Kinetic amplification of enzyme discrimination.

No abstract is available for this paper.

• Publication year

  1975

• Venue

  Biochimie

• Publication date

  1975-07-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0300-9084(75)80139-8PMID 1182215
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An analysis of replication errors made by a defective T4 DNA polymerase

  2004cited by this paper
• Correction of aminoacylation errors: Evidence for a non significant role of the aminoacyl‐tRNA synthetase catalysed deacylation of aminoacyl‐tRNAs

  1974cited by this paper
• Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.

  1974cited by this paper
• Enzymatic deacylation of methionyl-tRNAfMet catalysed by methionyl, isoleucyl and phenylalanyl-tRNA synthetases.

  1974cited by this paper
• Studies on the biochemical basis of spontaneous mutation. III. Rate model for DNA polymerase-effected nucleotide misincorporation.

  1974cited by this paper
• Studies on the biochemical basis of spontaneous mutation. II. The incorporation of a base and its analogue into DNA by wild-type, mutator and antimutator DNA polymerases.

  1974cited by this paper
• A semi-quantitative treatment of missense and nonsense suppression in the strA and ram ribosomal mutants of Escherichia coli. Evaluation of some molecular parameters of translation in vivo.

  1974cited by this paper
• On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation.

  1973cited by this paper
• Recognition in nucleic acids and the anticodon families.

  1973cited by this paper
• Analog approaches to the structure of the transition state in enzyme reactions

  1972cited by this paper
• Phenylalanyl-tRNA synthetase and isoleucyl-tRNA Phe : a possible verification mechanism for aminoacyl-tRNA.

  1972cited by this paper
• Lack of specificity in the aminoacyl‐tRNA synthetase‐catalysed deacylation of aminoacyl‐tRNA

  1972cited by this paper
• Intrinsic precision of aminoacyl-tRNA synthesis enhanced through parallel systems of ligands.

  1972cited by this paper
• Rapid deacylation by isoleucyl transfer ribonucleic acid synthetase of isoleucine-specific transfer ribonucleic acid aminoacylated with valine.

  1972cited by this paper
• Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

  1972cited by this paper
• Investigation of the transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid.

  1972cited by this paper
• Restriction, de-restriction and mistranslation in missense suppression. Ribosomal discrimination of transfer RNA's.

  1972cited by this paper
• Enzymatic Synthesis of Deoxyribonucleic Acid XXXVI. A PROOFREADING FUNCTION FOR THE 3' → 5' EXONUCLEASE ACTIVITY IN DEOXYRIBONUCLEIC ACID POLYMERASES

  1972cited by this paper
• Enzymatic synthesis of deoxyribonucleic acid. 36. A proofreading function for the 3' leads to 5' exonuclease activity in deoxyribonucleic acid polymerases.

  1972cited by this paper
• Ribosomal discrimination of tRNAs.

  1971cited by this paper
• Ribosomal mutations affecting efficiency of amber suppression.

  1970cited by this paper
• A ribosomal ambiguity mutation.

  1969cited by this paper
• Recognition of tRNA by isoleucyl-tRNA synthetase. Effect of substrates on the dynamics of tRNA-enzyme interaction.

  1969cited by this paper
• An in vitro transversion by a mutationally altered T4-induced DNA polymerase.

  1968cited by this paper
• Antimutagenic DNA polymerases of bacteriophage T4.

  1968cited by this paper
• On the specificity of DNA polymerase.

  1967cited by this paper
• On the role of DNA polymerase in base selection.

  1966cited by this paper
• IDENTIFICATION OF THE ALTERED BASES IN MUTATED SINGLE-STRANDED DNA. II. IN VIVO MUTAGENESIS BY 5-BROMODEOXYURIDINE AND 2-AMINOPURINE.

  1964cited by this paper
• Application of a Theory of Enzyme Specificity to Protein Synthesis.

  1958cited by this paper

• Fluctuation-Response Design Rules for Nonequilibrium Flows.

  2026cites this paper
• Multimolecular proofreading overcomes the activity-fidelity trade-off

  2026influential citation
• Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1

  2025cites this paper
• Mismatched Nucleotide Rejections at the Open and Ajar States of DNA Polymerase I Ensure High Fidelity.

