Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.180.2.825PMID 18178821
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Paralysis of CD4(+)CD25(+) regulatory T cell response in chronic autoimmune encephalomyelitis.

  2007cited by this paper
• Control of experimental autoimmune encephalomyelitis by CD4+ suppressor T cells: peripheral versus in situ immunoregulation.

  2007cited by this paper
• Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE

  2007cited by this paper
• MP4- and MOG:35-55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum.

  2007cited by this paper
• Experimental models of multiple sclerosis.

  2007cited by this paper
• A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies.

  2007cited by this paper
• Antigen-Specific Suppression of Experimental Autoimmune Encephalomyelitis by a Novel Bifunctional Peptide Inhibitor

  2007influential reference
• Glatiramer acetate: mechanisms of action in multiple sclerosis.

  2007cited by this paper
• Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities.

  2006influential reference
• CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice.

  2006cited by this paper
• Active induction of experimental allergic encephalomyelitis

  2006cited by this paper
• The immunoregulatory effects of Qa‐1

  2006cited by this paper
• Regulatory T cells

  2006cited by this paper
• Adoptive transfer of myelin basic protein-induced experimental autoimmune encephalomyelitis between SJL and B10.S mice: correlation of priming milieus with susceptibility and resistance phenotypes.

  2006influential reference
• Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells1

  2006cited by this paper
• CD25 regulatory T cells determine secondary but not primary remission in EAE: impact on long-term disease progression.

  2006cited by this paper
• Cutting Edge: CD8+CD122+ Regulatory T Cells Produce IL-10 to Suppress IFN-γ Production and Proliferation of CD8+ T Cells1

  2005cited by this paper
• Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

  2005cited by this paper
• The cytokine signature of MOG-specific CD4 cells in the EAE of C57BL/6 mice.

  2005cited by this paper
• Specificity, magnitude, and kinetics of MOG‐specific CD8+ T cell responses during experimental autoimmune encephalomyelitis

  2005influential reference
• Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis1

  2005cited by this paper
• IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells.

  2004cited by this paper
• Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.

  2004cited by this paper
• Evaluation of a rat model of experimental autoimmune encephalomyelitis with human MBP as antigen.

  2004influential reference
• Studies on the Effect of Calcium in Interactions Between Heparin and Heparin Cofactor II Using Surface Plasmon Resonance

  2004cited by this paper
• An MHC anchor‐substituted analog of myelin oligodendrocyte glycoprotein 35–55 induces IFN‐γ and autoantibodies in the absence of experimental autoimmune encephalomyelitis and optic neuritis

  2004cited by this paper
• Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis

  2004cited by this paper
• Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies.

  2004cited by this paper
• Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls.

  2003cited by this paper
• EncephalomyelitisExperimental Autoimmune System Inflammation During Active Immune Responses and Central Nervous Cells Suppress Antigen-Specific Autoreactive Regulatory T + CD25+ Cutting Edge: CD4

  2002cited by this paper
• The Human T Cell Response to Myelin Oligodendrocyte Glycoprotein: A Multiple Sclerosis Family-Based Study1

  2002cited by this paper
• Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE).

  2001cited by this paper
• Myelin Antigen-Specific CD8+ T Cells Are Encephalitogenic and Produce Severe Disease in C57BL/6 Mice1

  2001cited by this paper
• A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

  2001cited by this paper
• Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis

  1997cited by this paper
• Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis.

  1995cited by this paper
• Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8-/- Mice

  1992cited by this paper
• Role of CD8+ T Cells in Murine Experimental Allergic Encephalomyelitis

  1992cited by this paper
• Experimental Autoimmune Demyelination: Chronic Relapsing Models and Their Therapeutic Implications for Multiple Sclerosis a

  1984cited by this paper

• Autoimmune skin disease pathogenesis: a chronological immune cascade and multi-hit model

  2026cites this paper
• Gzmk+ CD8 T cells in inflammatory diseases

  2025cites this paper
• Regulatory T cells as novel cell-based therapy for ischemic stroke

  2025cites this paper
• Foxp3+CD8+ regulatory T cells: bona fide Tregs with cytotoxic function.

  2025cites this paper
• Integrative genomics and functional immunology reveal Clostridia species as modulators of neuroinflammation in amyotrophic lateral sclerosis

  2025cites this paper
• An angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis

  2024cites this paper
• Dimethyl fumarate modulates the regulatory T cell response in the mesenteric lymph nodes of mice with experimental autoimmune encephalomyelitis

  2024cites this paper
• CD8 + CD103 + iTregs protect against ischemia-reperfusion-induced acute kidney Injury by inhibiting pyroptosis

  2024cites this paper
• Cytokine‐armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells

  2024cites this paper
• CSF1R blockade slows progression of cerebral hemorrhage by reducing microglial proliferation and increasing infiltration of CD8 + CD122+ T cells into the brain.

  2024cites this paper
• Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes

  2024cites this paper
• Upregulation of CD8+ regulatory T cells following liver-directed AAV gene therapy.

