Regulation of the Hippo pathway in cancer biology

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cellular and Molecular Life Sciences

• Publication date

  2018-03-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00018-018-2804-1PMID 29602952PMCID PMC11105795
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ.

  2017cited by this paper
• Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

  2017cited by this paper
• The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells

  2017cited by this paper
• Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway

  2017cited by this paper
• VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

  2017cited by this paper
• Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma.

  2017cited by this paper
• Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

  2017cited by this paper
• Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation.

  2017cited by this paper
• Regulation of the Hippo Pathway Transcription Factor TEAD.

  2017cited by this paper
• Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells

  2017cited by this paper
• Hippo signaling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

  2017cited by this paper
• Dendritic cell MST1 inhibits Th17 differentiation

  2017cited by this paper
• The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

  2017cited by this paper
• Single tumor-initiating cells evade immune clearance by recruiting type II macrophages

  2017cited by this paper
• Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation

  2016cited by this paper
• The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

  2016cited by this paper
• Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

  2016cited by this paper
• New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

  2016cited by this paper
• Phosphorylation by NLK inhibits YAP‐14‐3‐3‐interactions and induces its nuclear localization

  2016cited by this paper
• The Emerging Hallmarks of Cancer Metabolism.

  2016cited by this paper
• Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies

  2016cited by this paper
• Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila.

  2016cited by this paper
• Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations

  2016cited by this paper
• Characterization of Hippo Pathway Components by Gene Inactivation.

  2016cited by this paper
• Autopalmitoylation of TEAD Proteins Regulates Transcriptional Output of Hippo Pathway

  2016cited by this paper
• Mechanisms of Hippo pathway regulation

  2016cited by this paper
• Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP

  2016cited by this paper
• YAP/TAZ at the Roots of Cancer.

  2016cited by this paper
• Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

  2016cited by this paper
• Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.

  2016cited by this paper
• Regulating Rho GTPases and their regulators

  2016cited by this paper
• The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.

  2016cited by this paper
• Aerobic glycolysis tunes YAP/TAZ transcriptional activity

  2015cited by this paper
• The emerging roles of YAP and TAZ in cancer

  2015cited by this paper
• Targeting YAP-dependent MDSC infiltration impairs tumor progression

  2015cited by this paper
• AMPK modulates Hippo pathway activity to regulate energy homeostasis

  2015cited by this paper
• A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

  2015cited by this paper
• The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

  2015cited by this paper
• Alternative Wnt Signaling Activates YAP/TAZ.

  2015cited by this paper
• The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

  2015cited by this paper
• Estrogen regulates Hippo signaling via GPER in breast cancer.

  2015cited by this paper
• Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts.

  2015cited by this paper
• Targeting Hippo pathway by specific interruption of YAP‐TEAD interaction using cyclic YAP‐like peptides

  2015cited by this paper
• Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system

  2015cited by this paper
• Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

  2015cited by this paper
• β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

  2015cited by this paper
• Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila

  2015cited by this paper
• Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade.

  2015cited by this paper
• Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins.

  2015cited by this paper
• Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

  2015cited by this paper
• Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

  2015cited by this paper
• Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells.

  2015cited by this paper
• MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

  2015cited by this paper
• YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.

  2014cited by this paper
• The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.

  2014cited by this paper
• Crumbs promotes expanded recognition and degradation by the SCFSlimb/β-TrCP ubiquitin ligase

  2014cited by this paper
• Metabolic control of YAP and TAZ by the mevalonate pathway

  2014cited by this paper
• Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

  2014cited by this paper
• Faculty Opinions recommendation of Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

  2014cited by this paper
• Cytokinesis failure triggers hippo tumor suppressor pathway activation.

  2014cited by this paper
• Organization and execution of the epithelial polarity programme

  2014cited by this paper
• Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

  2014cited by this paper
• VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

  2014cited by this paper
• Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein.

  2014cited by this paper
• Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.

  2014cited by this paper
• Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration

  2014cited by this paper
• A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer.

  2014cited by this paper
• A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

  2013cited by this paper
• Ajuba Family Proteins Link JNK to Hippo Signaling

  2013cited by this paper
• Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

  2013cited by this paper
• A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

  2013cited by this paper
• Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

  2013cited by this paper
• cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

  2013cited by this paper
• Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma.

  2013cited by this paper
• The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity

  2013cited by this paper
• PTPN14 interacts with and negatively regulates the oncogenic function of YAP

  2013cited by this paper
• Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation.

  2013cited by this paper
• Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics

  2013cited by this paper
• The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.

  2013cited by this paper
• A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity

  2013cited by this paper
• The Hippo Signaling Pathway Interactome

  2013cited by this paper
• Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.

  2012cited by this paper
• Identification of a mechanism that couples multisite phosphorylation of Yes-associated protein (YAP) with transcriptional coactivation and regulation of apoptosis.

  2012cited by this paper
• Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

  2012cited by this paper
• Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs).

  2012cited by this paper
• b-Catenin-Driven Cancers Require a YAP 1 Transcriptional Complex for Survival and Tumorigenesis

  2012cited by this paper
• YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

  2012cited by this paper
• Role of TAZ as mediator of Wnt signaling.

  2012cited by this paper
• Normal Hematopoietic Stem Cell Function in Mice with Enforced Expression of the Hippo Signaling Effector YAP1

  2012cited by this paper
• Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell

  2012cited by this paper
• Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control.

  2012cited by this paper
• Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila

  2012cited by this paper
• Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila

  2012cited by this paper
• Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP.

  2012cited by this paper
• YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

  2012cited by this paper
• PTPN14 is required for the density-dependent control of YAP1.