  2025cites this paper
• Adaptive mechanical proofreading toward faithful clonal selection

  2025cites this paper
• Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading

  2025cites this paper
• Spatial Proofreading Amplification of in situ Transcript and Protein Signals

  2025cites this paper
• Thermodynamic limits in far-from-equilibrium molecular templating networks

  2025cites this paper
• Non-enzymatic error correction in self-replicators without extraneous energy supply

  2025cites this paper
• Coarse-graining dynamics to maximize irreversibility

  2025cites this paper
• Spatial statistics of submicron size clusters of activating and inhibitory Natural Killer cell receptors in the resting state regulate early time signal discrimination

  2025cites this paper
• Ecosystems as adaptive living circuits

  2025cites this paper
• Emergent and Convergent Features in the Laboratory Evolution of Polymerase Ribozymes.

  2025cites this paper
• Translation Accuracy in E. coli

  2025cites this paper
• FIRST PASSAGE TIMES TO T CELL ACTIVATION

  2025cites this paper
• Biological Processes as Exploratory Dynamics.

  2025cites this paper
• Many Will Enter, Few Will Win: Cost and Sensitivity of Exploratory Dynamics

  2025cites this paper
• Machinery, mechanism, and information in post-transcription control of gene expression, from the perspective of unstable RNA

  2025cites this paper
• Non-equilibrium strategies enabling ligand specificity by signaling receptors

  2025cites this paper
• Human Protein Synthesis Requires aminoacyl-tRNA Pivoting During Proofreading

  2025cites this paper
• Leveraging mathematical models to predict and control T-cell activation

  2025cites this paper
• Learning the Principles of T Cell Antigen Discernment.

  2025cites this paper
• Many Will Enter, Few Will Win: Cost and Sensitivity of Exploratory Dynamics.

  2025cites this paper
• Why life is hot

  2025cites this paper
• Kinetic mechanisms for the sequence dependence of transcriptional errors

  2025cites this paper
• Life sets off a cascade of machines

  2025cites this paper
• Fast decisions with biophysically constrained gene promoter architectures

  2025cites this paper
• Simulating mono- and multiprotein phosphorylation within nanoclusters.

  2025cites this paper
• Biological Processes as Exploratory Dynamics

  2025cites this paper
• Noisy active matter

  2025cites this paper
• Ecosystems as adaptive living circuits

  2025cites this paper
• Critical lack of equilibrium in stochastic kinetic proofreading

  2025cites this paper
• Magnetic decoupling as a proofreading strategy for high-yield, time-efficient microscale self-assembly.

  2025cites this paper
• Optimal entropic properties of SARS-CoV-2 RNA sequences

  2024cites this paper
• Stochastic thermodynamics for biological functions

  2024cites this paper
• Multiscale Responsive Kinetic Modeling: Quantifying Biomolecular Reaction Flux under Varying Electrochemical Conditions.

  2024cites this paper
• Reliable ligand discrimination in stochastic multistep kinetic proofreading: First passage time vs. product counting strategies

  2024cites this paper
• Kinetic Proofreading Can Enhance Specificity in a Nonenzymatic DNA Strand Displacement Network

  2024cites this paper
• The ribosome comes to life.

  2024cites this paper
• Single-Molecule Imaging Reveals the Mechanism of Bidirectional Replication Initiation in Metazoa

  2024cites this paper
• Understanding the dynamic design of the spliceosome.

  2024cites this paper
• Direct and indirect selection in a proofreading polymerase

  2024cites this paper
• Thermodynamic limits on general far-from-equilibrium molecular templating networks

  2024cites this paper
• Multiscale Responsive Kinetic Modeling: Quantifying Biomolecular Reaction Flux under Varying Electrochemical Conditions

  2024cites this paper
• Linear-Decoupling Enables Accurate Speed and Accuracy Predictions for Copolymerization Processes.

  2024cites this paper
• Ligand induced receptor multimerization achieves the specificity enhancement of kinetic proofreading without associated costs

  2024cites this paper
• The interplay of heterogeneity and product detachment in templated polymer copying.

  2024cites this paper
• Active self-disassembly enhances the yield of self-assembled structures

  2024cites this paper
• A Stochastic Version of the Hopfield-Ninio Kinetic Proofreading Model

  2024cites this paper
• Conformational changes of ribosomes during translation elongation resolved by molecular dynamics simulations.

  2024cites this paper
• Insights into Error Control Mechanisms in Biological Processes: Copolymerization and Enzyme-Kinetics Revisited.

