The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Developmental Cell

• Publication date

  2014-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.devcel.2014.09.012PMID 25453828PMCID PMC4254555
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fly-FUCCI: A versatile tool for studying cell proliferation in complex tissues.

  2014cited by this paper
• Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling.

  2014cited by this paper
• Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

  2014cited by this paper
• Intestinal stem cells and their defining niche.

  2014cited by this paper
• Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex.

  2014cited by this paper
• The Hippo Signaling Pathway Interactome

  2013cited by this paper
• Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.

  2013influential reference
• A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

  2013cited by this paper
• Trachea-derived dpp controls adult midgut homeostasis in Drosophila.

  2013cited by this paper
• Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration

  2013cited by this paper
• Caspase signalling in the absence of apoptosis drives Jnk‐dependent invasion

  2013cited by this paper
• Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling[S]

  2013cited by this paper
• The UPD3 cytokine couples environmental challenge and intestinal stem cell division through modulation of JAK/STAT signaling in the stem cell microenvironment.

  2013influential reference
• Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract.

  2013cited by this paper
• Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis

  2013cited by this paper
• Identification of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation

  2012cited by this paper
• Autocrine Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) Pathway Activity Controls Intestinal Stem Cell Proliferation in the Adult Drosophila Midgut*

  2012influential reference
• Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Drosophila Intestinal Stem Cell Lineage

  2012cited by this paper
• The hippo pathway.

  2012cited by this paper
• Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells

  2012cited by this paper
• Tissue stem cells: new tools and functional diversity.

  2012cited by this paper
• Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.

  2012cited by this paper
• Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

  2012cited by this paper
• The Par Complex and Integrins Direct Asymmetric Cell Division in Adult Intestinal Stem Cells

  2012cited by this paper
• Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila

  2012cited by this paper
• A Screen for Round Egg Mutants in Drosophila Identifies Tricornered, Furry, and Misshapen as Regulators of Egg Chamber Elongation

  2012influential reference
• Altered modes of stem cell division drive adaptive intestinal growth.

  2011cited by this paper
• Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine

  2011cited by this paper
• A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

  2011cited by this paper
• EGF signaling regulates the proliferation of intestinal stem cells in Drosophila

  2011cited by this paper
• Modulating F‐actin organization induces organ growth by affecting the Hippo pathway

  2011cited by this paper
• Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells

  2011cited by this paper
• Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

  2011cited by this paper
• The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

  2011cited by this paper
• EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells.

  2011cited by this paper
• Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

  2011cited by this paper
• Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway

  2011cited by this paper
• Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells

  2011cited by this paper
• EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila.

  2011cited by this paper
• Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila.

  2011cited by this paper
• Smad inhibition by the Ste20 kinase Misshapen

  2011cited by this paper
• The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

  2011cited by this paper
• Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

  2010cited by this paper
• Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

  2010influential reference
• Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis

  2010cited by this paper
• Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

  2010cited by this paper
• The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila

  2010cited by this paper
• JAK–STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells

  2010cited by this paper
• Characterization of midgut stem cell‐ and enteroblast‐specific Gal4 lines in drosophila

  2010cited by this paper
• The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

  2010influential reference
• JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage.

  2010cited by this paper
• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut.

  2009influential reference
• Tissue damage-induced intestinal stem cell division in Drosophila.

  2009cited by this paper
• Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

  2009cited by this paper
• Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation.

  2009cited by this paper
• Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

  2008cited by this paper
• The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.

  2008cited by this paper
• Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor

  2008cited by this paper
• JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.

  2008cited by this paper
• Bmi1 is expressed in vivo in intestinal stem cells

  2008cited by this paper
• Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation

  2008cited by this paper
• Multipotent Drosophila Intestinal Stem Cells Specify Daughter Cell Fates by Differential Notch Signaling

  2007cited by this paper
• Identification of stem cells in small intestine and colon by marker gene Lgr5

  2007cited by this paper
• The adult Drosophila posterior midgut is maintained by pluripotent stem cells

  2006cited by this paper
• Evidence that stem cells reside in the adult Drosophila midgut epithelium

  2006influential reference
• Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume.

  2006influential reference
• Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila.

  2002influential reference
• Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development.

