Obesity, Inflammation, and Insulin Resistance – A Mini-Review

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Gerontology

• Publication date

  2009-04-08

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1159/000212758PMID 19365105
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity.

  2008cited by this paper
• Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway*

  2008cited by this paper
• Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations.

  2008cited by this paper
• Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice

  2008cited by this paper
• Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.

  2008cited by this paper
• Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis

  2008cited by this paper
• Visceral Adipose Tissue Inflammation Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

  2008cited by this paper
• Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

  2008cited by this paper
• Loss of PPARγ in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

  2008cited by this paper
• Obesity and the Metabolic Syndrome in the Elderly – A Mini-Review

  2008cited by this paper
• Glucose and leptin induce apoptosis in human β‐ cells and impair glucose‐stimulated insulin secretion through activation of c‐Jun N‐terminal kinases

  2008cited by this paper
• Salicylate Blocks Lipolytic Actions of Tumor Necrosis Factor-α in Primary Rat Adipocytes

  2008cited by this paper
• Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

  2008cited by this paper
• Salicylate blocks lipolytic actions of tumor necrosis factor-alpha in primary rat adipocytes.

  2008cited by this paper
• Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum

  2008cited by this paper
• Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

  2007cited by this paper
• Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.

  2007cited by this paper
• Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis.

  2007cited by this paper
• Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production

  2007cited by this paper
• Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

  2007cited by this paper
• Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity.

  2007cited by this paper
• C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

  2007cited by this paper
• Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids

  2007cited by this paper
• Macrophage TNF-α contributes to insulin resistance and hepatic steatosis in diet-induced obesity

  2007cited by this paper
• Obesity induces a phenotypic switch in adipose tissue macrophage polarization.

  2007cited by this paper
• Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue

  2007cited by this paper
• Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

  2007cited by this paper
• A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

  2007cited by this paper
• Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue1

  2007cited by this paper
• Adipose tissue macrophages.

  2007cited by this paper
• Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

  2007cited by this paper
• Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

  2007cited by this paper
• Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes.

  2007cited by this paper
• Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

  2006cited by this paper
• Resveratrol improves health and survival of mice on a high-calorie diet

  2006cited by this paper
• Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids

  2006cited by this paper
• Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity

  2006cited by this paper
• Differences in Expression of Cardiovascular Risk Factors among Type 2 Diabetes Mellitus Patients of Different Age

  2006cited by this paper
• Direct Cross-talk of Interleukin-6 and Insulin Signal Transduction via Insulin Receptor Substrate-1 in Skeletal Muscle Cells*

  2006cited by this paper
• TLR4 links innate immunity and fatty acid-induced insulin resistance.

  2006cited by this paper
• CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

  2006cited by this paper
• Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells.

  2006cited by this paper
• Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.

  2006cited by this paper
• MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.

  2006cited by this paper
• Effect of Aging on the Expression of Peroxisome Proliferator-Activated Receptor γ and the Possible Relation to Insulin Resistance

  2006cited by this paper
• Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

  2006cited by this paper
• Pathways leading to muscle insulin resistance – The muscle – fat connection

  2006cited by this paper
• IKK-beta links inflammation to obesity-induced insulin resistance.

  2005cited by this paper
• Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500294-JLR200

  2005cited by this paper
• IKK-β links inflammation to obesity-induced insulin resistance

  2005cited by this paper
• Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling*

  2004cited by this paper
• Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

  2004cited by this paper
• Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.

  2004cited by this paper
• Pioglitazone and sodium salicylate protect human β-cells against apoptosis and impaired function induced by glucose and interleukin-1β

  2004cited by this paper
• Obesity is associated with macrophage accumulation in adipose tissue.

  2003cited by this paper
• Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis.

  2003cited by this paper
• Immunomodulation by Polyunsaturated Fatty Acids: Mechanisms and Effects

  2003cited by this paper
• Age-related inflammatory cytokines and disease.

  2003cited by this paper
• Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

  2002cited by this paper
• Leptin and the regulation of body weight in mammals

  1998cited by this paper
• Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.