  2024cites this paper
• Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa.

  2024cites this paper
• Trade-offs and thermodynamics of energy-relay proofreading

  2024cites this paper
• Scaling laws of molecular residence time

  2024cites this paper
• Characterizing the detailed balance property by means of measurements in chemical networks

  2024cites this paper
• Dissipation at limited resolutions: power law and detection of hidden dissipative scales

  2024cites this paper
• Nucleosome flipping drives kinetic proofreading and processivity by SWR1

  2024cites this paper
• Specificity, synergy, and mechanisms of splice-modifying drugs

  2024cites this paper
• Characterizing the nonmonotonic behavior of mutual information along biochemical reaction cascades.

  2023cites this paper
• Specificity, synergy, and mechanisms of splice-modifying drugs

  2023cites this paper
• Is stochastic thermodynamics the key to understanding the energy costs of computation?

  2023cites this paper
• Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding

  2023cites this paper
• Description of chemical systems by means of response functions

  2023cites this paper
• Trapping non-cognate nucleotide upon initial binding for replication fidelity control in SARS-CoV-2 RNA dependent RNA polymerase

  2023cites this paper
• The divergence of mutation rates and spectra across the Tree of Life

  2023cites this paper
• Proofreading does not result in more reliable ligand discrimination in receptor signaling due to its inherent stochasticity

  2023cites this paper
• Quantitative modeling of EGF receptor ligand discrimination via internalization proofreading

  2023cites this paper
• Nonequilibrium Antigen Recognition during Infections and Vaccinations

  2023influential citation
• Nonequilibrium Self-Assembly Time Forecasting by the Stochastic Landscape Method

  2023cites this paper
• Immune recognition dynamics of a primary infection

  2023influential citation
• E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.

  2023cites this paper
• Size limits the sensitivity of kinetic schemes

  2023cites this paper
• Cells as the first data scientists

  2023cites this paper
• The tRNA identity landscape for aminoacylation and beyond

  2023cites this paper
• A universal method for analyzing copolymer growth.

  2023cites this paper
• Rapid adaptation of cellular metabolic rate to the MicroRNA complements of mammals and its relevance to the evolution of endothermy

  2023cites this paper
• Avoidance of error catastrophe via proofreading innate to template-directed polymerization

  2023cites this paper
• Proofreading Is Too Noisy For Effective Ligand Discrimination

  2023cites this paper
• The individual and combined benefits of different non-equilibrium proofreading mechanisms

  2023cites this paper
• Synergy among Pausing, Intrinsic Proofreading, and Accessory Proteins Results in Optimal Transcription Speed and Tolerable Accuracy.

  2023cites this paper
• A review paper A review on quality control agents of protein translation- The role of Trans-editing proteins.

  2022cites this paper
• Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity

  2022cites this paper
• The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering

  2022cites this paper
• The Energetics of Activator-Promoter Recognition

  2022cites this paper
• Error-suppression mechanism of PCR by blocker strands

  2022cites this paper
• Competing constraints shape the nonequilibrium limits of cellular decision-making

  2022cites this paper
• Prp43/DHX15 exemplify RNA helicase multifunctionality in the gene expression network

  2022cites this paper
• Pareto optimal fronts of kinetic proofreading

  2022cites this paper
• Kinetic error suppression of PCR

  2022cites this paper
• The optimal strategy balancing risk and speed predicts DNA damage checkpoint override times

  2022cites this paper
• Energy Cost for Flocking of Active Spins: The Cusped Dissipation Maximum at the Flocking Transition.

  2022cites this paper
• Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

  2022cites this paper
• The perception and response of T cells to a changing environment are based on the law of initial value

  2022cites this paper
• Interplay of Energy, Dissipation, and Error in Kinetic Proofreading: Control Via Concentration and Binding Energy

  2021cites this paper
• Genetic code degeneracy is established by the decoding center of the ribosome

  2021cites this paper
• Multiscale kinetic analysis of proteins.

  2021cites this paper
• The Illusions of the Modern Synthesis

  2021cites this paper
• The essence of life revisited: how theories can shed light on it

  2021cites this paper
• The energy cost and optimal design of networks for biological discrimination

  2021cites this paper
• Error Catastrophe Can Be Avoided by Proofreading Innate to Template-Directed Polymerization

  2021cites this paper