  2001cited by this paper
• The Drosophila STE20‐like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling

  1999cited by this paper
• The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway.

  1998cited by this paper
• misshapen encodes a protein kinase involved in cell shape control in Drosophila.

  1997influential reference
• Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap.

  1997cited by this paper
• Scholarship at UWindsor Scholarship at UWindsor The Hippo tumor suppressor pathway regulates intestinal stem The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration cell regeneration

  year unknowncited by this paper

• Gut microbiota–mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila

  2025cites this paper
• The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis.

  2025cites this paper
• RIPK4 promotes epidermal differentiation through phase separation and activation of LATS1/2.

  2025cites this paper
• Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology

  2025cites this paper
• Pharmacological regulators of Hippo pathway: Advances and challenges of drug development

  2025cites this paper
• Novel Short Peptides Enhance the Intestinal Barrier to Promote Nutrient Absorption via the JAK-STAT Pathway Based on Transcriptomics and AlphaFold3.

  2025cites this paper
• Regulation of the Intestinal Stem Cell Pool and Proliferation in Drosophila

  2024cites this paper
• Gene therapy for diffuse pleural mesotheliomas in preclinical models by concurrent expression of NF2 and SuperHippo

  2024cites this paper
• Hippo signaling modulation and its biological implications in urological malignancies.

  2024cites this paper
• Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges.

  2024cites this paper
• Hippo pathway in cell–cell communication: emerging roles in development and regeneration

  2024cites this paper
• The Hippo signaling pathway in development and regeneration.

  2024cites this paper
• Hippo-warts-yorkie pathway is crucial for larval survival and shell development in Pacific abalone (Haliotis discus hannai)

  2024cites this paper
• MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer

  2024cites this paper
• Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer

  2024cites this paper
• Advances towards potential cancer therapeutics targeting Hippo signaling.

  2024cites this paper
• Outstretched wing is controlled by intestinal enteroblasts‐derived unpaired 2 cytokine signaling in Drosophila

  2024cites this paper
• Functional annotation of the Hippo pathway somatic mutations in human cancers

  2024cites this paper
• Evolutionary Analysis of the hnRNP Interactomes and Their Functions in Eukaryotes

  2024cites this paper
• Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells

  2023cites this paper
• Two Hippo signaling modules orchestrate liver size and tumorigenesis

  2023cites this paper
• Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development

  2023cites this paper
• Reconstructing the Hippo signaling network.

  2023cites this paper
• The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress.

  2023cites this paper
• Bacillus thuringiensis toxins divert progenitor cells toward enteroendocrine fate by decreasing cell adhesion with intestinal stem cells in Drosophila

  2023cites this paper
• Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging

  2022cites this paper
• MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility

  2022cites this paper
• The Hippo signalling pathway and its implications in human health and diseases

  2022cites this paper
• Tiny Drosophila intestinal stem cells, big power

  2022cites this paper
• Clinical potential of the Hippo-YAP pathway in bladder cancer

  2022cites this paper
• Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides

  2022cites this paper
• The Hippo pathway drives the cellular response to hydrostatic pressure

  2022cites this paper
• Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling

  2022cites this paper
• Cellular mechanisms underlying adult tissue plasticity in Drosophila

  2022cites this paper
• Bacillus thuringiensis Cry1A toxins divert progenitor cell fate toward enteroendocrine lineage by diminishing cell adhesion with intestinal stem cells

  2022cites this paper
• The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1

  2022cites this paper
• The hippo pathway: A master regulator of liver metabolism, regeneration, and disease

  2021cites this paper
• Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View

  2021cites this paper
• An allosteric regulation mechanism of Arabidopsis Serine/Threonine kinase 1 (SIK1) through phosphorylation

  2021cites this paper
• EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

  2021cites this paper
• Hinfp is a guardian of the somatic genome by repressing transposable elements

  2021cites this paper
• Thermal stress induces tissue damage and a broad shift in regenerative signaling pathways in the honey bee digestive tract.

  2021cites this paper
• Cellular feedback dynamics and multilevel regulation driven by the hippo pathway

  2021cites this paper
• Insect Gut Regeneration.