  2024cites this paper
• CD8+ Regulatory T Cells Induced by Lipopolysaccharide Improve Mouse Endotoxin Shock

  2023cites this paper
• Study of Effector CD8+ T Cell Interactions with Cortical Neurons in Response to Inflammation in Mouse Brain Slices and Neuronal Cultures

  2023cites this paper
• Extra-islet expression of islet antigen boosts T-cell exhaustion to prevent autoimmune diabetes

  2023cites this paper
• B cells intervention in inflammatory mechanism of ankylosing spondylitis: A visualization analysis for the past 20 years

  2023cites this paper
• Revisiting regulatory T cells for stroke therapy

  2022cites this paper
• The implications of IL-15 trans-presentation on the immune response.

  2022cites this paper
• Low-Dose rIL-15 Protects from Nephrotoxic Serum Nephritis via CD8+ T Cells

  2022cites this paper
• Vaccination with a shared oncogenic tumor-self antigen elicits a population of CD8+ T cells with a regulatory phenotype

  2022cites this paper
• Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice

  2022cites this paper
• The impact of the gut microbiome on extra-intestinal autoimmune diseases

  2022cites this paper
• Members of the Regulatory Lymphocyte Club in Common Variable Immunodeficiency

  2022cites this paper
• CD8+ Tregs revisited: A heterogeneous population with different phenotypes and properties

  2021cites this paper
• Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4+ and CD8+ T Cells

  2021cites this paper
• CD8+ Regulatory T Cell – A Mystery to Be Revealed

  2021cites this paper
• A Functionally Distinct CXCR3+/IFN-γ+/IL-10+ Subset Defines Disease-Suppressive Myelin-Specific CD8 T Cells

  2021cites this paper
• Regulatory T Cells: Concept, Classification, Phenotype, and Biological Characteristics.

  2021cites this paper
• Immune autoregulatory CD8 T cells require IFNγ responsiveness to optimally suppress CNS autoimmunity

  2020cites this paper
• CD8 Treg Cells Inhibit B-Cell Proliferation and Immunoglobulin Production

  2020cites this paper
• Immune Autoregulatory CD8 T Cells Require IFN-γ Responsiveness to Optimally Suppress Central Nervous System Autoimmunity

  2020cites this paper
• In vitro Effects of CD8+ Regulatory T Cells on Human B Cell Subpopulations

  2020cites this paper
• Role of Regulatory Immune Cells and Molecules in Autoimmune Bullous Dermatoses

  2019cites this paper
• Antibody-suppressor CD8+ T cells require CXCR5.

  2019cites this paper
• CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival

  2019cites this paper
• Analysis of the CD8+ IL-10+ T cell response elicited by vaccination with the oncogenic tumor-self protein D52

  2019cites this paper
• The Proportion of Regulatory T Cells in Patients with Ankylosing Spondylitis: A Meta-Analysis

  2019cites this paper
• CD8+CD103+ iTregs Inhibit Chronic Graft-versus-Host Disease with Lupus Nephritis by the Increased Expression of CD39

  2019cites this paper
• Phenotypic Analysis of CD4+ Treg, CD8+ Treg, and Breg Cells in Adult Common Variable Immunodeficiency Patients

  2019cites this paper
• The expanding family of noncanonical regulatory cell subsets

  2019cites this paper
• Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis

  2018cites this paper
• IL‐10 producing CD8+ CD122+ PD‐1+ regulatory T cells are expanded by dendritic cells silenced for Allograft Inflammatory Factor‐1

  2018cites this paper
• Changes and clinical significance of CD8+CD122+ T cells in the peripheral blood of patients with ankylosing spondylitis

  2018cites this paper
• Experimental Autoimmune Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis (MS).

  2018cites this paper
• Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment

  2017cites this paper
• Selective IgM Deficiency—An Underestimated Primary Immunodeficiency

  2017cites this paper
• The Effects of Intestinal Nematode L4 Stage on Mouse Experimental Autoimmune Encephalomyelitis

  2017cites this paper
• Effects of Probiotic Enterococci and Glatiramer Acetate on the Severity of Experimental Allergic Encephalomyelitis in Rats

  2017cites this paper
• Infection with neuroantigen-encoding Listeria: induction of CD8 T cell responses and suppression of demyelinating disease

  2017cites this paper
• Immune-mediated processes in neurodegeneration: where do we stand?

  2016cites this paper
• Effects of Probiotic Enterococci and Glatiramer Acetate on the Severity of Experimental Allergic Encephalomyelitis in Rats

  2016cites this paper
• Pathophysiology of Experimental Autoimmune Encephalomyelitis

  2016cites this paper
• CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity

  2016cites this paper
• The Janus face of immunity : how anti-tumor immunity leads to autoimmunity in paraneoplastic neurological diseases

  2016cites this paper
• Role of Cytokine-Mediated Crosstalk between T Cells and Nonimmune Cells in the Pathophysiology of Multiple Sclerosis

  2016cites this paper
• Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies.

  2016cites this paper
• Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency.

