Pregnane X Receptor Is a Target of Farnesoid X Receptor*

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Biological Chemistry

• Publication date

  2006-07-14

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1074/jbc.M600116200PMID 16682417
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nuclear receptors and drug disposition gene regulation.

  2005cited by this paper
• The Involvement of the Pregnane X Receptor in Hepatic Gene Regulation during Inflammation in Mice

  2005cited by this paper
• Exercising the nuclear option to treat cholestasis: CAR and PXR ligands

  2005cited by this paper
• The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition*

  2005cited by this paper
• Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

  2005cited by this paper
• Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta.

  2005cited by this paper
• CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

  2005cited by this paper
• Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.

  2005cited by this paper
• Perinatal lipopolysaccharide exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver.

  2005cited by this paper
• The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity*

  2004cited by this paper
• CAR: detailing new models.

  2004cited by this paper
• The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

  2003cited by this paper
• Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes

  2003cited by this paper
• The nuclear pregnane X receptor regulates xenobiotic detoxification.

  2003cited by this paper
• Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression.

  2003cited by this paper
• Hepatocyte nuclear factor 1α: A key mediator of the effect of bile acids on gene expression

  2003cited by this paper
• Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

  2003cited by this paper
• Induction of Drug Metabolism: The Role of Nuclear Receptors

  2003cited by this paper
• Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor*

  2002cited by this paper
• Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

  2002cited by this paper
• Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis

  2002cited by this paper
• Pxr, car and drug metabolism

  2002cited by this paper
• NUBIScan, an in silico approach for prediction of nuclear receptor response elements.

  2002cited by this paper
• Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor.

  2002cited by this paper
• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

  2002cited by this paper
• Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

  2002cited by this paper
• Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis.

  2002cited by this paper
• Redundant pathways for negative feedback regulation of bile acid production.

  2002cited by this paper
• Lithocholic Acid Decreases Expression of Bile Salt Export Pump through Farnesoid X Receptor Antagonist Activity*

  2002cited by this paper
• Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.

  2002cited by this paper
• Characterization of the Human OATP-C (SLC21A6) Gene Promoter and Regulation of Liver-specific OATP Genes by Hepatocyte Nuclear Factor 1α*

  2001cited by this paper
• Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.

  2001cited by this paper
• Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450*

  2001cited by this paper
• Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors.

  2001cited by this paper
• Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

  2001cited by this paper
• The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

  2001cited by this paper
• An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

  2001cited by this paper
• The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

  2001cited by this paper
• Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor*

  2001cited by this paper
• Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.

  2001cited by this paper
• Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin*

  2001cited by this paper
• Phenobarbital response elements of cytochrome P450 genes and nuclear receptors.

  2001cited by this paper
• The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

  2000cited by this paper
• Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research.

  2000cited by this paper
• The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

  2000cited by this paper
• Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor*

  2000cited by this paper
• The effect of rifampin treatment on intestinal expression of human MRP transporters.

  2000cited by this paper
• Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.

  2000cited by this paper
• A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

  2000cited by this paper
• Bile acids: natural ligands for an orphan nuclear receptor.

  1999cited by this paper
• Identification of a nuclear receptor for bile acids.

  1999cited by this paper
• Postnatal ontogeny and hormonal regulation of sulfotransferase SULT1B1 in male and female rats.

  1999cited by this paper
• Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

  1999cited by this paper
• SXR, a novel steroid and xenobiotic-sensing nuclear receptor.

  1998cited by this paper
• An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

  1998cited by this paper
• The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

  1998cited by this paper
• Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.

  1998cited by this paper
• Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse.

  1997cited by this paper
• Stimulation of bile acid 6 alpha-hydroxylation by rifampin.

  1996cited by this paper
• Stimulation of bile acid 6α-hydroxylation by rifampin

  1996cited by this paper
• Sulfotransferase gene expression in primary cultures of rat hepatocytes.

  1996cited by this paper
• Identification of a nuclear receptor that is activated by farnesol metabolites.

  1995cited by this paper
• Differential responses of rat hepatic microsomal carboxylesterase isozymes to glucocorticoids and pregnenolone 16 alpha-carbonitrile.

  1993cited by this paper
• Bile Acid Metabolism and the Pathophysiology of Cholestasis

  1993cited by this paper
• Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.

  1991cited by this paper
• Lithocholic acid-induced cholestasis in newborn rats.

  1983cited by this paper
• Acute cholestasis induced by lithocholic acid in the rat. A freeze-fracture replica and thin section study.

