The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.

In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until they reach the target tissue. The ligand on the NP surface recognizes its specific receptor expressed on the target tissue and the drug is released in a controlled manner. However, once injected in a physiological environment, NPs interact with biological components and are surrounded by a protein corona (PC). This can trigger an immune response and affect NP toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the NP-PC interactions and discuss how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.

• Publication year

  2016

• Venue

  Nanomedicine

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.2217/nnm.15.188PMID 26653875PMCID PMC4910943
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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