  2016cites this paper
• Sialoadhesin promotes neuroinflammation‐related disease progression in two mouse models of CLN disease

  2016influential citation
• Herbal supplement formula of Elephantopus scaber and Sauropus androgynus promotes IL-2 cytokine production of CD4+T cells in pregnant mice with typhoid fever

  2016cites this paper
• Immune response in peripheral axons delays disease progression in SOD1G93A mice

  2016cites this paper
• CD8+ T-Cells as Immune Regulators of Multiple Sclerosis

  2015cites this paper
• Multiple Sclerosis and T Lymphocytes: An Entangled Story

  2015cites this paper
• Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants

  2015cites this paper
• CD8+CD122+ T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes

  2015influential citation
• The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy

  2015cites this paper
• Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia

  2015cites this paper
• Neurons and T cells: Understanding this interaction for inflammatory neurological diseases

  2015cites this paper
• The Mechanism of Suppression By a Protective Peptide in a Mouse Model of Multiple Sclerosis

  2015cites this paper
• Modulation of Granulocyte Cells Development by VipAlbumin® Administration in BALB/C Mice with Diabetes Mellitus

  2015cites this paper
• the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy

  2015cites this paper
• B Cells Producing Pathogenic Autoantibodies

  2015cites this paper
• SYNERGETIC MODULATION OF T LYMPHOCYTE AND TER119+ CELL USING COMBINATION OF ELEPHANTOPUS SCABER AND POLYSCIAS OBTUSA EXTRACT IN PREGNANT MICE AFTER SALMONELLA TYPHI INFECTION

  2015cites this paper
• TheSharedandContrastingRolesof IL 2 and IL 15 in the Life and Death of Normal and Neoplastic Lymphocytes : Implications for Cancer Therapy

  2015cites this paper
• Regulatory CD8+CD122+ T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells

  2015cites this paper
• Short report Open Access

  2015cites this paper
• Apoptotic Cell-induced Tolerogenic Dendritic Cells Facilitate Development of CD4+ and CD8+ Regulatory T cell Subsets

  2014cites this paper
• IL‐15‐dependent CD8+CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL‐17 production by CD4+ T cells

  2014cites this paper
• A naturally occurring CD8+CD122+ T-cell subset as a memory-like Treg family

  2014cites this paper
• Significance of propolis administration for homeostasis of CD4+CD25+ immunoregulatory T cells controlling hyperglycemia

  2014cites this paper
• Role of CD8+ regulatory T cells in organ transplantation

  2014cites this paper
• T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases

  2014cites this paper
• Neuroantigen-Specific Autoregulatory CD8+ T Cells Inhibit Autoimmune Demyelination through Modulation of Dendritic Cell Function

  2014cites this paper
• A Trichosanthin-derived peptide suppresses type 1 immune responses by TLR2-dependent activation of CD8(+)CD28(-) Tregs.

  2014cites this paper
• Immune regulation of multiple sclerosis by CD8+ T cells

  2014cites this paper
• Interleukin-15 in the treatment of cancer

  2014cites this paper
• From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development.

  2014cites this paper
• Hematopoietic progenitor populations for cell therapy of autoimmune diseases : characterization and comparison of their mechanism of action in Type I Diabetes and Experimental Autoimmune Encephalomyelitis

  2014cites this paper
• ETHANOL EXTRACTS OF PROPOLIS (EEP) AGAINST LYMPHOCYTE ACTIVATION CELLS IN HEALTHY MICE (Mus Musculus) BALB/C

  2014cites this paper
• Les lymphocytes T régulateurs périphériques qui recirculent dans le thymus inhibent le développement de leurs précurseurs

  2014cites this paper
• CD 4 + CD 25 + T cells maintain homeostasis by promoting TER-119 cell development and inhibiting T cell activation

  2014cites this paper
• CD4+CD25+ T cells maintain homeostasis by promoting TER-119 cell development and inhibiting T cell activation

  2014cites this paper
• Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells.

  2014cites this paper
• CD4CD25 T cells maintain homeostasis by promoting TER-119 cell development and inhibiting T cell activation

  2014cites this paper
• Vaccination with the Prostate Cancer Over-Expressed Tumor Self-Protein TPD52 Elicits Protective Tumor Immunity and a Potentially Unique Subset of CD8+ T Cells

  2014cites this paper
• Immune regulation of multiple sclerosis by CD8+ T cells

  2014cites this paper
• Potential roles for CD8(+) T cells in rheumatoid arthritis.

  2013cites this paper
• Aktivitas Imunomodulator Polyscias obtusa Terhadap Sistem Imunitas Pada Bone Marrow Broiler Setelah Pemberian Salmonella typhimurium

  2013cites this paper
• CD8+ T cells in multiple sclerosis

  2013cites this paper
• Ex vivo imaging immune cell interactions in T cell vaccine-induced immunity and CD8+CD25+ T regulatory cell-mediated immune suppression

  2013influential citation
• Phenotype and function of regulatory T cells in Th1- and Th2-mediated inflammatory diseases

  2013cites this paper