Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 15472206
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

  2004cited by this paper
• Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

  2004cited by this paper
• Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

  2004cited by this paper
• Pioglitazone preserves pancreatic islet structure and insulin secretory function in three murine models of type 2 diabetes.

  2004cited by this paper
• The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

  2003cited by this paper
• Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.

  2003cited by this paper
• Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis.

  2003cited by this paper
• Beta-cell rejuvenation with thiazolidinediones.

  2003cited by this paper
• The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

  2003cited by this paper
• Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

  2003cited by this paper
• Aspirin and diabetes: inhibition of amylin aggregation by nonsteroidal anti-inflammatory drugs.

  2003cited by this paper
• The pharmacokinetics of pioglitazone in patients with impaired renal function.

  2003cited by this paper
• Genetic Engineering of a Suboptimal Islet Graft with A20 Preserves β Cell Mass and Function1

  2003cited by this paper
• Contrasting effects of nateglinide and rosiglitazone on insulin secretion and phospholipase C activation.

  2003cited by this paper
• Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.

  2003cited by this paper
• Protection of Islets by in SituPeptide-mediated Transduction of the IκB Kinase Inhibitor Nemo-binding Domain Peptide*

  2003cited by this paper
• Chronic treatment with the thiazolidinedione, MCC‐555, is associated with reductions in nitric oxide synthase activity and β‐cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat

  2003cited by this paper
• Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

  2002cited by this paper
• Effect of pioglitazone on blood proinsulin levels in patients with type 2 diabetes mellitus.

  2002cited by this paper
• Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function.

  2002cited by this paper
• Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells.

  2002cited by this paper
• Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.

  2002cited by this paper
• The role of PPARs in atherosclerosis.

  2002cited by this paper
• Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes.

  2002cited by this paper
• Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro

  2002cited by this paper
• PPAR-gamma decreases endometrial stromal cell transcription and translation of RANTES in vitro.

  2002cited by this paper
• 17beta-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality.

  2002cited by this paper
• Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.

  2002cited by this paper
• FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication

  2002cited by this paper
• Repression of Glucagon Gene Transcription by Peroxisome Proliferator-activated Receptor γ through Inhibition of Pax6 Transcriptional Activity*

  2002cited by this paper
• Constitutive Activation of Peroxisome Proliferator-activated Receptor-γ Suppresses Pro-inflammatory Adhesion Molecules in Human Vascular Endothelial Cells*

  2002cited by this paper
• Synergistic effects of troglitazone and oleate on the translatability of preproinsulin mRNA from INS-1 cells.

  2002cited by this paper
• Effect of Rosiglitazone on the Differential Expression of Diabetes-associated Proteins in Pancreatic Islets of C57Bl/6 lep/lep Mice*

  2002cited by this paper
• 1,25-dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20.

  2002cited by this paper
• Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.

  2001cited by this paper
• Rosiglitazone (BRL 49653) enhances insulin secretory response via phosphatidylinositol 3-kinase pathway.

  2001cited by this paper
• Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

  2001cited by this paper
• Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death.

  2001cited by this paper
• PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth.

  2001cited by this paper
• The effect of salicylates on insulin sensitivity.

  2001cited by this paper
• Prevention of fat-induced insulin resistance by salicylate.

  2001cited by this paper
• Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets.

  2001cited by this paper
• Expression of a dominant negative inhibitor of NF-kappaB protects MIN6 beta-cells from cytokine-induced apoptosis.

  2001cited by this paper
• beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.

  2001cited by this paper
• Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in normal human pancreatic islet cells.

  2000cited by this paper
• Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor.

  2000cited by this paper
• Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.

  2000cited by this paper
• Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B.

  2000cited by this paper
• Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations.

  2000cited by this paper
• A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor κB–Dependent Gene Activation in Islets

  1999cited by this paper
• Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

  1999cited by this paper
• PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function.

  1999cited by this paper
• Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.

  1999cited by this paper
• Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats.

