The NLR protein SUMM2 senses the disruption of an immune signaling MAP kinase cascade via CRCK3

No abstract is available for this paper.

• Publication year

  2016

• Venue

  EMBO Reports

• Publication date

  2016-12-16

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.15252/embr.201642704PMID 27986791PMCID PMC5286374
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Effector-triggered immunity: from pathogen perception to robust defense.

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• NLRs in plants.

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  2014influential reference
• Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity.

  2014cited by this paper
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  2012cited by this paper
• Plant pattern recognition receptor complexes at the plasma membrane.

  2012influential reference
• Activation of the Arabidopsis thaliana mitogen-activated protein kinase MPK11 by the flagellin-derived elicitor peptide, flg22.

  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Mitogen-activated protein kinase signaling in plants.

  2010cited by this paper
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  2009cited by this paper
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  2008cited by this paper
• Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases.

  2008cited by this paper
• From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors

  2008cited by this paper
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  2008cited by this paper
• Arabidopsis Mitogen-Activated Protein Kinase Kinases MKK1 and MKK2 Have Overlapping Functions in Defense Signaling Mediated by MEKK1, MPK4, and MKS11[W]

  2008cited by this paper
• Faculty Opinions recommendation of Firefly luciferase complementation imaging assay for protein-protein interactions in plants.

  2008cited by this paper
• The structural basis for activation of plant immunity by bacterial effector protein AvrPto

  2007cited by this paper
• The Phosphothreonine Lyase Activity of a Bacterial Type III Effector Family

  2007cited by this paper
• A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants.

  2007influential reference
• The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants

  2007cited by this paper
• Firefly Luciferase Complementation Imaging Assay for Protein-Protein Interactions in Plants1[C][W][OA]

  2007cited by this paper
• MEKK 1 Is Required for flg 22-Induced MPK 4 Activation in Arabidopsis Plants 1 [ C ] [ W ]

  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
• The plant immune system

  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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• Microbial Elicitors Induce Activation and Dual Phosphorylation of the Arabidopsis thaliana MAPK 6*

  2000influential reference
• Plant disease-resistance proteins and the gene-for-gene concept.

  1998cited by this paper
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  1996cited by this paper
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  2020cites this paper
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