Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator–activated receptor γ coactivator 1α promoter

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Hepatology

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.23927PMID 20890895
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

  2009cited by this paper
• Recent advances in nonalcoholic fatty liver disease

  2009cited by this paper
• Role of mitochondrial dysfunction in insulin resistance.

  2008cited by this paper
• A Decreased Mitochondrial DNA Content Is Related to Insulin Resistance in Adolescents

  2008influential reference
• Fatty Liver: A Novel Component of the Metabolic Syndrome

  2007cited by this paper
• Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies.

  2007cited by this paper
• Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

  2007cited by this paper
• PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

  2006cited by this paper
• Mitochondrial DNA Depletion in Small‐ and Large‐for‐Gestational‐Age Newborns

  2006cited by this paper
• A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.

  2005cited by this paper
• Design and validation of a histological scoring system for nonalcoholic fatty liver disease

  2005influential reference
• Sigmoidal curve-fitting redefines quantitative real-time PCR with the prospective of developing automated high-throughput applications.

  2004cited by this paper
• Transcriptional regulatory circuits controlling mitochondrial biogenesis and function.

  2004cited by this paper
• The ins and outs of mitochondrial dysfunction in NASH.

  2004cited by this paper
• Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data.

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• Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference

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• Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

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• AliBaba2: Context Specific Identification of Transcription Factor Binding Sites

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• MethPrimer: designing primers for methylation PCRs

  2002cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients.

  2001cited by this paper
• Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities.

  2001cited by this paper
• Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions

  1999cited by this paper
• 18 – SAMPLE PREPARATION FROM BLOOD, CELLS, AND OTHER FLUIDS

  1990cited by this paper
• Role of Insulin Resistance in Human Disease

  1988cited by this paper
• Banting lecture 1988. Role of insulin resistance in human disease.

  1988cited by this paper

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