  1999cited by this paper
• PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

  1998cited by this paper
• Troglitazone (CS-045) inhibits beta-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells.

  1998cited by this paper
• Effect of troglitazone on B cell function, insulin sensitivity, and glycemic control in subjects with type 2 diabetes mellitus.

  1998cited by this paper
• PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.

  1998cited by this paper
• Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats*

  1998cited by this paper
• Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.

  1998cited by this paper
• Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rats

  1998cited by this paper
• Improved Human Islet Isolation Using a New Enzyme Blend, Liberase

  1997cited by this paper
• Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets.

  1997cited by this paper
• Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

  1997cited by this paper
• Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

  1996cited by this paper
• Insulin Secretory Defect in Zucker fa/fa Rats Is Improved by Ameliorating Insulin Resistance

  1995cited by this paper
• An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).

  1995cited by this paper
• Inhibition of NF-kappa B by sodium salicylate and aspirin.

  1994cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of B-cell function by chronic exposure to high glucose.

  1991cited by this paper
• Automated Method for Isolation of Human Pancreatic Islets

  1988cited by this paper
• Receptor-Mediated Adenylate Cyclase—Coupled Mechanism for PGE2 Inhibition of Insulin Secretion in HIT Cells

  1987cited by this paper
• Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

  1982cited by this paper
• Modulation of insulin secretion in normal and diabetic humans by prostaglandin E and sodium salicylate.

  1977cited by this paper
• On the Treatment of Glycosuria and Diabetes Mellitus with Sodium Salicylate

  1901cited by this paper

• Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization

  2024cites this paper
• Effect of pioglitazone on the expression of ubiquitin proteasome system and autophagic proteins in rat pancreas with metabolic syndrome

  2021cites this paper
• Vitamin D Combined with Pioglitazone Mitigates Type-2 Diabetes-induced Hepatic Injury Through Targeting Inflammation, Apoptosis, and Oxidative Stress

  2021cites this paper
• Non-glucose modulators of insulin secretion in healthy humans: (dis)similarities between islet and in vivo studies.

  2021cites this paper
• Pharmacological strategies for insulin sensitivity: thiazolidinediones and metformin.

  2020cites this paper
• Functional loss of pancreatic islets in type 2 diabetes: how can we halt it?

  2020cites this paper
• Cytoprotective effects of olesoxime on isolated human pancreatic islets in order to attenuate apoptotic pathway.

  2019cites this paper
• Thiazolidinediones Cause Cardiotoxicity via PPARγ- Independent Mechanism

  2018cites this paper
• Benzoate and Sorbate Salts: A Systematic Review of the Potential Hazards of These Invaluable Preservatives and the Expanding Spectrum of Clinical Uses for Sodium Benzoate.

  2017cites this paper
• Improving glycemic control in type 2 diabetes : stimulate insulin secretion or provide beta-cell rest ?

  2017cites this paper
• Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action

  2017cites this paper
• IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents

  2017cites this paper
• Improving glycaemic control in type 2 diabetes: Stimulate insulin secretion or provide beta‐cell rest?

  2017cites this paper
• Treatment of Mitochondrial Diabetes with a Peroxisome Proliferator-activated Receptor (PPAR)-gamma Agonist.

  2016cites this paper
• Nicotinamide Mononucleotide in the Context of Elevated Plasma Levels of Free Fatty Acids Improves Glucose Tolerance by Decreasing Insulin Clearance

  2016cites this paper
• Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary

  2016cites this paper
• 5 Pancreatic beta-cell failure in the pathogenesis of type 2 diabetes

  2015cites this paper
• BLX‐1002 restores glucose sensitivity and enhances insulin secretion stimulated by GLP‐1 and sulfonylurea in type 2 diabetic pancreatic islets

  2014cites this paper
• Rosiglitazone, a PPARγ agonist, ameliorates palmitate‐induced insulin resistance and apoptosis in skeletal muscle cells

  2014cites this paper
• Inflammation in type 2 diabetes and the neuroendocrine role of IL-18

  2013cites this paper
• Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes

  2013cites this paper
• Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone

  2013cites this paper
• Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

  2013cites this paper
• Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction

  2013cites this paper
• Effect of Pioglitazone on the Course of New-Onset Type 1 Diabetes Mellitus

  2013cites this paper
• The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions.

