Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes

Highlights • Nidoviral RNA signals and protein co-factors control RdRp processivity and fidelity.• The RdRp directs a complex process of replication and subgenomic mRNA synthesis.• A unique N-terminal nucleotidyl transferase is connected to the nidovirus RdRp.• Nidoviral RNA synthesis depends on recruiting host cell factors and infrastructure.• The nidovirus RdRp is an important yet poorly explored antiviral drug target.

• Publication year

  2017

• Venue

  Virus Research

• Publication date

  2017-02-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virusres.2017.01.023PMID 28174054PMCID 7114556
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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