  1975cited by this paper

• Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage

  2025cites this paper
• Impact of Nuclear Receptors on the Control of Bile Acid Metabolism and Synthesis: A Comprehensive Review

  2025cites this paper
• FXR crosstalk with other nuclear receptors

  2025cites this paper
• Targeting farnesoid X receptor as aging intervention therapy

  2025cites this paper
• The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health

  2025cites this paper
• Determination of OTNE-Induced Thyroid Effects within an Adverse Outcome Pathway (AOP) Network.

  2024cites this paper
• Interaction of pregnane X receptor with hypoxia-inducible factor-1 regulates chemoresistance of prostate cancer cells

  2023cites this paper
• RNA-seq transcriptome profiling of pigs’ liver in response to diet with different sources of fatty acids

  2023cites this paper
• Bile acid-mediated signaling in cholestatic liver diseases

  2023cites this paper
• Personalized Risk Assessment of Hepatic Fibrosis after Cholecystectomy in Metabolic-Associated Steatotic Liver Disease: A Machine Learning Approach

  2023cites this paper
• Obeticholic acid alleviates intrauterine growth restriction induced by di-ethyl-hexyl phthalate in pregnant female mice by improving bile acid disorder

  2023influential citation
• The role of pregnane X receptor (PXR) in substance metabolism

  2022cites this paper
• Cooperative Interaction of Phenolic Acids and Flavonoids Contained in Activated Charcoal with Herb Extracts, Involving Cholesterol, Bile Acid, and FXR/PXR Activation in Broilers Fed with Mycotoxin-Containing Diets

  2022cites this paper
• Bile components affect the functions and transcriptome of the rainbow trout intestinal epithelial cell line RTgutGC.

  2022cites this paper
• Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis

  2022influential citation
• Tutorial: Microbiome studies in drug metabolism

  2022cites this paper
• Nuclear Receptor Pathways Mediating the Development of Boar Taint

  2022cites this paper
• Bile acids and their receptors: modulators and therapeutic targets in liver inflammation

  2022cites this paper
• Pregnane X Receptor and the Gut-Liver Axis: A Recent Update

  2021cites this paper
• Overview of bile acid signaling in the cardiovascular system

  2021cites this paper
• Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

  2021cites this paper
• Novel ι-Carrageenan Tetrasaccharide Alleviates Liver Lipid Accumulation via the Bile Acid-FXR-SHP/PXR Pathway to Regulate Cholesterol Conversion and Fatty Acid Metabolism in Insulin-Resistant Mice.

  2021cites this paper
• Bile Acids, Their Receptors, and the Gut Microbiota.

  2021cites this paper
• Effect of Vitamin K-Mediated PXR Activation on Drug-Metabolizing Gene Expression in Human Intestinal Carcinoma LS180 Cell Line

  2021cites this paper
• The Role of Vitamin K in Cholestatic Liver Disease

  2021cites this paper
• Cadmium induced Fak -mediated anoikis activation in kidney via nuclear receptors (AHR/CAR/PXR)-mediated xenobiotic detoxification pathway.

  2021cites this paper
• The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

  2021cites this paper
• Identification of Farnesoid X Receptor as a Novel Nuclear Receptor Sensing for Gallstone Diseases

  2020cites this paper
• Regulation of CAR and PXR Expression in Health and Disease

  2020cites this paper
• Mechanism of Hydrophobic Bile Acid-Induced Hepatocyte Injury and Drug Discovery

  2020cites this paper
• The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice.

  2020cites this paper
• Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease

  2020cites this paper
• Urinary concentrations of phthalate metabolites during gestation and intrahepatic cholestasis of pregnancy: a population-based birth cohort study

  2020cites this paper
• Constitutive Androstane Receptor contributes towards increased drug clearance in cholestasis

  2019cites this paper
• The Biosynthesis, Signaling, and Neurological Functions of Bile Acids

  2019cites this paper
• Reviewing the mechanisms of natural product-drug interactions involving efflux transporters and metabolic enzymes.

  2019cites this paper
• Circadian modulation of genome-wide RXR binding in mouse liver tissue

  2019cites this paper
• Activated FXR promotes xenobiotic metabolism of T-2 toxin and attenuates oxidative stress in broiler chicken liver.

  2019cites this paper
• HEPATIC XENOBIOTIC RECEPTORS IN THE UBIQUITIN-PROTEASOME SYSTEM

  2018influential citation
• Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases

  2018cites this paper
• Drug Response And Metabolism In Crohn's Disease

  2018cites this paper
• Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart

  2018influential citation
• Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1‐mediated deacetylation of FXR and PGC‐1α

  2018cites this paper
• Bile Acids Activated Receptors Regulate Innate Immunity

  2018cites this paper
• 1 Bile Acid Signaling and Cardioprotection 2

  2018influential citation
• β‐Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis

  2018influential citation
• The interrelationship between bile acid and vitamin A homeostasis.

