Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)‐induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP‐induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p‐21 activated kinase 1 (PAK1), and p‐smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP‐induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant‐based interventions screened for cardioprotective effect in ISP‐induced cardiotoxicity, and their probable mechanistic profile is summarized.
Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention
Prince Allawadhi,Amit Khurana,Nilofer Sayed,P. Kumari,C. Godugu
Published 2018 in Phytotherapy Research
ABSTRACT
PUBLICATION RECORD
- Publication year
2018
- Venue
Phytotherapy Research
- Publication date
2018-07-15
- Fields of study
Biology, Medicine, Environmental Science
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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