  1997cited by this paper
• Protection from obesity-induced insulin resistance in mice lacking TNF-α function

  1997cited by this paper
• IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

  1996cited by this paper
• Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

  1993cited by this paper
• Interleukin-1 (cid:1) -Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

  year unknowncited by this paper
• The FASEB Journal • Research Communication Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects

  year unknowncited by this paper

• Enhancing metabolic syndrome prediction using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography data and machine learning: a comprehensive analysis

  2025cites this paper
• New insight in human sperm pro-survival and pro-apoptotic pathways: potential new therapeutical targets in male infertility.

  2025cites this paper
• The Burden of Weight on Joint Replacement: A 1.6 Million-Patient Analysis of BMI and Hip Arthroplasty Outcomes

  2025cites this paper
• A comprehensive review on the implications of Yogic/Sattvic diet in reducing inflammation in type 2 diabetes

  2025cites this paper
• Glycemic Management of Patients with Hospital Hyperglycemia: A Retrospective Cohort Study on Adults Admitted in the Non-ICU Wards

  2025cites this paper
• Heavy Metals, Gut Microbiota, and Biochemical Markers: Unraveling the Complexities of Obesity

  2025cites this paper
• Revitalizing elixir with orange peel amplification of alginate fish oil beads for enhanced anti-aging efficacy

  2024cites this paper
• Role and mechanism of specialized pro-resolving mediators in obesity-associated insulin resistance

  2024cites this paper
• Blocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis

  2024cites this paper
• Associations of the cardiometabolic index with insulin resistance, prediabetes, and diabetes in U.S. adults: a cross-sectional study

  2024cites this paper
• Subacute Effects of Moderate-Intensity Aerobic Exercise in the Fasted State on Cell Metabolism and Signaling in Sedentary Rats

  2024cites this paper
• In-Vitro and In-Silico Studies of Brevifoliol Ester Analogues against Insulin Resistance Condition.

  2024cites this paper
• Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression

  2024cites this paper
• Metabolic flux analysis in adipose tissue reprogramming

  2024cites this paper
• The effect of long-chain n-3 PUFA on liver transcriptome in human obesity.

  2024cites this paper
• Clinical and Biochemical Parameters in Relation to Serum Fetuin-A Levels in Overweight and Obese with and without Metabolic Syndrome in the North-eastern States of Indian Population

  2024cites this paper
• Antidiabetic Potential of Tea and Its Active Compounds: From Molecular Mechanism to Clinical Evidence.

  2024cites this paper
• Is there a link between obesity phenotype and thyroid diseases? A mini-review of current concepts

  2023cites this paper
• Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial

  2023cites this paper
• Management of Obesity-Related Inflammatory and Cardiovascular Diseases by Medicinal Plants: From Traditional Uses to Therapeutic Targets

  2023cites this paper
• Football training as a non-pharmacological treatment of the global aging population—A topical review

  2023influential citation
• Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice

  2023cites this paper
• Novel Approach for Glycemic Management Incorporating Vibration Stimulation of Skeletal Muscle in Obesity

  2023influential citation
• Bone marrow microenvironment: roles and therapeutic implications in obesity-associated cancer.

  2023cites this paper
• The damaging duo: Obesity and excess dietary salt contribute to hypertension and cardiovascular disease

  2023cites this paper
• Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review

  2022cites this paper
• Analysis of the miRNA expression from the adipose tissue surrounding the adrenal neoplasia

  2022cites this paper
• Ceramide metabolism associated with chronic dietary nutrient surplus and diminished insulin sensitivity in the liver, muscle, and adipose tissue of cattle

  2022cites this paper
• Prevention and Treatment of Obesity-Related Inflammatory Diseases by Edible and Medicinal Plants and Their Active Compounds

  2022cites this paper
• Anti-inflammatory effect of exercise training through reducing inflammasome activation-related inflammatory cytokine levels in overweight/obese populations: A systematic review and meta-analysis.

