Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neuroscience

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.22-05-01763.2002PMID 11880505PMCID PMC6758858
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum.

  2001cited by this paper
• Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation

  2001influential reference
• Oxidative post‐translational modifications of α‐synuclein in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson's disease

  2001cited by this paper
• Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

  2001influential reference
• The parkinsonian toxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP): a technical review of its utility and safety

  2001influential reference
• Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

  2001influential reference
• Minocycline Reduces Traumatic Brain Injury-mediated Caspase-1 Activation, Tissue Damage, and Neurological Dysfunction

  2001cited by this paper
• The role of glial cells in Parkinson's disease

  2001influential reference
• Minocycline Provides Neuroprotection Against N-Methyl-d-aspartate Neurotoxicity by Inhibiting Microglia1

  2001influential reference
• The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system.

  2000cited by this paper
• Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

  2000cited by this paper
• Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

  2000cited by this paper
• Deficiency of Inducible Nitric Oxide Synthase Protects Against MPTP Toxicity In Vivo

  2000influential reference
• Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model.

  2000cited by this paper
• The parkinsonian toxin MPTP: action and mechanism

  2000influential reference
• FcεRII/CD23 Is Expressed in Parkinson’s Disease and Induces, In Vitro, Production of Nitric Oxide and Tumor Necrosis Factor-α in Glial Cells

  1999cited by this paper
• Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

  1999influential reference
• FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.

  1999cited by this paper
• Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.

  1999cited by this paper
• A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.

  1999influential reference
• Mass Spectrometric Quantification of 3-Nitrotyrosine, ortho-Tyrosine, and o,o′-Dityrosine in Brain Tissue of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Mice, a Model of Oxidative Stress in Parkinson's Disease*

  1999cited by this paper
• Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

  1998cited by this paper
• Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System

  1998cited by this paper
• Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia.

  1998influential reference
• Microglia: a sensor for pathological events in the CNS.

  1996influential reference
• Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

  1996cited by this paper
• A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.

  1996cited by this paper
• Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  1995cited by this paper
• Microglia: intrinsic immuneffector cell of the brain.

  1995cited by this paper
• Cytokines and the nervous system. I: Expression and recognition.

  1995cited by this paper
• Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

  1995cited by this paper
• Cytotoxicity of microglia

  1993influential reference
• Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

  1992cited by this paper
• Early development of levodopa‐induced dyskinesias and response fluctuations in young‐onset Parkinson's disease

  1991cited by this paper
• The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method.

  1991cited by this paper
• Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice.

  1991cited by this paper
• Free Radicals in Biology and Medicine

  1990cited by this paper
• An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats.

  1990cited by this paper
• Biochemical pathophysiology of Parkinson's disease.

  1987cited by this paper
• Mitochondrial and metabolic toxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine.

  1987cited by this paper
• Free radicals in biology and medicine

  1985cited by this paper
• Pharmacotherapeutics of the newer tetracyclines.

  1980cited by this paper
• Parkinsonism

  1967cited by this paper

• Decoding synaptic imbalance in neurodegenerative diseases: From pathological analysis to targeted intervention.

  2026cites this paper
• Minocycline treatment affects astrocyte – microglia – neuron interaction and functional compensation of motor deficits in rat model of combined fluorocitrate and 6-OHDA lesion and early Parkinson’s disease

  2025cites this paper
• Aqueous Extract of Bacopa procumbens and the NAPEL Formulation Mitigate MPTP-Induced Neurotoxicity via Nrf2/HSF1/HIF-1α Signaling in a Parkinson’s Disease Model

  2025cites this paper
• MIF downregulation attenuates neuroinflammation via TLR4/MyD88/TRAF6/NF-κB pathway to protect dopaminergic neurons in Parkinson’s disease model

  2025cites this paper
• The contribution of type-I IFN-mediated neuroinflammation to Parkinson's disease progression

  2025cites this paper
• The role of gasotransmitters in Parkinson's disease: Interplay of nitric oxide, carbon monoxide, and hydrogen sulfide

  2025cites this paper
• TUDCA combined with Syndopa protects the midbrain and gut from MPTP toxicity in a Parkinson’s disease mouse model: Immunohistochemical evidence

  2025cites this paper
• Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage

  2025cites this paper
• Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease.

  2024cites this paper
• TMEM119-positive microglia were increased in the brains of patients with amyotrophic lateral sclerosis.