  2012cites this paper
• Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes

  2012cites this paper
• Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15.

  2012cites this paper
• Pioglitazone

  2012cites this paper
• Exenatide and Pioglitazone Regulate Fatty Acid-Induced Gene Expression in Normal and Diabetic Human Islets

  2011cites this paper
• Randomized Clinical Trial Assessing the Efficacy and Safety of Bromocriptine-QR when Added to Ongoing Thiazolidinedione Therapy in Patients with Type 2 Diabetes Mellitus

  2011cites this paper
• Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase‐4 inhibitor, and pioglitazone on glycemic control and measures of β‐cell function in patients with type 2 diabetes

  2011cites this paper
• Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes.

  2011cites this paper
• Mechanisms of High Glucose-induced Decrease in β-cell Function

  2011cites this paper
• Radioisotopes in Drug Research and Development: Focus on Positron Emission Tomography

  2011cites this paper
• Mechanism for antioxidative effects of thiazolidinediones in pancreatic β-cells.

  2011cites this paper
• Dual acting and pan-PPAR activators as potential anti-diabetic therapies.

  2011cites this paper
• Which is the eligible patient to be treated with pioglitazone? The expert view

  2011cites this paper
• Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids.

  2010cites this paper
• Acute and Long-term Effects of Peroxisome Proliferator-activated Receptor-γ Activation on the Function and Insulin Secretory Responsiveness of Clonal Beta-Cells

  2010cites this paper
• Cytokines in the Progression of Pancreatic β-Cell Dysfunction

  2010cites this paper
• DPP-4 inhibitors: what may be the clinical differentiators?

  2010cites this paper
• Obesity, Inflammation, and Insulin Resistance – A Mini-Review

  2009cites this paper
• The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men.

  2009cites this paper
• Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment.

  2009cites this paper
• Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment

  2009cites this paper
• Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice

  2009cites this paper
• Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects.

  2009cites this paper
• Molecular mechanism by which pioglitazone preserves pancreatic β-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARγ agonist

  2009cites this paper
• Effect of Salicylate on the Expression of Adipokines and Glucose Transporters in Human Adipocytes is Modulated by Hypoxia

  2009cites this paper
• Inhibition of human insulin gene transcription by peroxisome proliferator‐activated receptor γ and thiazolidinedione oral antidiabetic drugs

  2009cites this paper
• Interleukin-1 beta targeted therapy for type 2 diabetes

  2009cites this paper
• Glimepiride-pioglitazone Hydrochloride in the Treatment of Type 2 Diabetes

  2009cites this paper
• Mechanisms of fatty acid induced decrease in β-cell function.

  2009influential citation
• Protection of pancreatic beta-cells: is it feasible?

  2008cites this paper
• Thrombosis and Inflammation in Intraportal Islet Transplantation: A Review of Pathophysiology and Emerging Therapeutics

  2008cites this paper
• Transcriptional regulation of healthy and diabetic pancreatic beta-cell gene expression

  2008cites this paper
• Thiazolidinediones and the preservation of β‐cell function, cellular proliferation and apoptosis

  2008cites this paper
• Homeostasis Model Assessment (HOMA) as Surrogate Insulinization Criteria in Patients With Type 2 Diabetes

  2008cites this paper
• Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.

  2008cites this paper
• Rosiglitazone prevents diabetes by increasing beta‐cell mass in an animal model of type 2 diabetes characterized by reduced beta‐cell mass at birth

  2008cites this paper
• Preservation of beta-cell function by targeting beta-cell mass.