  2012cited by this paper
• Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

  2012cited by this paper
• A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β‐catenin signalling

  2012cited by this paper
• Identification of Mechanism That Couples Multisite Phosphorylation of Yes-associated Protein (YAP) with Transcriptional Coactivation and Regulation of Apoptosis

  2012cited by this paper
• Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.

  2011cited by this paper

• Control of mitochondrial dynamics by the metabolic regulator dPGC1 limits Yorkie-induced oncogenic growth in Drosophila

  2025cites this paper
• Transcription coactivator YAP1 promotes CCND1/CDK6 expression, stimulating cell proliferation in cloned cattle placentas

  2025cites this paper
• Hippo signaling pathway in cervical cancer: insights into mechanisms and therapeutic potential

  2025cites this paper
• Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond

  2025cites this paper
• Unraveling the Hippo pathway: YAP/TAZ as central players in cancer metastasis and drug resistance

  2025cites this paper
• Alisol A Inhibited Nasopharyngeal Carcinoma Cells by Inhibiting the Hippo Signaling Pathway

  2025cites this paper
• Noncanonical role of Golgi-associated macrophage TAZ in chronic inflammation and tumorigenesis

  2025cites this paper
• Cancer signaling, cell/gene therapy, diagnosis and role of nanobiomaterials

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• Pan-Transcriptional Enhanced Associated Domain Palmitoylation Pocket Covalent Inhibitor.

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• Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities

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• YAP in development and disease: Navigating the regulatory landscape from retina to brain.

  2024cites this paper
• LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization

  2024cites this paper
• TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage

  2023cites this paper
• Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration.

  2023cites this paper
• Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth.

  2023cites this paper
• Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.

  2023cites this paper
• Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors

  2023cites this paper
• Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation.

  2023cites this paper
• Crosstalk between Metabolite Production and Signaling Activity in Breast Cancer

  2023cites this paper
• Leveraging Advanced In Silico Techniques in Early Drug Discovery: A Study of Potent Small-Molecule YAP-TEAD PPI Disruptors

  2023cites this paper
• Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction

  2023cites this paper
• Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule

  2022cites this paper
• Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

  2022cites this paper
• Functions of Yes-association protein (YAP) in cancer progression and anticancer therapy resistance

  2022cites this paper
• Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

  2022cites this paper
• Collagen Modified Anisotropic PLA Scaffold as a base for Peripheral Nerve Regeneration.

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• New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges

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• microRNAs Promoting Growth of Gastric Cancer Xenografts and Correlation to Clinical Prognosis

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• Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development

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• Serine Metabolism Regulates YAP Activity Through USP7 in Colon Cancer

  2021cites this paper
• A Novel miRNA-Based Model Can Predict the Prognosis of Clear Cell Renal Cell Carcinoma

  2021cites this paper
• Hot Spot Analysis of YAP-TEAD Protein-Protein Interaction Using the Fragment Molecular Orbital Method and Its Application for Inhibitor Discovery

  2021cites this paper
• Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation

  2021cites this paper
• Alisol A Inhibited the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells by Inhibiting the Hippo Signaling Pathway

  2021cites this paper
• Deletion of Nf2 in neural crest‐derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region‐ and stage‐specific manner

  2021cites this paper
• Facile discovery of a therapeutic agent for NK-mediated synergistic antitumor effects using a patient-derived 3D platform.

  2021cites this paper
• Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

  2020cites this paper
• Regulation of Hippo signaling pathway in cancer: A MicroRNA perspective.

  2020cites this paper
• Rox8 promotes microRNA-dependent yki messenger RNA decay

  2020cites this paper
• The hippo kinase STK38 ensures functionality of XPO1

  2020cites this paper
• High glypican-1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma

  2020cites this paper
• Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation.

  2020cites this paper
• The potential role of YAP in head and neck squamous cell carcinoma

  2020cites this paper
• Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma

  2020cites this paper
• Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

  2020cites this paper
• The STK38–XPO1 axis, a new actor in physiology and cancer

  2020cites this paper
• regulation-mediated HPV-positive OSCC progression

  2020cites this paper
• Interplay between cancer cells and M2 macrophages is necessary for miR-550a-3-5p down-regulation-mediated HPV-positive OSCC progression

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• MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis

  2020cites this paper
• Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma.

  2020cites this paper
• Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers?

  2020cites this paper
• Polyethylenimine-dextran-coated magnetic nanoparticles loaded with miR-302b suppress osteosarcoma in vitro and in vivo.

  2020cites this paper
• Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells.

  2019cites this paper
• YAPping about and not forgetting TAZ

  2019cites this paper
• The complex entanglement of Hippo-Yap/Taz signaling in tumor immunity

  2019cites this paper
• Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

  2019cites this paper
• ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

  2019cites this paper
• High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.

  2019cites this paper
• Recent Advances of the Hippo/YAP Signaling Pathway in Brain Development and Glioma

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• Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors

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• Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

  2019cites this paper
• Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus

  2019cites this paper
• Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance Induced by Membranous/Cytoplasmic/Nuclear Translocation of Epidermal Growth Factor Receptor.

  2019cites this paper
• Regulation of TEAD Transcription Factors in Cancer Biology

  2019cites this paper
• Hippo Pathway in Mammalian Adaptive Immune System

  2019cites this paper
• A prognostic 3‐long noncoding RNA signature for patients with gastric cancer

  2018cites this paper
• Loss of HACE1 promotes colorectal cancer cell migration via upregulation of YAP1

  2018cites this paper
• The Ambivalent Function of YAP in Apoptosis and Cancer

  2018cites this paper
• The emergence of solid stress as a potent biomechanical marker of tumour progression.

  2018cites this paper