  2024cites this paper
• The association between age-related macular degeneration and risk of Parkinson disease: A systematic review and meta-analysis

  2024cites this paper
• Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson’s disease

  2024cites this paper
• Octadecaneuropeptide, ODN, Promotes Cell Survival against 6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes

  2024cites this paper
• Lysosomal storage, impaired autophagy and innate immunity in Gaucher and Parkinson's diseases: insights for drug discovery

  2024cites this paper
• A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases

  2024cites this paper
• Roles of Microglia in Neurodegenerative Diseases.

  2024cites this paper
• Cortistatin as a Novel Multimodal Therapy for the Treatment of Parkinson’s Disease

  2024cites this paper
• (Re)building the nervous system: A review of neuron–glia interactions from development to disease

  2024cites this paper
• Immunomodulatory Effects of Clozapine: More Than Just a Side Effect in Schizophrenia

  2023cites this paper
• Activation and polarization of striatal microglia and astrocytes are involved in bradykinesia and allodynia in early-stage parkinsonian mice

  2023cites this paper
• Anti oxidative/neuro-inflammation properties of Withania somnifera root extract on rotenone induced stress in rat brain

  2023cites this paper
• Differentiated Embryo-Chondrocyte Expressed Gene1 and Parkinson’s Disease: New Insights and Therapeutic Perspectives

  2023cites this paper
• Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

  2023cites this paper
• Mitigating neuroinflammation in Parkinson's disease: Exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics.

  2023cites this paper
• Therapeutic potential of Lipid Nanosystems for the treatment of Parkinson's disease: an updated review.

  2023cites this paper
• Structural and Functional Changes in Cerebral Aging

  2023cites this paper
• Minocycline treatment improves cognitive and functional plasticity in a preclinical mouse model of major depressive disorder.

  2023cites this paper
• Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives

  2023cites this paper
• Novel therapeutic approaches to target neurodegeneration

  2023cites this paper
• Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective

  2022cites this paper
• Zebrafish as a potential model for stroke: A comparative study with standardized models.

  2022cites this paper
• New models of Parkinson’s like neuroinflammation in human microglia clone 3: Activation profiles induced by INF-γ plus high glucose and mitochondrial inhibitors

  2022influential citation
• The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment

  2022cites this paper
• Role of caspases, apoptosis and additional factors in pathology of Alzheimer's disease

  2022cites this paper
• Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment

  2022cites this paper
• Neuroinflammation and Autophagy in Parkinson’s Disease—Novel Perspectives

  2022cites this paper
• Regulatory T Cell Therapeutics for Neuroinflammatory Disorders.

  2022cites this paper
• Extracellular alpha-synuclein: Sensors, receptors, and responses.

  2022cites this paper
• GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease.

  2022cites this paper
• Repositioning and development of new treatments for neurodegenerative diseases: Focus on neuroinflammation.

  2022cites this paper
• Immune responses in the Parkinson ’ s disease brain Neurobiology of Disease

  2022cites this paper
• Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound

  2022cites this paper
• Alpha-synuclein/MPP+ mediated activation of NLRP3 inflammasome through microtubule-driven mitochondrial perinuclear transport.

  2022cites this paper
• Freshwater Clam Extract Mitigates Neuroinflammation and Amplifies Neurotrophic Activity of Glia: Insights from In Vitro Model of Neurodegenerative Pathomechanism

  2022cites this paper
• The potential use of tetracyclines in neurodegenerative diseases and the role of nano-based drug delivery systems.

  2022cites this paper
• Challenges of repurposing tetracyclines for the treatment of Alzheimer’s and Parkinson’s disease

  2022cites this paper
• AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System

  2022cites this paper
• Emerging Roles for Aberrant Astrocytic Calcium Signals in Parkinson’s Disease

  2022cites this paper
• Protection of dopaminergic neurons in hemiparkinsonian monkeys by flavouring ingredient glyceryl tribenzoate

  2022cites this paper
• Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease

  2022cites this paper
• The Role of Pathogens and Anti-Infective Agents in Parkinson’s Disease, from Etiology to Therapeutic Implications

  2021influential citation
• Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation

  2021cites this paper
• Disease modifying therapies III: Novel targets.