  2022cites this paper
• Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice

  2022cites this paper
• The Relationships of Fibrinogen and C-Reactive Protein With Gait Performance: A 20-Year Longitudinal Study

  2022cites this paper
• The protective effects of Aster yomena (Kitam.) Honda on high-fat diet-induced obese C57BL/6J mice

  2022cites this paper
• Plasmapheresis in hypertriglyceridemia-induced acute pancreatitis

  2022cites this paper
• Interleukins and redox impairment in type 2 diabetes mellitus: mini-review and pilot study

  2022cites this paper
• Role of potential bioactive metabolites from traditional Chinese medicine for type 2 diabetes mellitus: An overview

  2022cites this paper
• β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway

  2022cites this paper
• Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice

  2022cites this paper
• Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes

  2022cites this paper
• P-cymene prevent high-fat diet-associated colorectal cancer by improving the structure of intestinal flora

  2021cites this paper
• Associations of Obesity with Linear Growth and Puberty

  2021cites this paper
• COVID-19 Infection and Circulating Microparticles—Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel Disease

  2021cites this paper
• Diagnostic efficacy of serum and urinary netrin-1 in the early detection of diabetic nephropathy

  2021cites this paper
• Effect of a combination of aerobic exercise and dietary modification on liver function in overweight and obese men

  2021cites this paper
• Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma

  2021cites this paper
• Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals

  2021influential citation
• Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

  2021cites this paper
• Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation

  2021cites this paper
• Biomedical application of Indole-3-carbinol: A mini-review

  2021cites this paper
• Association between Toxoplasma gondii infection and metabolic syndrome in obese adolescents: A possible immune-metabolic link.

  2021cites this paper
• Microbiota-Host Interactions , Aging and Stress Response : Diagnostic and Therapeutic Applications of the Physiological Fitness

  2021cites this paper
• A scoring system for the preoperative evaluation of prognosis in spinal infection: the MSI-20 Score.

  2021cites this paper
• Host characteristics associated with serologic inflammatory biomarkers in women.

  2021cites this paper
• Dietary Annatto-Extracted Tocotrienol Reduces Inflammation and Oxidative Stress, and Improves Macronutrient Metabolism in Obese Mice: A Metabolic Profiling Study

  2021cites this paper
• Does Losing 5-7% of Prediabetic Body Weight from a Diabetes Prevention Program decrease Cardiovascular Risks?

  2021cites this paper
• Diet-induced obesity differentially modulates cardiac inflammatory status in the C57 and FVB mouse strains.

  2021cites this paper
• Effects of Lactic Acid Bacteria Isolated from Equine on Salmonella-Infected Gut Mouse Model

  2021cites this paper
• MicroRNA Expression Profiles in the Subcutaneous Adipose Tissues of Morbidly Obese Chinese Women

  2021cites this paper
• The role of Wnt pathway in obesity induced inflammation and diabetes: a review

  2021cites this paper
• Prospective study of inflammatory response in patients submitted to abdominoplasty after bariatric surgery

  2021cites this paper
• Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis

  2021cites this paper
• A Combination of Glucagon-Like Peptide-1 Receptor Agonist and Dietary Intervention Could Be a Promising Approach for Obesity Treatment

  2021cites this paper
• The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: Regular physical exercise.

  2021cites this paper
• Sweetpotato Leaves Inhibit Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophages via Suppression of NF-κB Signaling Pathway

  2021cites this paper
• Nonalcoholic fatty liver disease or metabolic dysfunction‐associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches

  2021cites this paper
• Role of Chemerin as a Putative Biomarker of Cardiovascular Risk in Metabolic Syndrome: A Brief Review

  2020cites this paper
• Effects of biscuit fortified with whey protein isolate and wheat bran on weight loss, energy intake, appetite score, and appetite regulating hormones among overweight or obese adults

  2020cites this paper
• Small intestinal bacterial overgrowth and orocecal transit time in patients of nonalcoholic fatty liver disease

  2020cites this paper
• High Fat High Calories Diet (HFD) Increase Gut Susceptibility to Carcinogens by Altering the Gut Microbial Community

  2020cites this paper
• Multigrain Beetroot Crisps: A Healthy Snacking Option

  2020cites this paper
• Insulin Resistance as a Prognostic Indicator in Severe Sepsis, Septic Shock and Multiorgan Dysfunction Syndrome

  2020cites this paper
• Aging, Diabetes, Obesity, and Cognitive Decline: A Population‐Based Study

  2020cites this paper
• Relationship Between Vitamin D Level and Mortality in Adults With Psoriasis: A Retrospective Cohort Study of NHANES Data.