  2017cites this paper
• A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice.

  2017cites this paper
• Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view

  2017cites this paper
• Does Modification of the Large Intestinal Microbiome Contribute to the Anti-Inflammatory Activity of Fermentable Fiber?

  2017cites this paper
• Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage.

  2017cites this paper
• Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

  2016cites this paper
• Effects of Polymorphisms in NR1H4, NR1I2, SLCO1B1, and ABCG2 on the Pharmacokinetics of Rosuvastatin in Healthy Chinese Volunteers

  2016cites this paper
• Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids

  2016cites this paper
• THE ROLE OF PXR AND IKKβ SIGNALING IN CARDIOMETABOLIC DISEASE

  2016influential citation
• Nuclear Receptors in DrugMetabolism , Drug Response and Drug Interactions

  2016cites this paper
• Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.

  2015cites this paper
• Studies on the promiscuous xenobiotic receptor (PXR, NR1I2) in zebrafish: antibody characterisation and genetic variation in zebrafish embryos

  2014influential citation
• Attenuation of anti-tuberculosis therapy induced hepatotoxicity by Spirulina fusiformis, a candidate food supplement

  2014cites this paper
• Developmental Regulation of Phase-I Drug Metabolizing Genes in Mouse Liver

  2014cites this paper
• Farnesoid X receptor and reproduction

  2014cites this paper
• Bile acid receptors as targets for drug development

  2014cites this paper
• Exercise training decreases gene expression of endo- and xeno-sensors in rat small intestine.

  2014cites this paper
• Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis

  2014cites this paper
• Pregnane X receptor and drug-induced liver injury

  2014cites this paper
• Effect of drug transporter pharmacogenetics on cholestasis

  2014cites this paper
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

  2013cites this paper
• Dietary Regulation of Mouse Intestinal P450 Expression and Drug Metabolism

  2013influential citation
• Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s

  2013cites this paper
• Genetic variation in Aldo-keto reductase 1 D 1 ( AKR 1 D 1 ) affects the expression and activity of multiple Cytochrome P 450 s ( CYPs )

  2013cites this paper
• Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury.

  2013influential citation
• Effects of nuclear receptor transactivation on boar taint metabolism and gene expression in porcine hepatocytes.

  2013cites this paper
• Bile acid receptors as targets for drug

  2013cites this paper
• Role of Nuclear Receptors and Their Splice Variants in Regulating Boar Taint Metabolism and Steroidogenesis

  2013cites this paper
• The role of vitamin A in bile acid synthesis and transport and the relevance for cholestatic liver disease

  2013cites this paper
• Nuclear Receptors as Drug Targets in Cholestatic Liver Diseases

  2013cites this paper
• Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence.

  2012cites this paper
• The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin[S]

  2012cites this paper
• Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders.

  2012cites this paper
• Identificación de nuevos genes diana del receptor nuclear FXR

  2012cites this paper
• Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury.

  2012cites this paper
• Transcriptional Regulation of Mouse PXR Gene: An Interplay of Transregulatory Factors

  2012cites this paper
• [Effects of intestinal flora on the expression of cytochrome P450 3A in the liver].

  2012cites this paper
• Role of CAR and PXR in xenobiotic sensing and metabolism

  2012cites this paper
• Evaluation of the in vivo role of p-glycoprotein in the maintenance of cholesterol homeostasis

  2012influential citation
• Marine sponge steroids as nuclear receptor ligands.

  2012cites this paper
• FXR and PXR: potential therapeutic targets in cholestasis.

  2012cites this paper
• The impact of cholesterol and its metabolites on drug metabolism

  2011cites this paper
• SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts

  2011cites this paper
• Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids

  2011cites this paper
• Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA.

  2011cites this paper
• Farnesoid X receptor agonists for primary biliary cirrhosis

  2011cites this paper
• The role of circadian timing system on drug metabolism and detoxification

  2011influential citation
• PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts.

  2011cites this paper
• Nuclear receptor PXR, transcriptional circuits and metabolic relevance.

  2011cites this paper
• Transcriptional Control of Hepatocyte Differentiation

  2011cites this paper
• The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.

  2011cites this paper
• Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha.

  2010cites this paper
• Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment.

  2010cites this paper
• Cytochrome P450 Enzymes

  2010cites this paper