  2021cites this paper
• The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease

  2021cites this paper
• Pharmacological, Biochemical and Immunological Studies on Protective Effect of Mangiferin in 6-Hydroxydopamine (6-OHDA)-Induced Parkinson’s Disease in Rats

  2021cites this paper
• Interplay among norepinephrine, NOX2, and neuroinflammation: key players in Parkinson’s disease and prime targets for therapies

  2021cites this paper
• Pharmacological, Biochemical and Molecular Investigations in 6-OHDA Induced Parkinson’s Disease Rats on the Protection Benefits of Mangiferin in Behavioral, Inflammatory and Oxidative Biomarkers

  2021cites this paper
• Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy

  2021cites this paper
• Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

  2021cites this paper
• A Characterization of the Effects of Minocycline Treatment During Adolescence on Structural, Metabolic, and Oxidative Stress Parameters in a Maternal Immune Stimulation Model of Neurodevelopmental Brain Disorders

  2021cites this paper
• A Novel Long-Noncoding RNA LncZFAS1 Prevents MPP+-Induced Neuroinflammation Through MIB1 Activation

  2021cites this paper
• Minocycline Mitigation of Tremor Syndrome and Defect of Cognitive and Balance Induced by Harmaline

  2021cites this paper
• Determination of the antibiotic minocycline by integrated optofluidic microstructured polymer optical fiber chemiluminescence

  2021cites this paper
• Dual Roles of Microglia in the Basal Ganglia in Parkinson’s Disease

  2021cites this paper
• Microglial IL-10 and β-endorphin expression mediates gabapentinoids antineuropathic pain.

  2021cites this paper
• Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction

  2021cites this paper
• Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons’ Degeneration: Link to Parkinson’s Disease

  2021cites this paper
• Adipose-derived Mesenchymal Stem Cells Protect Neurons by Inhibiting Microglial In�ammation

  2021cites this paper
• Stroke and immunotherapy: Potential mechanisms and its implications as immune‐therapeutics

  2021cites this paper
• Can tetracyclines ensure help in multiple sclerosis immunotherapy?

  2021cites this paper
• New Avenues for Parkinson’s Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota

  2021cites this paper
• Hyperbaric oxygen therapy restores cognitive function and hippocampal pathologies in both aging and aging-obese rats.

  2021cites this paper
• The cannabinoid system and microglia in health and disease.

  2021cites this paper
• Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism

  2021cites this paper
• Multifaceted Role of Matrix Metalloproteinases in Neurodegenerative Diseases: Pathophysiological and Therapeutic Perspectives

  2021cites this paper
• Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson’s disease

  2021cites this paper
• Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

  2021cites this paper
• Parkinson’s Disease: Can Targeting Inflammation Be an Effective Neuroprotective Strategy?

  2021cites this paper
• Unravelling the role of gut microbiota in Parkinson's disease progression: Pathogenic and therapeutic implications.

  2021cites this paper
• GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis

  2021cites this paper
• Biomarkers and the Role of α-Synuclein in Parkinson’s Disease

  2021cites this paper
• Interferon-γ Involvement in the Neuroinflammation Associated with Parkinson’s Disease and L-DOPA-Induced Dyskinesia

  2021cites this paper
• The role of LRRK2 in interferon gamma-mediated neuronal immune response

  2021cites this paper
• Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression

  2021cites this paper
• The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease

  2021cites this paper
• G-CSF reduces loss of dopaminergic neurons by inhibiting TNF-α and IL-1β in mouse model of Parkinson’s disease

  2021cites this paper
• Translation Imaging in Parkinson’s Disease: Focus on Neuroinflammation

  2020cites this paper
• Remodeling microglia to a protective phenotype in Parkinson's disease?

  2020cites this paper
• Intrathecal injection of Brilliant Blue G, a P2X7 antagonist, attenuates the exercise pressor reflex in rats.

  2020cites this paper
• Genotoxic effect of non-lethal concentrations of minocycline in human glial cell culture.

  2020cites this paper
• Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration

  2020cites this paper
• Stimulation of toll-like receptor 4 downregulates the expression of α7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia.

  2020cites this paper
• Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice.

  2020cites this paper
• Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease

  2020cites this paper
• Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice.

  2020cites this paper
• Minocycline reduces experimental muscle hyperalgesia induced by repeated nerve growth factor injections in humans: A placebo‐controlled double‐blind drug‐crossover study

  2020influential citation
• Microglia and Parkinson's disease: footprints to pathology

  2020cites this paper
• The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease

  2020cites this paper
• Innate and adaptive immune responses in Parkinson's disease.

  2020cites this paper
• Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease

  2020cites this paper