and without Periodontitis

  2012cites this paper
• Role of Medicinal Plants and Natural Products on Osteoporotic Fracture Healing

  2012cites this paper
• On the biology of the bony otic capsule and the pathogenesis of otosclerosis.

  2012cites this paper
• The regulation of osteoclastogenesis by bone morphogenetic proteins, twisted gastrulation, and histone deacetylases.

  2012cites this paper
• The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis

  2012cites this paper
• The regulation of osteoclastogenesis by bone morphogenetic proteins, twisted gastrulation, and histone deacetylases.

  2012cites this paper
• Inverse association of serum 25-hydroxyvitamin D with markers of inflammation and suppression of osteoclastic activity in hemodialysis patients.

  2012cites this paper
• A Systems Approach to Understanding Bone Cell Interactions in Health and Disease

  2012cites this paper
• The Role of Antioxidant Rich Berries in the Prevention of Postmenopausal Bone Loss

  2012cites this paper
• rhBMP-2/calcium phosphate matrix induces bone formation while limiting transient bone resorption in a nonhuman primate core defect model.

  2012cites this paper
• The Treatment of Inflammation, Pain, and Fever Using Medicinal Plants

  2012cites this paper
• How vitamin D works on bone.

  2012cites this paper
• Involvement of soluble receptor activator of nuclear factor-κB ligand (sRANKL) in collagenase-induced murine osteoarthritis and human osteoarthritis

  2012cites this paper
• Clinical and genetic findings in early-onset primary osteoporosis

  2012cites this paper
• No influence of OPG and its ligands, RANKL and TRAIL, on proliferation and regulation of the calcification process in primary human vascular smooth muscle cells.

  2012cites this paper
• The neuro-osteogenic network: The sympathetic regulation of bone resorption

  2012cites this paper
• The role of the osteoprotegerin/RANKL/RANK system in diabetic vascular disease.

  2011cites this paper
• (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis

  2011cites this paper
• Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor

  2011cites this paper
• Effects of inflammation on bone: an update

  2011cites this paper
• Evidence for a link between TNFRSF11A and risk of breast cancer

  2011cites this paper