  2008cites this paper
• Beta cells in type 2 diabetes – a crucial contribution to pathogenesis

  2008cites this paper
• Tumour necrosis factor-alpha-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucose-stimulated Ca2+ influx.

  2008cites this paper
• Differences in insulin sensitivity, pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese and non-obese women

  2008cites this paper
• Islet Inflammation in Type 2 Diabetes

  2008cites this paper
• The vicious cycle of apoptotic β‐cell death in type 1 diabetes

  2007cites this paper
• [Anatomical and functional plasticity of pancreatic beta-cells and type 2 diabetes].

  2007cites this paper
• The vicious cycle of apoptotic beta-cell death in type 1 diabetes.

  2007cites this paper
• [Prevention of type 2 diabetes mellitus: proven and new aspects].

  2007cites this paper
• Pioglitazone plus glimepiride: a promising alternative in metabolic control

  2007cites this paper
• The importance of beta-cell management in type 2 diabetes.

  2007cites this paper
• Effects of Pioglitazone in Combination with Metformin or a Sulfonylurea Compared to a Fixed-Dose Combination of Metformin and Glibenclamide in Patients with Type 2 Diabetes

  2007cites this paper
• Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

  2007cites this paper
• The importance of β‐cell management in type 2 diabetes

  2007cites this paper
• Prävention des Typ-2-Diabetes mellitus: Bewährtes und Neues

  2007cites this paper
• Pioglitazone and sulfonylureas: effectively treating type 2 diabetes

  2007cites this paper
• Influence of Coenzyme Q10 on release of pro‐inflammatory chemokines in the human monocytic cell line THP‐1

  2007influential citation
• Plasticité anatomique et fonctionnelle des cellules β du pancréas endocrine et diabète de type 2

  2007cites this paper
• Pro-Survival Role of Gelsolin in Mouse β-Cells

  2007cites this paper
• beta-cell failure in diabetes and preservation by clinical treatment.

  2007cites this paper
• Pro-survival role of gelsolin in mouse beta-cells.

  2007cites this paper
• Beta-cell preservation with thiazolidinediones.

  2007cites this paper
• The Expanding Role of Oxidative Stress, Renin Angiotensin System, and β-Cell Dysfunction in the Cardiometabolic Syndrome and Type 2 Diabetes Mellitus

  2007cites this paper
• Risk factors for stroke in type 2 diabetes mellitus

  2006cites this paper
• A fixed-dose combination of pioglitazone and metformin:a promising alternative in metabolic control

  2006cites this paper
• Pioglitazone acutely influences glucose-sensitive insulin secretion in normal and diabetic human islets.

  2006cites this paper
• The role of beta-cell dysfunction in the cardiometabolic syndrome.

  2006cites this paper
• Therapeutic approaches to preserve islet mass in type 2 diabetes.

  2006cites this paper
• Relationship Between β-Cell Mass and Fasting Blood Glucose Concentration in Humans

  2006cites this paper
• Insulin sensitizers may prevent metabolic inflammation.

  2006cites this paper
• Would blockage of cytokines improve the outcome of pancreatic islet transplantation?

  2006cites this paper
• Comparison of glycaemic control over 1 year with pioglitazone or gliclazide in patients with Type 2 diabetes

  2006cites this paper
• n-3 fatty acids and gene expression.

  2006cites this paper
• Effects of rosiglitazone and metformin on pancreatic beta cell gene expression

  2006cites this paper
• Metformin and pioglitazone: effectively treating insulin resistance

  2006cites this paper
• Extracellular matrix-induced signaling pathways and pancreatic beta cell survival

  2005cites this paper
• Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

  2005cites this paper
• Endocrine–metabolic effects of the treatment with pioglitazonein obese patients with polycystic ovary syndrome

  2005cites this paper
• Role of histone and transcription factor acetylation in diabetes pathogenesis

  2005cites this paper