  2020cites this paper
• Blood pool activity on F-18 FDG PET/CT as a possible imaging biomarker of metabolic syndrome

  2020cites this paper
• Purified Gymnemic Acids from Gymnema inodorum Tea Inhibit 3T3-L1 Cell Differentiation into Adipocytes

  2020cites this paper
• Hipotiroidizm, obezite ve depresyon: Zincirin halkaları

  2020cites this paper
• Caulerpa okamurae extract attenuates inflammatory interaction, regulates glucose metabolism and increases insulin sensitivity in 3T3-L1 adipocytes and RAW 264.7 macrophages.

  2020cites this paper
• Interleukin 6, Matrix Metalloproteinase-8 and Tissue Inhibitor-1 Levels in Obesity

  2020cites this paper
• The Other Side of Alzheimer’s Disease: Influence of Metabolic Disorder Features for Novel Diagnostic Biomarkers

  2020cites this paper
• Anti-Inflammatory and Cytotoxicity Effects of Cudrania tricuspidata Fruits Vinegar in a Co-Culture System with RAW264.7 Macrophages and 3T3-L1 Adipocytes

  2020cites this paper
• Renal Changes (Structural and Functional) in The High Fat Diet-Induced Obesity and The Effect of Food Restriction: An Experimental Study

  2020cites this paper
• Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity

  2020cites this paper
• Preceding infection and risk of stroke: An old concept revived by the COVID-19 pandemic

  2020cites this paper
• NOD2 Deficiency Promotes Intestinal CD4+ T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model

  2020cites this paper
• Association of weight change in young adulthood with subsequent risk of hepatocellular carcinoma: a national cohort study.

  2020cites this paper
• Time Course of Changes in Leptin Levels and their Relationships with Oxidant Status Biomarkers in Pregnant Women with Obesity

  2020cites this paper
• Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index.

  2020cites this paper
• Sea buckthorn (Hippophae rhamnoides L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells

  2020cites this paper
• Palmitic acid causes insulin resistance in granulosa cells via activation of JNK.

  2019cites this paper
• KSK19 - novel histamine H3 receptor ligand reduces body weight in diet induced obese mice.

  2019cites this paper
• IKK/NF-κB-regulated Inflammatory Pathway in Human Adipocytes: Implication in Subsequent Contribution to Insulin Resistance and Atherosclerosis

  2019cites this paper
• Effect of Diet on the Gut Microbiota Associated with Obesity

  2019cites this paper
• Thiazolidinediones: the Forgotten Diabetes Medications

  2019cites this paper
• Comparative Proteomic Analysis of Visceral Adipose Tissue in Morbidly Obese and Normal Weight Chinese Women

  2019cites this paper
• Phenolic compounds as natural and multifunctional anti-obesity agents: A review

  2019cites this paper
• Effect of electrical stimulation combined with diet therapy on insulin resistance via mTOR signaling

  2019cites this paper
• Dietary arachidonic acid decreases the expression of transcripts related to adipocyte development and chronic inflammation in the adipose tissue of juvenile grass carp, Ctenopharyngodon idella.

  2019cites this paper
• In vitro tissue-engineered adipose constructs for modeling disease

  2019cites this paper
• Circulating CTRP6 Levels are Increased in Overweight or Obese Chinese Individuals and Associated with Insulin Resistance Parameters: A Pilot Study

  2019cites this paper
• Frequency of insulin resistance in nondiabetic adult Bangladeshi individuals of different obesity phenotypes.

  2019cites this paper