  2021cites this paper
• Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression

  2021cites this paper
• New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges

  2021cites this paper
• Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis

  2021cites this paper
• The Hippo Pathway as a Driver of Select Human Cancers.

  2020cites this paper
• The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway

  2020cites this paper
• The Hippo Pathway in Liver Homeostasis and Pathophysiology.

  2020cites this paper
• Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis

  2020cites this paper
• Lats1/2 Sustain Intestinal Stem Cells through TEAD-Dependent and Independent Transcription

  2020cites this paper
• Research advances in the molecular functions and relevant diseases of TAOKs, novel STE20 kinase family members.

  2020cites this paper
• Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways

  2020cites this paper
• Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut

  2020cites this paper
• Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.

  2020cites this paper
• MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.

  2020cites this paper
• The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila

  2020influential citation
• The Convergence of VEGF-Neuropilin and YAP/TAZ Signaling Promotes Stem-Like Traits and DNA Repair in Breast Cancer

  2019cites this paper
• The Hippo Pathway: Biology and Pathophysiology.

  2019cites this paper
• TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

  2019cites this paper
• JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates

  2019cites this paper
• WW Domain-Containing Proteins YAP and TAZ in the Hippo Pathway as Key Regulators in Stemness Maintenance, Tissue Homeostasis, and Tumorigenesis

  2019cites this paper
• Identification of the kinase STK25 as an upstream activator of LATS signaling

  2019cites this paper
• The Hippo Pathway in Prostate Cancer

  2019cites this paper
• The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium

  2019cites this paper
• Cell contact and Nf2/Merlin-dependent regulation of TEAD palmitoylation and activity

  2019cites this paper
• The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin

  2019cites this paper
• Human Marfan and Marfan-like Syndrome associated mutations lead to altered trafficking of the Type II TGFβ receptor in Caenorhabditis elegans

  2019cites this paper
• Hippo Signaling in Cancer: Lessons From Drosophila Models

  2019cites this paper
• Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila

  2019cites this paper
• Recycling endosomes in mature epithelia restrain tumorigenic signaling.

  2019cites this paper
• The Hippo Signaling Pathway in Development and Disease.

  2019influential citation
• Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration

  2019cites this paper
• Control of cellular responses to mechanical cues through YAP/TAZ regulation

  2019cites this paper
• The Hippo Pathway, YAP/TAZ, and the Plasma Membrane.

  2019cites this paper
• Modulation of hippo pathway by alternative splicing

  2019cites this paper
• Misshapen Connects Food, Mechanosensing, and Intestinal Growth.

  2018cites this paper
• C. elegans models of Marfan and Marfan-like Syndromes reveal trafficking defects of the type II TGFβ receptor as a potential novel disease mechanism

  2018cites this paper
• Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth.

  2018influential citation
• Isoform-specific regulation of Drosophila gut immunity and regeneration by the POU/Oct transcription factor Nub/Pdm1

  2018cites this paper
• Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies

  2018cites this paper
• Identification of STK25 as a direct activator of LATS signaling

  2018cites this paper
• A network of bHLH factors controls self-renewal and bipotential differentiation in the Drosophila intestine

  2018cites this paper
• STK25 directly activates LATS1/2 independent of MST/MAP4Ks

  2018cites this paper
• Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K

  2018cites this paper
• The role of Hippo signal pathway in breast cancer metastasis

  2018cites this paper
• Intravital imaging of metastasis in zebrafish

  2018cites this paper
• The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber.

  2018cites this paper
• Regulation of the Hippo pathway in cancer biology

  2018cites this paper
• Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

  2018cites this paper
• A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster.

  2018cites this paper
• From single cells to tissue self‐organization

  2018cites this paper
• The Hippo Signaling Network and Its Biological Functions.

  2018cites this paper
• Interplay between YAP/TAZ and Metabolism.

  2018cites this paper
• Hippo signaling dysfunction induces cancer cell addiction to YAP

  2018cites this paper
• YAP/TAZ upstream signals and downstream responses

  2018cites this paper
• Activation mechanisms of the Hippo kinase signaling cascade

  2018cites this paper
• VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs.

  2018cites this paper
• The functional characterisation of MOB1-regulated Hippo core cassette kinase signalling

  2017cites this paper